{"id":"https://openalex.org/W2140193633","doi":null,"title":"Highly metastatic human prostate cancer growing within the prostate of athymic mice overexpresses vascular endothelial growth factor.","display_name":"Highly metastatic human prostate cancer growing within the prostate of athymic mice overexpresses vascular endothelial growth factor.","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W2140193633","mag":"2140193633","pmid":"https://pubmed.ncbi.nlm.nih.gov/10213213"},"language":"en","primary_location":{"id":"pmid:10213213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10213213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112172015","display_name":"Mevlana Derya Balbay","orcid":"https://orcid.org/0000-0001-9706-1587","observed_orcids":["https://orcid.org/0000-0001-9706-1587"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M D Balbay","raw_affiliation_strings":["Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068197546","display_name":"Curtis Alvin Pettaway","orcid":"https://orcid.org/0000-0003-1697-1840","observed_orcids":["https://orcid.org/0000-0003-1697-1840"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C A Pettaway","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046783529","display_name":"Hiroki Kuniyasu","orcid":"https://orcid.org/0000-0003-2298-8825","observed_orcids":["https://orcid.org/0000-0003-2298-8825"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Kuniyasu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064464692","display_name":"Keiji Inoue","orcid":"https://orcid.org/0000-0001-5321-2216","observed_orcids":["https://orcid.org/0000-0001-5321-2216"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Inoue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"E Ramirez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Ramirez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"E Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111754323","display_name":"I. J. Fidler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I J Fidler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109065033","display_name":"C P Dinney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C P Dinney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6403,"has_fulltext":false,"cited_by_count":117,"citation_normalized_percentile":{"value":0.93969011,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"4","first_page":"783","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8960000276565552},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9760000109672546},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/metastatic-variants","display_name":"metastatic variants","score":0.8420000076293945},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.8920000195503235},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9660000205039978},{"id":"https://openalex.org/keywords/flk-1","display_name":"Flk-1","score":0.9269999861717224},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.871999979019165},{"id":"https://openalex.org/keywords/nude-mice","display_name":"nude mice","score":0.9020000100135803},{"id":"https://openalex.org/keywords/angiogenic-factors","display_name":"angiogenic factors","score":0.640999972820282},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.4620000123977661},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.4449999928474426},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.9596681594848633},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7718421220779419},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.657632052898407},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.6061451435089111},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5419974327087402},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.5350403189659119},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5080850124359131},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5006093978881836},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46070921421051025},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4032212197780609},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.39731666445732117},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3918783366680145},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.3771516978740692},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32271647453308105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3016347885131836},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05151718854904175},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017978","descriptor_name":"Receptors, Growth Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10213213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10213213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2140193633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10213213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8238216569","display_name":"BIOLOGY OF BLADDER CANCER METASTASES","funder_award_id":"R29CA067914","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W153934429","https://openalex.org/W1044883788","https://openalex.org/W1519412172","https://openalex.org/W1569333935","https://openalex.org/W1624346216","https://openalex.org/W1624649331","https://openalex.org/W1740440689","https://openalex.org/W1784095256","https://openalex.org/W1903437307","https://openalex.org/W1969328947","https://openalex.org/W1980755389","https://openalex.org/W1988814101","https://openalex.org/W1989514276","https://openalex.org/W1993170771","https://openalex.org/W1999223106","https://openalex.org/W2014604539","https://openalex.org/W2015292449","https://openalex.org/W2015344488","https://openalex.org/W2026151657","https://openalex.org/W2028952750","https://openalex.org/W2029790299","https://openalex.org/W2037309650","https://openalex.org/W2038808630","https://openalex.org/W2039138053","https://openalex.org/W2047823355","https://openalex.org/W2051819610","https://openalex.org/W2066335476","https://openalex.org/W2095346194","https://openalex.org/W2098856542","https://openalex.org/W2111033200","https://openalex.org/W2122794487","https://openalex.org/W2150908379","https://openalex.org/W2158743409","https://openalex.org/W2162472165","https://openalex.org/W2312223326","https://openalex.org/W2319962899","https://openalex.org/W2406430560","https://openalex.org/W2412728867"],"related_works":["https://openalex.org/W1576299934","https://openalex.org/W2366941639","https://openalex.org/W1992670367","https://openalex.org/W1986660950","https://openalex.org/W2414505086","https://openalex.org/W1567785660","https://openalex.org/W181615032","https://openalex.org/W2080709087","https://openalex.org/W2134999841","https://openalex.org/W2014604539"],"abstract_inverted_index":{"Angiogenesis":[0],"is":[1,9],"essential":[2],"for":[3],"tumor":[4,19,237],"progression":[5],"and":[6,36,42,73,79,85,95,119,123,154,162,190,193,195,200,213,222,236],"metastasis.":[7,258],"It":[8],"mediated":[10],"by":[11,17,29,77,91,103,114,132,138],"the":[12,18,24,30,167],"release":[13],"of":[14,26,54,59,126,148,166,174,187,196,244],"angiogenic":[15,27,61],"factors":[16,28],"or":[20,176,216],"host.":[21],"We":[22],"analyzed":[23],"expression":[25,98,109,122],"prostate":[31,229,241,256],"cancer":[32,230,242,257],"cell":[33,49,128,169],"line":[34],"LNCaP":[35,78,127,150,208],"two":[37],"derived":[38],"variants,":[39,81],"in":[40,43,101,112,115,178,255],"vitro":[41,102],"vivo,":[44,181],"to":[45],"determine":[46],"whether":[47],"metastatic":[48,227,246],"lines":[50,170],"express":[51],"higher":[52,145,185,202],"levels":[53,173,186],"these":[55],"factors.":[56],"The":[57],"production":[58,137,235],"three":[60,168],"factors,":[62],"vascular":[63],"endothelial":[64],"growth":[65,70],"factor":[66,71],"(VEGF),":[67],"basic":[68],"fibroblast":[69],"(bFGF),":[72],"interleukin":[74],"8":[75],"(IL-8),":[76],"its":[80],"LNCaP-LN3":[82,139,182],"(highly":[83],"metastatic)":[84],"LNCaP-Pro5":[86,155,217],"(slightly":[87],"metastatic),":[88],"was":[89,99,110,143],"measured":[90],"ELISA.":[92],"VEGF,":[93],"bFGF,":[94],"IL-8":[96,177],"mRNA":[97,108,189],"determined":[100,111],"Northern":[104],"blot":[105],"analysis.":[106],"VEGF":[107,118,136,188,234,249],"vivo":[113],"situ":[116],"hybridization.":[117],"flk-1":[120,197],"protein":[121,191,198],"microvessel":[124,203],"density":[125,204],"tumors":[129,183,209,218],"were":[130],"quantified":[131],"immunohistochemistry.":[133],"In":[134,180,225],"vitro,":[135],"(3.15+/-0.04":[140],"pg/ml/10(3)":[141,152,157],"cells)":[142,153],"significantly":[144],"than":[146,206],"those":[147],"both":[149],"(2.38+/-0.34":[151],"(1.67+/-0.37":[156],"cells;":[158],"P":[159],"=":[160],"0.049":[161],"0.001,":[163],"respectively).":[164,224],"None":[165],"produced":[171],"detectable":[172],"bFGF":[175],"vitro.":[179],"exhibited":[184,232],"(152.2+/-28.5":[192],"200.5+/-28.3)":[194],"(156.5+/-20.6)":[199],"had":[201],"(16.4+/-4.2)":[205],"either":[207],"(89+/-17.5,":[210],"173.3+/-23.0,":[211],"124.6+/-21.6,":[212],"12.4+/-3.5,":[214],"respectively)":[215],"(63+/-14.7,":[219],"141.2+/-38.1,":[220],"126.1+/-20,":[221],"5.8+/-2.2,":[223],"conclusion,":[226],"human":[228],"cells":[231,243],"enhanced":[233],"vascularity":[238],"compared":[239],"with":[240],"lower":[245],"potential.":[247],"Thus,":[248],"may":[250],"play":[251],"an":[252],"important":[253],"role":[254]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}