{"id":"https://openalex.org/W2140257707","doi":"https://doi.org/10.1016/0166-2236(95)93946-u","title":"Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications","display_name":"Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W2140257707","doi":"https://doi.org/10.1016/0166-2236(95)93946-u","mag":"2140257707","pmid":"https://pubmed.ncbi.nlm.nih.gov/7535487"},"language":"en","primary_location":{"id":"doi:10.1016/0166-2236(95)93946-u","doi":"https://doi.org/10.1016/0166-2236(95)93946-u","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0166-2236(95)93946-u","pdf_url":null,"source":{"id":"https://openalex.org/S114966740","display_name":"Trends in Neurosciences","issn_l":"0166-2236","issn":["0166-2236","1878-108X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Neurosciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Alfred Mansour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfred Mansour","raw_affiliation_strings":["Mental Health Research Institute, University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mental Health Research Institute, University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110483980","display_name":"Charles A. Fox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A. Fox","raw_affiliation_strings":["Mental Health Research Institute and Dept of Psychiatry, University of Michigan, Ann Arbor, MI, USA","Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mental Health Research Institute and Dept of Psychiatry, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007964297","display_name":"Huda Akil","orcid":"https://orcid.org/0000-0003-0623-1056","observed_orcids":["https://orcid.org/0000-0003-0623-1056"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huda Akil","raw_affiliation_strings":["Mental Health Research Institute and Dept of Psychiatry, University of Michigan, Ann Arbor, MI, USA","Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mental Health Research Institute and Dept of Psychiatry, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049286080","display_name":"Stanley J. Watson","orcid":"https://orcid.org/0000-0003-4980-5523","observed_orcids":["https://orcid.org/0000-0003-4980-5523"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley J. Watson","raw_affiliation_strings":["Mental Health Research Institute and Dept of Psychiatry, University of Michigan, Ann Arbor, MI, USA","Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mental Health Research Institute and Dept of Psychiatry, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":6.3483,"has_fulltext":false,"cited_by_count":1269,"citation_normalized_percentile":{"value":0.98559078,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"18","issue":"1","first_page":"22","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/receptor-localization","display_name":"receptor localization","score":0.4320000112056732},{"id":"https://openalex.org/keywords/receptor-trafficking","display_name":"receptor trafficking","score":0.6399999856948853},{"id":"https://openalex.org/keywords/receptor-transport","display_name":"receptor transport","score":0.7059999704360962},{"id":"https://openalex.org/keywords/nigrostriatal-dopamine-system","display_name":"nigrostriatal dopamine system","score":0.8460000157356262},{"id":"https://openalex.org/keywords/mesolimbic-dopamine-system","display_name":"mesolimbic dopamine system","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pain-pathways","display_name":"pain pathways","score":0.6449999809265137},{"id":"https://openalex.org/keywords/postsynaptic-localization","display_name":"postsynaptic localization","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7246193289756775},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.619791567325592},{"id":"https://openalex.org/C2779886867","wikidata":"https://www.wikidata.org/wiki/Q421797","display_name":"Opioid receptor","level":4,"score":0.6004416346549988},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5632655620574951},{"id":"https://openalex.org/C141087196","wikidata":"https://www.wikidata.org/wiki/Q18030283","display_name":"\u03b4-opioid receptor","level":4,"score":0.4989910125732422},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.44786542654037476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4403940439224243},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12439373135566711}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009294","descriptor_name":"Narcotics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0166-2236(95)93946-u","doi":"https://doi.org/10.1016/0166-2236(95)93946-u","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0166-2236(95)93946-u","pdf_url":null,"source":{"id":"https://openalex.org/S114966740","display_name":"Trends in Neurosciences","issn_l":"0166-2236","issn":["0166-2236","1878-108X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Neurosciences","raw_type":"journal-article"},{"id":"pmid:7535487","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7535487","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in neurosciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2190867355","display_name":"ORPHANIN SYSTEM--ROLE IN STRESS AND ADDICTION","funder_award_id":"R01DA008920","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2201729747","display_name":"MU &DELTA RECEPTORS--ROLE IN TRANSMISSION &ADDICTION","funder_award_id":"R01DA002265","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2698355098","display_name":null,"funder_award_id":"DA08920","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G3841610924","display_name":null,"funder_award_id":"MH 42251","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G62754510","display_name":"Molecular Elements, Neurocircuits and Mental Illness","funder_award_id":"P01MH042251","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6885203603","display_name":null,"funder_award_id":"DA02265","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1786467339","https://openalex.org/W1900414416","https://openalex.org/W1957478854","https://openalex.org/W1958969306","https://openalex.org/W1960449411","https://openalex.org/W1967827706","https://openalex.org/W1970822193","https://openalex.org/W1979385488","https://openalex.org/W1985841554","https://openalex.org/W1999045435","https://openalex.org/W2011645297","https://openalex.org/W2012119611","https://openalex.org/W2023021788","https://openalex.org/W2024435286","https://openalex.org/W2025884351","https://openalex.org/W2026128203","https://openalex.org/W2040754874","https://openalex.org/W2045112376","https://openalex.org/W2049647535","https://openalex.org/W2057432773","https://openalex.org/W2061099467","https://openalex.org/W2063535857","https://openalex.org/W2073867630","https://openalex.org/W2079978238","https://openalex.org/W2081271913","https://openalex.org/W2084891453","https://openalex.org/W2084913220","https://openalex.org/W2085711348","https://openalex.org/W2085930977","https://openalex.org/W2092526105","https://openalex.org/W2102420653","https://openalex.org/W2153292899","https://openalex.org/W2153912689","https://openalex.org/W2787012987"],"related_works":["https://openalex.org/W2081271913","https://openalex.org/W2071998745","https://openalex.org/W2132027342","https://openalex.org/W1974674594","https://openalex.org/W2053051844","https://openalex.org/W2081901007","https://openalex.org/W2036453774","https://openalex.org/W2094973127","https://openalex.org/W2079852966","https://openalex.org/W2062897867"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":28},{"year":2020,"cited_by_count":49},{"year":2019,"cited_by_count":36},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":34},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":58},{"year":2013,"cited_by_count":43},{"year":2012,"cited_by_count":46}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}