{"id":"https://openalex.org/W2139808459","doi":"https://doi.org/10.1085/jgp.90.2.209","title":"Activation of electroneutral K flux in Amphiuma red blood cells by N-ethylmaleimide. Distinction between K/H exchange and KCl cotransport.","display_name":"Activation of electroneutral K flux in Amphiuma red blood cells by N-ethylmaleimide. Distinction between K/H exchange and KCl cotransport.","publication_year":1987,"publication_date":"1987-08-01","ids":{"openalex":"https://openalex.org/W2139808459","doi":"https://doi.org/10.1085/jgp.90.2.209","mag":"2139808459","pmid":"https://pubmed.ncbi.nlm.nih.gov/3655717","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2228834"},"language":"en","primary_location":{"id":"doi:10.1085/jgp.90.2.209","doi":"https://doi.org/10.1085/jgp.90.2.209","is_oa":false,"landing_page_url":"https://doi.org/10.1085/jgp.90.2.209","pdf_url":null,"source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2228834","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078160625","display_name":"Joseph S. Adorante","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J S Adorante","raw_affiliation_strings":["Department of Human Physiology, School of Medicine, University of California, Davis 95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Physiology, School of Medicine, University of California, Davis 95616","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109091165","display_name":"Peter M. Cala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P M Cala","raw_affiliation_strings":["Department of Human Physiology, School of Medicine, University of California, Davis 95616"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Physiology, School of Medicine, University of California, Davis 95616","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":0.8273,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.72727273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"90","issue":"2","first_page":"209","last_page":"227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amphiuma","display_name":"Amphiuma","score":0.7400000095367432},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.9200000166893005},{"id":"https://openalex.org/keywords/n-ethylmaleimide","display_name":"N-ethylmaleimide","score":0.9480000138282776},{"id":"https://openalex.org/keywords/potassium-flux","display_name":"potassium flux","score":0.6669999957084656},{"id":"https://openalex.org/keywords/cell-swelling","display_name":"cell swelling","score":0.7350000143051147},{"id":"https://openalex.org/keywords/potassium-conductance","display_name":"potassium conductance","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8301939964294434},{"id":"https://openalex.org/C188053792","wikidata":"https://www.wikidata.org/wiki/Q3640664","display_name":"Cotransporter","level":3,"score":0.6765910983085632},{"id":"https://openalex.org/C2777646807","wikidata":"https://www.wikidata.org/wiki/Q292393","display_name":"N-Ethylmaleimide","level":2,"score":0.5857402086257935},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.5754976272583008},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3941217064857483},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3403016924858093},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32501089572906494},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22807520627975464},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.20893451571464539},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.18622872233390808},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06458145380020142},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005033","descriptor_name":"Ethylmaleimide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005033","descriptor_name":"Ethylmaleimide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005033","descriptor_name":"Ethylmaleimide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007474","descriptor_name":"Ion Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007474","descriptor_name":"Ion Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007474","descriptor_name":"Ion Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011189","descriptor_name":"Potassium Chloride","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011189","descriptor_name":"Potassium Chloride","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011189","descriptor_name":"Potassium Chloride","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014562","descriptor_name":"Caudata","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014562","descriptor_name":"Urodela","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014562","descriptor_name":"Caudata","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1085/jgp.90.2.209","doi":"https://doi.org/10.1085/jgp.90.2.209","is_oa":false,"landing_page_url":"https://doi.org/10.1085/jgp.90.2.209","pdf_url":null,"source":{"id":"https://openalex.org/S168548653","display_name":"The Journal of General Physiology","issn_l":"0022-1295","issn":["0022-1295","1540-7748"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2228834","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2228834","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gen Physiol","raw_type":"Text"},{"id":"pmid:3655717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3655717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general physiology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt0s61b2gt","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/0s61b2gt","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of general physiology, vol 90, iss 2","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt0s61b2gt","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/0s61b2gt","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of General Physiology, vol 90, iss 2","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2228834","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2228834","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gen Physiol","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","score":0.5099999904632568,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1324565964","display_name":null,"funder_award_id":"HL/GM-06917","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4899820555","display_name":null,"funder_award_id":"HL-21179","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1975518622","https://openalex.org/W1992116520","https://openalex.org/W1997401530","https://openalex.org/W1997674502","https://openalex.org/W1998077260","https://openalex.org/W2016914762","https://openalex.org/W2035356855","https://openalex.org/W2039638368","https://openalex.org/W2042958721","https://openalex.org/W2044082016","https://openalex.org/W2092726945","https://openalex.org/W2098757654","https://openalex.org/W2105965747","https://openalex.org/W2123180105","https://openalex.org/W2126254778","https://openalex.org/W2140622211","https://openalex.org/W2146268498","https://openalex.org/W2155447439","https://openalex.org/W2271095860","https://openalex.org/W2411323302"],"related_works":["https://openalex.org/W7099417484","https://openalex.org/W1015061070","https://openalex.org/W2433273414","https://openalex.org/W2441819225","https://openalex.org/W2123180105","https://openalex.org/W2182762460","https://openalex.org/W7096677968","https://openalex.org/W2416631256","https://openalex.org/W2016914762","https://openalex.org/W2400861962"],"abstract_inverted_index":{"Exposure":[0],"of":[1,9,44,62,76,92,138,189,212,244,250,291],"Amphiuma":[2,117],"red":[3,118],"blood":[4,119],"cells":[5],"to":[6,19,48,80,98,129,203,226,278,288,296],"millimolar":[7],"concentrations":[8],"N-ethylmaleimide":[10],"(NEM)":[11],"resulted":[12],"in":[13,42,147],"net":[14,22,65],"K":[15,23,40,50,66,81,95,110,206,218,301],"loss.":[16,207],"In":[17,127,196],"order":[18],"determine":[20],"whether":[21],"loss":[24,219],"was":[25,28,151,194,224],"conductive":[26],"or":[27,33,83,158,187],"by":[29,52,114,122,153],"electroneutral":[30,84,124],"K/H":[31,103,125,143,170,191,221,270,292],"exchange":[32,144,171,192,271],"KCl":[34,85,173],"cotransport,":[35,174],"studies":[36,163,264],"were":[37,201],"performed":[38],"evaluating":[39],"flux":[41,51,67,96,145,251],"terms":[43],"the":[45,53,63,72,77,88,93,99,130,135,139,178,204,210,237,242,258,261,289],"thermodynamic":[46],"forces":[47,78],"which":[49],"above":[54,131],"pathways":[55,146],"should":[56],"couple.":[57],"The":[58,160,274],"direction":[59,73,91],"and":[60,74,90,141,172,234,285,302],"magnitude":[61,75,89],"NEM-induced":[64,109,142,205,217],"did":[68,164],"not":[69,165],"correspond":[70],"with":[71,241,257],"relevant":[79],"conductance":[82],"cotransport.":[86],"Both":[87],"NEM-activated":[94],"responded":[97],"driving":[100],"force":[101],"for":[102],"exchange.":[104],"We":[105],"therefore":[106,235],"conclude":[107],"that":[108,113,266,281],"loss,":[111],"like":[112],"osmotically":[115],"swollen":[116],"cells,":[120],"is":[121],"an":[123],"exchanger.":[126],"addition":[128],"studies,":[132,260],"we":[133],"evaluated":[134],"kinetic":[136],"behavior":[137],"volume-":[140],"media":[148],"where":[149],"Cl":[150,183,262],"replaced":[152],"SCN,":[154],"NO3,":[155],"para-aminohippurate":[156],"(PAH),":[157],"gluconate.":[159],"anion":[161,179,245,267],"replacement":[162,246,263],"permit":[166],"a":[167,182,248],"distinction":[168],"between":[169],"since,":[175],"depending":[176],"upon":[177,269,300],"used":[180,200],"as":[181,232,247,294],"replacement,":[184],"partial":[185],"inhibition":[186],"stimulation":[188],"volume-activated":[190],"fluxes":[193],"observed.":[195],"contrast,":[197],"all":[198],"anions":[199,230,276],"stimulatory":[202],"Since,":[208],"on":[209],"basis":[211],"force-flow":[213,259],"analysis,":[214],"both":[215],"volume-and":[216],"are":[220,272],"exchange,":[222,293],"it":[223],"necessary":[225],"reevaluate":[227],"assumptions":[228],"(i.e.,":[229],"serve":[231],"substrates":[233],"probe":[236],"translocation":[238],"step)":[239],"associated":[240],"use":[243],"means":[249],"route":[252],"identification.":[253],"When":[254],"viewed":[255],"together":[256],"suggest":[265],"effects":[268,299],"indirect.":[273],"different":[275],"appear":[277],"alter":[279],"mechanisms":[280],"couple":[282],"NEM":[283],"exposure":[284],"cell":[286],"swelling":[287],"activation":[290],"opposed":[295],"exerting":[297],"direct":[298],"H":[303],"translocation.":[304]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}