{"id":"https://openalex.org/W2140544523","doi":null,"title":"Radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells in culture transduced with cytosine deaminase gene.","display_name":"Radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells in culture transduced with cytosine deaminase gene.","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2140544523","mag":"2140544523","pmid":"https://pubmed.ncbi.nlm.nih.gov/9816090"},"language":"en","primary_location":{"id":"pmid:9816090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9816090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048269624","display_name":"Mark S. Khil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M S Khil","raw_affiliation_strings":["Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan 48202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan 48202, USA","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100649967","display_name":"Jae Ho Kim","orcid":"https://orcid.org/0000-0003-4323-4790","observed_orcids":["https://orcid.org/0000-0003-4323-4790"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J H Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108438484","display_name":"Craig A. Mullen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C A Mullen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081294081","display_name":"Sang Hie Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S H Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037922132","display_name":"Svend O. Freytag","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S O Freytag","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":12.8537,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.99264337,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2","issue":"1","first_page":"53","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.5449000000953674,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.5449000000953674,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.22380000352859497,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.12330000102519989,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.9800000190734863},{"id":"https://openalex.org/keywords/5-fluorocytosine","display_name":"5-fluorocytosine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cytosine-deaminase","display_name":"cytosine deaminase","score":0.949999988079071},{"id":"https://openalex.org/keywords/suicide-gene-therapy","display_name":"suicide gene therapy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9760000109672546},{"id":"https://openalex.org/keywords/radiation-dose-enhancement","display_name":"radiation enhancement","score":0.6489999890327454},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9539999961853027},{"id":"https://openalex.org/keywords/retroviral-gene-transfer","display_name":"retroviral gene transfer","score":0.8610000014305115},{"id":"https://openalex.org/keywords/radiation-induced-cytotoxicity","display_name":"radiation-induced cytotoxicity","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2777748644","wikidata":"https://www.wikidata.org/wiki/Q5201383","display_name":"Cytosine deaminase","level":4,"score":0.9581177830696106},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7092374563217163},{"id":"https://openalex.org/C34981463","wikidata":"https://www.wikidata.org/wiki/Q3311663","display_name":"Suicide gene","level":4,"score":0.6132553219795227},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5876122117042542},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.5710862874984741},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4359472393989563},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41110509634017944},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33745551109313965},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.313579261302948},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.2995428442955017},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2698330283164978},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21073582768440247},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0980733335018158},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07570666074752808}],"mesh":[{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005437","descriptor_name":"Flucytosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009700","descriptor_name":"Nucleoside Deaminases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043525","descriptor_name":"Cytosine Deaminase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9816090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9816090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2140544523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9816090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3706309078","display_name":"COMBINED BRACHYTHERAPY AND HYPERTHERMIA","funder_award_id":"R01CA053114","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W31619819","https://openalex.org/W1536466995","https://openalex.org/W1577834808","https://openalex.org/W1580759730","https://openalex.org/W1601525817","https://openalex.org/W1639883523","https://openalex.org/W1976579475","https://openalex.org/W1979984946","https://openalex.org/W1989012267","https://openalex.org/W2015445088","https://openalex.org/W2015481819","https://openalex.org/W2017593380","https://openalex.org/W2022179776","https://openalex.org/W2025505666","https://openalex.org/W2028354865","https://openalex.org/W2038925947","https://openalex.org/W2041783096","https://openalex.org/W2049266649","https://openalex.org/W2059533489","https://openalex.org/W2072785474","https://openalex.org/W2072910910","https://openalex.org/W2095507740","https://openalex.org/W2104722366","https://openalex.org/W2113534698","https://openalex.org/W2131728068","https://openalex.org/W2185148317","https://openalex.org/W2297979680"],"related_works":["https://openalex.org/W2135913770","https://openalex.org/W2130161106","https://openalex.org/W1715378727","https://openalex.org/W2405239201","https://openalex.org/W2329301926","https://openalex.org/W3029349054","https://openalex.org/W2382130535","https://openalex.org/W2128917900","https://openalex.org/W2093464046","https://openalex.org/W1592976438"],"abstract_inverted_index":{"Recently,":[0],"use":[1],"of":[2,15,34,61,75,86,100,148,164,172,179],"the":[3,32,45,54,69,84,97,106,114,162,169,177],"suicide":[4,63],"gene,":[5],"cytosine":[6],"deaminase":[7],"(CD),":[8],"has":[9],"shown":[10],"a":[11,41,72,79],"selective":[12],"antitumor":[13],"activity":[14],"5-fluorocytosine":[16],"(5-FC)":[17],"on":[18,68],"human":[19,35,101],"colorectal":[20,36,102,182],"carcinoma":[21,37,103,110],"cells":[22,38,104,111,126],"grown":[23],"in":[24,27],"vitro":[25],"and":[26,88],"vivo.":[28],"We":[29],"hypothesized":[30],"that":[31,71,154,161],"radiosensitivity":[33],"transduced":[39,112],"with":[40,113,124,156],"retroviral":[42],"vector":[43],"encoding":[44],"bacterial":[46],"CD":[47,107,115,173],"gene":[48,64,116,174],"would":[49,166],"be":[50],"selectively":[51,96],"enhanced":[52],"by":[53],"nontoxic":[55],"prodrug":[56],"5-FC.":[57],"The":[58,140],"radiobiological":[59],"rationale":[60],"using":[62],"therapy":[65,175],"is":[66,78,151],"based":[67],"fact":[70],"toxic":[73],"metabolite":[74],"5-FC,":[76],"5-fluorouracil,":[77],"well-known":[80],"radiation":[81,98,122,149,165],"enhancer":[82],"for":[83,134,176],"treatment":[85,178],"gastrointestinal":[87],"other":[89],"tumors.":[90],"5-FC":[91,133],"was":[92,144],"found":[93],"to":[94,121,130,138,153],"enhance":[95],"cytotoxicity":[99],"expressing":[105],"gene.":[108],"Colorectal":[109],"(WiDr-CD)":[117],"were":[118],"highly":[119],"sensitive":[120],"compared":[123],"parental":[125],"(WiDr)":[127],"when":[128],"exposed":[129],"20":[131],"microgram/ml":[132],"72":[135],"h":[136],"prior":[137],"irradiation.":[139],"sensitization":[141],"enhancement":[142,150],"ratio":[143],"2.38.":[145],"This":[146],"magnitude":[147],"comparable":[152],"obtained":[155],"5-fluorouracil.":[157],"These":[158],"results":[159],"suggest":[160],"addition":[163],"substantially":[167],"improve":[168],"therapeutic":[170],"potential":[171],"locally":[180],"advanced":[181],"carcinomas.":[183]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
