{"id":"https://openalex.org/W2139773174","doi":"https://doi.org/10.1523/jneurosci.21-04-01127.2001","title":"Structural Determinants of Fast Desensitization and Desensitization\u2013Deactivation Coupling in GABAAReceptors","display_name":"Structural Determinants of Fast Desensitization and Desensitization\u2013Deactivation Coupling in GABAAReceptors","publication_year":2001,"publication_date":"2001-02-15","ids":{"openalex":"https://openalex.org/W2139773174","doi":"https://doi.org/10.1523/jneurosci.21-04-01127.2001","mag":"2139773174","pmid":"https://pubmed.ncbi.nlm.nih.gov/11160383"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.21-04-01127.2001","doi":"https://doi.org/10.1523/jneurosci.21-04-01127.2001","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.21-04-01127.2001","pdf_url":"https://www.jneurosci.org/content/jneuro/21/4/1127.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/21/4/1127.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065493403","display_name":"Matt Travis Bianchi","orcid":"https://orcid.org/0000-0002-0213-0859","observed_orcids":["https://orcid.org/0000-0002-0213-0859","https://orcid.org/0009-0001-0682-7549"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matt T. Bianchi","raw_affiliation_strings":["Neuroscience Graduate Program and the Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Graduate Program and the Departments of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110500416","display_name":"Kevin F. Haas","orcid":"https://orcid.org/0000-0001-8444-3551","observed_orcids":["https://orcid.org/0000-0001-8444-3551"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin F. Haas","raw_affiliation_strings":["Neuroscience Graduate Program and the Departments of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Graduate Program and the Departments of","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044198884","display_name":"Robert L. Macdonald","orcid":"https://orcid.org/0000-0002-9539-5556","observed_orcids":["https://orcid.org/0000-0002-9539-5556"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Macdonald","raw_affiliation_strings":["Neurology and","Physiology, University of Michigan, Ann Arbor, Michigan 48104-1687"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology and","institution_ids":[]},{"raw_affiliation_string":"Physiology, University of Michigan, Ann Arbor, Michigan 48104-1687","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4796,"has_fulltext":true,"cited_by_count":97,"citation_normalized_percentile":{"value":0.93788485,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"4","first_page":"1127","last_page":"1136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.9110000133514404},{"id":"https://openalex.org/keywords/delta-subunit","display_name":"delta subunit","score":0.699999988079071},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.5019999742507935},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.6899999976158142},{"id":"https://openalex.org/keywords/channel-gating","display_name":"channel gating","score":0.6039999723434448},{"id":"https://openalex.org/keywords/gabaergic-synapses","display_name":"GABAergic synapses","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.9482207298278809},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.622327983379364},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5343716740608215},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.5078087449073792},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.47449326515197754},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4684450924396515},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3996862471103668},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.29589390754699707},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2479235827922821},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.211359441280365},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17829391360282898},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.06472301483154297}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.21-04-01127.2001","doi":"https://doi.org/10.1523/jneurosci.21-04-01127.2001","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.21-04-01127.2001","pdf_url":"https://www.jneurosci.org/content/jneuro/21/4/1127.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:11160383","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11160383","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6762234","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6762234","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.21-04-01127.2001","doi":"https://doi.org/10.1523/jneurosci.21-04-01127.2001","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.21-04-01127.2001","pdf_url":"https://www.jneurosci.org/content/jneuro/21/4/1127.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G129821724","display_name":null,"funder_award_id":"R01 NS 33300","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2738044884","display_name":null,"funder_award_id":"T32-DA07281-03","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G4642055278","display_name":null,"funder_award_id":"T32DA007281","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G8999039667","display_name":null,"funder_award_id":"R01 NS033300","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000343337","display_name":null,"funder_award_id":"NS33300","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139773174.pdf","grobid_xml":"https://content.openalex.org/works/W2139773174.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1485916201","https://openalex.org/W1500719964","https://openalex.org/W1548603509","https://openalex.org/W1583705151","https://openalex.org/W1810180105","https://openalex.org/W1942381117","https://openalex.org/W1963497414","https://openalex.org/W1967743127","https://openalex.org/W1993695011","https://openalex.org/W1994397958","https://openalex.org/W1999154941","https://openalex.org/W2004349398","https://openalex.org/W2006606811","https://openalex.org/W2012148599","https://openalex.org/W2013596724","https://openalex.org/W2015236121","https://openalex.org/W2015290558","https://openalex.org/W2023468172","https://openalex.org/W2033364942","https://openalex.org/W2035263031","https://openalex.org/W2041203007","https://openalex.org/W2043385322","https://openalex.org/W2044669542","https://openalex.org/W2049276472","https://openalex.org/W2066562577","https://openalex.org/W2071709232","https://openalex.org/W2073286007","https://openalex.org/W2074990246","https://openalex.org/W2081556250","https://openalex.org/W2091737589","https://openalex.org/W2094426376","https://openalex.org/W2099883420","https://openalex.org/W2106001183","https://openalex.org/W2118922355","https://openalex.org/W2129842868","https://openalex.org/W2131645763","https://openalex.org/W2140869385","https://openalex.org/W2148598721","https://openalex.org/W2163119877","https://openalex.org/W2176076159","https://openalex.org/W2212871432","https://openalex.org/W2342067858","https://openalex.org/W2404061401","https://openalex.org/W4285719527","https://openalex.org/W4405989138"],"related_works":["https://openalex.org/W1999794618","https://openalex.org/W2065141443","https://openalex.org/W4385706107","https://openalex.org/W1978441684","https://openalex.org/W2125584695","https://openalex.org/W3165252389","https://openalex.org/W1964761936","https://openalex.org/W2348970329","https://openalex.org/W4390078146","https://openalex.org/W2066063160"],"abstract_inverted_index":{"Fast":[0],"IPSCs":[1,20],"in":[2,136,156,179,220],"the":[3,24,51,89,113,127,137,143,159,196,210],"brain":[4],"are":[5,21,59],"predominantly":[6],"caused":[7],"by":[8,23,47],"presynaptic":[9],"release":[10],"of":[11,29,142,158,174,189,195,203],"GABA":[12],"that":[13,126,206],"activates":[14],"GABA(A)":[15],"receptor":[16],"(GABA(A)R)":[17],"channels.":[18],"The":[19],"shaped":[22],"gating":[25],"and":[26,42,56,74,85,106,119,130,191],"desensitization":[27,34,118,184,190,221],"properties":[28],"postsynaptic":[30],"GABA(A)Rs.":[31],"Specifically,":[32],"fast":[33,72,83,117,151],"has":[35],"been":[36],"suggested":[37],"to":[38,43,93,109,122,149,169,209],"decrease":[39],"IPSC":[40,45],"amplitude":[41],"increase":[44],"duration":[46],"slowing":[48],"deactivation;":[49],"however,":[50],"mechanisms":[52],"underlying":[53],"desensitization,":[54],"deactivation,":[55],"their":[57],"coupling":[58,121],"poorly":[60],"understood.":[61],"Consistent":[62],"with":[63,69],"this":[64],"suggestion,":[65],"alpha1beta3gamma2L":[66],"GABA(A)Rs":[67,79,98],"desensitize":[68,80],"a":[70,82,216],"prominent":[71],"phase":[73,84],"deactivate":[75,86],"slowly,":[76],"whereas":[77],"alpha1beta3delta":[78],"without":[81],"rapidly.":[87],"Using":[88],"concentration-jump":[90],"technique":[91],"applied":[92],"excised":[94],"patches,":[95],"we":[96],"studied":[97],"containing":[99],"chimeras":[100],"or":[101,199],"exchange":[102],"mutants":[103],"between":[104],"delta":[105,144,200],"gamma2L":[107,160],"subunits":[108],"gain":[110],"insight":[111],"into":[112],"structural":[114],"bases":[115],"for":[116,166],"its":[120],"deactivation.":[123],"We":[124],"demonstrated":[125],"N":[128],"terminus":[129],"two":[131],"adjacent":[132],"residues":[133,155],"(V233,":[134],"Y234)":[135],"first":[138],"transmembrane":[139],"domain":[140],"(TM1)":[141],"subunit":[145,161,201],"were":[146,164],"both":[147],"required":[148],"abolish":[150],"desensitization.":[152],"Additionally,":[153],"these":[154],"TM1":[157],"(Y235,":[162],"F236)":[163],"critical":[165],"desensitized":[167],"states":[168],"prolong":[170],"deactivation":[171,181,192],"after":[172],"removal":[173],"GABA,":[175],"because":[176],"mutations":[177],"resulted":[178],"accelerated":[180],"despite":[182],"unaltered":[183],"time":[185],"course.":[186],"Interestingly,":[187],"control":[188],"was":[193],"independent":[194],"identity":[197],"(gamma2L":[198],"sequence)":[202],"TM2,":[204],"indicating":[205],"structures":[207],"related":[208],"putative":[211],"channel":[212],"gate":[213],"may":[214],"play":[215],"less":[217],"direct":[218],"role":[219],"than":[222],"previously":[223],"suggested.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
