{"id":"https://openalex.org/W2140396456","doi":"https://doi.org/10.1074/jbc.m504106200","title":"Nuclear Import of \u03b1B-crystallin Is Phosphorylation-dependent and Hampered by Hyperphosphorylation of the Myopathy-related Mutant R120G","display_name":"Nuclear Import of \u03b1B-crystallin Is Phosphorylation-dependent and Hampered by Hyperphosphorylation of the Myopathy-related Mutant R120G","publication_year":2005,"publication_date":"2005-08-30","ids":{"openalex":"https://openalex.org/W2140396456","doi":"https://doi.org/10.1074/jbc.m504106200","mag":"2140396456","pmid":"https://pubmed.ncbi.nlm.nih.gov/16129694"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m504106200","doi":"https://doi.org/10.1074/jbc.m504106200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m504106200","pdf_url":"http://www.jbc.org/article/S0021925820593538/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820593538/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071102062","display_name":"John den Engelsman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"John den Engelsman","raw_affiliation_strings":["Department of Biochemistry 161, Nijmegen Center for Molecular Life Sciences, Radboud University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry 161, Nijmegen Center for Molecular Life Sciences, Radboud University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036020176","display_name":"Danny Gerrits","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Danny Gerrits","raw_affiliation_strings":["Department of Biochemistry 161, Nijmegen Center for Molecular Life Sciences, Radboud University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry 161, Nijmegen Center for Molecular Life Sciences, Radboud University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032998470","display_name":"Wilfried W. DE JONG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wilfried W. de Jong","raw_affiliation_strings":["Department of Biochemistry 161, Nijmegen Center for Molecular Life Sciences, Radboud University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry 161, Nijmegen Center for Molecular Life Sciences, Radboud University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005272366","display_name":"Jeffrey M. Robbins","orcid":"https://orcid.org/0000-0002-3345-5226","observed_orcids":["https://orcid.org/0000-0002-3345-5226"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Robbins","raw_affiliation_strings":["Division of Molecular Cardiovascular Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Cardiovascular Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108801450","display_name":"Kanefusa Kato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160234","display_name":"Aichi Human Service Center","ror":"https://ror.org/00c4ncp37","country_code":"JP","type":"other","lineage":["https://openalex.org/I4210160234"]},{"id":"https://openalex.org/I4405287295","display_name":"Institute for Developmental Research","ror":"https://ror.org/04qywsk58","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210166504","https://openalex.org/I4405287295"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kanefusa Kato","raw_affiliation_strings":["Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi 480-0392, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi 480-0392, Japan","institution_ids":["https://openalex.org/I4210160234","https://openalex.org/I4405287295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080044915","display_name":"Wilbert C. Boelens","orcid":"https://orcid.org/0000-0001-8518-4096","observed_orcids":["https://orcid.org/0000-0001-8518-4096"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Wilbert C. Boelens","raw_affiliation_strings":["Department of Biochemistry 161, Nijmegen Center for Molecular Life Sciences, Radboud University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry 161, Nijmegen Center for Molecular Life Sciences, Radboud University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5080044915"],"corresponding_institution_ids":["https://openalex.org/I145872427"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.3689,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.88398484,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"280","issue":"44","first_page":"37139","last_page":"37148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alphab-crystallin","display_name":"alphaB-crystallin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nuclear-import","display_name":"nuclear import","score":0.9610000252723694},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/hyperphosphorylation","display_name":"hyperphosphorylation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.7770000100135803},{"id":"https://openalex.org/keywords/survival-motor-neuron-protein","display_name":"survival motor neuron protein","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nuclear-export-inhibition","display_name":"nuclear export inhibition","score":0.6980000138282776},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/cytoplasmic-inclusions","display_name":"cytoplasmic inclusions","score":0.9369999766349792},{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.8410000205039978},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.8532816171646118},{"id":"https://openalex.org/C2778198054","wikidata":"https://www.wikidata.org/wiki/Q15195154","display_name":"Hyperphosphorylation","level":3,"score":0.7068032622337341},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.634483814239502},{"id":"https://openalex.org/C54757728","wikidata":"https://www.wikidata.org/wiki/Q3511067","display_name":"Nuclear export signal","level":4,"score":0.6140803098678589},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.6048446297645569},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47720012068748474},{"id":"https://openalex.org/C2908584439","wikidata":"https://www.wikidata.org/wiki/Q2076770","display_name":"Small nuclear ribonucleoprotein","level":5,"score":0.4595692455768585},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.45558011531829834},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.4231826066970825},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.3832753896713257},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35950642824172974},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.356808602809906},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24012598395347595},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.2315266728401184},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.06677380204200745},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021581","descriptor_name":"Active Transport, Cell Nucleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038203","descriptor_name":"alpha-Crystallin B Chain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038203","descriptor_name":"alpha-Crystallin B Chain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038203","descriptor_name":"alpha-Crystallin B Chain","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038203","descriptor_name":"alpha-Crystallin B Chain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D038203","descriptor_name":"alpha-Crystallin B Chain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D038203","descriptor_name":"alpha-Crystallin B Chain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055532","descriptor_name":"SMN Complex Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055532","descriptor_name":"SMN Complex Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055532","descriptor_name":"SMN Complex Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m504106200","doi":"https://doi.org/10.1074/jbc.m504106200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m504106200","pdf_url":"http://www.jbc.org/article/S0021925820593538/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:16129694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16129694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Comparative Study"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/32794","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/32794","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/32794","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2066/32794","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biological Chemistry, 280, 37139 - 37148","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m504106200","doi":"https://doi.org/10.1074/jbc.m504106200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m504106200","pdf_url":"http://www.jbc.org/article/S0021925820593538/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5699999928474426,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2140396456.pdf","grobid_xml":"https://content.openalex.org/works/W2140396456.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W3085817","https://openalex.org/W255738520","https://openalex.org/W634409901","https://openalex.org/W1549536215","https://openalex.org/W1561970976","https://openalex.org/W1597276667","https://openalex.org/W1604252033","https://openalex.org/W1866253636","https://openalex.org/W1876533241","https://openalex.org/W1965667084","https://openalex.org/W1972409308","https://openalex.org/W1979283454","https://openalex.org/W1981498008","https://openalex.org/W1990652761","https://openalex.org/W1993285789","https://openalex.org/W2005664674","https://openalex.org/W2008359273","https://openalex.org/W2008630986","https://openalex.org/W2009293506","https://openalex.org/W2011997792","https://openalex.org/W2019175855","https://openalex.org/W2023610686","https://openalex.org/W2036023681","https://openalex.org/W2044122905","https://openalex.org/W2046478965","https://openalex.org/W2048119460","https://openalex.org/W2069463512","https://openalex.org/W2069760980","https://openalex.org/W2069866232","https://openalex.org/W2076154342","https://openalex.org/W2093586212","https://openalex.org/W2096575861","https://openalex.org/W2099882266","https://openalex.org/W2102392672","https://openalex.org/W2104774735","https://openalex.org/W2107128774","https://openalex.org/W2110924006","https://openalex.org/W2116426914","https://openalex.org/W2122329067","https://openalex.org/W2123892444","https://openalex.org/W2127812911","https://openalex.org/W2130466887","https://openalex.org/W2136105123","https://openalex.org/W2144929560","https://openalex.org/W2148718900","https://openalex.org/W2148982122","https://openalex.org/W2150736802","https://openalex.org/W2159081113","https://openalex.org/W2166500974","https://openalex.org/W2171348904","https://openalex.org/W2203252197","https://openalex.org/W2242222218","https://openalex.org/W2437085630"],"related_works":["https://openalex.org/W2154061303","https://openalex.org/W2290326674","https://openalex.org/W2897769260","https://openalex.org/W2292853132","https://openalex.org/W1866253636","https://openalex.org/W3177329184","https://openalex.org/W1993718695","https://openalex.org/W948039569","https://openalex.org/W2017408747","https://openalex.org/W2036023681"],"abstract_inverted_index":{"Phosphorylation":[0],"modulates":[1],"the":[2,13,18,43,71,83,136,154],"functioning":[3],"of":[4,15,24,30,36,73,106,138,153,156],"alphaB-crystallin":[5,25,37,74,109,117,157],"as":[6,149],"a":[7],"molecular":[8],"chaperone.":[9],"We":[10],"here":[11],"explore":[12],"role":[14],"phosphorylation":[16,35,50,59],"in":[17,26,92,112,135],"nuclear":[19,31,56,94,96,113,131],"import":[20,41,72,97],"and":[21,58,98,130,133],"cellular":[22],"localization":[23],"HeLa":[27],"cells.":[28],"Inhibition":[29],"export":[32],"demonstrated":[33],"that":[34,70],"is":[38,53,62,75],"required":[39,63],"for":[40,55,64,142],"into":[42],"nucleus.":[44],"As":[45],"revealed":[46],"by":[47,78,104],"mutant":[48,118],"analysis,":[49],"at":[51,60],"Ser-59":[52],"crucial":[54],"import,":[57,132],"Ser-45":[61],"speckle":[65],"localization.":[66],"Co-immunoprecipitation":[67],"experiments":[68],"suggested":[69],"possibly":[76],"regulated":[77],"its":[79],"phosphorylation-dependent":[80],"interaction":[81,101,129],"with":[82,110],"survival":[84],"motor":[85],"neuron":[86],"(SMN)":[87],"protein,":[88],"an":[89,150],"important":[90,151],"factor":[91],"small":[93],"ribonucleoprotein":[95],"assembly.":[99],"This":[100],"was":[102,120],"supported":[103],"co-localization":[105],"endogenous":[107],"phosphorylated":[108],"SMN":[111,128],"structures.":[114],"The":[115],"cardiomyopathy-causing":[116],"R120G":[119],"found":[121],"to":[122],"be":[123],"excessively":[124],"phosphorylated,":[125],"which":[126],"disturbed":[127],"resulted":[134],"formation":[137],"cytoplasmic":[139],"inclusions.":[140],"Like":[141],"other":[143],"protein":[144],"aggregation":[145],"disorders,":[146],"hyperphosphorylation":[147],"appears":[148],"aspect":[152],"pathogenicity":[155],"R120G.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2016-06-24T00:00:00"}