{"id":"https://openalex.org/W2139807161","doi":"https://doi.org/10.1128/jvi.00114-11","title":"E6 and E7 from Human Papillomavirus Type 16 Cooperate To Target the PDZ Protein Na/H Exchange Regulatory Factor 1","display_name":"E6 and E7 from Human Papillomavirus Type 16 Cooperate To Target the PDZ Protein Na/H Exchange Regulatory Factor 1","publication_year":2011,"publication_date":"2011-06-17","ids":{"openalex":"https://openalex.org/W2139807161","doi":"https://doi.org/10.1128/jvi.00114-11","mag":"2139807161","pmid":"https://pubmed.ncbi.nlm.nih.gov/21680517"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.00114-11","doi":"https://doi.org/10.1128/jvi.00114-11","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.00114-11","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3147992","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080289439","display_name":"Rosita Accardi","orcid":"https://orcid.org/0000-0002-5456-8297","observed_orcids":["https://orcid.org/0000-0002-5456-8297"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Rosita Accardi","raw_affiliation_strings":["International Agency for Research on Cancer, World Health Organization, Lyon, France","International Agency for Research on Cancer, World Health Organization Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Agency for Research on Cancer, World Health Organization, Lyon, France","institution_ids":["https://openalex.org/I42237331"]},{"raw_affiliation_string":"International Agency for Research on Cancer, World Health Organization Lyon, France","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070653290","display_name":"Rosa Rubino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]},{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["FR","IT"],"is_corresponding":false,"raw_author_name":"Rosa Rubino","raw_affiliation_strings":["Department of General and Environmental Physiology, University of Bari, Bari, Italy","International Agency for Research on Cancer, World Health Organization, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General and Environmental Physiology, University of Bari, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]},{"raw_affiliation_string":"International Agency for Research on Cancer, World Health Organization, Lyon, France","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002150589","display_name":"Mariafrancesca Scalise","orcid":"https://orcid.org/0000-0003-3860-6844","observed_orcids":["https://orcid.org/0000-0003-3860-6844"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]},{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["FR","IT"],"is_corresponding":false,"raw_author_name":"Mariafrancesca Scalise","raw_affiliation_strings":["Dipartimento di Biologia Cellulare, Universit\u00e0 della Calabria, Cosenza, Italy","International Agency for Research on Cancer, World Health Organization, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Biologia Cellulare, Universit\u00e0 della Calabria, Cosenza, Italy","institution_ids":["https://openalex.org/I45204951"]},{"raw_affiliation_string":"International Agency for Research on Cancer, World Health Organization, Lyon, France","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047876202","display_name":"Tarik Gheit","orcid":"https://orcid.org/0000-0001-7088-337X","observed_orcids":["https://orcid.org/0000-0001-7088-337X"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Tarik Gheit","raw_affiliation_strings":["International Agency for Research on Cancer, World Health Organization, Lyon, France","International Agency for Research on Cancer, World Health Organization Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Agency for Research on Cancer, World Health Organization, Lyon, France","institution_ids":["https://openalex.org/I42237331"]},{"raw_affiliation_string":"International Agency for Research on Cancer, World Health Organization Lyon, France","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101833162","display_name":"Naveed Shahzad","orcid":"https://orcid.org/0000-0002-3624-5953","observed_orcids":["https://orcid.org/0000-0002-3624-5953"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Naveed Shahzad","raw_affiliation_strings":["International Agency for Research on Cancer, World Health Organization, Lyon, France","International Agency for Research on Cancer, World Health Organization Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Agency for Research on Cancer, World Health Organization, Lyon, France","institution_ids":["https://openalex.org/I42237331"]},{"raw_affiliation_string":"International Agency for Research on Cancer, World Health Organization Lyon, France","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083609637","display_name":"Miranda Thomas","orcid":"https://orcid.org/0000-0002-7451-9185","observed_orcids":["https://orcid.org/0000-0002-7451-9185"]},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Miranda Thomas","raw_affiliation_strings":["International Center for Genetic Engineering and Biotechnology, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Center for Genetic Engineering and Biotechnology, Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061855498","display_name":"Lawrence Banks","orcid":"https://orcid.org/0000-0003-4360-5731","observed_orcids":["https://orcid.org/0000-0003-4360-5731"]},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lawrence Banks","raw_affiliation_strings":["International Center for Genetic Engineering and Biotechnology, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Center for Genetic Engineering and Biotechnology, Trieste, Italy","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023301307","display_name":"Cesare Indiveri","orcid":"https://orcid.org/0000-0001-9818-6621","observed_orcids":["https://orcid.org/0000-0001-9818-6621"]},"institutions":[{"id":"https://openalex.org/I45204951","display_name":"University of Calabria","ror":"https://ror.org/02rc97e94","country_code":"IT","type":"education","lineage":["https://openalex.org/I45204951"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cesare Indiveri","raw_affiliation_strings":["Dipartimento di Biologia Cellulare, Universit\u00e0 della Calabria, Cosenza, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Biologia Cellulare, Universit\u00e0 della Calabria, Cosenza, Italy","institution_ids":["https://openalex.org/I45204951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113567704","display_name":"Bakary Sidiki Sylla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bakary S. Sylla","raw_affiliation_strings":["International Agency for Research on Cancer, World Health Organization, Lyon, France","International Agency for Research on Cancer, World Health Organization Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Agency for Research on Cancer, World Health Organization, Lyon, France","institution_ids":["https://openalex.org/I42237331"]},{"raw_affiliation_string":"International Agency for Research on Cancer, World Health Organization Lyon, France","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043434300","display_name":"Rosa Angela Cardone","orcid":"https://orcid.org/0000-0002-2011-9135","observed_orcids":["https://orcid.org/0000-0002-2011-9135"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosa A. Cardone","raw_affiliation_strings":["Department of General and Environmental Physiology, University of Bari, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General and Environmental Physiology, University of Bari, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020885136","display_name":"Stephan J. Reshkin","orcid":"https://orcid.org/0000-0001-9757-5908","observed_orcids":["https://orcid.org/0000-0001-9757-5908"]},"institutions":[{"id":"https://openalex.org/I5561750","display_name":"University of Bari Aldo Moro","ror":"https://ror.org/027ynra39","country_code":"IT","type":"education","lineage":["https://openalex.org/I5561750"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stephan J. Reshkin","raw_affiliation_strings":["Department of General and Environmental Physiology, University of Bari, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General and Environmental Physiology, University of Bari, Bari, Italy","institution_ids":["https://openalex.org/I5561750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059805941","display_name":"Massimo Tommasino","orcid":"https://orcid.org/0000-0002-0890-8596","observed_orcids":["https://orcid.org/0000-0002-0890-8596","https://orcid.org/0000-0001-5779-2449"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Massimo Tommasino","raw_affiliation_strings":["International Agency for Research on Cancer, World Health Organization, Lyon, France","International Agency for Research on Cancer, World Health Organization Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Agency for Research on Cancer, World Health Organization, Lyon, France","institution_ids":["https://openalex.org/I42237331"]},{"raw_affiliation_string":"International Agency for Research on Cancer, World Health Organization Lyon, France","institution_ids":["https://openalex.org/I42237331"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5059805941"],"corresponding_institution_ids":["https://openalex.org/I42237331"],"apc_list":null,"apc_paid":null,"fwci":3.6738,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.9287866,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"85","issue":"16","first_page":"8208","last_page":"8216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hpv-16","display_name":"HPV16","score":0.9520000219345093},{"id":"https://openalex.org/keywords/hpv-e6","display_name":"E6 oncoprotein","score":0.9330000281333923},{"id":"https://openalex.org/keywords/hpv-e7","display_name":"E7 oncoprotein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nherf1","display_name":"NHERF1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/pdz-binding-motif","display_name":"PDZ-binding motif","score":0.9079999923706055},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pdz-domain-proteins","display_name":"PDZ domain proteins","score":0.5559999942779541},{"id":"https://openalex.org/keywords/hpv-18","display_name":"HPV 18","score":0.5860000252723694},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cervical-intraepithelial-neoplasia","display_name":"cervical intraepithelial neoplasia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cyclin-dependent-kinases","display_name":"cyclin-dependent kinases","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.5529999732971191},{"id":"https://openalex.org/keywords/oncogenic-cooperation","display_name":"oncogene cooperation","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C154428179","wikidata":"https://www.wikidata.org/wiki/Q24721050","display_name":"PDZ domain","level":2,"score":0.9708549380302429},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5602200031280518},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.556786298751831},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.47582629323005676},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4657747447490692},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.44293534755706787},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.39083385467529297},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3801318109035492},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3285340666770935},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32192322611808777}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017923","descriptor_name":"Sodium-Hydrogen Exchangers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050725","descriptor_name":"Papillomavirus E7 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050725","descriptor_name":"Papillomavirus E7 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050725","descriptor_name":"Papillomavirus E7 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052162","descriptor_name":"Human papillomavirus 16","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052162","descriptor_name":"Human papillomavirus 16","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052162","descriptor_name":"Human papillomavirus 16","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054731","descriptor_name":"PDZ Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054731","descriptor_name":"PDZ Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054731","descriptor_name":"PDZ Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/jvi.00114-11","doi":"https://doi.org/10.1128/jvi.00114-11","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.00114-11","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmid:21680517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21680517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3147992","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3147992","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmh:oai:iris.unical.it:20.500.11770/157772","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11770/157772","pdf_url":null,"source":{"id":"https://openalex.org/S4377196898","display_name":"Archive of Doctoral Theses and Digital Collections (University of Calabria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45204951","host_organization_name":"University of Calabria","host_organization_lineage":["https://openalex.org/I45204951"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ricerca.uniba.it:11586/74181","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11586/74181","pdf_url":null,"source":{"id":"https://openalex.org/S4377196296","display_name":"CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5561750","host_organization_name":"University of Bari Aldo Moro","host_organization_lineage":["https://openalex.org/I5561750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3147992","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3147992","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6200000047683716,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W94534164","https://openalex.org/W1965801617","https://openalex.org/W1974327314","https://openalex.org/W1996836065","https://openalex.org/W2005252392","https://openalex.org/W2006659499","https://openalex.org/W2011363727","https://openalex.org/W2033297572","https://openalex.org/W2033846769","https://openalex.org/W2065368315","https://openalex.org/W2072339920","https://openalex.org/W2076984061","https://openalex.org/W2082115514","https://openalex.org/W2083879234","https://openalex.org/W2088852868","https://openalex.org/W2088911519","https://openalex.org/W2095267300","https://openalex.org/W2098765233","https://openalex.org/W2101196984","https://openalex.org/W2101653819","https://openalex.org/W2113565443","https://openalex.org/W2115742226","https://openalex.org/W2129288850","https://openalex.org/W2138216581","https://openalex.org/W2139548721","https://openalex.org/W2147796959","https://openalex.org/W2153672941","https://openalex.org/W2166608377"],"related_works":["https://openalex.org/W2735227557","https://openalex.org/W3006083475","https://openalex.org/W2051108283","https://openalex.org/W1964515703","https://openalex.org/W4362623556","https://openalex.org/W4362610326","https://openalex.org/W1978425204","https://openalex.org/W2001828594","https://openalex.org/W2166608377","https://openalex.org/W2022403117"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"have":[2,41],"shown":[3],"that":[4,61,173,217],"the":[5,9,13,42,49,111,121,131,134,139,223,226],"PDZ-binding":[6,123],"motif":[7,124],"of":[8,48,76,98,113,125,133,141,145,187,225],"E6":[10,39,81,106,164,180],"oncoprotein":[11],"from":[12,181],"mucosal":[14],"high-risk":[15],"(HR)":[16],"human":[17],"papillomavirus":[18],"(HPV)":[19],"types":[20],"plays":[21],"a":[22,73,83,96,142,237],"key":[23,238],"role":[24,239],"in":[25,29,30,33,95,159,194,240],"HPV-mediated":[26],"cellular":[27,99],"transformation":[28],"vitro":[31],"and":[32,103,109,115,203],"vivo":[34],"experimental":[35],"models.":[36],"HR":[37,183],"HPV":[38,77,184],"oncoproteins":[40,155],"ability":[43],"to":[44,157,168,235],"efficiently":[45],"degrade":[46],"members":[47],"PDZ":[50,63,84],"motif-containing":[51],"membrane-associated":[52],"guanylate":[53],"kinase":[54,136,228],"(MAGUK)":[55],"family;":[56],"however,":[57],"it":[58],"is":[59,93,118,148,165,176,233],"possible":[60],"other":[62],"proteins":[64],"are":[65],"also":[66,192],"targeted":[67,150],"by":[68,151],"E6.":[69,126,152],"Here,":[70],"we":[71],"describe":[72],"novel":[74],"interaction":[75],"type":[78],"16":[79],"(HPV16)":[80],"with":[82,108,179,222],"protein,":[85],"Na(+)/H(+)":[86],"exchange":[87],"regulatory":[88],"factor":[89],"1":[90],"(NHERF-1),":[91],"which":[92,147,232],"involved":[94],"number":[97],"processes,":[100],"including":[101],"signaling":[102,230],"transformation.":[104],"HPV16":[105,128],"associates":[107],"promotes":[110],"degradation":[112,220],"NHERF-1,":[114,146],"this":[116,174],"property":[117,175],"dependent":[119],"on":[120],"C-terminal":[122],"Interestingly,":[127],"E7,":[129],"via":[130],"activation":[132,224],"cyclin-dependent":[135],"complexes,":[137],"promoted":[138],"accumulation":[140],"phosphorylated":[143],"form":[144],"preferentially":[149],"Thus,":[153],"both":[154],"appear":[156],"cooperate":[158],"targeting":[160],"NHERF-1.":[161],"Notably,":[162],"HPV18":[163],"not":[166,177],"able":[167],"induce":[169],"NHERF-1":[170,188,219],"degradation,":[171],"indicating":[172],"shared":[178],"all":[182],"types.":[185],"Downregulation":[186],"protein":[189],"levels":[190],"was":[191],"observed":[193],"HPV16-positive":[195,208],"cervical":[196,209],"cancer-derived":[197],"cell":[198],"lines,":[199],"such":[200],"as":[201,205,207],"SiHa":[202],"CaSki,":[204],"well":[206],"intraepithelial":[210],"neoplasia":[211],"(CIN).":[212],"Finally,":[213],"our":[214],"data":[215],"show":[216],"HPV16-mediated":[218],"correlates":[221],"phosphatidylinositol-3'-OH":[227],"(PI3K)/AKT":[229],"pathway,":[231],"known":[234],"play":[236],"carcinogenesis.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}
