{"id":"https://openalex.org/W2140317841","doi":"https://doi.org/10.1371/journal.pone.0059787","title":"Prevalence of HIV-1 Drug Resistance among Women Screening for HIV Prevention Trials in KwaZulu-Natal, South Africa (MTN-009)","display_name":"Prevalence of HIV-1 Drug Resistance among Women Screening for HIV Prevention Trials in KwaZulu-Natal, South Africa (MTN-009)","publication_year":2013,"publication_date":"2013-04-09","ids":{"openalex":"https://openalex.org/W2140317841","doi":"https://doi.org/10.1371/journal.pone.0059787","mag":"2140317841","pmid":"https://pubmed.ncbi.nlm.nih.gov/23585827","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3621859"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0059787","doi":"https://doi.org/10.1371/journal.pone.0059787","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0059787","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0059787&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0059787&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089446248","display_name":"Urvi M. Parikh","orcid":"https://orcid.org/0000-0002-4016-0629","observed_orcids":["https://orcid.org/0000-0002-4016-0629"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Urvi M. Parikh","raw_affiliation_strings":["Department of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America. ump3@pitt.edu","Department of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America. ump3@pitt.edu","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085152597","display_name":"Photini Kiepiela","orcid":"https://orcid.org/0000-0003-2563-7617","observed_orcids":["https://orcid.org/0000-0003-2563-7617"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Photini Kiepiela","raw_affiliation_strings":["HIV Prevention Research Unit, Medical Research Council, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Prevention Research Unit, Medical Research Council, Durban, South Africa","institution_ids":["https://openalex.org/I10947320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106945195","display_name":"Shayhana Ganesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Shayhana Ganesh","raw_affiliation_strings":["HIV Prevention Research Unit, Medical Research Council, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Prevention Research Unit, Medical Research Council, Durban, South Africa","institution_ids":["https://openalex.org/I10947320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110692434","display_name":"Kailazarid Gomez","orcid":"https://orcid.org/0000-0001-5849-8372","observed_orcids":["https://orcid.org/0000-0001-5849-8372"]},"institutions":[{"id":"https://openalex.org/I1290866511","display_name":"Family Health International 360","ror":"https://ror.org/007kp6q87","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1290866511"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kailazarid Gomez","raw_affiliation_strings":["FHI 360, Research Triangle Park, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FHI 360, Research Triangle Park, North Carolina, United States of America","institution_ids":["https://openalex.org/I1290866511"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stephanie Horn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290866511","display_name":"Family Health International 360","ror":"https://ror.org/007kp6q87","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1290866511"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Horn","raw_affiliation_strings":["FHI 360, Research Triangle Park, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FHI 360, Research Triangle Park, North Carolina, United States of America","institution_ids":["https://openalex.org/I1290866511"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057801120","display_name":"Krista Eskay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krista Eskay","raw_affiliation_strings":["Department of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111505895","display_name":"Cliff Kelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cliff Kelly","raw_affiliation_strings":["Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025788697","display_name":"Barbara Mensch","orcid":"https://orcid.org/0000-0003-1073-9135","observed_orcids":["https://orcid.org/0000-0003-1073-9135"]},"institutions":[{"id":"https://openalex.org/I4210132262","display_name":"Population Council","ror":"https://ror.org/03zjj0p70","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210132262"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Mensch","raw_affiliation_strings":["Population Council, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Population Council, New York, New York, United States of America","institution_ids":["https://openalex.org/I4210132262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025092594","display_name":"Pamina M. Gorbach","orcid":"https://orcid.org/0000-0003-2100-7765","observed_orcids":["https://orcid.org/0000-0003-2100-7765"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamina Gorbach","raw_affiliation_strings":["Department of Epidemiology, University of California Los Angeles, Los Angeles, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of California Los Angeles, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112050539","display_name":"Lydia E Soto-Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lydia Soto-Torres","raw_affiliation_strings":["Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110141057","display_name":"Gita Ramjee H","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Gita Ramjee","raw_affiliation_strings":["HIV Prevention Research Unit, Medical Research Council, Durban, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HIV Prevention Research Unit, Medical Research Council, Durban, South Africa","institution_ids":["https://openalex.org/I10947320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038307269","display_name":"John W. Mellors","orcid":"https://orcid.org/0000-0002-3737-9742","observed_orcids":["https://orcid.org/0000-0002-3737-9742"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Mellors","raw_affiliation_strings":["Department of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":null,"display_name":"on behalf of the IPTc Taskforce","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"on behalf of the IPTc Taskforce","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5089446248"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.8781,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.93622512,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"4","first_page":"e59787","last_page":"e59787"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.06599999964237213,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-drug-resistance","display_name":"HIV-1 drug resistance","score":0.824999988079071},{"id":"https://openalex.org/keywords/hiv-1-subtype-c","display_name":"HIV-1 subtype C","score":0.7279999852180481},{"id":"https://openalex.org/keywords/hiv-prevention","display_name":"HIV prevention","score":0.47999998927116394},{"id":"https://openalex.org/keywords/antiretroviral-therapy-eligibility","display_name":"antiretroviral therapy eligibility","score":0.7910000085830688},{"id":"https://openalex.org/keywords/hiv-screening","display_name":"HIV screening","score":0.3400000035762787},{"id":"https://openalex.org/keywords/drug-resistance-mutations","display_name":"drug resistance mutations","score":0.5419999957084656},{"id":"https://openalex.org/keywords/reverse-transcriptase","display_name":"reverse transcriptase","score":0.6579999923706055},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.7739999890327454},{"id":"https://openalex.org/keywords/non-nucleoside-reverse-transcriptase-inhibitors","display_name":"non-nucleoside reverse transcriptase inhibitors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/nucleoside-reverse-transcriptase-inhibitors","display_name":"nucleoside reverse transcriptase inhibitors","score":0.8149999976158142},{"id":"https://openalex.org/keywords/kwazulu-natal","display_name":"KwaZulu-Natal","score":0.7379999756813049},{"id":"https://openalex.org/keywords/durban","display_name":"Durban","score":0.7590000033378601},{"id":"https://openalex.org/keywords/hiv-1-rna","display_name":"HIV-1 RNA","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.7115399241447449},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6296224594116211},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6206981539726257},{"id":"https://openalex.org/C2778451633","wikidata":"https://www.wikidata.org/wiki/Q5629934","display_name":"HIV drug resistance","level":5,"score":0.6199560761451721},{"id":"https://openalex.org/C2777351918","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Reverse-transcriptase inhibitor","level":5,"score":0.615308403968811},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.6119396686553955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5404065847396851},{"id":"https://openalex.org/C2781143361","wikidata":"https://www.wikidata.org/wiki/Q55761529","display_name":"Protease inhibitor (pharmacology)","level":5,"score":0.4977703392505646},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.49437570571899414},{"id":"https://openalex.org/C2909970146","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Nucleoside Reverse Transcriptase Inhibitor","level":5,"score":0.49107837677001953},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.43811389803886414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.364822655916214},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3490923047065735},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32782694697380066},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.31949907541275024},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.2214559018611908},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.20140305161476135},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.19935822486877441},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.12729284167289734},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09695398807525635},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.09665387868881226},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08619734644889832}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006679","descriptor_name":"HIV Seropositivity","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006679","descriptor_name":"HIV Seropositivity","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006679","descriptor_name":"HIV Seropositivity","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008403","descriptor_name":"Mass Screening","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013019","descriptor_name":"South Africa","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0059787","doi":"https://doi.org/10.1371/journal.pone.0059787","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0059787","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0059787&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2623996","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3621859","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3621859","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3621859","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23585827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23585827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:d-scholarship.pitt.edu:18327","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/18327/8/licence.txt","pdf_url":null,"source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.789.4393","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.789.4393","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/30/4c/pone.0059787.PMC3621859.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:9e08a933ee54400dbb411006c9798289","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9e08a933ee54400dbb411006c9798289","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 4, p e59787 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0059787","doi":"https://doi.org/10.1371/journal.pone.0059787","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0059787","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0059787&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3021320693","display_name":"Leadership and Operations Center (LOC): Microbicide Trials Network","funder_award_id":"UM1AI068633","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320320672","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2140317841.pdf","grobid_xml":"https://content.openalex.org/works/W2140317841.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W114558098","https://openalex.org/W622557290","https://openalex.org/W1603685120","https://openalex.org/W1965869461","https://openalex.org/W1969623552","https://openalex.org/W1991893197","https://openalex.org/W2001511329","https://openalex.org/W2001821060","https://openalex.org/W2038369742","https://openalex.org/W2046596313","https://openalex.org/W2056539403","https://openalex.org/W2060571248","https://openalex.org/W2064314936","https://openalex.org/W2067878197","https://openalex.org/W2077380470","https://openalex.org/W2086783015","https://openalex.org/W2099991866","https://openalex.org/W2103920597","https://openalex.org/W2109046728","https://openalex.org/W2116258000","https://openalex.org/W2116758166","https://openalex.org/W2117057469","https://openalex.org/W2118784602","https://openalex.org/W2129810760","https://openalex.org/W2138162130","https://openalex.org/W2146634980","https://openalex.org/W2151945184","https://openalex.org/W2152896082","https://openalex.org/W2154164013","https://openalex.org/W2162226934","https://openalex.org/W2162598494","https://openalex.org/W2166124948","https://openalex.org/W2312959099","https://openalex.org/W2800262825","https://openalex.org/W4247917425"],"related_works":["https://openalex.org/W4281893704","https://openalex.org/W1969979909","https://openalex.org/W2184002906","https://openalex.org/W2104591118","https://openalex.org/W1969623552","https://openalex.org/W2859985921","https://openalex.org/W2557772666","https://openalex.org/W7098791294","https://openalex.org/W2152896082","https://openalex.org/W7095469171"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1,50],"major":[2],"concern":[3],"with":[4,96,187,244,251,296],"using":[5,106],"antiretroviral":[6,144,298],"(ARV)-based":[7],"products":[8],"for":[9,60,93,143,154,163,262],"HIV":[10,37,62,99,264,268,274,304,313],"prevention":[11,47,63,265,292,314],"is":[12],"the":[13,34,85,107,115,267,284,320],"potential":[14,43,285],"spread":[15,321],"of":[16,27,36,45,53,84,311,322],"drug":[17,40,164,182,275],"resistance,":[18,165,188],"particularly":[19],"from":[20,257],"individuals":[21],"who":[22,56],"are":[23],"HIV-infected":[24],"but":[25],"unaware":[26],"their":[28],"status.":[29],"Limited":[30],"data":[31],"exist":[32],"on":[33],"prevalence":[35,269,277],"infection":[38,305],"or":[39,178],"resistance":[41,183,194,276],"among":[42,306],"users":[44],"ARV-based":[46,291,312],"products.":[48],"METHODS:":[49],"cross-sectional":[51],"study":[52,282],"reproductive-aged":[54],"women":[55,95,256,307],"presented":[57],"to":[58,302],"screen":[59],"an":[61,263,290],"trial":[64],"was":[65,129,270,278],"conducted":[66],"at":[67],"7":[68],"clinical":[69],"sites":[70],"in":[71,131,136,202,309,318],"Durban,":[72,258],"South":[73,259],"Africa.":[74],"CD4+T":[75],"cell":[76,147],"counts,":[77],"HIV-1":[78,127],"RNA":[79,128],"levels":[80],"and":[81,87,133,150,195,224,236,273],"population":[82],"sequencing":[83],"protease":[86,179],"reverse":[88,169,174,203],"transcriptase":[89,170,175,204],"genes":[90],"were":[91,104,120,141,231,242],"performed":[92],"all":[94],"2":[97],"positive":[98],"rapid":[100],"tests.":[101],"Resistance":[102,111],"mutations":[103,201,230],"identified":[105],"Stanford":[108],"Calibrated":[109],"Population":[110],"Tool.":[112],"RESULTS:":[113],"Of":[114,124,157],"1073":[116],"evaluable":[117],"women,":[118],"400(37%)":[119],"confirmed":[121],"as":[122],"HIV-infected.":[123],"those,":[125],"plasma":[126,159],"detectable":[130],"365/400(91%)":[132],"undetectable(<40":[134],"copies/ml)":[135,161],"35/400(9%)":[137],"women.":[138],"156":[139],"women(39%)":[140],"eligible":[142],"therapy":[145],"(CD4+T":[146],"counts<350":[148],"cells/mm(3))":[149],"50(13%)":[151],"met":[152],"criteria":[153],"AIDS(CD4<200":[155],"cells/mm(3)).":[156],"352":[158],"samples(>200":[160],"analyzed":[162],"26(7.4%)":[166],"had":[167,191,197],"nucleoside":[168],"inhibitor":[171,176,180],"(NRTI),":[172],"non-nucleoside":[173],"(NNRTI)":[177],"(PI)":[181],"mutations.":[184],"Among":[185],"those":[186],"18/26":[189],"participants(62%)":[190],"single-class":[192],"NNRTI":[193],"5/26(19%)":[196],"dual-class":[198],"NRTI/NNRTI.":[199],"Major":[200,228],"included":[205],"K65R(n":[206],"=":[207,210,213,216,219,222,226,234,238],"1),":[208,211],"L74I(n":[209],"K103N(n":[212],"19),":[214],"V106M(n":[215],"4),":[217,223],"Y181C(n":[218],"2),":[220],"M184V(n":[221],"K219E/R(n":[225],"2).":[227],"PI-resistance":[229],"rare:":[232],"M46L(n":[233],"1)":[235],"I85V(n":[237],"1).":[239],"All":[240],"participants":[241],"infected":[243,250],"subtype":[245,252],"C":[246],"virus,":[247],"except":[248],"one":[249],"A.":[253],"CONCLUSIONS:":[254],"In":[255],"Africa":[260],"screening":[261,301],"trial,":[266],"high":[271],"(37%)":[272],"above":[279],"5%.":[280],"This":[281],"highlights":[283],"challenges":[286],"faced":[287],"when":[288],"implementing":[289],"product":[293],"that":[294],"overlaps":[295],"first-line":[297],"therapy.":[299],"Effective":[300],"exclude":[303],"interested":[308],"uptake":[310],"will":[315],"be":[316],"essential":[317],"limiting":[319],"ARV":[323],"resistance.":[324]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}