{"id":"https://openalex.org/W2140446904","doi":"https://doi.org/10.1371/journal.pone.0002865","title":"Iron Accumulation with Age, Oxidative Stress and Functional Decline","display_name":"Iron Accumulation with Age, Oxidative Stress and Functional Decline","publication_year":2008,"publication_date":"2008-08-05","ids":{"openalex":"https://openalex.org/W2140446904","doi":"https://doi.org/10.1371/journal.pone.0002865","mag":"2140446904","pmid":"https://pubmed.ncbi.nlm.nih.gov/18682742","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2481398"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0002865","doi":"https://doi.org/10.1371/journal.pone.0002865","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0002865","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0002865&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0002865&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111885024","display_name":"Jinze Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinze Xu","raw_affiliation_strings":["Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of The Institute on Aging, University of Florida, Gainesville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of The Institute on Aging, University of Florida, Gainesville, Florida, United States of America","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071830954","display_name":"Mitchell D. Knutson","orcid":"https://orcid.org/0000-0001-9135-4696","observed_orcids":["https://orcid.org/0000-0001-9135-4696"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mitchell D. Knutson","raw_affiliation_strings":["Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida, United States of America","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072500293","display_name":"Christy S. Carter","orcid":"https://orcid.org/0000-0001-9657-3193","observed_orcids":["https://orcid.org/0000-0001-9657-3193"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christy S. Carter","raw_affiliation_strings":["Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of The Institute on Aging, University of Florida, Gainesville, Florida, United States of America","Gainesville VA Geriatric Research, Education and Clinical Center (GRECC), Gainesville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of The Institute on Aging, University of Florida, Gainesville, Florida, United States of America","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Gainesville VA Geriatric Research, Education and Clinical Center (GRECC), Gainesville, Florida, United States of America","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028177578","display_name":"Christiaan Leeuwenburgh","orcid":"https://orcid.org/0000-0003-0826-4257","observed_orcids":["https://orcid.org/0000-0003-0826-4257"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christiaan Leeuwenburgh","raw_affiliation_strings":["Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of The Institute on Aging, University of Florida, Gainesville, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of The Institute on Aging, University of Florida, Gainesville, Florida, United States of America","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028177578","https://openalex.org/A5071830954"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":5.8604,"has_fulltext":true,"cited_by_count":132,"citation_normalized_percentile":{"value":0.96680058,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"3","issue":"8","first_page":"e2865","last_page":"e2865"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.13459999859333038,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.1273999959230423,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-accumulation","display_name":"iron accumulation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9639999866485596},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6859999895095825},{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.7540000081062317},{"id":"https://openalex.org/keywords/non-heme-iron","display_name":"non-heme iron","score":0.8320000171661377},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.9639999866485596},{"id":"https://openalex.org/keywords/muscle-aging","display_name":"muscle aging","score":0.7549999952316284},{"id":"https://openalex.org/keywords/handgrip-strength","display_name":"grip strength","score":0.9359999895095825},{"id":"https://openalex.org/keywords/muscle-mass","display_name":"muscle mass","score":0.8610000014305115},{"id":"https://openalex.org/keywords/functional-decline","display_name":"functional decline","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.8882414102554321},{"id":"https://openalex.org/C2778707264","wikidata":"https://www.wikidata.org/wiki/Q1332886","display_name":"Calorie restriction","level":2,"score":0.7691682577133179},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7661168575286865},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6070516109466553},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5929831266403198},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.5915213823318481},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.5809181928634644},{"id":"https://openalex.org/C40438245","wikidata":"https://www.wikidata.org/wiki/Q130964","display_name":"Calorie","level":2,"score":0.5783551335334778},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.5779881477355957},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5340449213981628},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5186954736709595},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4904191195964813},{"id":"https://openalex.org/C2775872116","wikidata":"https://www.wikidata.org/wiki/Q943203","display_name":"Gastrocnemius muscle","level":3,"score":0.41256457567214966},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40758392214775085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3584561347961426},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3338238000869751},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3144845962524414},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09802761673927307}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002149","descriptor_name":"Energy Intake","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003433","descriptor_name":"Crosses, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004038","descriptor_name":"Diet, Reducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011914","descriptor_name":"Rats, Inbred BN","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018737","descriptor_name":"Hand Strength","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pone.0002865","doi":"https://doi.org/10.1371/journal.pone.0002865","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0002865","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0002865&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2481398","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2481398","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:18682742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18682742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.275.3410","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.3410","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/dd/e8/PLoS_ONE_2008_Aug_6_3(8)_e2865.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.908.6394","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.908.6394","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://knutsonlab.org/wp-content/uploads/2012/08/2008.Xu-et-al.-PLoSONE.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.917.4141","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.917.4141","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Christiaan_Leeuwenburgh/publication/23151727_Iron_Accumulation_with_Age_Oxidative_Stress_and_Functional_Decline/links/5496e8730cf20f487d31636e.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:04bcdde704f04e588f8c362556fd1457","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/04bcdde704f04e588f8c362556fd1457","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 3, Iss 8, p e2865 (2008)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt6r86j1gq","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/6r86j1gq","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PloS one, vol 3, iss 8","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt6r86j1gq","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6r86j1gq","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS ONE, vol 3, iss 8","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0002865","doi":"https://doi.org/10.1371/journal.pone.0002865","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0002865","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0002865&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.6735000014305115,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2375542829","display_name":"ACE Inhibition and Physical Performance in Aged Rats","funder_award_id":"R01AG024526","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3420384484","display_name":null,"funder_award_id":"P30 AG028740","funder_id":"https://openalex.org/F4320310009","funder_display_name":"University of Florida"},{"id":"https://openalex.org/G451360555","display_name":"Molecular mechanisms of oxidative stress in aging muscle","funder_award_id":"R01AG017994","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5672409827","display_name":"Apoptosis and Life-Long Caloric Restriction","funder_award_id":"R01AG021042","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G644155597","display_name":null,"funder_award_id":"1 P30 AG028740","funder_id":"https://openalex.org/F4320310009","funder_display_name":"University of Florida"},{"id":"https://openalex.org/G881392295","display_name":"Ferroportin and iron export from the macrophage","funder_award_id":"K01DK065064","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000863523","display_name":"University of Florida Older Americans Independence Center (OAIC)","funder_award_id":"P30AG028740","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320310009","display_name":"University of Florida","ror":"https://ror.org/02y3ad647"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2140446904.pdf","grobid_xml":"https://content.openalex.org/works/W2140446904.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W165421384","https://openalex.org/W1485146635","https://openalex.org/W1532173460","https://openalex.org/W1562149213","https://openalex.org/W1606726207","https://openalex.org/W1867596925","https://openalex.org/W1889843409","https://openalex.org/W1923065653","https://openalex.org/W1937174794","https://openalex.org/W1967922486","https://openalex.org/W1970787525","https://openalex.org/W1971436783","https://openalex.org/W1982147309","https://openalex.org/W1982900915","https://openalex.org/W1987029683","https://openalex.org/W1987699755","https://openalex.org/W2001111653","https://openalex.org/W2001854860","https://openalex.org/W2003880622","https://openalex.org/W2006121224","https://openalex.org/W2007711341","https://openalex.org/W2012465360","https://openalex.org/W2016718505","https://openalex.org/W2026711486","https://openalex.org/W2031995424","https://openalex.org/W2032007508","https://openalex.org/W2036686133","https://openalex.org/W2037134213","https://openalex.org/W2043286349","https://openalex.org/W2044078855","https://openalex.org/W2051961807","https://openalex.org/W2053893341","https://openalex.org/W2054382152","https://openalex.org/W2054523680","https://openalex.org/W2065129644","https://openalex.org/W2065917729","https://openalex.org/W2066350453","https://openalex.org/W2069853638","https://openalex.org/W2072059377","https://openalex.org/W2080675346","https://openalex.org/W2081024713","https://openalex.org/W2081397294","https://openalex.org/W2082686558","https://openalex.org/W2085771824","https://openalex.org/W2094332493","https://openalex.org/W2097952463","https://openalex.org/W2106005889","https://openalex.org/W2106342888","https://openalex.org/W2108926627","https://openalex.org/W2113216706","https://openalex.org/W2116386746","https://openalex.org/W2126662372","https://openalex.org/W2127808488","https://openalex.org/W2131885261","https://openalex.org/W2142833570","https://openalex.org/W2143730031","https://openalex.org/W2144577761","https://openalex.org/W2148362837","https://openalex.org/W2156124821","https://openalex.org/W2156251255","https://openalex.org/W2161267210","https://openalex.org/W2168556500","https://openalex.org/W2172014884","https://openalex.org/W2322053818","https://openalex.org/W2340324006","https://openalex.org/W2411448412","https://openalex.org/W2971963895","https://openalex.org/W7044181980"],"related_works":["https://openalex.org/W184715712","https://openalex.org/W1535763798","https://openalex.org/W4286697037","https://openalex.org/W2168556500","https://openalex.org/W2319344229","https://openalex.org/W2051266381","https://openalex.org/W2104948079","https://openalex.org/W196294543","https://openalex.org/W7095918526","https://openalex.org/W2172014884"],"abstract_inverted_index":{"Identification":[0],"of":[1,11,31,77,103,128,137,146,156,168,185,191],"biological":[2,36],"mediators":[3],"in":[4,35,47,57,97,110,152,178,188,203,212,218,233],"sarcopenia":[5,104,213],"is":[6,19,39,52,69],"pertinent":[7],"to":[8,14,94,236],"the":[9,29,153,170,183,219,229],"development":[10],"targeted":[12],"interventions":[13,72],"alleviate":[15],"this":[16],"condition.":[17],"Iron":[18],"recognized":[20],"as":[21,81,197],"a":[22,26,123],"potent":[23],"pro-oxidant":[24],"and":[25,59,100,107,143,165,206,210,240,242],"catalyst":[27],"for":[28],"formation":[30],"reactive":[32],"oxygen":[33],"species":[34],"systems.":[37],"It":[38],"well":[40],"accepted":[41],"that":[42,228,243],"iron":[43,55,85,90,150,172,205,231],"accumulates":[44],"with":[45,161],"senescence":[46],"several":[48],"organs,":[49],"but":[50],"little":[51],"known":[53],"about":[54],"accumulation":[56,232],"muscle":[58,64,78,99,155,190,234],"how":[60],"it":[61,68],"may":[62],"affect":[63],"function.":[65],"In":[66],"addition,":[67],"unclear":[70],"if":[71],"which":[73],"reduced":[74],"age-related":[75,230],"loss":[76],"quality,":[79],"such":[80],"calorie":[82,124,220],"restriction,":[83],"impact":[84],"accumulation.":[86],"We":[87],"investigated":[88],"non-heme":[89,149,171,204],"concentration,":[91],"oxidative":[92,238],"stress":[93],"nucleic":[95],"acids":[96],"gastrocnemius":[98,154,189],"key":[101],"indices":[102,214],"(muscle":[105],"mass":[106],"grip":[108],"strength)":[109],"male":[111],"Fischer":[112],"344":[113],"X":[114],"Brown":[115],"Norway":[116],"rats":[117,158,193],"fed":[118],"ad":[119,129],"libitum":[120,130],"(AL)":[121],"or":[122],"restricted":[125],"diet":[126],"(60%":[127],"food":[131],"intake":[132],"starting":[133],"at":[134,139],"4":[135],"months":[136,145,167],"age)":[138],"8,":[140],"18,":[141],"29":[142,164],"37":[144,166],"age.":[147,162],"Total":[148],"levels":[151,184,209],"AL":[157,192],"increased":[159,174,196,237],"progressively":[160],"Between":[163],"age,":[169],"concentration":[173],"by":[175],"approximately":[176],"200%":[177],"AL-fed":[179],"rats.":[180,223],"Most":[181],"importantly,":[182],"oxidized":[186,207],"RNA":[187,208],"were":[194,215],"significantly":[195],"well.":[198],"The":[199],"striking":[200],"age-associated":[201],"increase":[202],"decrease":[211],"all":[216],"attenuated":[217],"restriction":[221],"(CR)":[222],"These":[224],"findings":[225],"strongly":[226],"suggest":[227],"contributes":[235],"damage":[239],"sarcopenia,":[241],"CR":[244],"effectively":[245],"attenuates":[246],"these":[247],"negative":[248],"effects.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
