{"id":"https://openalex.org/W2140474672","doi":"https://doi.org/10.3109/03602539709002237","title":"Prediction of Hepatic Clearance from Microsomes, Hepatocytes, and Liver Slices","display_name":"Prediction of Hepatic Clearance from Microsomes, Hepatocytes, and Liver Slices","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2140474672","doi":"https://doi.org/10.3109/03602539709002237","mag":"2140474672","pmid":"https://pubmed.ncbi.nlm.nih.gov/9421679"},"language":"en","primary_location":{"id":"doi:10.3109/03602539709002237","doi":"https://doi.org/10.3109/03602539709002237","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03602539709002237","pdf_url":null,"source":{"id":"https://openalex.org/S133743172","display_name":"Drug Metabolism Reviews","issn_l":"0360-2532","issn":["0360-2532","1097-9883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism Reviews","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109162124","display_name":"James Brian. Houston","orcid":"https://orcid.org/0000-0002-9322-0533","observed_orcids":["https://orcid.org/0000-0002-9322-0533","https://orcid.org/0000-0003-0962-0620"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Brian Houston","raw_affiliation_strings":["School of Pharmacy, University of Manchester, UK","School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9Pl, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Manchester, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9Pl, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084394194","display_name":"David John Carlile","orcid":"https://orcid.org/0009-0002-2379-3253","observed_orcids":["https://orcid.org/0009-0002-2379-3253"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J. Carlile","raw_affiliation_strings":["School of Pharmacy and Pharmaceutical Sciences University of Manchester, Manchester, M13 9PL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmaceutical Sciences University of Manchester, Manchester, M13 9PL, UK","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I28407311"],"apc_list":null,"apc_paid":null,"fwci":6.2173,"has_fulltext":false,"cited_by_count":304,"citation_normalized_percentile":{"value":0.97921946,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"29","issue":"4","first_page":"891","last_page":"922"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.026499999687075615,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6140000224113464},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.9279999732971191},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/liver-slices","display_name":"liver slices","score":0.9810000061988831},{"id":"https://openalex.org/keywords/in-vitro-in-vivo-extrapolation","display_name":"in vitro-in vivo extrapolation","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.790219783782959},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.7326787114143372},{"id":"https://openalex.org/C2909957684","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Metabolic clearance rate","level":3,"score":0.6337273120880127},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.5801360011100769},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.562247633934021},{"id":"https://openalex.org/C2776524530","wikidata":"https://www.wikidata.org/wiki/Q4119721","display_name":"Microsoma","level":4,"score":0.5197107791900635},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5154836773872375},{"id":"https://openalex.org/C2908801736","wikidata":"https://www.wikidata.org/wiki/Q9368","display_name":"Liver metabolism","level":2,"score":0.5086842179298401},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4272434115409851},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.37306225299835205},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34952491521835327},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3482207655906677},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.290569007396698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.275967001914978},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20012027025222778},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18485227227210999},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14782583713531494}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008110","descriptor_name":"Liver Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3109/03602539709002237","doi":"https://doi.org/10.3109/03602539709002237","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03602539709002237","pdf_url":null,"source":{"id":"https://openalex.org/S133743172","display_name":"Drug Metabolism Reviews","issn_l":"0360-2532","issn":["0360-2532","1097-9883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism Reviews","raw_type":"journal-article"},{"id":"pmid:9421679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9421679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug metabolism reviews","raw_type":"Comparative Study"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/54b465ac-0845-44ba-8d9d-c959bd25b00c","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/54b465ac-0845-44ba-8d9d-c959bd25b00c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brian Houston, J & Carlile, D J 1997, 'Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices', Drug Metabolism Reviews, vol. 29, no. 4, pp. 891-922.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W74649421","https://openalex.org/W1829225133","https://openalex.org/W1898727161","https://openalex.org/W1989940581","https://openalex.org/W2017494635","https://openalex.org/W2028573860","https://openalex.org/W2036501695","https://openalex.org/W2059973305","https://openalex.org/W2060606509","https://openalex.org/W2061681634","https://openalex.org/W2061717797","https://openalex.org/W2064799851","https://openalex.org/W2078719547","https://openalex.org/W2105621653","https://openalex.org/W2133376208","https://openalex.org/W2135748547","https://openalex.org/W2138387131","https://openalex.org/W2158899586","https://openalex.org/W2291459515","https://openalex.org/W2343628658","https://openalex.org/W2397145079","https://openalex.org/W2405140139","https://openalex.org/W2408756991","https://openalex.org/W2734369608","https://openalex.org/W4255982026","https://openalex.org/W4406996861"],"related_works":["https://openalex.org/W4396850491","https://openalex.org/W7100614915","https://openalex.org/W251754356","https://openalex.org/W2586076887","https://openalex.org/W2911137197","https://openalex.org/W7127553645","https://openalex.org/W4396850536","https://openalex.org/W2529973461","https://openalex.org/W2489611738","https://openalex.org/W4396850520"],"abstract_inverted_index":{"(1997).":[0],"Prediction":[1],"of":[2],"Hepatic":[3],"Clearance":[4],"from":[5],"Microsomes,":[6],"Hepatocytes,":[7],"and":[8],"Liver":[9],"Slices.":[10],"Drug":[11],"Metabolism":[12],"Reviews:":[13],"Vol.":[14],"29,":[15],"No.":[16],"4,":[17],"pp.":[18],"891-922.":[19]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}