{"id":"https://openalex.org/W2140303115","doi":"https://doi.org/10.1517/14728214.13.1.135","title":"Emerging drugs in the treatment of advanced gastric cancer","display_name":"Emerging drugs in the treatment of advanced gastric cancer","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2140303115","doi":"https://doi.org/10.1517/14728214.13.1.135","mag":"2140303115","pmid":"https://pubmed.ncbi.nlm.nih.gov/18321153"},"language":"en","primary_location":{"id":"doi:10.1517/14728214.13.1.135","doi":"https://doi.org/10.1517/14728214.13.1.135","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14728214.13.1.135","pdf_url":null,"source":{"id":"https://openalex.org/S66445379","display_name":"Expert Opinion on Emerging Drugs","issn_l":"1472-8214","issn":["1472-8214","1744-7623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Emerging Drugs","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078325539","display_name":"Eric Daniel Tetzlaff","orcid":"https://orcid.org/0000-0002-8855-327X","observed_orcids":["https://orcid.org/0000-0002-8855-327X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric D Tetzlaff","raw_affiliation_strings":["University of Texas, M.D. Anderson Cancer Center, Department of Gastrointestinal Medical Oncology, Houston, Texas 77030, USA","+1 713 745 1163","M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 426, Houston, Texas 77030, USA +1 713 792 2828"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas, M.D. Anderson Cancer Center, Department of Gastrointestinal Medical Oncology, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"+1 713 745 1163","institution_ids":[]},{"raw_affiliation_string":"M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 426, Houston, Texas 77030, USA +1 713 792 2828","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004135808","display_name":"Putao Cen","orcid":"https://orcid.org/0000-0001-5633-311X","observed_orcids":["https://orcid.org/0000-0001-5633-311X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Putao Cen","raw_affiliation_strings":["M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 426, Houston, Texas 77030, USA +1 713 792 2828; +1 713 745 1163; jajani@mdanderson.org","+1 713 745 1163","M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 426, Houston, Texas 77030, USA +1 713 792 2828"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 426, Houston, Texas 77030, USA +1 713 792 2828; +1 713 745 1163; jajani@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"+1 713 745 1163","institution_ids":[]},{"raw_affiliation_string":"M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 426, Houston, Texas 77030, USA +1 713 792 2828","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044064524","display_name":"Jaffer A. Ajani","orcid":"https://orcid.org/0000-0001-9946-0629","observed_orcids":["https://orcid.org/0000-0001-9946-0629"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaffer A Ajani","raw_affiliation_strings":["M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 426, Houston, Texas 77030, USA +1 713 792 2828; +1 713 745 1163; jajani@mdanderson.org","+1 713 745 1163","M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 426, Houston, Texas 77030, USA +1 713 792 2828"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 426, Houston, Texas 77030, USA +1 713 792 2828; +1 713 745 1163; jajani@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"+1 713 745 1163","institution_ids":[]},{"raw_affiliation_string":"M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 426, Houston, Texas 77030, USA +1 713 792 2828","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.4226,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.38,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"13","issue":"1","first_page":"135","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-gastric-cancer","display_name":"advanced gastric cancer","score":0.984000027179718},{"id":"https://openalex.org/keywords/gastroesophageal-cancer","display_name":"gastroesophageal cancer","score":0.8709999918937683},{"id":"https://openalex.org/keywords/chemotherapy-regimens","display_name":"chemotherapy regimens","score":0.9129999876022339},{"id":"https://openalex.org/keywords/best-supportive-care","display_name":"best supportive care","score":0.7310000061988831},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8600000143051147},{"id":"https://openalex.org/keywords/conventional-chemotherapy","display_name":"cytotoxic chemotherapy","score":0.828000009059906},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.8240000009536743},{"id":"https://openalex.org/keywords/palliative-care","display_name":"palliative care","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.910857081413269},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6698135733604431},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.664181113243103},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6277421712875366},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5773471593856812},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5379574298858643},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.535449743270874},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5309637784957886},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45210927724838257},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015507","descriptor_name":"Drugs, Investigational","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017322","descriptor_name":"Clinical Trials, Phase II as Topic","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D017326","descriptor_name":"Clinical Trials, Phase III as Topic","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1517/14728214.13.1.135","doi":"https://doi.org/10.1517/14728214.13.1.135","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14728214.13.1.135","pdf_url":null,"source":{"id":"https://openalex.org/S66445379","display_name":"Expert Opinion on Emerging Drugs","issn_l":"1472-8214","issn":["1472-8214","1744-7623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Emerging Drugs","raw_type":"journal-article"},{"id":"pmid:18321153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18321153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on emerging drugs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W200233776","https://openalex.org/W1525737532","https://openalex.org/W1573363574","https://openalex.org/W1596261235","https://openalex.org/W1843791750","https://openalex.org/W1848862702","https://openalex.org/W1940613095","https://openalex.org/W1944693814","https://openalex.org/W1964321121","https://openalex.org/W1964589941","https://openalex.org/W1969495433","https://openalex.org/W1974449546","https://openalex.org/W1976651872","https://openalex.org/W1992408996","https://openalex.org/W2008575122","https://openalex.org/W2010496647","https://openalex.org/W2018530699","https://openalex.org/W2018619890","https://openalex.org/W2020830322","https://openalex.org/W2024949026","https://openalex.org/W2026986976","https://openalex.org/W2051120695","https://openalex.org/W2068225833","https://openalex.org/W2077902459","https://openalex.org/W2101020979","https://openalex.org/W2106787323","https://openalex.org/W2112944030","https://openalex.org/W2115072149","https://openalex.org/W2122866527","https://openalex.org/W2130522735","https://openalex.org/W2131926022","https://openalex.org/W2133127344","https://openalex.org/W2139994556","https://openalex.org/W2143863553","https://openalex.org/W2146434000","https://openalex.org/W2158118791","https://openalex.org/W2164832531","https://openalex.org/W2166691176","https://openalex.org/W2208638853","https://openalex.org/W2222330038","https://openalex.org/W2240930050","https://openalex.org/W2279052620","https://openalex.org/W2282703690","https://openalex.org/W2290882986","https://openalex.org/W2296894838","https://openalex.org/W2528428498","https://openalex.org/W2608027589","https://openalex.org/W2623454034"],"related_works":["https://openalex.org/W1949058399","https://openalex.org/W2131463911","https://openalex.org/W2153061032","https://openalex.org/W2081177451","https://openalex.org/W2596202683","https://openalex.org/W2464185620","https://openalex.org/W2005069994","https://openalex.org/W2461775305","https://openalex.org/W4281703253","https://openalex.org/W4210975948"],"abstract_inverted_index":{"BACKGROUND:":[0],"Gastroesopheal":[1],"cancer":[2,20,50],"is":[3,16,21,29],"one":[4],"of":[5,37,47,87,110],"the":[6,45,83,108,115],"most":[7],"common":[8],"cancers":[9],"worldwide.":[10],"If":[11],"detected":[12,22],"early,":[13],"curative":[14],"treatment":[15,46,109],"possible.":[17],"Often,":[18],"gastroesophageal":[19,49],"at":[23,64],"an":[24],"advanced":[25,48,92],"stage":[26],"when":[27],"therapy":[28],"palliative.":[30],"OBJECTIVES:":[31],"To":[32],"provide":[33],"a":[34,74],"critical":[35],"evaluation":[36],"historic":[38],"and":[39,85,101],"recently":[40],"developed":[41],"chemotherapy":[42,100],"regimens":[43],"for":[44,89,107,114],"(AGC).":[51],"METHODS:":[52],"Published":[53],"clinical":[54],"trials":[55,97,104],"in":[56],"AGC":[57,111],"as":[58,60],"well":[59],"selected":[61],"abstracts":[62],"presented":[63],"international":[65],"oncology":[66],"meetings":[67],"were":[68],"selected.":[69],"RESULTS/CONCLUSION:":[70],"Chemotherapy":[71],"has":[72],"demonstrated":[73],"benefit":[75],"over":[76],"best":[77],"supportive":[78],"care":[79],"alone":[80],"by":[81],"improving":[82],"quality":[84],"quantity":[86],"life":[88],"patients":[90],"with":[91],"disease.":[93],"Recent":[94],"Phase":[95,102],"III":[96],"investigating":[98],"cytotoxic":[99],"II":[103],"incorporating":[105],"biotherapy":[106],"show":[112],"promise":[113],"future.":[116]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}