{"id":"https://openalex.org/W2140640937","doi":"https://doi.org/10.3324/haematol.2008.004572","title":"A polymorphism in NFKB1 is associated with improved effect of interferon- maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support","display_name":"A polymorphism in NFKB1 is associated with improved effect of interferon- maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support","publication_year":2009,"publication_date":"2009-09-01","ids":{"openalex":"https://openalex.org/W2140640937","doi":"https://doi.org/10.3324/haematol.2008.004572","mag":"2140640937","pmid":"https://pubmed.ncbi.nlm.nih.gov/19734419","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2738720"},"language":"en","primary_location":{"id":"doi:10.3324/haematol.2008.004572","doi":"https://doi.org/10.3324/haematol.2008.004572","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2008.004572","pdf_url":"https://haematologica.org/article/download/5350/23622","source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://haematologica.org/article/download/5350/23622","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070696114","display_name":"Annette Juul Vangsted","orcid":"https://orcid.org/0000-0002-2131-731X","observed_orcids":["https://orcid.org/0000-0002-2131-731X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2799546111","display_name":"Roskilde Sygehus","ror":"https://ror.org/00t2n7611","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799546111"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"A. J. Vangsted","raw_affiliation_strings":["Department of Oncology and Haematology, Roskilde Hospital, Copenhagen University, K\u00f8gevej 9-13, Roskilde, Denmark. avag@regionsjaelland.dk","Department of Oncology and Haematology, Roskilde Hospital, Copenhagen University, K\u00f8gevej 9-13, Roskilde, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Haematology, Roskilde Hospital, Copenhagen University, K\u00f8gevej 9-13, Roskilde, Denmark. avag@regionsjaelland.dk","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2799546111"]},{"raw_affiliation_string":"Department of Oncology and Haematology, Roskilde Hospital, Copenhagen University, K\u00f8gevej 9-13, Roskilde, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2799546111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026139263","display_name":"Tobias Wirenfeldt Klausen","orcid":"https://orcid.org/0000-0002-1339-3275","observed_orcids":["https://orcid.org/0000-0002-1339-3275"]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"T. W. Klausen","raw_affiliation_strings":["Dept. of Haematology , University Hospital of Copenhagen at Herlev ;","Copenhagen University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Haematology , University Hospital of Copenhagen at Herlev ;","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"raw_affiliation_string":"Copenhagen University Hospital","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003689547","display_name":"Peter Gimsing","orcid":"https://orcid.org/0000-0002-9403-3860","observed_orcids":["https://orcid.org/0000-0002-9403-3860"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"P. Gimsing","raw_affiliation_strings":["Dept. of Haematology , University Hospital of Copenhagen at Rigshospitalet , Copenhagen ;","Copenhagen University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Haematology , University Hospital of Copenhagen at Rigshospitalet , Copenhagen ;","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]},{"raw_affiliation_string":"Copenhagen University Hospital","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112276617","display_name":"NF Andersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"N. F. Andersen","raw_affiliation_strings":["Dept. of Haematology , Aarhus University Hospital , Aarhus ;","Aarhus University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Haematology , Aarhus University Hospital , Aarhus ;","institution_ids":["https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Aarhus University","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060699933","display_name":"Niels Abildgaard","orcid":"https://orcid.org/0000-0001-6852-2014","observed_orcids":["https://orcid.org/0000-0001-6852-2014"]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"funder","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"N. Abildgaard","raw_affiliation_strings":["Dept. of Haematology , Odense University Hospital , Odense ;","Odense University hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Haematology , Odense University Hospital , Odense ;","institution_ids":["https://openalex.org/I2801498763"]},{"raw_affiliation_string":"Odense University hospital","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060244358","display_name":"Hans N. Gregersen","orcid":"https://orcid.org/0000-0002-5792-2845","observed_orcids":["https://orcid.org/0000-0002-5792-2845"]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"H. Gregersen","raw_affiliation_strings":["Dept. of Haematology , Aalborg University Hospital , Aalborg , and","H\u00e6matologisk Afd. R, THG"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Haematology , Aalborg University Hospital , Aalborg , and","institution_ids":["https://openalex.org/I2799976261"]},{"raw_affiliation_string":"H\u00e6matologisk Afd. R, THG","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016513487","display_name":"Ulla Birgitte Vogel","orcid":"https://orcid.org/0000-0001-6807-1524","observed_orcids":["https://orcid.org/0000-0001-6807-1524"]},"institutions":[{"id":"https://openalex.org/I107707843","display_name":"Roskilde University","ror":"https://ror.org/014axpa37","country_code":"DK","type":"education","lineage":["https://openalex.org/I107707843"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"U. Vogel","raw_affiliation_strings":["National Food Institute , Technical University of Denmark , Copenhagen and Institute for Science, Systems and Models , Roskilde University , Roskilde , Denmark","National Food Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Food Institute , Technical University of Denmark , Copenhagen and Institute for Science, Systems and Models , Roskilde University , Roskilde , Denmark","institution_ids":["https://openalex.org/I107707843","https://openalex.org/I96673099"]},{"raw_affiliation_string":"National Food Institute","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2000,"currency":"EUR","value_usd":2157},"apc_paid":{"value":2000,"currency":"EUR","value_usd":2157},"fwci":2.5568,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.90290951,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"94","issue":"9","first_page":"1274","last_page":"1281"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.9160000085830688},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7960000038146973},{"id":"https://openalex.org/keywords/high-dose-therapy","display_name":"high-dose therapy","score":0.7649999856948853},{"id":"https://openalex.org/keywords/stem-cell-transplantation","display_name":"stem cell transplantation","score":0.781000018119812},{"id":"https://openalex.org/keywords/ppp1r13l","display_name":"PPP1R13L","score":1.0},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7400000095367432},{"id":"https://openalex.org/keywords/time-to-treatment-failure","display_name":"time to treatment failure","score":0.8650000095367432},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6938332319259644},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5984710454940796},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5551943182945251},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47911739349365234},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4754997193813324},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4739435017108917},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3504808843135834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2202254831790924},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18285048007965088},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.17264646291732788},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14000004529953003}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052002","descriptor_name":"NF-kappa B p50 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.3324/haematol.2008.004572","doi":"https://doi.org/10.3324/haematol.2008.004572","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2008.004572","pdf_url":"https://haematologica.org/article/download/5350/23622","source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1876098","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2738720","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2738720","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2738720","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Text"},{"id":"pmid:19734419","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19734419","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Clinical Trial"},{"id":"pmh:oai:doaj.org/article:e510be0ab7a34f98bf0ea7635f943cea","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e510be0ab7a34f98bf0ea7635f943cea","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 94, Iss 9 (2009)","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/4d31b470-746b-11df-928f-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/4d31b470-746b-11df-928f-000ea68e967b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vangsted, A J, Klausen, T W, Gimsing, P, Andersen, N F, Abildgaard, N, Gregersen, H & Vogel, U 2009, 'A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support', Haematologica, vol. 94, no. 9, pp. 1274-81. https://doi.org/10.3324/haematol.2008.004572","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:publications/00898f3f-9c21-4ed1-8164-17e9af62c083","doi":null,"is_oa":false,"landing_page_url":"https://orbit.dtu.dk/en/publications/00898f3f-9c21-4ed1-8164-17e9af62c083","pdf_url":null,"source":{"id":"https://openalex.org/S4306400705","display_name":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I96673099","host_organization_name":"Technical University of Denmark","host_organization_lineage":["https://openalex.org/I96673099"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vangsted , A J , Klausen , T W , Gimsing , P , Andersen , N F , Abildgaard , N , Gregersen , H & Vogel , U B 2009 , ' A polymorphism in NFKB1 is associated with improved effect of interferon-alpha maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support ' , Haematologica , vol. 94 , no. 9 , pp. 1274-1281 . https://doi.org/10.3324/haematol.2008.004572","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:publications/1cd7ce90-dd9e-11de-9e3b-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/1cd7ce90-dd9e-11de-9e3b-000ea68e967b","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vangsted, A J, Klausen, T W, Gimsing, P, Andersen, N F, Abildgaard, N, Gregersen, H & Vogel, U 2009, 'A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support', Haematologica, vol. 94, no. 9, pp. 1274-81. https://doi.org/10.3324/haematol.2008.004572","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.atira.dk:publications/77954260-f93f-11de-89af-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://forskning.ruc.dk/da/publications/77954260-f93f-11de-89af-000ea68e967b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401457","display_name":"RUCforsk (Roskilde University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I107707843","host_organization_name":"Roskilde University","host_organization_lineage":["https://openalex.org/I107707843"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vangsted, A J, Klausen, T W, GimsingD, P, Andersen, N F, Abildgaard, N, Gregersen, H & Vogel, U 2009, 'A polymorphism in NFKB1 is associated with improved effect of interferon-alpha maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support', Haematologica, vol. 94, no. 9, pp. 1274-1281. https://doi.org/10.3324/haematol.2008.004572","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:sdu.dk:openaire_cris_publications/cc760630-001e-11df-aefb-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/cc760630-001e-11df-aefb-000ea68e967b","pdf_url":null,"source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vangsted, A J, Klausen, T W, Gimsing, P, Andersen, N F, Abildgaard, N, Gregersen, H & Vogel, U 2009, 'A polymorphism in NF\u03baB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support', Haematologica, vol. 94, no. 9, pp. 1274-81. https://doi.org/10.3324/haematol.2008.004572","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3324/haematol.2008.004572","doi":"https://doi.org/10.3324/haematol.2008.004572","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2008.004572","pdf_url":"https://haematologica.org/article/download/5350/23622","source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321957","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90"},{"id":"https://openalex.org/F4320324994","display_name":"Kong Christian den Tiendes Fond","ror":"https://ror.org/04rf54t04"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2140640937.pdf","grobid_xml":"https://content.openalex.org/works/W2140640937.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1483653400","https://openalex.org/W1967529642","https://openalex.org/W1976306827","https://openalex.org/W1983520152","https://openalex.org/W1994000551","https://openalex.org/W2010562722","https://openalex.org/W2010737907","https://openalex.org/W2032734113","https://openalex.org/W2043225979","https://openalex.org/W2049877091","https://openalex.org/W2059213807","https://openalex.org/W2089022749","https://openalex.org/W2103565638","https://openalex.org/W2118094114","https://openalex.org/W2127974676","https://openalex.org/W2135788842","https://openalex.org/W2143611358","https://openalex.org/W2146108176","https://openalex.org/W2152333590","https://openalex.org/W2156456343","https://openalex.org/W2163376926","https://openalex.org/W2163479668","https://openalex.org/W2315613727","https://openalex.org/W4235854784","https://openalex.org/W4239981911","https://openalex.org/W7075674808"],"related_works":["https://openalex.org/W7100672840","https://openalex.org/W2030069996","https://openalex.org/W2417228733","https://openalex.org/W2730642895","https://openalex.org/W1971431395","https://openalex.org/W2321441842","https://openalex.org/W1975146567","https://openalex.org/W2471025609","https://openalex.org/W2269407420","https://openalex.org/W2050923834"],"abstract_inverted_index":{"BACKGROUND:":[0],"Maintenance":[1],"therapy":[2,55],"with":[3,8,28,50,64,86,94,114,137,145,228,275],"interferon-alpha":[4,29,65,97,138,154,246,276,284],"after":[5,277],"high-dose":[6,54,278],"treatment":[7,27,89,118,128,164,204,227,247,274,285],"stem":[9],"cell":[10],"support":[11],"in":[12,30,35,131,230,259,286],"multiple":[13,51,269],"myeloma":[14,52,270],"has":[15],"been":[16],"intensively":[17],"debated.":[18],"In":[19,43,150],"this":[20],"study,":[21],"we":[22],"evaluated":[23],"the":[24,71,132,139,151,161,171,193,215,220,235,243,251,257],"response":[25],"to":[26,32,38,88,117,232,288],"relation":[31,287],"genetic":[33],"variation":[34],"genes":[36],"related":[37],"inflammation.":[39],"DESIGN":[40],"AND":[41],"METHODS:":[42],"a":[44,264],"retrospective":[45],"study":[46,282],"of":[47,104,134,153,176,214,219,245,253,283],"296":[48],"patients":[49,61,135,168,233,271],"undergoing":[53],"between":[56,127,160,192],"1994":[57],"and":[58,80,91,95,121,130,163,199,203,256],"2004,":[59],"146":[60],"were":[62],"treated":[63,136],"as":[66],"maintenance":[67,273],"therapy.":[68,279],"We":[69],"tested":[70,126],"polymorphisms":[72,162,194],"IL1B":[73,195],"T-31C,":[74,196],"IL6":[75,177],"G-174C,":[76],"NFKB1-94ins/delATTG,":[77],"CD3EAP":[78,197],"G-21A":[79,198],"PPP1R13L":[81,200],"IVS1":[82,201],"A4364G":[83,202],"for":[84,167,170,206,268],"associations":[85],"time":[87,116],"failure":[90,119],"overall":[92,122,147],"survival":[93,123,148],"without":[96],"treatment.":[98],"RESULTS:":[99],"The":[100],"wild":[101,140,172,216],"type":[102,141,173,217],"ins-allele":[103,142,218],"polymorphism":[105,223,258],"NFKB1-94":[106],"ins/delATTG":[107],"was,":[108],"by":[109],"multivariate":[110],"Cox":[111],"analysis,":[112],"associated":[113,144],"longer":[115,146,181],"(p=0.01)":[120],"(p=0.0084)":[124],"when":[125],"arms":[129],"subgroup":[133],"was":[143,157,189],"(p=0.002).":[149],"absence":[152],"treatment,":[155],"there":[156],"no":[158,190],"association":[159,191],"outcome,":[165],"except":[166],"homozygous":[169,212],"G":[174],"allele":[175,186],"G-174C":[178],"who":[179,210],"survived":[180],"(p=":[182],"0.0074)":[183],"than":[184],"variant":[185,236],"carriers.":[187],"There":[188],"outcome":[205],"interferon-alpha.":[207],"CONCLUSIONS:":[208],"Patients":[209],"are":[211],"carriers":[213],"NFKB1":[221,260,289],"-94ins/delATTG":[222,290],"may":[224,240],"benefit":[225],"from":[226],"interferon-alpha,":[229],"contrast":[231],"carrying":[234],"allele.":[237],"This":[238],"result":[239],"indicate":[241],"that":[242],"effect":[244],"is":[248,291],"dependent":[249],"on":[250,272],"availability":[252],"nuclear":[254],"factor-kappaB":[255],"may,":[261],"therefore,":[262],"be":[263],"good":[265],"prognostic":[266],"marker":[267],"A":[280],"prospective":[281],"highly":[292],"warranted.":[293]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}