{"id":"https://openalex.org/W2140447771","doi":"https://doi.org/10.1002/ijc.22235","title":"The thymidylate synthase tandem repeat promoter polymorphism: A predictor for tumor\u2010related survival in neoadjuvant treated locally advanced gastric cancer","display_name":"The thymidylate synthase tandem repeat promoter polymorphism: A predictor for tumor\u2010related survival in neoadjuvant treated locally advanced gastric cancer","publication_year":2006,"publication_date":"2006-08-23","ids":{"openalex":"https://openalex.org/W2140447771","doi":"https://doi.org/10.1002/ijc.22235","mag":"2140447771","pmid":"https://pubmed.ncbi.nlm.nih.gov/16929515"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.22235","doi":"https://doi.org/10.1002/ijc.22235","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.22235","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.22235","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.22235","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029670435","display_name":"Katja Ott","orcid":"https://orcid.org/0000-0002-9979-2460","observed_orcids":["https://orcid.org/0000-0002-9979-2460"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katja Ott","raw_affiliation_strings":["Department of Surgery, Technical University, Munich, Germany","Departments of Surgery, Technical University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Technical University, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Departments of Surgery, Technical University, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019012883","display_name":"H. Vogelsang","orcid":"https://orcid.org/0000-0001-9750-8924","observed_orcids":["https://orcid.org/0000-0001-9750-8924"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Holger Vogelsang","raw_affiliation_strings":["Departments of Surgery, Technical University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, Technical University, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024887382","display_name":"Noemi Marton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Noemi Marton","raw_affiliation_strings":["Departments of Surgery, Technical University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, Technical University, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104016338","display_name":"Karen Becker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karen Becker","raw_affiliation_strings":["Institute of Pathology, Technical University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Technical University, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050136275","display_name":"Florian Lordick","orcid":"https://orcid.org/0000-0001-8591-9339","observed_orcids":["https://orcid.org/0000-0001-8591-9339"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian Lordick","raw_affiliation_strings":["3rd Department of Internal Medicine, Technical University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3rd Department of Internal Medicine, Technical University, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004778001","display_name":"Michael Kobl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Kobl","raw_affiliation_strings":["Medical Statistics, Technical University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Statistics, Technical University, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021198297","display_name":"Christoph P. Schuhmacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Schuhmacher","raw_affiliation_strings":["Departments of Surgery, Technical University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, Technical University, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043739417","display_name":"Alexander Novotny","orcid":"https://orcid.org/0000-0002-8029-5958","observed_orcids":["https://orcid.org/0000-0002-8029-5958"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Novotny","raw_affiliation_strings":["Departments of Surgery, Technical University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, Technical University, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109226919","display_name":"James Mueller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1338449461","display_name":"Baystate Medical Center","ror":"https://ror.org/01q2nz307","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1338449461"]},{"id":"https://openalex.org/I4210123955","display_name":"Baystate Health","ror":"https://ror.org/02x011m46","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123955"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Mueller","raw_affiliation_strings":["Department of Pathology, Baystate Medical Center, Springfield, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Baystate Medical Center, Springfield, MA","institution_ids":["https://openalex.org/I1338449461","https://openalex.org/I4210123955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089122116","display_name":"U. Fink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich Fink","raw_affiliation_strings":["Departments of Surgery, Technical University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, Technical University, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057720144","display_name":"Kurt Ulm","orcid":"https://orcid.org/0000-0001-8540-9849","observed_orcids":["https://orcid.org/0000-0001-8540-9849"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kurt Ulm","raw_affiliation_strings":["Medical Statistics, Technical University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Statistics, Technical University, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108506693","display_name":"J\u00f6rg R\u00fcdiger Siewert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg R\u00fcdiger Siewert","raw_affiliation_strings":["Departments of Surgery, Technical University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Surgery, Technical University, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111392933","display_name":"Heinz H\u00f6fler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heinz H\u00f6fler","raw_affiliation_strings":["Institute of Pathology, National Research Center for Environment and Health, GSF-Forschungszentrum, Oberschleissheim, Germany","Institute of Pathology, Technical University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, National Research Center for Environment and Health, GSF-Forschungszentrum, Oberschleissheim, Germany","institution_ids":["https://openalex.org/I3018134672"]},{"raw_affiliation_string":"Institute of Pathology, Technical University, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086031636","display_name":"Gisela Keller","orcid":"https://orcid.org/0000-0003-2886-0371","observed_orcids":["https://orcid.org/0000-0003-2886-0371"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Gisela Keller","raw_affiliation_strings":["","Institute of Pathology, Technical University, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Institute of Pathology, Technical University, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5086031636"],"corresponding_institution_ids":["https://openalex.org/I62916508"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":3.9279,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.93955074,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"119","issue":"12","first_page":"2885","last_page":"2894"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9423999786376953,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymidylate-synthase","display_name":"thymidylate synthase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mthfr-c677t-polymorphism","display_name":"MTHFR C677T polymorphism","score":0.9330000281333923},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.75},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9049999713897705},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9860000014305115},{"id":"https://openalex.org/keywords/locally-advanced-gastric-cancer","display_name":"locally advanced gastric cancer","score":0.8230000138282776},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8600000143051147},{"id":"https://openalex.org/keywords/r0-resection","display_name":"R0 resection","score":0.8029999732971191},{"id":"https://openalex.org/keywords/histopathological-response","display_name":"histopathological response","score":0.628000020980835},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C123321153","wikidata":"https://www.wikidata.org/wiki/Q22676802","display_name":"Thymidylate synthase","level":4,"score":0.9013327360153198},{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.8376006484031677},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7716259360313416},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.7672284245491028},{"id":"https://openalex.org/C27149982","wikidata":"https://www.wikidata.org/wiki/Q3456514","display_name":"Tandem repeat","level":4,"score":0.6637048721313477},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5876133441925049},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5584360957145691},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.43608349561691284},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.39246803522109985},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35058051347732544},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33557623624801636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2892981767654419},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2801624536514282},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.19155338406562805},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D013940","descriptor_name":"Thymidylate Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020080","descriptor_name":"Tandem Repeat Sequences","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/ijc.22235","doi":"https://doi.org/10.1002/ijc.22235","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.22235","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.22235","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:16929515","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16929515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1329695","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1329695","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/ijc.22235","doi":"https://doi.org/10.1002/ijc.22235","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.22235","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.22235","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2140447771.pdf","grobid_xml":"https://content.openalex.org/works/W2140447771.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1831535185","https://openalex.org/W1858406656","https://openalex.org/W1893723137","https://openalex.org/W1977879763","https://openalex.org/W1979788220","https://openalex.org/W1990763949","https://openalex.org/W1991932352","https://openalex.org/W2001337137","https://openalex.org/W2007732133","https://openalex.org/W2014992126","https://openalex.org/W2025945212","https://openalex.org/W2032480351","https://openalex.org/W2034781059","https://openalex.org/W2037501837","https://openalex.org/W2042143199","https://openalex.org/W2051836198","https://openalex.org/W2055083952","https://openalex.org/W2070555748","https://openalex.org/W2103006620","https://openalex.org/W2104389711","https://openalex.org/W2123794181","https://openalex.org/W2125306030","https://openalex.org/W2147062206","https://openalex.org/W2147270594","https://openalex.org/W2163168416","https://openalex.org/W2165715420","https://openalex.org/W2200882253","https://openalex.org/W2268809420","https://openalex.org/W2269806819","https://openalex.org/W2336413877"],"related_works":["https://openalex.org/W2467393333","https://openalex.org/W2243019933","https://openalex.org/W90687662","https://openalex.org/W2567735318","https://openalex.org/W2147062206","https://openalex.org/W7014531461","https://openalex.org/W2269806819","https://openalex.org/W2042143199","https://openalex.org/W2072512303","https://openalex.org/W2038589169"],"abstract_inverted_index":{"We":[0],"evaluated":[1],"DNA":[2,33],"polymorphisms":[3,170],"in":[4,21,74,78,157,171,193],"the":[5,63,67,71,75,79,83,88,92,99,111,148,158,164,168,172,194,200,209,216,236,252,265],"thymidylate":[6],"synthase":[7],"(TS)":[8],"and":[9,19,70,86,109,147,190,224],"5,10-methylene-tetrahydrofolate":[10],"reductase":[11],"(MTHFR)":[12],"genes":[13],"for":[14,208,215,235,276],"an":[15],"association":[16],"with":[17,27,106,182,189,211,251,264],"response":[18,108],"survival":[20,120,185,206,246,261],"locally":[22],"advanced":[23],"gastric":[24],"cancer":[25],"treated":[26],"5-FU":[28],"based":[29],"preoperative":[30],"chemotherapy":[31],"(CTx).":[32],"of":[34,66,82,87,91,98,167,199,262],"238":[35],"patients":[36,122,131,188,210,263],"(CTx-group:":[37],"total":[38],"n":[39,45,51,123,132],"=":[40,46,52,124,127,133,136,161,219,222,228,231,240,243],"135,":[41,125],"completely":[42],"resected":[43,130],"(R0)":[44],"102;":[47],"without":[48,174,191],"CTx:":[49],"R0":[50,129,187],"103)":[53],"was":[54,95,116,213,249],"isolated":[55],"from":[56,59],"blood":[57],"or":[58,101],"nontumorous":[60],"tissues.":[61],"In":[62],"CTx-group,":[64],"genotyping":[65],"tandem":[68,113,150,201,254],"repeat":[69,77,114,151,202,255],"G/C":[72],"polymorphism":[73,90,115,152],"triple":[76],"promoter":[80],"region":[81],"TS":[84,100,112,149,169,176,196,253],"gene":[85,94],"C677T":[89],"MTHFR":[93,102],"performed.":[96],"None":[97],"genotypes":[103,177,226],"were":[104,178],"associated":[105,181,250],"histopathological":[107],"only":[110],"significantly":[117,180],"related":[118],"to":[119],"(all":[121],"p":[126,135,221,230,242],"0.002;":[128],"102,":[134],"0.007;":[137],"log-rank":[138],"test).":[139],"Multivariate":[140],"analysis":[141],"revealed":[142],"ypN":[143],"(p":[144,160],"<":[145],"0.001)":[146],"as":[153],"independent":[154],"prognostic":[155,165],"factors":[156],"CTx-R0-group":[159],"0.003).":[162],"Analyzing":[163],"significance":[166],"R0-group":[173],"CTx,":[175],"not":[179,234,259],"survival.":[183],"Comparing":[184],"between":[186],"CTx":[192,212,248,257],"respective":[195],"genotype":[197,238],"groups":[198],"polymorphism,":[203],"a":[204,269],"significant":[205],"benefit":[207],"found":[214],"2rpt/2rpt":[217],"(n":[218,227,239],"49;":[220],"0.002)":[223],"2rpt/3rpt":[225],"99;":[229],"0.004),":[232],"but":[233],"3rpt/3rpt":[237,266],"57;":[241],"0.93).":[244],"Patients'":[245],"after":[247],"polymorphism.":[256],"did":[258],"improve":[260],"genotype.":[267],"Thus,":[268],"different":[270],"therapy":[271],"might":[272],"be":[273],"more":[274],"appropriate":[275],"these":[277],"patients.":[278]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
