{"id":"https://openalex.org/W2140408658","doi":"https://doi.org/10.1091/mbc.11.10.3365","title":"The Doa4 Deubiquitinating Enzyme Is Functionally Linked to the Vacuolar Protein-sorting and Endocytic Pathways","display_name":"The Doa4 Deubiquitinating Enzyme Is Functionally Linked to the Vacuolar Protein-sorting and Endocytic Pathways","publication_year":2000,"publication_date":"2000-10-01","ids":{"openalex":"https://openalex.org/W2140408658","doi":"https://doi.org/10.1091/mbc.11.10.3365","mag":"2140408658","pmid":"https://pubmed.ncbi.nlm.nih.gov/11029042","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/14998"},"language":"en","primary_location":{"id":"doi:10.1091/mbc.11.10.3365","doi":"https://doi.org/10.1091/mbc.11.10.3365","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.11.10.3365","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/14998","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029844882","display_name":"Alexander Yu. Amerik","orcid":"https://orcid.org/0000-0003-1437-2692","observed_orcids":["https://orcid.org/0000-0003-1437-2692"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Y. Amerik","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520; and","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058614093","display_name":"Jonathan Andrew Nowak","orcid":"https://orcid.org/0000-0002-0943-7407","observed_orcids":["https://orcid.org/0000-0002-0943-7407"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Nowak","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043891753","display_name":"Sowmya Swaminathan","orcid":"https://orcid.org/0000-0002-0285-4910","observed_orcids":["https://orcid.org/0000-0002-0285-4910"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sowmya Swaminathan","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032098391","display_name":"Mark Hochstrasser","orcid":"https://orcid.org/0000-0002-1131-5484","observed_orcids":["https://orcid.org/0000-0002-1131-5484"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Hochstrasser","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520; and","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.873,"has_fulltext":false,"cited_by_count":295,"citation_normalized_percentile":{"value":0.97489092,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"10","first_page":"3365","last_page":"3380"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.7401999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.7401999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.24609999358654022,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deubiquitinase","display_name":"deubiquitinase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9580000042915344},{"id":"https://openalex.org/keywords/vacuolar-protein-sorting","display_name":"vacuolar protein sorting","score":0.8429999947547913},{"id":"https://openalex.org/keywords/endocytic-pathway","display_name":"endocytic pathway","score":0.7649999856948853},{"id":"https://openalex.org/keywords/late-endosomes","display_name":"late endosomes","score":0.8360000252723694},{"id":"https://openalex.org/keywords/prevacuolar-compartment","display_name":"prevacuolar compartment","score":0.9380000233650208},{"id":"https://openalex.org/keywords/multivesicular-bodies","display_name":"multivesicular bodies","score":0.9750000238418579},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.7919999957084656},{"id":"https://openalex.org/keywords/extragenic-suppressors","display_name":"extragenic suppressors","score":0.7450000047683716},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C102658986","wikidata":"https://www.wikidata.org/wiki/Q5266092","display_name":"Deubiquitinating enzyme","level":4,"score":0.8544226884841919},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.82718825340271},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.750207781791687},{"id":"https://openalex.org/C2777867350","wikidata":"https://www.wikidata.org/wiki/Q7908031","display_name":"Vacuolar protein sorting","level":4,"score":0.7446842789649963},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7140243649482727},{"id":"https://openalex.org/C102568950","wikidata":"https://www.wikidata.org/wiki/Q127702","display_name":"Vacuole","level":3,"score":0.709233283996582},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.706293523311615},{"id":"https://openalex.org/C206052861","wikidata":"https://www.wikidata.org/wiki/Q899827","display_name":"Endomembrane system","level":4,"score":0.6271902322769165},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.5876865983009338},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.5836873054504395},{"id":"https://openalex.org/C559089031","wikidata":"https://www.wikidata.org/wiki/Q658882","display_name":"Protein targeting","level":4,"score":0.5009641647338867},{"id":"https://openalex.org/C143876685","wikidata":"https://www.wikidata.org/wiki/Q22327705","display_name":"ESCRT","level":4,"score":0.454546183347702},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37877029180526733},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.2917702794075012},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.25140804052352905},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23914021253585815},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.23437157273292542},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.2012418806552887},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.11588731408119202},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013489","descriptor_name":"Suppression, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014452","descriptor_name":"Ubiquitins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014617","descriptor_name":"Vacuoles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043222","descriptor_name":"Ubiquitin Thiolesterase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056827","descriptor_name":"Endosomal Sorting Complexes Required for Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1091/mbc.11.10.3365","doi":"https://doi.org/10.1091/mbc.11.10.3365","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.11.10.3365","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1780612","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/14998","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:14998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/14998","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},{"id":"pmid:11029042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11029042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology of the cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1780612","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/14998","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4683416520","display_name":null,"funder_award_id":"GM53756","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G762134814","display_name":null,"funder_award_id":"R01-GM053756","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8198393323","display_name":"Functions and Mechanisms of Deubiquitinating Enzymes","funder_award_id":"5r01gm053756-23","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W135235169","https://openalex.org/W1507367785","https://openalex.org/W1654447069","https://openalex.org/W1666755687","https://openalex.org/W1874958320","https://openalex.org/W1878680302","https://openalex.org/W1895018249","https://openalex.org/W1897176773","https://openalex.org/W1965476757","https://openalex.org/W1966223027","https://openalex.org/W1967390330","https://openalex.org/W1975085160","https://openalex.org/W1978611748","https://openalex.org/W1981515958","https://openalex.org/W1981916517","https://openalex.org/W1988617344","https://openalex.org/W2001528956","https://openalex.org/W2001597380","https://openalex.org/W2003979167","https://openalex.org/W2012531467","https://openalex.org/W2019215631","https://openalex.org/W2024645073","https://openalex.org/W2024812887","https://openalex.org/W2028278224","https://openalex.org/W2032579724","https://openalex.org/W2052562460","https://openalex.org/W2054490392","https://openalex.org/W2057163724","https://openalex.org/W2063053734","https://openalex.org/W2071056869","https://openalex.org/W2074286043","https://openalex.org/W2076874733","https://openalex.org/W2082543204","https://openalex.org/W2082752030","https://openalex.org/W2088220924","https://openalex.org/W2089865526","https://openalex.org/W2094866737","https://openalex.org/W2100158530","https://openalex.org/W2103237796","https://openalex.org/W2104017803","https://openalex.org/W2104176053","https://openalex.org/W2111211256","https://openalex.org/W2115073295","https://openalex.org/W2121781216","https://openalex.org/W2122730639","https://openalex.org/W2131423447","https://openalex.org/W2132099293","https://openalex.org/W2134671651","https://openalex.org/W2139474586","https://openalex.org/W2144593863","https://openalex.org/W2144918538","https://openalex.org/W2145216906","https://openalex.org/W2147057682","https://openalex.org/W2150285114","https://openalex.org/W2154534551","https://openalex.org/W2155885530","https://openalex.org/W2157740023","https://openalex.org/W2159676193","https://openalex.org/W2169290377","https://openalex.org/W2169333620","https://openalex.org/W2170298918","https://openalex.org/W2178503716","https://openalex.org/W2187132725","https://openalex.org/W2414472146","https://openalex.org/W2414624970","https://openalex.org/W2416123939"],"related_works":["https://openalex.org/W2099967205","https://openalex.org/W2560138426","https://openalex.org/W2068294690","https://openalex.org/W7098481594","https://openalex.org/W2122730639","https://openalex.org/W2131623292","https://openalex.org/W7097212010","https://openalex.org/W2155885530","https://openalex.org/W2089340389","https://openalex.org/W2170283917"],"abstract_inverted_index":{"The":[0],"Saccharomyces":[1],"cerevisiae":[2],"DOA4":[3],"gene":[4],"encodes":[5],"a":[6,97,134,144],"deubiquitinating":[7],"enzyme":[8],"that":[9,25,104],"is":[10],"required":[11],"for":[12],"rapid":[13],"degradation":[14],"of":[15,47,52,62,68,77,96,111,147],"ubiquitin-proteasome":[16],"pathway":[17,30],"substrates.":[18],"Both":[19],"genetic":[20],"and":[21,126,177],"biochemical":[22],"data":[23],"suggest":[24,170],"Doa4":[26,183],"acts":[27,184],"in":[28,93,122,138,181],"this":[29],"by":[31],"facilitating":[32],"ubiquitin":[33,192],"recycling":[34],"from":[35,193],"ubiquitinated":[36,194],"intermediates":[37],"targeted":[38],"to":[39,165,190,199],"the":[40,45,53,69,78,94,108,112,141,158,166,186,200],"proteasome.":[41],"Here":[42],"we":[43],"describe":[44],"isolation":[46],"12":[48],"spontaneous":[49],"extragenic":[50],"suppressors":[51],"doa4-1":[54],"mutation;":[55],"these":[56],"involve":[57],"seven":[58],"different":[59],"genes,":[60],"six":[61,113],"which":[63,91,182],"were":[64],"cloned.":[65],"Surprisingly,":[66],"all":[67,85],"cloned":[70],"DID":[71],"(Doa4-independent":[72],"degradation)":[73],"genes":[74],"encode":[75],"components":[76],"vacuolar":[79],"protein-sorting":[80],"(Vps)":[81],"pathway.":[82],"In":[83,124],"particular,":[84],"are":[86,116],"class":[87,161],"E":[88,162],"Vps":[89,154],"factors,":[90,155],"function":[92],"maturation":[95],"late":[98,159,187],"endosome/prevacuolar":[99,188],"compartment":[100,163,189],"into":[101],"multivesicular":[102],"bodies":[103],"then":[105],"fuse":[106],"with":[107],"vacuole.":[109,167,201],"Four":[110],"Did":[114],"proteins":[115,196],"structurally":[117],"related,":[118],"suggesting":[119],"an":[120,171],"overlap":[121],"function.":[123],"wild-type":[125],"several":[127,152],"vps":[128],"strains,":[129],"Doa4-green":[130,148],"fluorescent":[131,149],"protein":[132,175,179],"displays":[133],"cytoplasmic/nuclear":[135],"distribution.":[136],"However,":[137],"cells":[139],"lacking":[140],"Vps4/Did6":[142],"ATPase,":[143],"large":[145],"fraction":[146],"protein,":[150],"like":[151],"other":[153],"concentrates":[156],"at":[157,185],"endosome-like":[160],"adjacent":[164],"These":[168],"results":[169],"unanticipated":[172],"connection":[173],"between":[174],"deubiquitination":[176],"endomembrane":[178],"trafficking":[180],"recover":[191],"membrane":[195],"en":[197],"route":[198]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
