{"id":"https://openalex.org/W2140359999","doi":"https://doi.org/10.1001/archsurg.1967.01330180157025","title":"Combined Systemic and Topical Therapy of Experimental Burn Wound Sepsis","display_name":"Combined Systemic and Topical Therapy of Experimental Burn Wound Sepsis","publication_year":1967,"publication_date":"1967-12-01","ids":{"openalex":"https://openalex.org/W2140359999","doi":"https://doi.org/10.1001/archsurg.1967.01330180157025","mag":"2140359999","pmid":"https://pubmed.ncbi.nlm.nih.gov/4964594"},"language":"en","primary_location":{"id":"doi:10.1001/archsurg.1967.01330180157025","doi":"https://doi.org/10.1001/archsurg.1967.01330180157025","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archsurg.1967.01330180157025","pdf_url":null,"source":{"id":"https://openalex.org/S61251237","display_name":"Archives of Surgery","issn_l":"0004-0010","issn":["0004-0010","0272-5533","1538-3644","2376-3590"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110021915","display_name":"Donald P. Dressler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Donald P. Dressler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110021915"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9582,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.79238754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"95","issue":"6","first_page":"1009","last_page":"1009"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/burn-sepsis","display_name":"burn sepsis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mafenide-acetate","display_name":"mafenide acetate","score":0.8769999742507935},{"id":"https://openalex.org/keywords/topical-antibiotics","display_name":"topical antibiotics","score":0.7570000290870667},{"id":"https://openalex.org/keywords/systemic-antibiotics","display_name":"systemic antibiotics","score":0.9089999794960022},{"id":"https://openalex.org/keywords/burn-mortality","display_name":"burn mortality","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.966477632522583},{"id":"https://openalex.org/C3019879682","wikidata":"https://www.wikidata.org/wiki/Q170518","display_name":"Burn wound","level":3,"score":0.7495765686035156},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7178016901016235},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6727714538574219},{"id":"https://openalex.org/C185926286","wikidata":"https://www.wikidata.org/wiki/Q1929812","display_name":"Systemic therapy","level":4,"score":0.5095234513282776},{"id":"https://openalex.org/C3019325995","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Systemic antibiotics","level":3,"score":0.485099196434021},{"id":"https://openalex.org/C2779232120","wikidata":"https://www.wikidata.org/wiki/Q1511599","display_name":"Negative-pressure wound therapy","level":3,"score":0.48040488362312317},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32173508405685425},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.3159937858581543},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.09966668486595154},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08896586298942566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000891","descriptor_name":"Anti-Infective Agents, Local","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002056","descriptor_name":"Burns","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003091","descriptor_name":"Colistin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013424","descriptor_name":"Sulfanilamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1001/archsurg.1967.01330180157025","doi":"https://doi.org/10.1001/archsurg.1967.01330180157025","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archsurg.1967.01330180157025","pdf_url":null,"source":{"id":"https://openalex.org/S61251237","display_name":"Archives of Surgery","issn_l":"0004-0010","issn":["0004-0010","0272-5533","1538-3644","2376-3590"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Surgery","raw_type":"journal-article"},{"id":"pmid:4964594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4964594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of surgery (Chicago, Ill. : 1960)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1985961571","https://openalex.org/W2032707539","https://openalex.org/W2062599939","https://openalex.org/W2405116390","https://openalex.org/W2465889958"],"related_works":["https://openalex.org/W2122712243","https://openalex.org/W2320584293","https://openalex.org/W4235583089","https://openalex.org/W2046598970","https://openalex.org/W2413513256","https://openalex.org/W211394278","https://openalex.org/W2095196963","https://openalex.org/W1988566394","https://openalex.org/W4402574470","https://openalex.org/W2032707539"],"abstract_inverted_index":{"TOPICAL":[0],"mafenide":[1,82],"(Sulfamylon)":[2],"acetate":[3],"B":[4],"in":[5,23,42,121],"a":[6,73,78],"hydrophilic":[7],"base":[8],"has":[9,30,83,141],"recently":[10],"been":[11,31,84],"shown":[12,85],"to":[13,52,114,117],"effectively":[14],"reduce":[15],"the":[16,24,35,47,53,69,93,122,135],"mortality":[17,48,111],"from":[18],"burn":[19,56,74,110,123],"wound":[20,57,75],"sepsis":[21,58],"both":[22],"laboratory":[25,44],"and":[26,63,67],"clinically.":[27],"This":[28],"therapy":[29],"based":[32],"largely":[33],"on":[34],"work":[36],"of":[37,55,72,134],"Teplitz1and":[38],"Lindberg2and":[39],"subsequently":[40],"substantiated":[41],"our":[43],"showing":[45],"that":[46,68],"is":[49,96],"directly":[50],"related":[51],"degree":[54],"as":[59],"measured":[60],"by":[61,86],"eschar":[62],"subeschar":[64],"bacterial":[65,70],"counts":[66],"invasion":[71],"occurs":[76],"at":[77],"predictable":[79],"rate.":[80],"Topical":[81],"Lindberg3to":[87],"be":[88],"progressively":[89],"less":[90],"effective":[91,119],"if":[92],"initial":[94],"application":[95],"delayed":[97],"until":[98],"48":[99],"hours":[100],"postburn":[101],"or":[102],"longer.":[103],"Systemic":[104],"antibiotics":[105],"have":[106],"not":[107],"significantly":[108],"reduced":[109],"probably":[112],"due":[113],"their":[115],"inability":[116],"achieve":[118],"concentrations":[120],"with":[124],"its":[125],"damaged":[126],"vascularity,4,5and":[127],"still":[128],"remain":[129],"within":[130],"safe":[131],"systemic":[132],"levels":[133],"antibiotic.":[136],"Sodium":[137],"colistimethate":[138],"(Coly-Mycin":[139],"Injectable)":[140]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
