{"id":"https://openalex.org/W2139782266","doi":"https://doi.org/10.1158/1538-7445.am2014-3532","title":"Abstract 3532: Hypoxia is a master regulator of Drosha- and Dicer-dependent miRNA biogenesis in cancer","display_name":"Abstract 3532: Hypoxia is a master regulator of Drosha- and Dicer-dependent miRNA biogenesis in cancer","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2139782266","doi":"https://doi.org/10.1158/1538-7445.am2014-3532","mag":"2139782266"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-3532","doi":"https://doi.org/10.1158/1538-7445.am2014-3532","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-3532","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052973096","display_name":"Rajesha Rupaimoole","orcid":"https://orcid.org/0000-0002-4795-7921","observed_orcids":["https://orcid.org/0000-0002-4795-7921"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesha Rupaimoole","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082498438","display_name":"Cristina Ivan","orcid":"https://orcid.org/0000-0002-4848-0168","observed_orcids":["https://orcid.org/0000-0002-4848-0168"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Ivan","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017773172","display_name":"Chad Victor Pecot","orcid":"https://orcid.org/0000-0002-5250-2999","observed_orcids":["https://orcid.org/0000-0002-5250-2999"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chad Pecot","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027588399","display_name":"Sherry Y. Wu","orcid":"https://orcid.org/0000-0002-6051-4252","observed_orcids":["https://orcid.org/0000-0002-6051-4252"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherry Wu","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043392987","display_name":"Sunila Pradeep","orcid":"https://orcid.org/0000-0003-2441-7727","observed_orcids":["https://orcid.org/0000-0003-2441-7727"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunila Pradeep","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105369415","display_name":"Behrouz Zand","orcid":"https://orcid.org/0000-0002-8327-3535","observed_orcids":["https://orcid.org/0000-0002-8327-3535"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Behrouz Zand","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090920271","display_name":"Archana Sidalaghatta Nagaraja","orcid":"https://orcid.org/0000-0002-2851-9272","observed_orcids":["https://orcid.org/0000-0002-2851-9272"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Archana Nagaraja","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008801459","display_name":"Kshipra M. Gharpure","orcid":"https://orcid.org/0000-0003-4954-5696","observed_orcids":["https://orcid.org/0000-0003-4954-5696"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kshipra Gharpure","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080528785","display_name":"Heather Dalton","orcid":"https://orcid.org/0000-0002-3424-9782","observed_orcids":["https://orcid.org/0000-0002-3424-9782"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Dalton","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071002527","display_name":"Nouara C. Sadaoui","orcid":"https://orcid.org/0000-0001-6339-5618","observed_orcids":["https://orcid.org/0000-0001-6339-5618"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nouara Sadaoui","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441752","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0003-1516-3307","observed_orcids":["https://orcid.org/0000-0003-1516-3307"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023542865","display_name":"Gabriel Lopez\u2010Berestein","orcid":"https://orcid.org/0000-0002-0366-0720","observed_orcids":["https://orcid.org/0000-0002-0366-0720"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Lopez-Berestein","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100640276","display_name":"Anil K. Sood","orcid":"https://orcid.org/0000-0002-5415-9901","observed_orcids":["https://orcid.org/0000-0002-5415-9901"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil Sood","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"3532","last_page":"3532"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.871999979019165},{"id":"https://openalex.org/keywords/drosha","display_name":"Drosha","score":0.8009999990463257},{"id":"https://openalex.org/keywords/dicer","display_name":"Dicer","score":1.0},{"id":"https://openalex.org/keywords/microrna-biogenesis","display_name":"microRNA biogenesis","score":0.925000011920929},{"id":"https://openalex.org/keywords/mir-630","display_name":"miR-630","score":0.8040000200271606},{"id":"https://openalex.org/keywords/ets1","display_name":"ETS1","score":0.9430000185966492},{"id":"https://openalex.org/keywords/elk-1","display_name":"Elk-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7089999914169312},{"id":"https://openalex.org/keywords/carbonic-anhydrase-ix","display_name":"carbonic anhydrase IX","score":0.6679999828338623},{"id":"https://openalex.org/keywords/arid5b","display_name":"ARID5B","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hdac1","display_name":"HDAC1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7649999856948853},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.9279999732971191},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.7480000257492065},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.6110000014305115},{"id":"https://openalex.org/keywords/let-7-microrna","display_name":"let-7 microRNA","score":0.453000009059906},{"id":"https://openalex.org/keywords/mir-30c","display_name":"miR-30c","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C2776802755","wikidata":"https://www.wikidata.org/wiki/Q261483","display_name":"Drosha","level":5,"score":0.9827852249145508},{"id":"https://openalex.org/C2779867133","wikidata":"https://www.wikidata.org/wiki/Q21111297","display_name":"Dicer","level":5,"score":0.9637400507926941},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7418898940086365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6060017347335815},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4829403758049011},{"id":"https://openalex.org/C79750893","wikidata":"https://www.wikidata.org/wiki/Q3430180","display_name":"Ribonuclease III","level":5,"score":0.4696580469608307},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.4346040189266205},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.41726452112197876},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39557188749313354},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38558971881866455},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21547099947929382},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.21080976724624634},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.20607727766036987},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.16023766994476318},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08023619651794434}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-3532","doi":"https://doi.org/10.1158/1538-7445.am2014-3532","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-3532","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2039737850","https://openalex.org/W202875590","https://openalex.org/W4299639263","https://openalex.org/W1963931743","https://openalex.org/W1460455391","https://openalex.org/W2565769875","https://openalex.org/W2078160295","https://openalex.org/W2899104725","https://openalex.org/W2410062781","https://openalex.org/W2058326304"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Drosha":[2,48,57,88,124,175,196,325,337,365],"and":[3,49,52,58,65,89,106,111,125,138,160,168,192,255,305,326,338,366,371,412],"Dicer":[4,16,59,79,90,126,202,246,327,339,367],"are":[5,26,91,129,170,212,216],"2":[6],"key":[7],"enzymes":[8],"involved":[9],"in":[10,40,47,95,148,247,287,291,302,314,323,334,345,349,416],"miRNA":[11,38,140,149,226,264,414],"biogenesis.":[12],"Individual":[13],"regulators":[14],"of":[15,35,37,56,104,116,123,132,245,252,298,410,421,426],"(e.g":[17],"let7)":[18],"have":[19],"been":[20],"implicated,":[21],"but":[22],"the":[23,121,282,295,362,422,427],"underlying":[24,364],"mechanisms":[25,34,363],"currently":[27],"poorly":[28],"understood.":[29],"Here,":[30],"we":[31,164,237,293],"identified":[32,262],"new":[33,359],"deregulation":[36],"biogenesis":[39,415],"tumor":[41,63,113,223,316],"cells,":[42],"whereby":[43],"hypoxia":[44,73,128,178,215,290,370],"causes":[45],"reduction":[46,348],"Dicer.":[50,220],"Methods":[51],"Results:":[53],"Differential":[54],"levels":[55],"was":[60],"found":[61,86,165],"between":[62],"samples":[64,317],"their":[66,256],"expression":[67,176,340],"correlated":[68],"negatively":[69],"with":[70,225,232,319],"CA9,":[71],"a":[72,102,145,242,346,407],"marker":[74],"(Drosha":[75],"vs.":[76,80],"CA9":[77,81],"r=-0.65,":[78],"r=-0.69;":[82],"p<0.05).":[83],"We":[84,185,310],"further":[85,186],"that":[87,120,166,188,211,239,313],"down-regulated":[92],"by":[93,179],">70%":[94],"hypoxic":[96,248],"compared":[97],"to":[98,155,181,194,200,218],"normoxic":[99],"conditions":[100],"across":[101],"panel":[103],"ovarian":[105,304],"breast":[107,306],"cancer":[108,307,350,375],"cell":[109],"lines":[110],"microdisected":[112],"tissues.":[114],"Analysis":[115],"TCGA":[117],"data":[118,261],"showed":[119,238],"expressions":[122],"or":[127,228,300,330],"independent":[130],"predictors":[131],"poor":[133],"patient":[134],"survival.":[135],"Furthermore,":[136],"RNA-sequencing":[137],"mature":[139],"array":[141],"analyses":[142],"both":[143],"revealed":[144],"significant":[146,289,324,347],"disruption":[147],"maturation":[150],"when":[151],"cells":[152,224],"were":[153],"exposed":[154],"hypoxia.":[156,208,280],"Through":[157],"ChIP":[158],"assays":[159],"promoter":[161,183],"reporter":[162],"studies,":[163],"ETS1":[167],"ELK1":[169],"responsible":[171],"for":[172,284,430],"transcriptionally":[173],"repressing":[174],"under":[177,207,214,279,341],"binding":[180],"its":[182],"region.":[184],"show":[187],"ETS1/ELK1":[189],"recruit":[190],"ARID5B":[191],"HDAC1":[193],"methylate":[195],"promoter.":[197],"In":[198,354],"contrast":[199],"Drosha,":[201],"level":[203],"is":[204,241,406],"altered":[205],"post-transcriptionally":[206],"Several":[209],"miRNAs":[210,254],"up-regulated":[213],"predicted":[217],"target":[219],"By":[221],"transfecting":[222],"mimics":[227],"anti-miR":[229],"constructs":[230],"along":[231],"3\u2032":[233],"UTR":[234],"luciferase":[235],"assays,":[236],"miR-630":[240],"strong":[243],"regulator":[244,409],"conditions.":[249],"Bioinformatics":[250],"analysis":[251],"downregulated":[253],"gene":[257],"targets":[258],"from":[259],"RNA-seq":[260],"novel":[263],"(let7a,":[265],"miR-30c,":[266],"miR-135a,":[267],"miR-146a)-mRNA":[268],"(RHOB,":[269],"TAGLN,":[270],"JUN,":[271],"CTGF,":[272],"SERTAD,":[273],"TXNIP,":[274],"JAG1)":[275],"interactions":[276],"aiding":[277],"metastasis":[278,351],"Given":[281],"potential":[283],"anti-VEGF":[285,320,342],"therapies":[286],"inducing":[288],"tumors,":[292],"examined":[294],"biological":[296],"effects":[297,373],"anti-miR-630":[299],"siETS1/ELK1":[301],"orthotopic":[303],"mouse":[308],"models.":[309],"first":[311],"demonstrated":[312],"vivo":[315,335],"treated":[318],"therapy":[321],"results":[322],"down-regulation.":[328],"ETS1+ELK1siRNA":[329],"anti-miR630":[331],"DOPC":[332],"nanoparticles":[333],"rescued":[336],"therapy,":[343],"resulting":[344],"(p<0.05).":[352],"Conclusion:":[353],"summary,":[355],"these":[356],"findings":[357],"provide":[358],"insights":[360],"into":[361],"downregulation":[368],"following":[369],"resultant":[372],"on":[374],"metastasis.":[376],"Citation":[377],"Format:":[378],"Rajesha":[379],"Rupaimoole,":[380],"Cristina":[381],"Ivan,":[382],"Chad":[383],"Pecot,":[384],"Sherry":[385],"Wu,":[386],"Sunila":[387],"Pradeep,":[388],"Behrouz":[389],"Zand,":[390],"Archana":[391],"Nagaraja,":[392],"Kshipra":[393],"Gharpure,":[394],"Heather":[395],"Dalton,":[396],"Nouara":[397],"Sadaoui,":[398],"Wei":[399],"Zhang,":[400],"Gabriel":[401],"Lopez-Berestein,":[402],"Anil":[403],"Sood.":[404],"Hypoxia":[405],"master":[408],"Drosha-":[411],"Dicer-dependent":[413],"cancer.":[417],"[abstract].":[418],"In:":[419],"Proceedings":[420],"105th":[423],"Annual":[424],"Meeting":[425],"American":[428],"Association":[429],"Cancer":[431,442],"Research;":[432],"2014":[433],"Apr":[434],"5-9;":[435],"San":[436],"Diego,":[437],"CA.":[438],"Philadelphia":[439],"(PA):":[440],"AACR;":[441],"Res":[443],"2014;74(19":[444],"Suppl):Abstract":[445],"nr":[446],"3532.":[447],"doi:10.1158/1538-7445.AM2014-3532":[448]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}
