{"id":"https://openalex.org/W2140264841","doi":null,"title":"Inhibition of estrogen-dependent breast cancer growth by a reaction product of alpha-fetoprotein and estradiol.","display_name":"Inhibition of estrogen-dependent breast cancer growth by a reaction product of alpha-fetoprotein and estradiol.","publication_year":1990,"publication_date":"1990-01-15","ids":{"openalex":"https://openalex.org/W2140264841","mag":"2140264841","pmid":"https://pubmed.ncbi.nlm.nih.gov/1688512"},"language":"en","primary_location":{"id":"pmid:1688512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1688512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108414937","display_name":"Herbert I. Jacobson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I77920804","display_name":"Albany Medical Center Hospital","ror":"https://ror.org/0307crw42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I77920804"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H I Jacobson","raw_affiliation_strings":["Department of Obstetrics/Gynecology, Albany Medical College, New York 12208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics/Gynecology, Albany Medical College, New York 12208","institution_ids":["https://openalex.org/I4405260259","https://openalex.org/I77920804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058754951","display_name":"James A. Bennett","orcid":"https://orcid.org/0000-0001-6251-673X","observed_orcids":["https://orcid.org/0000-0001-6251-673X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Bennett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112251655","display_name":"Gerald J. Mizejewski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G J Mizejewski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.175,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.87771811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"50","issue":"2","first_page":"415","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.9980000257492065},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9660000205039978},{"id":"https://openalex.org/keywords/estrogen-dependent-breast-cancer","display_name":"estrogen-dependent breast cancer","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.8119999766349792},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.8230000138282776},{"id":"https://openalex.org/keywords/allograft","display_name":"allograft","score":0.8690000176429749},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.3569999933242798},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.8228492736816406},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.59707111120224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5811185240745544},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5690193176269531},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48944178223609924},{"id":"https://openalex.org/C2777043721","wikidata":"https://www.wikidata.org/wiki/Q369887","display_name":"Yolk sac","level":3,"score":0.4554036557674408},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.426835298538208},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.41592922806739807},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36690160632133484},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24941298365592957},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.1356196403503418},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07987025380134583},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1688512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1688512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2140264841","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/50/2/415.full.pdf+html","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4639732796","display_name":"BIOMEDICAL RESEARCH SUPPORT","funder_award_id":"S07RR005394","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W120125979","https://openalex.org/W1867279571","https://openalex.org/W1978686224","https://openalex.org/W1990751555","https://openalex.org/W1999423316","https://openalex.org/W2020956918","https://openalex.org/W2026592554","https://openalex.org/W2032566319","https://openalex.org/W2034951671","https://openalex.org/W2091947586","https://openalex.org/W2168560528","https://openalex.org/W2409152303"],"related_works":["https://openalex.org/W1486880032","https://openalex.org/W2300314657","https://openalex.org/W2086399357","https://openalex.org/W1990989209","https://openalex.org/W1999423316","https://openalex.org/W1978686224","https://openalex.org/W2800481781","https://openalex.org/W2954804268","https://openalex.org/W2058201286","https://openalex.org/W2026309251"],"abstract_inverted_index":{"Reaction":[0],"of":[1,4,13,20,29,37,45,71,110,115,126,133,141,149,163,180],"picomolar":[2],"quantities":[3,12],"human":[5,52],"or":[6,156,178],"rodent":[7,38],"alpha-fetoprotein":[8],"(AFP)":[9],"with":[10,112,153],"nanomolar":[11],"17":[14],"beta-estradiol":[15],"(E2)":[16],"generates":[17],"a":[18,84,172],"product":[19],"unknown":[21],"structure,":[22],"designated":[23],"AFP/E2,":[24],"that":[25,103,169],"inhibits":[26],"estrogen-stimulated":[27],"growth":[28,44,127,148,162,188],"mouse":[30],"uterus.":[31],"We":[32],"describe":[33],"herein":[34],"the":[35,41,50,56,68,78,181],"effect":[36],"AFP/E2":[39,102,170],"on":[40],"in":[42,86,124,129],"vivo":[43],"two":[46],"estrogen-dependent":[47,186],"breast":[48,53],"cancers,":[49],"MCF-7":[51,134],"cancer":[54],"and":[55,145],"MTW9A":[57,79,142,150],"rat":[58],"mammary":[59],"cancer.":[60],"Both":[61],"cancers":[62],"were":[63],"grown":[64,82],"as":[65,83],"xenografts":[66],"under":[67],"kidney":[69],"capsule":[70],"cyclosporine-immunosuppressed":[72],"male":[73],"BDF1":[74],"mice.":[75],"In":[76],"addition,":[77],"tumor":[80,135,143,187],"was":[81,94,104],"homograft":[85],"syngeneic":[87],"ovariectomized":[88],"Wistar-Furth":[89],"female":[90],"rats.":[91],"Estrogen":[92],"support":[93],"provided":[95],"by":[96,106],"s.c.":[97],"Silastic":[98],"E2":[99,116,157],"implants.":[100],"Injecting":[101],"generated":[105],"incubating":[107],"1.0":[108],"microgram":[109,114],"AFP":[111,154],"0.5":[113],"for":[117],"1":[118],"h":[119],"at":[120],"room":[121],"temperature":[122],"resulted":[123],"cessation":[125],"and,":[128],"most":[130],"cases,":[131],"regression":[132,140],"xenografts.":[136,151],"It":[137],"also":[138],"produced":[139],"homografts":[144],"significantly":[146],"inhibited":[147],"Treatment":[152],"alone":[155,158],"did":[159],"not":[160],"inhibit":[161],"these":[164],"tumors.":[165],"The":[166],"data":[167],"suggest":[168],"has":[171],"unique":[173],"property":[174],"which":[175,185],"causes":[176],"attenuation":[177],"shut-down":[179],"biochemical":[182],"reactions":[183],"through":[184],"is":[189],"mediated.":[190]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}