{"id":"https://openalex.org/W2139883768","doi":"https://doi.org/10.15252/emmm.201404525","title":"Antigen delivery by filamentous bacteriophage fd displaying an anti\u2010DEC\u2010205 single\u2010chain variable fragment confers adjuvanticity by triggering a TLR9\u2010mediated immune response","display_name":"Antigen delivery by filamentous bacteriophage fd displaying an anti\u2010DEC\u2010205 single\u2010chain variable fragment confers adjuvanticity by triggering a TLR9\u2010mediated immune response","publication_year":2015,"publication_date":"2015-04-17","ids":{"openalex":"https://openalex.org/W2139883768","doi":"https://doi.org/10.15252/emmm.201404525","mag":"2139883768","pmid":"https://pubmed.ncbi.nlm.nih.gov/25888235","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4520660"},"language":"en","primary_location":{"id":"doi:10.15252/emmm.201404525","doi":"https://doi.org/10.15252/emmm.201404525","is_oa":true,"landing_page_url":"https://doi.org/10.15252/emmm.201404525","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/emmm.201404525","source":{"id":"https://openalex.org/S163075119","display_name":"EMBO Molecular Medicine","issn_l":"1757-4676","issn":["1757-4676","1757-4684"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/emmm.201404525","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041323958","display_name":"Rossella Sartorius","orcid":"https://orcid.org/0000-0003-0153-9377","observed_orcids":["https://orcid.org/0000-0003-0153-9377"]},"institutions":[{"id":"https://openalex.org/I4210129308","display_name":"Institute of Protein Biochemistry","ror":"https://ror.org/03eqeqg74","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210129308","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rossella Sartorius","raw_affiliation_strings":["Institute of Protein Biochemistry, National Council of Research, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Protein Biochemistry, National Council of Research, Naples, Italy","institution_ids":["https://openalex.org/I4210129308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039825193","display_name":"Luciana D\u2019Apice","orcid":"https://orcid.org/0000-0002-6513-2237","observed_orcids":["https://orcid.org/0000-0002-6513-2237"]},"institutions":[{"id":"https://openalex.org/I4210129308","display_name":"Institute of Protein Biochemistry","ror":"https://ror.org/03eqeqg74","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210129308","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luciana D'Apice","raw_affiliation_strings":["Institute of Protein Biochemistry, National Council of Research, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Protein Biochemistry, National Council of Research, Naples, Italy","institution_ids":["https://openalex.org/I4210129308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002211212","display_name":"Maria Trovato","orcid":"https://orcid.org/0000-0002-3831-6073","observed_orcids":["https://orcid.org/0000-0002-3831-6073"]},"institutions":[{"id":"https://openalex.org/I4210129308","display_name":"Institute of Protein Biochemistry","ror":"https://ror.org/03eqeqg74","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210129308","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Trovato","raw_affiliation_strings":["Institute of Protein Biochemistry, National Council of Research, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Protein Biochemistry, National Council of Research, Naples, Italy","institution_ids":["https://openalex.org/I4210129308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083941898","display_name":"Fausta Cuccaro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129308","display_name":"Institute of Protein Biochemistry","ror":"https://ror.org/03eqeqg74","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210129308","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fausta Cuccaro","raw_affiliation_strings":["Institute of Protein Biochemistry, National Council of Research, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Protein Biochemistry, National Council of Research, Naples, Italy","institution_ids":["https://openalex.org/I4210129308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028820532","display_name":"Valerio Costa","orcid":"https://orcid.org/0000-0002-7294-6933","observed_orcids":["https://orcid.org/0000-0002-7294-6933"]},"institutions":[{"id":"https://openalex.org/I4210137461","display_name":"Institute of Genetics and Biophysics","ror":"https://ror.org/04hadk112","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210137461","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valerio Costa","raw_affiliation_strings":["Institute of Genetics and Biophysics A. Buzzati-Traverso, National Council of Research, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics and Biophysics A. Buzzati-Traverso, National Council of Research, Naples, Italy","institution_ids":["https://openalex.org/I4210137461"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075851353","display_name":"Maria Giovanna De Leo","orcid":"https://orcid.org/0000-0003-1523-9121","observed_orcids":["https://orcid.org/0000-0003-1523-9121"]},"institutions":[{"id":"https://openalex.org/I4210152213","display_name":"Telethon Institute Of Genetics And Medicine","ror":"https://ror.org/04xfdsg27","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210152213","https://openalex.org/I4210154366"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Giovanna De Leo","raw_affiliation_strings":["Telethon Institute of Genetics and Medicine, Pozzuoli (NA), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Telethon Institute of Genetics and Medicine, Pozzuoli (NA), Italy","institution_ids":["https://openalex.org/I4210152213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059768275","display_name":"Vincenzo Manuel Marzullo","orcid":"https://orcid.org/0000-0001-8746-1296","observed_orcids":["https://orcid.org/0000-0001-8746-1296"]},"institutions":[{"id":"https://openalex.org/I4210129308","display_name":"Institute of Protein Biochemistry","ror":"https://ror.org/03eqeqg74","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210129308","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210152213","display_name":"Telethon Institute Of Genetics And Medicine","ror":"https://ror.org/04xfdsg27","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210152213","https://openalex.org/I4210154366"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Manuel Marzullo","raw_affiliation_strings":["Institute of Protein Biochemistry, National Council of Research, Naples, Italy Telethon Institute of Genetics and Medicine, Pozzuoli (NA), Italy","Institute of Protein Biochemistry National Council of Research Naples Italy","Telethon Institute of Genetics and Medicine Pozzuoli (NA) Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Protein Biochemistry, National Council of Research, Naples, Italy Telethon Institute of Genetics and Medicine, Pozzuoli (NA), Italy","institution_ids":["https://openalex.org/I4210129308","https://openalex.org/I4210152213"]},{"raw_affiliation_string":"Institute of Protein Biochemistry National Council of Research Naples Italy","institution_ids":["https://openalex.org/I4210129308"]},{"raw_affiliation_string":"Telethon Institute of Genetics and Medicine Pozzuoli (NA) Italy","institution_ids":["https://openalex.org/I4210152213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089959950","display_name":"Carmelo Biondo","orcid":"https://orcid.org/0000-0002-9489-2569","observed_orcids":["https://orcid.org/0000-0002-9489-2569"]},"institutions":[{"id":"https://openalex.org/I112862951","display_name":"University of Messina","ror":"https://ror.org/05ctdxz19","country_code":"IT","type":"education","lineage":["https://openalex.org/I112862951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carmelo Biondo","raw_affiliation_strings":["Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, University of Messina, Messina, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, University of Messina, Messina, Italy","institution_ids":["https://openalex.org/I112862951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038720075","display_name":"Sabato D\u2019Auria","orcid":"https://orcid.org/0000-0002-3082-8947","observed_orcids":["https://orcid.org/0000-0002-3082-8947"]},"institutions":[{"id":"https://openalex.org/I4210087001","display_name":"Institute of Food Science","ror":"https://ror.org/0013zhk30","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210087001","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210129308","display_name":"Institute of Protein Biochemistry","ror":"https://ror.org/03eqeqg74","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210129308","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sabato D'Auria","raw_affiliation_strings":["Institute of Protein Biochemistry, National Council of Research, Naples, Italy Institute of Food Science, National Council of Research, Avellino, Italy","Institute of Food Science National Council of Research Avellino Italy","Institute of Protein Biochemistry National Council of Research Naples Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Protein Biochemistry, National Council of Research, Naples, Italy Institute of Food Science, National Council of Research, Avellino, Italy","institution_ids":["https://openalex.org/I4210087001","https://openalex.org/I4210129308"]},{"raw_affiliation_string":"Institute of Food Science National Council of Research Avellino Italy","institution_ids":["https://openalex.org/I4210087001"]},{"raw_affiliation_string":"Institute of Protein Biochemistry National Council of Research Naples Italy","institution_ids":["https://openalex.org/I4210129308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047828654","display_name":"Maria Antonietta De Matteis","orcid":"https://orcid.org/0000-0003-0053-3061","observed_orcids":["https://orcid.org/0000-0003-0053-3061"]},"institutions":[{"id":"https://openalex.org/I4210152213","display_name":"Telethon Institute Of Genetics And Medicine","ror":"https://ror.org/04xfdsg27","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210152213","https://openalex.org/I4210154366"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Antonietta De Matteis","raw_affiliation_strings":["Telethon Institute of Genetics and Medicine, Pozzuoli (NA), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Telethon Institute of Genetics and Medicine, Pozzuoli (NA), Italy","institution_ids":["https://openalex.org/I4210152213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009911982","display_name":"Alfredo Ciccodicola","orcid":"https://orcid.org/0000-0002-9924-1482","observed_orcids":["https://orcid.org/0000-0002-9924-1482"]},"institutions":[{"id":"https://openalex.org/I183638586","display_name":"Parthenope University of Naples","ror":"https://ror.org/05pcv4v03","country_code":"IT","type":"education","lineage":["https://openalex.org/I183638586"]},{"id":"https://openalex.org/I4210137461","display_name":"Institute of Genetics and Biophysics","ror":"https://ror.org/04hadk112","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210137461","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alfredo Ciccodicola","raw_affiliation_strings":["Institute of Genetics and Biophysics A. Buzzati-Traverso, National Council of Research, Naples, Italy Department of Science and Technology, University Parthenope of Naples, Naples, Italy","Department of Science and Technology University Parthenope of Naples Naples Italy","Institute of Genetics and Biophysics A. Buzzati-Traverso National Council of Research Naples Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics and Biophysics A. Buzzati-Traverso, National Council of Research, Naples, Italy Department of Science and Technology, University Parthenope of Naples, Naples, Italy","institution_ids":["https://openalex.org/I183638586","https://openalex.org/I4210137461"]},{"raw_affiliation_string":"Department of Science and Technology University Parthenope of Naples Naples Italy","institution_ids":["https://openalex.org/I183638586"]},{"raw_affiliation_string":"Institute of Genetics and Biophysics A. Buzzati-Traverso National Council of Research Naples Italy","institution_ids":["https://openalex.org/I4210137461"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088141762","display_name":"Piergiuseppe De Berardinis","orcid":"https://orcid.org/0000-0001-6579-1729","observed_orcids":["https://orcid.org/0000-0001-6579-1729"]},"institutions":[{"id":"https://openalex.org/I4210129308","display_name":"Institute of Protein Biochemistry","ror":"https://ror.org/03eqeqg74","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210129308","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Piergiuseppe De Berardinis","raw_affiliation_strings":["Institute of Protein Biochemistry, National Council of Research, Naples, Italy p.deberardinis@ibp.cnr.it","Institute of Protein Biochemistry National Council of Research Naples Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Protein Biochemistry, National Council of Research, Naples, Italy p.deberardinis@ibp.cnr.it","institution_ids":["https://openalex.org/I4210129308"]},{"raw_affiliation_string":"Institute of Protein Biochemistry National Council of Research Naples Italy","institution_ids":["https://openalex.org/I4210129308"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5088141762"],"corresponding_institution_ids":["https://openalex.org/I4210129308"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":{"value":7990,"currency":"USD","value_usd":7990},"fwci":2.2975,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.87994891,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"7","first_page":"973","last_page":"988"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dec-205","display_name":"DEC-205","score":0.9139999747276306},{"id":"https://openalex.org/keywords/single-chain-variable-fragment","display_name":"scFv","score":0.9010000228881836},{"id":"https://openalex.org/keywords/antigen-delivery","display_name":"antigen delivery","score":0.871999979019165},{"id":"https://openalex.org/keywords/adjuvant-effect","display_name":"adjuvant effect","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":0.9670000076293945},{"id":"https://openalex.org/keywords/myd88","display_name":"MyD88","score":0.9269999861717224},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cpg-motifs","display_name":"CpG motifs","score":0.7549999952316284},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9110000133514404},{"id":"https://openalex.org/keywords/late-endosomes","display_name":"late endosomes","score":0.6610000133514404},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.824999988079071},{"id":"https://openalex.org/keywords/lamp1","display_name":"LAMP1","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cd8-t-cell-responses","display_name":"CD8+ T cell responses","score":0.8379999995231628},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.47600001096725464},{"id":"https://openalex.org/keywords/phage-display","display_name":"phage display","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.5890033841133118},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5787239670753479},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5531253218650818},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.496797114610672},{"id":"https://openalex.org/C2776235265","wikidata":"https://www.wikidata.org/wiki/Q18392052","display_name":"Fragment (logic)","level":2,"score":0.4845496714115143},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4461299180984497},{"id":"https://openalex.org/C2776967038","wikidata":"https://www.wikidata.org/wiki/Q290671","display_name":"Single-chain variable fragment","level":4,"score":0.41704031825065613},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41403651237487793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38446226716041565},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27123719453811646},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.17585644125938416},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13049563765525818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12325942516326904},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.08273378014564514},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.07432255148887634},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.059360235929489136},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017912","descriptor_name":"Inovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051217","descriptor_name":"Toll-Like Receptor 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057127","descriptor_name":"Single-Chain Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057127","descriptor_name":"Single-Chain Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061505","descriptor_name":"Cell Surface Display Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.15252/emmm.201404525","doi":"https://doi.org/10.15252/emmm.201404525","is_oa":true,"landing_page_url":"https://doi.org/10.15252/emmm.201404525","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/emmm.201404525","source":{"id":"https://openalex.org/S163075119","display_name":"EMBO Molecular Medicine","issn_l":"1757-4676","issn":["1757-4676","1757-4684"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4520660","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4520660","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Mol Med","raw_type":"Text"},{"id":"pmid:25888235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25888235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO molecular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cbfb13659ccf40a99bfb5377494cc1eb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/cbfb13659ccf40a99bfb5377494cc1eb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"EMBO Molecular Medicine, Vol 7, Iss 7, Pp 973-988 (2015)","raw_type":"article"},{"id":"pmh:oai:ricerca.uniparthenope.it:11367/81342","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11367/81342","pdf_url":null,"source":{"id":"https://openalex.org/S4377196432","display_name":"CINECA IRIS Institutial research information system (Parthenope University of Naples)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183638586","host_organization_name":"Parthenope University of Naples","host_organization_lineage":["https://openalex.org/I183638586"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.15252/emmm.201404525","doi":"https://doi.org/10.15252/emmm.201404525","is_oa":true,"landing_page_url":"https://doi.org/10.15252/emmm.201404525","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/emmm.201404525","source":{"id":"https://openalex.org/S163075119","display_name":"EMBO Molecular Medicine","issn_l":"1757-4676","issn":["1757-4676","1757-4684"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320322651","display_name":"Consiglio Nazionale delle Ricerche","ror":"https://ror.org/04zaypm56"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139883768.pdf","grobid_xml":"https://content.openalex.org/works/W2139883768.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1514540900","https://openalex.org/W1582451317","https://openalex.org/W1604392326","https://openalex.org/W1755125321","https://openalex.org/W1835419381","https://openalex.org/W1856321184","https://openalex.org/W1877391240","https://openalex.org/W1963998591","https://openalex.org/W1964184380","https://openalex.org/W1965146817","https://openalex.org/W1976139801","https://openalex.org/W1980741185","https://openalex.org/W1988202689","https://openalex.org/W1988492671","https://openalex.org/W1996242613","https://openalex.org/W1997977259","https://openalex.org/W1998955394","https://openalex.org/W2001583092","https://openalex.org/W2008519462","https://openalex.org/W2012179517","https://openalex.org/W2019845984","https://openalex.org/W2022943234","https://openalex.org/W2026575873","https://openalex.org/W2033455478","https://openalex.org/W2034570325","https://openalex.org/W2036867505","https://openalex.org/W2045006617","https://openalex.org/W2045909132","https://openalex.org/W2047081878","https://openalex.org/W2048067575","https://openalex.org/W2049490137","https://openalex.org/W2050216284","https://openalex.org/W2052521175","https://openalex.org/W2060351820","https://openalex.org/W2061203855","https://openalex.org/W2062350041","https://openalex.org/W2069258864","https://openalex.org/W2073694191","https://openalex.org/W2080399344","https://openalex.org/W2081430578","https://openalex.org/W2082083192","https://openalex.org/W2094746130","https://openalex.org/W2100305481","https://openalex.org/W2102799028","https://openalex.org/W2107277218","https://openalex.org/W2114741192","https://openalex.org/W2116763454","https://openalex.org/W2125615007","https://openalex.org/W2126361957","https://openalex.org/W2128963773","https://openalex.org/W2131914577","https://openalex.org/W2132929600","https://openalex.org/W2137053907","https://openalex.org/W2140729960","https://openalex.org/W2141354546","https://openalex.org/W2141458291","https://openalex.org/W2143360501","https://openalex.org/W2150444151","https://openalex.org/W2151777859","https://openalex.org/W2153135025","https://openalex.org/W2156596722","https://openalex.org/W2158217645","https://openalex.org/W2159923852","https://openalex.org/W2162076795","https://openalex.org/W2172168743","https://openalex.org/W2272642733","https://openalex.org/W2337475816","https://openalex.org/W2410721446","https://openalex.org/W2412143065","https://openalex.org/W2626473198","https://openalex.org/W6715707262"],"related_works":["https://openalex.org/W7100091804","https://openalex.org/W2316117034","https://openalex.org/W1482591563","https://openalex.org/W7099104050","https://openalex.org/W1965146817","https://openalex.org/W7095944138","https://openalex.org/W7099803309","https://openalex.org/W1536556103","https://openalex.org/W2033683294","https://openalex.org/W2808648428"],"abstract_inverted_index":{"Filamentous":[0],"bacteriophage":[1,148],"fd":[2,147],"particles":[3,106],"delivering":[4],"antigenic":[5,142],"determinants":[6],"via":[7,117],"DEC-205":[8,118],"(fdsc-\u03b1DEC)":[9],"represent":[10],"a":[11,108,149],"powerful":[12],"delivery":[13],"system":[14],"that":[15,73,93],"induces":[16],"CD8(+)":[17],"T-cell":[18],"responses":[19],"even":[20],"when":[21],"administered":[22],"in":[23,57,113],"the":[24,38,125,137,140],"absence":[25],"of":[26,40,44,54,75,139],"adjuvants":[27],"or":[28],"maturation":[29],"stimuli":[30],"for":[31,152],"dendritic":[32,46],"cells.":[33],"In":[34,66],"order":[35],"to":[36,121,135],"investigate":[37],"mechanisms":[39],"this":[41],"activity,":[42],"RNA-Sequencing":[43],"fd-pulsed":[45],"cells":[47],"was":[48,64,84],"performed.":[49],"A":[50],"significant":[51],"differential":[52],"expression":[53],"genes":[55],"involved":[56],"innate":[58,128],"immunity,":[59],"co-stimulation":[60],"and":[61,78,87,100,123,134],"cytokine":[62],"production":[63],"observed.":[65],"agreement":[67],"with":[68,102],"these":[69],"findings,":[70],"we":[71],"demonstrate":[72],"induction":[74],"proinflammatory":[76],"cytokines":[77],"type":[79],"I":[80],"interferon":[81],"by":[82],"fdsc-\u03b1DEC":[83,94],"MYD88":[85],"mediated":[86],"TLR9":[88,127],"dependent.":[89],"We":[90],"also":[91],"found":[92],"is":[95],"delivered":[96,116],"into":[97,131],"LAMP-1-positive":[98],"compartments":[99],"co-localizes":[101],"TLR9.":[103],"Thus,":[104],"phage":[105],"containing":[107],"single-strand":[109],"DNA":[110],"genome":[111],"rich":[112],"CpG":[114],"motifs":[115],"are":[119],"able":[120],"intercept":[122],"trigger":[124],"active":[126],"immune":[129],"receptor":[130],"late":[132],"endosome/lysosomes":[133],"enhance":[136],"immunogenicity":[138],"displayed":[141],"determinants.":[143],"These":[144],"findings":[145],"make":[146],"valuable":[150],"tool":[151],"immunization":[153],"without":[154],"administering":[155],"exogenous":[156],"adjuvants.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}