{"id":"https://openalex.org/W2140366787","doi":null,"title":"[Cerebral imaging and physiopathology of Alzheimer's disease].","display_name":"[Cerebral imaging and physiopathology of Alzheimer's disease].","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W2140366787","mag":"2140366787","pmid":"https://pubmed.ncbi.nlm.nih.gov/18048105"},"language":"fr","primary_location":{"id":"pmid:18048105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18048105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychologie & neuropsychiatrie du vieillissement","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://inserm.hal.science/inserm-00381055","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110740915","display_name":"Marine Fouquet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I159885104","display_name":"\u00c9cole Pratique des Hautes \u00c9tudes","ror":"https://ror.org/046b3cj80","country_code":"FR","type":"education","lineage":["https://openalex.org/I159885104","https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210114068","display_name":"Centre Hospitalier Universitaire de Caen Normandie","ror":"https://ror.org/027arzy69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210114068"]},{"id":"https://openalex.org/I4210154143","display_name":"Cyceron","ror":"https://ror.org/04zeq1c51","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210154143"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marine Fouquet","raw_affiliation_strings":["Inserm E0218, EPHE, Universit\u00e9 de Caen Basse-Normandie, GIP Cyceron, CHU C\u00f4te de Nacre, Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm E0218, EPHE, Universit\u00e9 de Caen Basse-Normandie, GIP Cyceron, CHU C\u00f4te de Nacre, Caen, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I159885104","https://openalex.org/I4210114068","https://openalex.org/I4210154143","https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034401588","display_name":"Nicolas Villain","orcid":"https://orcid.org/0000-0002-7429-4289","observed_orcids":["https://orcid.org/0000-0002-7429-4289"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicolas Villain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007086576","display_name":"Ga\u00ebl Ch\u00e9telat","orcid":"https://orcid.org/0000-0002-4889-7932","observed_orcids":["https://orcid.org/0000-0002-4889-7932"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ga\u00ebl Ch\u00e9telat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015645713","display_name":"Francis Eustache","orcid":"https://orcid.org/0000-0003-4460-8686","observed_orcids":["https://orcid.org/0000-0003-4460-8686"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francis Eustache","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069352392","display_name":"B\u00e9atrice Desgranges","orcid":"https://orcid.org/0000-0002-3657-9996","observed_orcids":["https://orcid.org/0000-0002-3657-9996"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B\u00e9atrice Desgranges","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.342,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.61516181,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"5","issue":"4","first_page":"269","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/amnestic-mild-cognitive-impairment","display_name":"amnestic mild cognitive impairment","score":0.9660000205039978},{"id":"https://openalex.org/keywords/fdg-pet","display_name":"FDG-PET","score":0.7649999856948853},{"id":"https://openalex.org/keywords/hypometabolism","display_name":"hypometabolism","score":0.6919999718666077},{"id":"https://openalex.org/keywords/hippocampal-atrophy","display_name":"hippocampal atrophy","score":0.8949999809265137},{"id":"https://openalex.org/keywords/posterior-cingulate-cortex","display_name":"posterior cingulate cortex","score":0.8700000047683716},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"functional connectivity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/structural-connectivity","display_name":"structural connectivity","score":0.8069999814033508},{"id":"https://openalex.org/keywords/diffusion-tensor-imaging","display_name":"diffusion tensor imaging","score":0.6980000138282776},{"id":"https://openalex.org/keywords/resting-state-fmri","display_name":"resting-state fMRI","score":0.9070000052452087},{"id":"https://openalex.org/keywords/functional-compensation","display_name":"functional compensation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/early-diagnosis-of-alzheimer-s-disease","display_name":"early detection of Alzheimer's disease","score":0.7139999866485596},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"neuroimaging","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C2778733324","wikidata":"https://www.wikidata.org/wiki/Q2998088","display_name":"Posterior cingulate","level":3,"score":0.7605443596839905},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6978464126586914},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.6574131846427917},{"id":"https://openalex.org/C66324658","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Resting state fMRI","level":2,"score":0.579996645450592},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5313753485679626},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5276224613189697},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5261161923408508},{"id":"https://openalex.org/C52338299","wikidata":"https://www.wikidata.org/wiki/Q1004354","display_name":"Functional neuroimaging","level":3,"score":0.4843915104866028},{"id":"https://openalex.org/C182752723","wikidata":"https://www.wikidata.org/wiki/Q1474590","display_name":"Functional imaging","level":2,"score":0.44284167885780334},{"id":"https://openalex.org/C2776228812","wikidata":"https://www.wikidata.org/wiki/Q2869816","display_name":"Posterior cortical atrophy","level":4,"score":0.4234659671783447},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.3556743860244751},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31575721502304077},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.24528589844703674},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1834697127342224}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006179","descriptor_name":"Gyrus Cinguli","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006179","descriptor_name":"Gyrus Cinguli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006179","descriptor_name":"Gyrus Cinguli","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:18048105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18048105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychologie & neuropsychiatrie du vieillissement","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:inserm-00381055v1","doi":null,"is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-00381055","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Psychologie & neuropsychiatrie du vieillissement, 2007, 5 (4), pp.269-79","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2140366787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18048105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:HAL:inserm-00381055v1","doi":null,"is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-00381055","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Psychologie & neuropsychiatrie du vieillissement, 2007, 5 (4), pp.269-79","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1522806115","https://openalex.org/W1855610705","https://openalex.org/W1965921983","https://openalex.org/W1970300450","https://openalex.org/W1976676059","https://openalex.org/W1978832801","https://openalex.org/W1980264147","https://openalex.org/W1983493842","https://openalex.org/W1984167936","https://openalex.org/W1989217296","https://openalex.org/W1993829874","https://openalex.org/W1994984364","https://openalex.org/W2000658130","https://openalex.org/W2018523864","https://openalex.org/W2024268497","https://openalex.org/W2024786968","https://openalex.org/W2045333811","https://openalex.org/W2045867209","https://openalex.org/W2046104092","https://openalex.org/W2052530454","https://openalex.org/W2060629467","https://openalex.org/W2067140282","https://openalex.org/W2069444194","https://openalex.org/W2070069429","https://openalex.org/W2081481111","https://openalex.org/W2087964262","https://openalex.org/W2113708991","https://openalex.org/W2132131830","https://openalex.org/W2133803945","https://openalex.org/W2133903921","https://openalex.org/W2134858198","https://openalex.org/W2143285014","https://openalex.org/W2152947287","https://openalex.org/W2158592797","https://openalex.org/W2159178995","https://openalex.org/W2162010696","https://openalex.org/W2162670762"],"related_works":["https://openalex.org/W7074057919","https://openalex.org/W2109862162","https://openalex.org/W1983493842","https://openalex.org/W1971136065","https://openalex.org/W1561100145","https://openalex.org/W1512927217","https://openalex.org/W1964104633","https://openalex.org/W4241128332","https://openalex.org/W2494429799","https://openalex.org/W2563460779"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"(AD)":[2],"is":[3],"characterised":[4],"by":[5,43,124],"macroscopic":[6],"cerebral":[7],"damages":[8],"which":[9],"can":[10],"be":[11],"studied":[12],"in":[13,26,99],"vivo":[14],"with":[15,28,69,73,82,106,113,118],"neuroimaging":[16,213],"techniques,":[17],"even":[18],"at":[19,161],"the":[20,58,65,77,100,107,129,135,138,147,156,162,165,173,183,186,210,215],"earliest":[21],"stage.":[22],"Studies":[23],"were":[24],"conducted":[25],"patients":[27,47],"amnestic":[29],"Mild":[30],"Cognitive":[31],"Impairment":[32],"(MCI)":[33],"who":[34,48,54],"best":[35],"represent":[36],"incipient":[37],"AD.":[38,219],"Right":[39],"temporo-parietal":[40],"hypometabolism,":[41],"assessed":[42],"resting-state":[44,88,199],"(18)FDG-PET,":[45],"distinguishes":[46],"further":[49],"develop":[50],"AD":[51],"from":[52,87,198],"those":[53,126],"remain":[55],"stable.":[56],"From":[57],"pre-dementia":[59,163],"stage":[60],"of":[61,64,76,93,131,149,175,212,218],"MCI,":[62],"atrophy":[63],"hippocampal":[66,101,136,166],"region":[67,102],"detected":[68],"structural":[70,120,187],"MRI":[71],"contrasts":[72],"functional":[74,94,103,151,178,189],"alteration":[75,190],"posterior":[78,108,139],"cingulate":[79,109,140],"gyrus":[80],"measured":[81],"(18)FDG-PET":[83],"and":[84,96,111,137,177,188,202],"SPECT.":[85],"Results":[86],"fMRI":[89,144,204],"confirm":[90],"this":[91,169,207],"pattern":[92],"abnormalities":[95],"highlight":[97],"changes":[98],"connectivity,":[104],"decreased":[105],"region,":[110],"increased":[112],"some":[114],"frontal":[115,157],"areas.":[116],"Altogether":[117],"a":[119,132,150],"connectivity":[121],"impairment":[122],"highlighted":[123],"DTI,":[125],"results":[127,197],"support":[128,146],"hypothesis":[130,148],"dysconnexion":[133,176],"between":[134,185],"regions.":[141],"Finally,":[142],"activation":[143,203],"data":[145],"compensation":[152],"involving":[153],"not":[154],"only":[155],"cortex":[158],"but":[159],"also,":[160],"stage,":[164],"region.":[167],"Thus,":[168],"synthesis":[170,208],"focuses":[171],"on":[172,195],"hypotheses":[174],"compensation,":[179],"suggested":[180],"to":[181],"explain":[182],"discrepancies":[184],"patterns,":[191],"as":[192,194],"well":[193],"relevant":[196],"fMRI,":[200],"DTI":[201],"studies.":[205],"Furthermore,":[206],"emphasizes":[209],"relevance":[211],"for":[214],"early":[216],"detection":[217]},"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
