{"id":"https://openalex.org/W2139806108","doi":"https://doi.org/10.1096/fj.13-236109","title":"Increased expression of CYP24A1 correlates with advanced stages of prostate cancer and can cause resistance to vitamin D 3 \u2010based therapies","display_name":"Increased expression of CYP24A1 correlates with advanced stages of prostate cancer and can cause resistance to vitamin D 3 \u2010based therapies","publication_year":2013,"publication_date":"2013-09-30","ids":{"openalex":"https://openalex.org/W2139806108","doi":"https://doi.org/10.1096/fj.13-236109","mag":"2139806108","pmid":"https://pubmed.ncbi.nlm.nih.gov/24081904","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6188232"},"language":"en","primary_location":{"id":"doi:10.1096/fj.13-236109","doi":"https://doi.org/10.1096/fj.13-236109","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.13-236109","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6188232","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073494857","display_name":"Mounia Tannour\u2010Louet","orcid":"https://orcid.org/0000-0003-0614-063X","observed_orcids":["https://orcid.org/0000-0003-0614-063X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mounia Tannour\u2010Louet","raw_affiliation_strings":["Scott Department of Urology Baylor College of Medicine Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scott Department of Urology Baylor College of Medicine Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020284072","display_name":"Shaye Lewis","orcid":"https://orcid.org/0000-0001-8937-0857","observed_orcids":["https://orcid.org/0000-0001-8937-0857"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaye K. Lewis","raw_affiliation_strings":["Scott Department of Urology Baylor College of Medicine Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scott Department of Urology Baylor College of Medicine Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010525495","display_name":"Jean\u2010Fran\u00e7ois Louet","orcid":"https://orcid.org/0000-0002-1626-7098","observed_orcids":["https://orcid.org/0000-0002-1626-7098"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean\u2010Fran\u00e7ois Louet","raw_affiliation_strings":["Department of Molecular and Cellular Biology Baylor College of Medicine Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology Baylor College of Medicine Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014009211","display_name":"Julie Stewart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Stewart","raw_affiliation_strings":["Scott Department of Urology Baylor College of Medicine Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scott Department of Urology Baylor College of Medicine Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040916283","display_name":"Josephine B. Addai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josephine B. Addai","raw_affiliation_strings":["Scott Department of Urology Baylor College of Medicine Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scott Department of Urology Baylor College of Medicine Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041098535","display_name":"Ay\u015feg\u00fcl A. \u015eahin","orcid":"https://orcid.org/0000-0001-8259-9624","observed_orcids":["https://orcid.org/0000-0001-8259-9624"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aysegul Sahin","raw_affiliation_strings":["Scott Department of Urology Baylor College of Medicine Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scott Department of Urology Baylor College of Medicine Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023232275","display_name":"Hima V. Vangapandu","orcid":"https://orcid.org/0000-0003-4762-1990","observed_orcids":["https://orcid.org/0000-0003-4762-1990"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hima V. Vangapandu","raw_affiliation_strings":["Scott Department of Urology Baylor College of Medicine Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scott Department of Urology Baylor College of Medicine Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021758891","display_name":"Annisa L. Lewis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annisa L. Lewis","raw_affiliation_strings":["Department of Pathology Weil Cornell Medical College and Methodist Hospital Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology Weil Cornell Medical College and Methodist Hospital Houston Texas USA","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078280939","display_name":"Kristin M. Dittmar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin Dittmar","raw_affiliation_strings":["Department of Radiology Weil Cornell Medical College and Methodist Hospital Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology Weil Cornell Medical College and Methodist Hospital Houston Texas USA","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056842858","display_name":"Robia G. Pautler","orcid":"https://orcid.org/0000-0001-7952-8526","observed_orcids":["https://orcid.org/0000-0001-7952-8526"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robia G. Pautler","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics Baylor College of Medicine Houston Texas USA","Department of Neuroscience Baylor College of Medicine Houston Texas USA","Department of Radiology Baylor College of Medicine Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics Baylor College of Medicine Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Neuroscience Baylor College of Medicine Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Radiology Baylor College of Medicine Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100617387","display_name":"Lixin Zhang","orcid":"https://orcid.org/0000-0003-1421-9612","observed_orcids":["https://orcid.org/0000-0003-1421-9612"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lixin Zhang","raw_affiliation_strings":["Scott Department of Urology Baylor College of Medicine Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scott Department of Urology Baylor College of Medicine Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103392357","display_name":"Roy G. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy G. Smith","raw_affiliation_strings":["Department of Metabolism and Aging Scripps Research Institute Florida Jupiter Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Metabolism and Aging Scripps Research Institute Florida Jupiter Florida USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088539818","display_name":"Dolores J. Lamb","orcid":"https://orcid.org/0000-0002-4389-5065","observed_orcids":["https://orcid.org/0000-0002-4389-5065"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dolores J. Lamb","raw_affiliation_strings":["Center for Reproductive Medicine Baylor College of Medicine Houston Texas USA","Department of Molecular and Cellular Biology Baylor College of Medicine Houston Texas USA","Scott Department of Urology Baylor College of Medicine Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Reproductive Medicine Baylor College of Medicine Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology Baylor College of Medicine Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Scott Department of Urology Baylor College of Medicine Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":1.8416,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.84908288,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"28","issue":"1","first_page":"364","last_page":"372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5067999958992004,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5067999958992004,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.49000000953674316,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp24a1","display_name":"CYP24A1","score":1.0},{"id":"https://openalex.org/keywords/vitamin-d3","display_name":"vitamin D3","score":0.6959999799728394},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9409999847412109},{"id":"https://openalex.org/keywords/vitamin-d-resistance","display_name":"vitamin D resistance","score":0.8119999766349792},{"id":"https://openalex.org/keywords/vitamin-d-catabolism","display_name":"vitamin D catabolism","score":0.7940000295639038},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5830000042915344},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.6340000033378601},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.5070000290870667},{"id":"https://openalex.org/keywords/shrna","display_name":"shRNA","score":0.7689999938011169},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8199999928474426},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.890999972820282},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7070000171661377},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C76743606","wikidata":"https://www.wikidata.org/wiki/Q21110757","display_name":"CYP24A1","level":4,"score":0.9149535298347473},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7952693700790405},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.7422144412994385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6915282607078552},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5723154544830322},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5456503033638},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5254096984863281},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5129644274711609},{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.4672990143299103},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.4466603994369507}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002762","descriptor_name":"Cholecalciferol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013250","descriptor_name":"Steroid Hydroxylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065668","descriptor_name":"Vitamin D3 24-Hydroxylase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1096/fj.13-236109","doi":"https://doi.org/10.1096/fj.13-236109","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.13-236109","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5141486","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6188232","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6188232","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6188232","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB J","raw_type":"Text"},{"id":"pmid:24081904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24081904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5141486","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6188232","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4990798811","display_name":null,"funder_award_id":"1C76HF02799\u201001\u201000","funder_id":"https://openalex.org/F4320332175","funder_display_name":"Health Resources and Services Administration"},{"id":"https://openalex.org/G5895401956","display_name":null,"funder_award_id":"1C76HF02799-01-00","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G5911461707","display_name":"Multidisciplinary K12 Urologic Research (KURe) Career Development Program","funder_award_id":"K12DK083014","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320314011","display_name":"William and Ella Owens Medical Research Foundation","ror":"https://ror.org/0101ppd69"},{"id":"https://openalex.org/F4320332175","display_name":"Health Resources and Services Administration","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W158904318","https://openalex.org/W1488591768","https://openalex.org/W1890251880","https://openalex.org/W1973392312","https://openalex.org/W1986655758","https://openalex.org/W1995781029","https://openalex.org/W2012382826","https://openalex.org/W2017519440","https://openalex.org/W2026644677","https://openalex.org/W2055725082","https://openalex.org/W2061029286","https://openalex.org/W2069205626","https://openalex.org/W2069665701","https://openalex.org/W2076811408","https://openalex.org/W2078348418","https://openalex.org/W2079972311","https://openalex.org/W2082311606","https://openalex.org/W2099438166","https://openalex.org/W2109191724","https://openalex.org/W2128569116","https://openalex.org/W2143289308","https://openalex.org/W2144662506","https://openalex.org/W2155127143","https://openalex.org/W2155183705","https://openalex.org/W2168472523","https://openalex.org/W2188678400"],"related_works":["https://openalex.org/W2318123506","https://openalex.org/W7208232248","https://openalex.org/W1991457522","https://openalex.org/W2007944666","https://openalex.org/W2234300045","https://openalex.org/W7040179847","https://openalex.org/W2224624982","https://openalex.org/W2035288702","https://openalex.org/W2100534366","https://openalex.org/W2028722469"],"abstract_inverted_index":{"A":[0],"major":[1,43],"limitation":[2],"of":[3,12,41,57,100,115,122,136,166,235,241],"exogenous":[4],"vitamin":[5,31,123,156,167,197,249],"D":[6,32,124,157,168,198,250],"3":[7,33,125,158,169,199,251],"administration":[8],"for":[9,26],"the":[10,16,24,27,30,39,55,109,119],"treatment":[11],"prostate":[13,48,81,101,128,137,176,242],"cancer":[14,102,129,138,243],"is":[15],"marginal,":[17],"if":[18],"any,":[19],"clinical":[20,170,194],"efficacy.":[21],"We":[22],"dissected":[23],"basis":[25],"resistance":[28,247],"to":[29,84,155,192,196,248],"antitumor":[34],"properties":[35],"and":[36,54,70,96,103,133,244],"specifically":[37],"examined":[38],"effect":[40,56],"its":[42],"catabolic":[44],"enzyme,":[45],"CYP24A1,":[46,182],"in":[47,78,93,108,126,144,148,172],"cancer.":[49,177],"Local":[50],"CYP24A1":[51,74,88,116,141,160,188,236],"expression":[52,234],"levels":[53,90],"selective":[58],"modulation":[59],"were":[60,91,153],"analyzed":[61],"using":[62],"tissue":[63],"microarrays":[64],"from":[65],"needle":[66],"core":[67],"biopsy":[68],"specimens":[69],"xenograft\u2010bearing":[71],"mouse":[72],"models.":[73],"mRNA":[75],"was":[76],"elevated":[77],"malignant":[79],"human":[80,127],"tissues":[82],"compared":[83],"benign":[85],"lesions.":[86],"High":[87],"protein":[89],"seen":[92],"poorly":[94],"differentiated":[95],"highly":[97],"advanced":[98,175,239],"stages":[99,240],"correlated":[104],"with":[105,174,180,185,238],"parallel":[106],"increase":[107],"tumor":[110,149],"proliferation":[111],"rate.":[112],"The":[113],"use":[114],"RNAi":[117,186],"enhanced":[118],"cytostatic":[120],"effects":[121],"cells.":[130],"Remarkably,":[131],"subcutaneous":[132],"orthotopic":[134],"xenografts":[135],"cells":[139],"harboring":[140],"shRNA":[142],"resulted":[143],"a":[145,163],"drastic":[146],"reduction":[147],"volume":[150],"when":[151],"mice":[152],"subjected":[154],"supplementation.":[159],"may":[161],"be":[162,190],"predictive":[164],"marker":[165],"efficacy":[171],"patients":[173],"For":[178],"those":[179],"up\u2010regulated":[181],"combination":[183],"therapy":[184],"targeting":[187],"could":[189],"considered":[191],"improve":[193],"responsiveness":[195],".\u2014Tannour\u2010Louet,":[200],"M.,":[201],"Lewis,":[202,217],"S.":[203],"K.,":[204,221],"Louet,":[205],"J.\u2010F.,":[206],"Stewart,":[207],"J.,":[208],"Addai,":[209],"J.":[210,232],"B.,":[211],"Sahin,":[212],"A.,":[213],"Vangapandu,":[214],"H.":[215],"V.,":[216],"A.":[218],"L.,":[219,226],"Dittmar,":[220],"Pautler,":[222],"R.":[223,228],"G.,":[224,229],"Zhang,":[225],"Smith,":[227],"Lamb,":[230],"D.":[231],"Increased":[233],"correlates":[237],"can":[245],"cause":[246],"\u2010based":[252],"therapies.":[253],"FASEB":[254],"J":[255],".":[256],"28,":[257],"364\u2013372":[258],"(2014).":[259],"www.fasebj.org":[260]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}