{"id":"https://openalex.org/W2140074985","doi":"https://doi.org/10.1186/s13046-014-0111-8","title":"Carfilzomib demonstrates broad anti-tumor activity in pre-clinical non-small cell and small cell lung cancer models","display_name":"Carfilzomib demonstrates broad anti-tumor activity in pre-clinical non-small cell and small cell lung cancer models","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W2140074985","doi":"https://doi.org/10.1186/s13046-014-0111-8","mag":"2140074985","pmid":"https://pubmed.ncbi.nlm.nih.gov/25612802","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4304157"},"language":"en","primary_location":{"id":"doi:10.1186/s13046-014-0111-8","doi":"https://doi.org/10.1186/s13046-014-0111-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-014-0111-8","pdf_url":"https://jeccr.biomedcentral.com/counter/pdf/10.1186/s13046-014-0111-8","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jeccr.biomedcentral.com/counter/pdf/10.1186/s13046-014-0111-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103147452","display_name":"Amanda F. Baker","orcid":"https://orcid.org/0000-0002-0670-5381","observed_orcids":["https://orcid.org/0000-0002-0670-5381"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amanda F Baker","raw_affiliation_strings":["University of Arizona Cancer Center, College of Medicine, Section of Hematology/Oncology, 1515 N Campbell Ave, Tucson, AZ, USA. abaker@uacc.arizona.edu","College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, Tucson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona Cancer Center, College of Medicine, Section of Hematology/Oncology, 1515 N Campbell Ave, Tucson, AZ, USA. abaker@uacc.arizona.edu","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]},{"raw_affiliation_string":"College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, Tucson, USA","institution_ids":["https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010807859","display_name":"Neale T. Hanke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neale T Hanke","raw_affiliation_strings":["College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ, USA","College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, Tucson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]},{"raw_affiliation_string":"College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, Tucson, USA","institution_ids":["https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114258980","display_name":"Barbara J. Sands","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara J Sands","raw_affiliation_strings":["College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ, USA","College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, Tucson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]},{"raw_affiliation_string":"College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, Tucson, USA","institution_ids":["https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036498928","display_name":"Liliana Carbajal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liliana Carbajal","raw_affiliation_strings":["College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ, USA","College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, Tucson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]},{"raw_affiliation_string":"College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, Tucson, USA","institution_ids":["https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028442257","display_name":"Janet L. Anderl","orcid":"https://orcid.org/0009-0001-3393-8666","observed_orcids":["https://orcid.org/0009-0001-3393-8666"]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet L Anderl","raw_affiliation_strings":["Onyx Pharmaceuticals, Inc., an Amgen subsidiary, South San Francisco, CA, USA","Onyx Pharmaceuticals, Inc., an Amgen Subsidiary, South San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Onyx Pharmaceuticals, Inc., an Amgen subsidiary, South San Francisco, CA, USA","institution_ids":["https://openalex.org/I1320553840"]},{"raw_affiliation_string":"Onyx Pharmaceuticals, Inc., an Amgen Subsidiary, South San Francisco, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110299902","display_name":"Linda L. Garland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda L Garland","raw_affiliation_strings":["College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ, USA","College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, Tucson, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, 1515 N Campbell Ave, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]},{"raw_affiliation_string":"College of Medicine, Section of Hematology/Oncology, University of Arizona Cancer Center, Tucson, USA","institution_ids":["https://openalex.org/I4390039223"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5103147452"],"corresponding_institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":1.9125,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.86150574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"33","issue":"1","first_page":"111","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.47189998626708984,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.47189998626708984,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.45559999346733093,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carfilzomib","display_name":"carfilzomib","score":1.0},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.9039999842643738},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9010000228881836},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":1.0},{"id":"https://openalex.org/keywords/immunoproteasome","display_name":"immunoproteasome","score":0.9110000133514404},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6060000061988831},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/parp-cleavage","display_name":"PARP cleavage","score":0.8130000233650208},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8859999775886536},{"id":"https://openalex.org/keywords/lc3b","display_name":"LC3B","score":0.8659999966621399},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.7419999837875366},{"id":"https://openalex.org/keywords/cisplatin-combination-therapy","display_name":"cisplatin combination therapy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C2780108899","wikidata":"https://www.wikidata.org/wiki/Q15366934","display_name":"Carfilzomib","level":4,"score":0.9024628400802612},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6884029507637024},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.652083694934845},{"id":"https://openalex.org/C2778367456","wikidata":"https://www.wikidata.org/wiki/Q7251235","display_name":"Proteasome inhibitor","level":3,"score":0.6318840384483337},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5448454022407532},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.5414154529571533},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5010678768157959},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4429605007171631},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3428664803504944},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.341230183839798},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2395499348640442},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18801787495613098},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.13255256414413452},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06622794270515442}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D055752","descriptor_name":"Small Cell Lung Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D061988","descriptor_name":"Proteasome Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13046-014-0111-8","doi":"https://doi.org/10.1186/s13046-014-0111-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-014-0111-8","pdf_url":"https://jeccr.biomedcentral.com/counter/pdf/10.1186/s13046-014-0111-8","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4304157","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4304157","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Clin Cancer Res","raw_type":"Text"},{"id":"pmid:25612802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25612802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental & clinical cancer research : CR","raw_type":"Journal Article"},{"id":"pmh:oai:repository.arizona.edu:10150/610318","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10150/610318","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/s13046-014-0111-8","doi":"https://doi.org/10.1186/s13046-014-0111-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-014-0111-8","pdf_url":"https://jeccr.biomedcentral.com/counter/pdf/10.1186/s13046-014-0111-8","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8933538267","display_name":null,"funder_award_id":"P30CA02374-32","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320309707","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/03m2x1q45"},{"id":"https://openalex.org/F4320310160","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45"},{"id":"https://openalex.org/F4320311073","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524"},{"id":"https://openalex.org/F4320332487","display_name":"Onyx Pharmaceuticals","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2140074985.pdf","grobid_xml":"https://content.openalex.org/works/W2140074985.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W155247308","https://openalex.org/W1967578320","https://openalex.org/W1970158990","https://openalex.org/W1973932751","https://openalex.org/W1978300360","https://openalex.org/W1986036865","https://openalex.org/W1993176598","https://openalex.org/W1995059263","https://openalex.org/W1995092890","https://openalex.org/W1995895276","https://openalex.org/W2000044224","https://openalex.org/W2005975820","https://openalex.org/W2008355658","https://openalex.org/W2014404730","https://openalex.org/W2016742872","https://openalex.org/W2020031294","https://openalex.org/W2024150712","https://openalex.org/W2038675473","https://openalex.org/W2048829869","https://openalex.org/W2054298919","https://openalex.org/W2058419129","https://openalex.org/W2072714194","https://openalex.org/W2080199075","https://openalex.org/W2081510209","https://openalex.org/W2082982918","https://openalex.org/W2083365324","https://openalex.org/W2085170203","https://openalex.org/W2086450157","https://openalex.org/W2087157354","https://openalex.org/W2089311432","https://openalex.org/W2090597698","https://openalex.org/W2093434729","https://openalex.org/W2096755977","https://openalex.org/W2100608938","https://openalex.org/W2109371953","https://openalex.org/W2121454432","https://openalex.org/W2126267349","https://openalex.org/W2127738863","https://openalex.org/W2130794506","https://openalex.org/W2133264993","https://openalex.org/W2135481148","https://openalex.org/W2136951601","https://openalex.org/W2138102966","https://openalex.org/W2141037581","https://openalex.org/W2150946410","https://openalex.org/W2154343997","https://openalex.org/W2160380481","https://openalex.org/W2163479859","https://openalex.org/W2409311416","https://openalex.org/W2412663900"],"related_works":["https://openalex.org/W2317489111","https://openalex.org/W2995944259","https://openalex.org/W2558564545","https://openalex.org/W3096324162","https://openalex.org/W2020313926","https://openalex.org/W2028820057","https://openalex.org/W2889682108","https://openalex.org/W2972683091","https://openalex.org/W4327743614","https://openalex.org/W2197870853"],"abstract_inverted_index":{"BACKGROUND:":[0],"Carfilzomib":[1],"(CFZ)":[2],"is":[3],"a":[4,76,241],"proteasome":[5,100],"inhibitor":[6],"that":[7],"selectively":[8],"and":[9,15,26,75,101,119,149,172,183,188,209,238,254,261],"irreversibly":[10],"binds":[11],"to":[12,55,86,138,163],"its":[13],"target":[14],"has":[16],"been":[17],"approved":[18],"in":[19,40,61,104,114,146,231,236,240,245,259],"the":[20,57,88,98,102,147],"US":[21],"for":[22,221],"treatment":[23,95],"of":[24,33,37,51,59,69,91,169,177,186,190,197,257],"relapsed":[25],"refractory":[27],"multiple":[28],"myeloma.":[29],"Phase":[30],"1B":[31],"studies":[32],"CFZ":[34,60,94,109,141,204,222,227,258],"reported":[35],"signals":[36],"clinical":[38,255],"activity":[39,58,90,113,230],"solid":[41],"tumors,":[42,203],"including":[43],"small":[44,78],"cell":[45,73,79,107,122,126,152,234],"lung":[46,62,71,80,105,123,232],"cancer":[47,63,72,81,106,124,233],"(SCLC).":[48],"The":[49],"aim":[50],"this":[52],"study":[53],"was":[54,219],"investigate":[56,87],"models.":[64],"METHODS:":[65],"A":[66],"diverse":[67],"panel":[68],"human":[70],"lines":[74,235],"SHP77":[77,148,173,200,248],"xenograft":[82,202],"model":[83],"were":[84],"used":[85],"anti-tumor":[89,217],"CFZ.":[92],"RESULTS:":[93],"inhibited":[96,206],"both":[97],"constitutive":[99],"immunoproteasome":[103],"lines.":[108],"had":[110,142],"marked":[111],"anti-proliferative":[112,229],"A549,":[115],"H1993,":[116],"H520,":[117],"H460,":[118],"H1299":[120],"non-small":[121],"(NSCLC)":[125],"lines,":[127,153],"with":[128,154,247],"IC50":[129,155],"values":[130,156],"after":[131],"96":[132,158],"hour":[133],"exposure":[134],"from":[135,160],"<1.0":[136],"nM":[137,162],"36":[139],"nM.":[140,165],"more":[143],"variable":[144],"effects":[145],"DMS114":[150],"SCLC":[151,249],"at":[157],"hours":[159],"<1":[161],"203":[164],"Western":[166],"blot":[167],"analysis":[168],"CFZ-treated":[170],"H1993":[171],"cells":[174],"showed":[175],"cleavage":[176],"poly":[178],"ADP":[179],"ribose":[180],"polymerase":[181],"(PARP)":[182],"caspase-3,":[184],"indicative":[185,196],"apoptosis,":[187],"induction":[189],"microtubule-associated":[191],"protein-1":[192],"light":[193],"chain-3B":[194],"(LC3B),":[195],"autophagy.":[198],"In":[199],"flank":[201],"monotherapy":[205],"tumor":[207],"growth":[208],"prolonged":[210],"survival,":[211],"while":[212],"no":[213],"additive":[214],"or":[215],"synergistic":[216],"efficacy":[218],"observed":[220],"+":[223],"cisplatin":[224],"(CDDP).":[225],"CONCLUSIONS:":[226],"demonstrated":[228],"vitro":[237],"resulted":[239],"significant":[242],"survival":[243],"advantage":[244],"mice":[246],"xenografts,":[250],"supporting":[251],"further":[252],"pre-clinical":[253],"investigations":[256],"NSCLC":[260],"SCLC.":[262]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}