{"id":"https://openalex.org/W2140492017","doi":"https://doi.org/10.1016/j.ejcts.2005.12.025","title":"The evidence on the effectiveness of management for malignant pleural effusion: a systematic review","display_name":"The evidence on the effectiveness of management for malignant pleural effusion: a systematic review","publication_year":2006,"publication_date":"2006-04-13","ids":{"openalex":"https://openalex.org/W2140492017","doi":"https://doi.org/10.1016/j.ejcts.2005.12.025","mag":"2140492017","pmid":"https://pubmed.ncbi.nlm.nih.gov/16626967"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejcts.2005.12.025","doi":"https://doi.org/10.1016/j.ejcts.2005.12.025","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejcts.2005.12.025","pdf_url":null,"source":{"id":"https://openalex.org/S10542796","display_name":"European Journal of Cardio-Thoracic Surgery","issn_l":"1010-7940","issn":["1010-7940","1873-734X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cardio-Thoracic Surgery","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2140492017"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112624762","display_name":"Carol Hui Chen Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carol Tan","raw_affiliation_strings":["Thoracic Unit, Guy's Hospital, St Thomas' Street, London SE1 9RT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Unit, Guy's Hospital, St Thomas' Street, London SE1 9RT, United Kingdom","institution_ids":["https://openalex.org/I1298207432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065244771","display_name":"Artyom Sedrakyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I82994568","display_name":"Agency for Healthcare Research and Quality","ror":"https://ror.org/03jmfdf59","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I82994568"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Artyom Sedrakyan","raw_affiliation_strings":["b Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, MD, USA","Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"b Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, MD, USA","institution_ids":["https://openalex.org/I82994568"]},{"raw_affiliation_string":"Center for Outcomes and Evidence, Agency for Healthcare Research and Quality, Rockville, MD, USA","institution_ids":["https://openalex.org/I82994568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004460967","display_name":"John Patrick Browne","orcid":"https://orcid.org/0000-0003-3494-4336","observed_orcids":["https://orcid.org/0000-0003-3494-4336"]},"institutions":[{"id":"https://openalex.org/I14746517","display_name":"Royal College of Surgeons of England","ror":"https://ror.org/02qrg5a24","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I14746517"]},{"id":"https://openalex.org/I4210089966","display_name":"London School of Hygiene & Tropical Medicine","ror":"https://ror.org/00a0jsq62","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210089966"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Browne","raw_affiliation_strings":["c Clinical Effectiveness Unit, Royal College of Surgeons of England, Keppel Street, London WC1E 7HT, United Kingdom","d Health Services Research Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom","Clinical Effectiveness Unit, Royal College of Surgeons of England, Keppel Street, London WC1E 7HT, United Kingdom","Health Services Research Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"c Clinical Effectiveness Unit, Royal College of Surgeons of England, Keppel Street, London WC1E 7HT, United Kingdom","institution_ids":["https://openalex.org/I14746517"]},{"raw_affiliation_string":"d Health Services Research Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom","institution_ids":["https://openalex.org/I4210089966"]},{"raw_affiliation_string":"Clinical Effectiveness Unit, Royal College of Surgeons of England, Keppel Street, London WC1E 7HT, United Kingdom","institution_ids":["https://openalex.org/I14746517"]},{"raw_affiliation_string":"Health Services Research Unit, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom","institution_ids":["https://openalex.org/I4210089966"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Simon Swift","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon Swift","raw_affiliation_strings":["a Thoracic Unit, Guy's Hospital, St Thomas\u2019 Street, London SE1 9RT, United Kingdom","Thoracic Unit, Guy's Hospital, St Thomas\u2019 Street, London SE1 9RT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Thoracic Unit, Guy's Hospital, St Thomas\u2019 Street, London SE1 9RT, United Kingdom","institution_ids":["https://openalex.org/I1298207432"]},{"raw_affiliation_string":"Thoracic Unit, Guy's Hospital, St Thomas\u2019 Street, London SE1 9RT, United Kingdom","institution_ids":["https://openalex.org/I1298207432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075833287","display_name":"Tom Treasure","orcid":"https://orcid.org/0000-0001-9358-7610","observed_orcids":["https://orcid.org/0000-0001-9358-7610"]},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Tom Treasure","raw_affiliation_strings":["a Thoracic Unit, Guy's Hospital, St Thomas\u2019 Street, London SE1 9RT, United Kingdom","Thoracic Unit, Guy's Hospital, St Thomas\u2019 Street, London SE1 9RT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a Thoracic Unit, Guy's Hospital, St Thomas\u2019 Street, London SE1 9RT, United Kingdom","institution_ids":["https://openalex.org/I1298207432"]},{"raw_affiliation_string":"Thoracic Unit, Guy's Hospital, St Thomas\u2019 Street, London SE1 9RT, United Kingdom","institution_ids":["https://openalex.org/I1298207432"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5075833287"],"corresponding_institution_ids":["https://openalex.org/I1298207432"],"apc_list":{"value":3273,"currency":"EUR","value_usd":3699},"apc_paid":null,"fwci":11.3596,"has_fulltext":false,"cited_by_count":265,"citation_normalized_percentile":{"value":0.98660061,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"29","issue":"5","first_page":"829","last_page":"838"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11356","display_name":"Pleural and Pulmonary Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11356","display_name":"Pleural and Pulmonary Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12291","display_name":"Pericarditis and Cardiac Tamponade","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-pleural-effusion","display_name":"malignant pleural effusion","score":1.0},{"id":"https://openalex.org/keywords/pleurodesis","display_name":"pleurodesis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/talc-pleurodesis","display_name":"talc pleurodesis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tetracycline","display_name":"tetracycline","score":0.996999979019165},{"id":"https://openalex.org/keywords/doxycycline","display_name":"doxycycline","score":0.9440000057220459},{"id":"https://openalex.org/keywords/talc-slurry","display_name":"talc slurry","score":0.7379999756813049},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.4490000009536743},{"id":"https://openalex.org/keywords/sclerosing-agents","display_name":"sclerosing agents","score":0.9380000233650208},{"id":"https://openalex.org/keywords/chest-tube-drainage","display_name":"chest tube drainage","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9071167707443237},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6348404884338379},{"id":"https://openalex.org/C2776232967","wikidata":"https://www.wikidata.org/wiki/Q6743514","display_name":"Malignant pleural effusion","level":3,"score":0.6204065084457397},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.5617912411689758},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4924848973751068},{"id":"https://openalex.org/C2771230","wikidata":"https://www.wikidata.org/wiki/Q4926699","display_name":"Blinding","level":3,"score":0.4454871416091919},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.4440832734107971},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4211598038673401},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.4123797118663788},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3745018243789673},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3526283800601959},{"id":"https://openalex.org/C2779634585","wikidata":"https://www.wikidata.org/wiki/Q1334541","display_name":"Pleural effusion","level":2,"score":0.30646929144859314},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.13635164499282837},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.08214089274406433},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004322","descriptor_name":"Drainage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013627","descriptor_name":"Talc","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015505","descriptor_name":"Chest Tubes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016066","descriptor_name":"Pleural Effusion, Malignant","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018700","descriptor_name":"Pleurodesis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020775","descriptor_name":"Thoracic Surgery, Video-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ejcts.2005.12.025","doi":"https://doi.org/10.1016/j.ejcts.2005.12.025","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejcts.2005.12.025","pdf_url":null,"source":{"id":"https://openalex.org/S10542796","display_name":"European Journal of Cardio-Thoracic Surgery","issn_l":"1010-7940","issn":["1010-7940","1873-734X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cardio-Thoracic Surgery","raw_type":"journal-article"},{"id":"pmid:16626967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16626967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.904.1770","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.904.1770","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ejcts.oxfordjournals.org/content/29/5/829.full.pdf","raw_type":"text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:131249","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/131249/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EUR J CARDIO-THORAC , 29 (5) 829 - 838. (2006)","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W30194346","https://openalex.org/W69346907","https://openalex.org/W72424563","https://openalex.org/W78417213","https://openalex.org/W1176852014","https://openalex.org/W1972823712","https://openalex.org/W1978133890","https://openalex.org/W1980416444","https://openalex.org/W1983642113","https://openalex.org/W1986215651","https://openalex.org/W1999072139","https://openalex.org/W2005019801","https://openalex.org/W2005075629","https://openalex.org/W2008055202","https://openalex.org/W2009072388","https://openalex.org/W2010228388","https://openalex.org/W2024975737","https://openalex.org/W2027733234","https://openalex.org/W2032356019","https://openalex.org/W2033956520","https://openalex.org/W2041509625","https://openalex.org/W2043354391","https://openalex.org/W2047715444","https://openalex.org/W2057634381","https://openalex.org/W2060027395","https://openalex.org/W2061498303","https://openalex.org/W2064643711","https://openalex.org/W2065748995","https://openalex.org/W2066337858","https://openalex.org/W2070628893","https://openalex.org/W2071865925","https://openalex.org/W2079860110","https://openalex.org/W2081121342","https://openalex.org/W2081224879","https://openalex.org/W2081974763","https://openalex.org/W2083835836","https://openalex.org/W2088026510","https://openalex.org/W2089417017","https://openalex.org/W2089877453","https://openalex.org/W2091716234","https://openalex.org/W2095811360","https://openalex.org/W2098354020","https://openalex.org/W2099981238","https://openalex.org/W2104634690","https://openalex.org/W2107430714","https://openalex.org/W2111204719","https://openalex.org/W2111247389","https://openalex.org/W2112615776","https://openalex.org/W2113506115","https://openalex.org/W2113719548","https://openalex.org/W2113893442","https://openalex.org/W2115734727","https://openalex.org/W2117806609","https://openalex.org/W2125370548","https://openalex.org/W2134944951","https://openalex.org/W2147481343","https://openalex.org/W2153605863","https://openalex.org/W2155027589","https://openalex.org/W2160591064","https://openalex.org/W2160881227","https://openalex.org/W2162615148","https://openalex.org/W2163561981","https://openalex.org/W2167642171","https://openalex.org/W2168283935","https://openalex.org/W2170286582","https://openalex.org/W2260624763","https://openalex.org/W2368914165","https://openalex.org/W2385163442","https://openalex.org/W2410523274","https://openalex.org/W2413217386","https://openalex.org/W2417644095","https://openalex.org/W2418380855","https://openalex.org/W4234601327","https://openalex.org/W4235797359","https://openalex.org/W4243853885","https://openalex.org/W4252733788"],"related_works":["https://openalex.org/W2113893442","https://openalex.org/W3106582177","https://openalex.org/W3010968880","https://openalex.org/W3136238904","https://openalex.org/W72424563","https://openalex.org/W2015477601","https://openalex.org/W2414815220","https://openalex.org/W2091174690"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,21,25,39,55,63,67,90,95,104,131,149,160,232,238,243,265,277],"this":[3,285],"study":[4],"was":[5,107,123,141,193,212],"to":[6,30,61,116,125,164,172,183,196,250,257],"review":[7],"systematically":[8],"the":[9,19,22,105,127,132,228,233,239,263,306],"available":[10],"evidence":[11],"on":[12,18,109,288],"pleurodesis":[13,298],"for":[14,81,137,158,267],"malignant":[15,68,153],"effusion,":[16],"focusing":[17],"choice":[20,266],"agents,":[23],"route":[24],"delivery":[26],"and":[27,41,51,58,92,114,241,260,304],"other":[28],"strategies":[29],"improve":[31],"outcomes.":[32],"Four":[33],"electronic":[34],"databases":[35],"(MEDLINE,":[36],"EMBASE,":[37],"Web":[38],"Science":[40],"Cochrane":[42],"Controlled":[43],"Trials":[44],"Register)":[45],"were":[46,73,87,156,247],"searched,":[47],"reference":[48],"lists":[49],"checked":[50],"letters":[52],"requesting":[53],"details":[54],"unpublished":[56],"trials":[57,106],"data":[59],"sent":[60],"authors":[62],"previous":[64],"trials.":[65],"Studies":[66],"pleural":[69,154],"effusion":[70,240],"in":[71,217],"humans":[72],"selected":[74],"with":[75,146,152,167,180,205,214,274,280],"no":[76],"language":[77],"restrictions":[78],"applied.":[79],"Criteria":[80],"randomised":[82],"clinical":[83],"trial":[84],"(RCT)":[85],"eligibility":[86],"random":[88,120],"allocation":[89,112],"patients":[91,151],"non-concurrent":[93],"use":[94,242],"another":[96],"experimental":[97],"medication":[98],"or":[99],"device.":[100],"Methodological":[101],"quality":[102],"evaluation":[103],"based":[108,287],"randomisation,":[110],"blinding,":[111],"concealment":[113],"intention":[115],"treat":[117],"analysis.":[118],"A":[119],"effect":[121,140],"model":[122],"used":[124],"combine":[126],"relative":[128],"risk":[129],"estimates":[130],"treatment":[133],"effects":[134],"whenever":[135],"pooling":[136],"an":[138],"overall":[139],"considered":[142],"appropriate.":[143],"Forty-six":[144],"RCTs":[145],"a":[147,215,300],"total":[148],"2053":[150],"effusions":[155,278],"reviewed":[157],"effectiveness":[159],"pleurodesis.":[161,268],"Talc":[162,255],"tended":[163],"be":[165,258,262],"associated":[166,213,273],"fewer":[168,275],"recurrences":[169,276],"when":[170],"compared":[171,204,279],"bleomycin":[173,197],"(RR,":[174,185,198,219],"0.64;":[175],"95%":[176,187,200,221],"CI,":[177,188,201,222],"0.34-1.20)":[178],"and,":[179],"more":[181],"uncertainty,":[182],"tetracycline":[184],"0.50;":[186],"0.06-4.42).":[189],"Tetracycline":[190],"(or":[191],"doxycycline)":[192],"not":[194,248],"superior":[195],"0.92;":[199],"0.61-1.38).":[202],"When":[203],"bedside":[206,281,296],"talc":[207,210,270,282,297],"slurry,":[208,283],"thoracoscopic":[209],"insufflation":[211,271],"reduction":[216],"recurrence":[218],"0.21;":[220],"0.05-0.93).":[223],"Strategies":[224],"such":[225],"as":[226],"rolling":[227],"patient":[229],"after":[230],"instillation":[231],"sclerosing":[234],"agent,":[235],"protracted":[236],"drainage":[237],"larger":[244],"chest":[245],"tubes":[246],"found":[249],"have":[251],"any":[252],"substantial":[253],"advantages.":[254],"appears":[256],"effective":[259],"should":[261],"agent":[264],"Thoracoscopic":[269],"is":[272,286,294,305],"but":[284],"two":[289],"small":[290],"studies.":[291],"Where":[292],"thoracoscopy":[293],"unavailable":[295],"has":[299],"high":[301],"success":[302],"rate":[303],"next":[307],"best":[308],"option.":[309]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}