{"id":"https://openalex.org/W2139992011","doi":"https://doi.org/10.1128/jvi.03824-13","title":"Core Binding Factor Beta Plays a Critical Role by Facilitating the Assembly of the Vif-Cullin 5 E3 Ubiquitin Ligase","display_name":"Core Binding Factor Beta Plays a Critical Role by Facilitating the Assembly of the Vif-Cullin 5 E3 Ubiquitin Ligase","publication_year":2014,"publication_date":"2014-01-04","ids":{"openalex":"https://openalex.org/W2139992011","doi":"https://doi.org/10.1128/jvi.03824-13","mag":"2139992011","pmid":"https://pubmed.ncbi.nlm.nih.gov/24390320","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3957930"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.03824-13","doi":"https://doi.org/10.1128/jvi.03824-13","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.03824-13","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3957930/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004357095","display_name":"Jennifer L. Fribourgh","orcid":"https://orcid.org/0000-0001-5954-4991","observed_orcids":["https://orcid.org/0000-0001-5954-4991"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Fribourgh","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055858006","display_name":"Henry C. Nguyen","orcid":"https://orcid.org/0000-0002-6142-8807","observed_orcids":["https://orcid.org/0000-0002-6142-8807"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry C. Nguyen","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069266926","display_name":"Leslie S. Wolfe","orcid":"https://orcid.org/0000-0003-4341-8899","observed_orcids":["https://orcid.org/0000-0003-4341-8899"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie S. Wolfe","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109034073","display_name":"David C. DeWitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David C. DeWitt","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441454","display_name":"Wenyan Zhang","orcid":"https://orcid.org/0000-0003-4507-521X","observed_orcids":["https://orcid.org/0000-0003-4507-521X"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyan Zhang","raw_affiliation_strings":["Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology and AIDS Research, First Hospital of Jilin University, Changchun, Jilin Province, China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067954758","display_name":"Xiao-Fang Yu","orcid":"https://orcid.org/0000-0002-1933-636X","observed_orcids":["https://orcid.org/0000-0002-1933-636X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao-Fang Yu","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026343887","display_name":"Elizabeth R. Rhoades","orcid":"https://orcid.org/0000-0002-1741-0650","observed_orcids":["https://orcid.org/0000-0002-1741-0650"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Rhoades","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA","Department of Physics, Yale University, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Physics, Yale University, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052997826","display_name":"Yong Xiong","orcid":"https://orcid.org/0000-0001-9625-9313","observed_orcids":["https://orcid.org/0000-0001-9625-9313"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Xiong","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0304,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.92396396,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"88","issue":"6","first_page":"3309","last_page":"3319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-vif","display_name":"HIV-1 Vif","score":0.878000020980835},{"id":"https://openalex.org/keywords/core-binding-factor-beta","display_name":"core binding factor beta","score":0.949999988079071},{"id":"https://openalex.org/keywords/cul5","display_name":"CUL5","score":0.9369999766349792},{"id":"https://openalex.org/keywords/apobec3g","display_name":"APOBEC3G","score":0.9520000219345093},{"id":"https://openalex.org/keywords/apobec3f","display_name":"APOBEC3F","score":1.0},{"id":"https://openalex.org/keywords/restriction-factors","display_name":"host restriction factors","score":0.7329999804496765},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-degradation","display_name":"ubiquitin-proteasome degradation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/elongin-b-c","display_name":"Elongin B/C","score":0.7149999737739563},{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.9369999766349792},{"id":"https://openalex.org/keywords/viral-immune-evasion","display_name":"viral immune evasion","score":0.6230000257492065},{"id":"https://openalex.org/keywords/protein-protein-interfaces","display_name":"protein-protein interfaces","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C2778567606","wikidata":"https://www.wikidata.org/wiki/Q41797435","display_name":"Cullin","level":5,"score":0.9417831897735596},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.8669870495796204},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8162742853164673},{"id":"https://openalex.org/C2781310106","wikidata":"https://www.wikidata.org/wiki/Q14916265","display_name":"APOBEC3G","level":4,"score":0.755230188369751},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.664391040802002},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6320102214813232},{"id":"https://openalex.org/C2776985229","wikidata":"https://www.wikidata.org/wiki/Q18021211","display_name":"Cytidine deaminase","level":3,"score":0.5750728249549866},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4775327444076538},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24907320737838745},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07136255502700806},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.059464871883392334}],"mesh":[{"descriptor_ui":"D000075065","descriptor_name":"Elongin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044842","descriptor_name":"Cullin Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044842","descriptor_name":"Cullin Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050658","descriptor_name":"Core Binding Factor beta Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050658","descriptor_name":"Core Binding Factor beta Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054320","descriptor_name":"vif Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054320","descriptor_name":"vif Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.03824-13","doi":"https://doi.org/10.1128/jvi.03824-13","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.03824-13","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmid:24390320","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24390320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3957930","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3957930/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.915.7768","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.915.7768","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jvi.asm.org/content/88/6/3309.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3957930","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3957930/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1006074686","display_name":"Structural Studies of HIV Vif and Its Cellular Binding Partners","funder_award_id":"R33AI078831","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1754287291","display_name":"Structural Studies of HIV Vif and Its Cellular Binding Partners","funder_award_id":"R21AI078831","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G33749474","display_name":"Predoctoral Program in Cellular and Molecular Biology","funder_award_id":"T32GM007223","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5753101563","display_name":null,"funder_award_id":"AI078831","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7464085385","display_name":"Identification of novel anti-HIV inhibitors based on Vif-E3 activity","funder_award_id":"R21AI102798","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1512755592","https://openalex.org/W1614881750","https://openalex.org/W1963594716","https://openalex.org/W1964493335","https://openalex.org/W1966343819","https://openalex.org/W1967513429","https://openalex.org/W1973598278","https://openalex.org/W1991069890","https://openalex.org/W1993897877","https://openalex.org/W2004640739","https://openalex.org/W2009808421","https://openalex.org/W2012564250","https://openalex.org/W2017585121","https://openalex.org/W2021736427","https://openalex.org/W2023035407","https://openalex.org/W2033631070","https://openalex.org/W2040313539","https://openalex.org/W2042486230","https://openalex.org/W2049948812","https://openalex.org/W2050830157","https://openalex.org/W2051622847","https://openalex.org/W2063244983","https://openalex.org/W2069676221","https://openalex.org/W2074076516","https://openalex.org/W2075049040","https://openalex.org/W2076626746","https://openalex.org/W2082570129","https://openalex.org/W2083585458","https://openalex.org/W2096197897","https://openalex.org/W2108448995","https://openalex.org/W2112014931","https://openalex.org/W2114677352","https://openalex.org/W2115662151","https://openalex.org/W2115728597","https://openalex.org/W2117914960","https://openalex.org/W2122021863","https://openalex.org/W2122612295","https://openalex.org/W2123685523","https://openalex.org/W2144878684","https://openalex.org/W2145572223","https://openalex.org/W2149643442","https://openalex.org/W2157876432","https://openalex.org/W4232273699"],"related_works":["https://openalex.org/W2073630258","https://openalex.org/W2116747707","https://openalex.org/W2076626746","https://openalex.org/W2050830157","https://openalex.org/W7097274981","https://openalex.org/W1983411290","https://openalex.org/W2009685783","https://openalex.org/W2075049040","https://openalex.org/W2164528842","https://openalex.org/W3083247471"],"abstract_inverted_index":{"UNLABELLED:":[0],"The":[1,34,150,159,197],"HIV-1":[2,160],"virion":[3],"infectivity":[4],"factor":[5,45,178],"(Vif)":[6],"targets":[7,163],"the":[8,20,41,53,57,62,90,93,111,128,135,176,193,205,210,229,283,296],"cellular":[9,27,42,177],"cytidine":[10],"deaminases":[11],"APOBEC3G":[12],"(A3G)":[13],"and":[14,56,80,84,209],"APOBEC3F":[15],"(A3F)":[16],"for":[17,165,189,240,280],"degradation":[18,298],"via":[19],"host":[21,151],"ubiquitin-proteasome":[22],"pathway.":[23],"Vif":[24,37,73,162,172,183,190,233,274],"recruits":[25],"a":[26,103,141,269],"E3":[28,63,215,285],"ubiquitin":[29],"ligase":[30,64,147,216],"to":[31,110,124,144,186,227,272,275],"polyubiquitinate":[32],"A3G/F.":[33,244],"activity":[35,170],"of":[36,59,72,76,92,130,171,182,212,231,253,292,299],"critically":[38],"depends":[39],"on":[40,175],"core":[43],"binding":[44,88,109,241],"beta":[46],"(CBF\u03b2).":[47],"In":[48,218],"this":[49],"study,":[50],"we":[51],"investigated":[52],"Vif-CBF\u03b2":[54,66,94,206,222],"interaction":[55,67,207,281],"role":[58,105,230],"CBF\u03b2":[60,101,138,213,242,254,265,294],"in":[61,106,127,214],"assembly.":[65,148,217],"requires":[68],"an":[69,249,277],"extensive":[70],"region":[71],"spanning":[74],"most":[75],"its":[77],"amino":[78],"terminus":[79],"zinc":[81],"finger":[82],"region,":[83],"cullin":[85],"5":[86],"(Cul5)":[87],"enhances":[89],"stability":[91],"interaction.":[95],"Our":[96,261],"results":[97,225,262],"further":[98],"demonstrate":[99],"that":[100,137,255,264],"plays":[102],"critical":[104],"facilitating":[107],"Cul5":[108,126],"Vif/elongin":[112],"B/elongin":[113],"C":[114],"complex.":[115],"Vif,":[116],"with":[117,282],"or":[118,243],"without":[119],"bound":[120],"substrate,":[121],"is":[122,173],"unable":[123],"bind":[125],"absence":[129],"CBF\u03b2.":[131,179],"These":[132],"studies":[133,198,247],"support":[134],"notion":[136],"serves":[139],"as":[140,268],"molecular":[142,270],"chaperone":[143,271],"facilitate":[145],"Vif-E3":[146],"IMPORTANCE:":[149],"antiviral":[152],"restriction":[153],"factors":[154],"A3G/F":[155,164],"inhibit":[156],"viral":[157],"replication.":[158],"protein":[161],"degradation.":[166],"This":[167,287],"immune":[168],"evasion":[169],"dependent":[174],"Multiple":[180],"regions":[181],"are":[184,195,238],"known":[185],"be":[187],"important":[188,202,239,250],"function,":[191],"but":[192],"mechanisms":[194],"unclear.":[196],"described":[199],"here":[200],"provide":[201],"information":[203],"about":[204],"interface":[208,223],"function":[211],"particular,":[219],"our":[220,246,290],"comprehensive":[221],"mapping":[224],"help":[226],"delineate":[228],"various":[232],"regions,":[234],"determining":[235],"if":[236],"they":[237],"Furthermore,":[245],"reveal":[248],"potential":[251],"mechanism":[252],"has":[256],"not":[257],"been":[258],"shown":[259],"before.":[260],"suggest":[263],"may":[266],"serve":[267],"enable":[273],"adopt":[276],"appropriate":[278],"conformation":[279],"Cul5-based":[284],"ligase.":[286],"study":[288],"advances":[289],"understanding":[291],"how":[293],"facilitates":[295],"Vif-mediated":[297],"APOBEC3":[300],"proteins.":[301]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
