{"id":"https://openalex.org/W2139972043","doi":"https://doi.org/10.17463/rcm.2015.04.010","title":"Ki-67 protein: a proliferation index in breast cancer","display_name":"Ki-67 protein: a proliferation index in breast cancer","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W2139972043","doi":"https://doi.org/10.17463/rcm.2015.04.010","mag":"2139972043"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:2d845c65c144442990100cd9bc478e0a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2d845c65c144442990100cd9bc478e0a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Reviews in Clinical Medicine, Vol 2, Iss 4, Pp 205-208 (2015)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/2d845c65c144442990100cd9bc478e0a","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056643710","display_name":"Shervin Kheirandish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]},{"id":"https://openalex.org/I4210158832","display_name":"Ghaem Hospital","ror":"https://ror.org/05n9fs062","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I165560825","https://openalex.org/I4210158832"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Shervin Kheirandish","raw_affiliation_strings":["Department of Pathology, Ghaem hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ghaem hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825","https://openalex.org/I4210158832"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113847408","display_name":"Fatemeh Homaee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]},{"id":"https://openalex.org/I4210158832","display_name":"Ghaem Hospital","ror":"https://ror.org/05n9fs062","country_code":"IR","type":"healthcare","lineage":["https://openalex.org/I165560825","https://openalex.org/I4210158832"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fatemeh Homaee","raw_affiliation_strings":["Department of Radiotherapy and Oncology, Ghaem hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiotherapy and Oncology, Ghaem hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825","https://openalex.org/I4210158832"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2071,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.496676,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.9940000176429749},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8759999871253967},{"id":"https://openalex.org/keywords/proliferation-markers","display_name":"cell proliferation markers","score":0.765999972820282},{"id":"https://openalex.org/keywords/proliferation-index","display_name":"proliferation index","score":0.7059999704360962},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9440000057220459},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.9589999914169312},{"id":"https://openalex.org/keywords/tumor-grading","display_name":"tumor grading","score":0.6259999871253967},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.7889999747276306},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.8180000185966492},{"id":"https://openalex.org/keywords/neoadjuvant-therapy","display_name":"neoadjuvant therapy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":1.0}],"concepts":[{"id":"https://openalex.org/C2777382242","wikidata":"https://www.wikidata.org/wiki/Q6017816","display_name":"Index (typography)","level":2,"score":0.5815305709838867},{"id":"https://openalex.org/C2910938049","wikidata":"https://www.wikidata.org/wiki/Q7249605","display_name":"Proliferation index","level":3,"score":0.5664104223251343},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5599793791770935},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4953278601169586},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4309210479259491},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3958439528942108},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3608459532260895},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35278579592704773},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1805519461631775},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.13537657260894775},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.10180008411407471}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:doaj.org/article:2d845c65c144442990100cd9bc478e0a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2d845c65c144442990100cd9bc478e0a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Reviews in Clinical Medicine, Vol 2, Iss 4, Pp 205-208 (2015)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:91c85e6448f7428e8b19f3ff4495e325","doi":"https://doi.org/10.17463/rcm.2015.04.010","is_oa":false,"landing_page_url":"https://doaj.org/article/91c85e6448f7428e8b19f3ff4495e325","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Reviews in Clinical Medicine, Vol 2, Iss 4, Pp 205-208 (2015)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:2d845c65c144442990100cd9bc478e0a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2d845c65c144442990100cd9bc478e0a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Reviews in Clinical Medicine, Vol 2, Iss 4, Pp 205-208 (2015)","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1857066264","https://openalex.org/W1984359805","https://openalex.org/W1999765733","https://openalex.org/W2028700197","https://openalex.org/W2032772058","https://openalex.org/W2039161031","https://openalex.org/W2043630729","https://openalex.org/W2045569268","https://openalex.org/W2076227688","https://openalex.org/W2079068906","https://openalex.org/W2090178205","https://openalex.org/W2112894406","https://openalex.org/W2117775530","https://openalex.org/W2124633824","https://openalex.org/W2126540255","https://openalex.org/W2134444110","https://openalex.org/W2140586374","https://openalex.org/W2142256144","https://openalex.org/W2151150230","https://openalex.org/W2152190583","https://openalex.org/W2154536753","https://openalex.org/W2164774797","https://openalex.org/W2164839546","https://openalex.org/W2167118789","https://openalex.org/W2436268769","https://openalex.org/W2441299845"],"related_works":["https://openalex.org/W3030034716","https://openalex.org/W2345859277","https://openalex.org/W3197162231","https://openalex.org/W2350825520","https://openalex.org/W3030794814","https://openalex.org/W2023200343","https://openalex.org/W2597983034","https://openalex.org/W1964191844","https://openalex.org/W4232513341","https://openalex.org/W7095743700"],"abstract_inverted_index":{"Various":[0],"clinicopathological":[1],"factors":[2],"are":[3],"evaluated":[4],"in":[5,44,60,73,91,143],"different":[6,61],"studies":[7],"on":[8],"carcinomas":[9],"to":[10,70,99,107],"demonstrate":[11],"their":[12],"prognostic":[13,126],"and":[14,20,40,46,83,112,127,140],"predictive":[15,128],"significance":[16],"during":[17,118],"the":[18,24,64,75,93,100,113,125,136],"diagnosis":[19],"therapeutic":[21],"procedures":[22],"of":[23,52,58,102,115,121,130,138],"malignancy.":[25],"Ki-67":[26,53,65,103,131],"is":[27],"a":[28,34,56],"biomarker":[29],"that":[30],"was":[31],"proposed":[32],"as":[33],"cell":[35],"proliferation":[36],"related":[37],"nuclear":[38],"antigen,":[39],"it":[41,55,87],"only":[42],"expresses":[43],"growing":[45],"proliferating":[47],"cells.":[48],"This":[49],"unique":[50],"feature":[51],"makes":[54],"subject":[57],"interest":[59],"investigations.":[62],"Evaluating":[63],"expression":[66,117],"has":[67],"been":[68],"demonstrated":[69],"be":[71,89,133],"beneficial":[72],"determining":[74],"tumor":[76,79],"behavior":[77],"including":[78],"size,":[80],"stage,":[81],"grading":[82],"patient":[84],"survival.":[85],"Moreover,":[86],"might":[88],"helpful":[90],"selecting":[92],"preferred":[94],"subsequent":[95],"treatment":[96],"strategy.":[97],"Due":[98],"importance":[101,114],"index,":[104],"we":[105],"aim":[106],"briefly":[108],"review":[109],"its":[110,116],"properties":[111],"various":[119],"types":[120],"malignancies.":[122],"At":[123],"last,":[124],"value":[129],"would":[132],"overviewed":[134],"regarding":[135],"efficacy":[137],"neoadjuvant":[139],"adjuvant":[141],"therapies":[142],"breast":[144],"cancer":[145],"patients.":[146]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}