{"id":"https://openalex.org/W2139763883","doi":"https://doi.org/10.1093/mutage/gei068","title":"Practical threshold for micronucleated reticulocyte induction observed for low doses of mitomycin C, Ara-C and colchicine","display_name":"Practical threshold for micronucleated reticulocyte induction observed for low doses of mitomycin C, Ara-C and colchicine","publication_year":2005,"publication_date":"2005-12-19","ids":{"openalex":"https://openalex.org/W2139763883","doi":"https://doi.org/10.1093/mutage/gei068","mag":"2139763883","pmid":"https://pubmed.ncbi.nlm.nih.gov/16364928"},"language":"en","primary_location":{"id":"doi:10.1093/mutage/gei068","doi":"https://doi.org/10.1093/mutage/gei068","is_oa":false,"landing_page_url":"https://doi.org/10.1093/mutage/gei068","pdf_url":null,"source":{"id":"https://openalex.org/S101337917","display_name":"Mutagenesis","issn_l":"0267-8357","issn":["0267-8357","1464-3804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutagenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102421280","display_name":"Norihide Asano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I171818078","display_name":"Nitto (Japan)","ror":"https://ror.org/01kq4az79","country_code":"JP","type":"company","lineage":["https://openalex.org/I171818078"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Norihide Asano","raw_affiliation_strings":["Toxicological Research Center, Nitto Denko Corporation, 1-1-2, Shimohozumi, Ibaraki Osaka 567-8680, Japan. asanonri@nitto.co.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxicological Research Center, Nitto Denko Corporation, 1-1-2, Shimohozumi, Ibaraki Osaka 567-8680, Japan. asanonri@nitto.co.jp","institution_ids":["https://openalex.org/I171818078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028450494","display_name":"Dorothea K. Torous","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dorothea K. Torous","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046702241","display_name":"Carol R. Tometsko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carol R. Tometsko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021440089","display_name":"Stephen D. Dertinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen D. Dertinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046109273","display_name":"Takeshi Morita","orcid":"https://orcid.org/0000-0002-7460-5040","observed_orcids":["https://orcid.org/0000-0002-7460-5040"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takeshi Morita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070698304","display_name":"Makoto Hayashi","orcid":"https://orcid.org/0000-0002-1195-8156","observed_orcids":["https://orcid.org/0000-0002-1195-8156"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Makoto Hayashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102421280"],"corresponding_institution_ids":["https://openalex.org/I171818078"],"apc_list":{"value":3162,"currency":"GBP","value_usd":4170},"apc_paid":null,"fwci":1.1584,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.79300891,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"21","issue":"1","first_page":"15","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/micronucleus-induction","display_name":"micronucleus induction","score":0.8259999752044678},{"id":"https://openalex.org/keywords/reticulocytes","display_name":"reticulocytes","score":0.9599999785423279},{"id":"https://openalex.org/keywords/mitomycin-c","display_name":"mitomycin C","score":0.921999990940094},{"id":"https://openalex.org/keywords/1-beta-d-arabinofuranosylcytosine","display_name":"1-beta-D-arabinofuranosylcytosine","score":0.8500000238418579},{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/clastogens","display_name":"clastogens","score":0.8529999852180481},{"id":"https://openalex.org/keywords/aneugens","display_name":"aneugens","score":0.9359999895095825},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.8169999718666077},{"id":"https://openalex.org/keywords/statistical-power","display_name":"statistical power","score":0.699999988079071},{"id":"https://openalex.org/keywords/acridine-orange-staining","display_name":"acridine orange staining","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C2778403015","wikidata":"https://www.wikidata.org/wiki/Q1404923","display_name":"Reticulocyte","level":4,"score":0.7806161046028137},{"id":"https://openalex.org/C2779338040","wikidata":"https://www.wikidata.org/wiki/Q19856779","display_name":"Mitomycin C","level":2,"score":0.7202199101448059},{"id":"https://openalex.org/C141710004","wikidata":"https://www.wikidata.org/wiki/Q744364","display_name":"Clastogen","level":4,"score":0.7105869054794312},{"id":"https://openalex.org/C2779102032","wikidata":"https://www.wikidata.org/wiki/Q342717","display_name":"Acridine orange","level":3,"score":0.6520600914955139},{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.5956629514694214},{"id":"https://openalex.org/C36681516","wikidata":"https://www.wikidata.org/wiki/Q1700733","display_name":"Micronucleus","level":4,"score":0.5911881327629089},{"id":"https://openalex.org/C45080847","wikidata":"https://www.wikidata.org/wiki/Q1658004","display_name":"Micronucleus test","level":3,"score":0.5596418976783752},{"id":"https://openalex.org/C2776639595","wikidata":"https://www.wikidata.org/wiki/Q221696","display_name":"Mutagen","level":3,"score":0.5311751961708069},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.530249297618866},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44319772720336914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39931514859199524},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.39776819944381714},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.35197770595550537},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.2409897744655609},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2214221954345703},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.22019538283348083},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21559885144233704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15416446328163147},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.07973676919937134},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000165","descriptor_name":"Acridine Orange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003561","descriptor_name":"Cytarabine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012156","descriptor_name":"Reticulocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012156","descriptor_name":"Reticulocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015162","descriptor_name":"Micronucleus Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016685","descriptor_name":"Mitomycin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/mutage/gei068","doi":"https://doi.org/10.1093/mutage/gei068","is_oa":false,"landing_page_url":"https://doi.org/10.1093/mutage/gei068","pdf_url":null,"source":{"id":"https://openalex.org/S101337917","display_name":"Mutagenesis","issn_l":"0267-8357","issn":["0267-8357","1464-3804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutagenesis","raw_type":"journal-article"},{"id":"pmid:16364928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16364928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutagenesis","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1973707217","https://openalex.org/W1976430549","https://openalex.org/W1989338267","https://openalex.org/W1995064185","https://openalex.org/W1997520209","https://openalex.org/W2002519505","https://openalex.org/W2004642777","https://openalex.org/W2006581393","https://openalex.org/W2008838636","https://openalex.org/W2010041119","https://openalex.org/W2011279163","https://openalex.org/W2026363632","https://openalex.org/W2033785453","https://openalex.org/W2040305737","https://openalex.org/W2052508582","https://openalex.org/W2052825715","https://openalex.org/W2065287149","https://openalex.org/W2066127518","https://openalex.org/W2066503107","https://openalex.org/W2069052235","https://openalex.org/W2071234262","https://openalex.org/W2072493209","https://openalex.org/W2080920110","https://openalex.org/W2086942082","https://openalex.org/W2090722482","https://openalex.org/W2092053242","https://openalex.org/W2105327309","https://openalex.org/W2109228518","https://openalex.org/W2114771936","https://openalex.org/W2126073253","https://openalex.org/W2146053013","https://openalex.org/W2154912015","https://openalex.org/W2161477415","https://openalex.org/W2164898699","https://openalex.org/W2170323651","https://openalex.org/W2310873296","https://openalex.org/W2497667729","https://openalex.org/W2888724818","https://openalex.org/W4234736483"],"related_works":["https://openalex.org/W2072493209","https://openalex.org/W1994323227","https://openalex.org/W2069052235","https://openalex.org/W1997520209","https://openalex.org/W2090722482","https://openalex.org/W1963908638","https://openalex.org/W1965403290","https://openalex.org/W2035232587","https://openalex.org/W4232402642","https://openalex.org/W2116748506"],"abstract_inverted_index":{"Micronucleus":[0],"induction":[1],"was":[2,42,51,116,161],"studied":[3],"for":[4,44,53,82,139,149,172,188,199,206],"the":[5,17,27,47,58,70,87,93,101,107,111,114,135,144,159,168,191,200,207,214],"DNA":[6,208],"target":[7,19,209,216],"clastogens":[8,210],"mitomycin":[9],"C":[10],"(MMC)":[11],"and":[12,15,46,77,141],"1-beta-D-arabinofuranosylcytosine":[13],"(Ara-C),":[14],"also":[16],"non-DNA":[18,215],"aneugen":[20,217],"colchicine":[21],"(COL)":[22],"in":[23,69],"order":[24],"to":[25,85],"evaluate":[26],"dose-response":[28,184],"relationship":[29],"at":[30,134],"very":[31],"low":[32],"dose":[33,137,147,170],"levels.":[34],"The":[35,95],"acridine":[36],"orange":[37],"(AO)":[38],"supravital":[39],"staining":[40],"method":[41,50],"used":[43,52],"microscopy":[45],"anti-CD71-FITC":[48],"based":[49],"flow":[54,71],"cytometric":[55,72],"analysis.":[56],"In":[57],"AO":[59],"method,":[60,73],"2000":[61],"reticulocytes":[62,79,180],"were":[63,80,131,156,186],"analysed":[64,81],"as":[65,118,163,211,213],"commonly":[66],"advised,":[67],"but":[68],"2000,":[74],"20,000,":[75],"200,000":[76],"1,000,000":[78],"each":[83,173,189],"sample":[84],"increase":[86,177],"detecting":[88],"power":[89,109],"(i.e.":[90],"sensitivity)":[91],"of":[92,103,110,178,190,202],"assay.":[94],"present":[96],"data":[97],"show":[98],"that":[99],"increasing":[100],"number":[102],"cells":[104,155],"scored":[105],"increases":[106],"statistical":[108,120,165],"assay":[112],"when":[113],"cell":[115],"considered":[117,162],"a":[119,164,203],"unit.":[121],"Even":[122],"so,":[123],"statistically":[124],"significant":[125,176],"differences":[126],"from":[127],"respective":[128],"vehicle":[129],"controls":[130],"not":[132],"observed":[133],"lowest":[136],"level":[138],"MMC":[140],"Ara-C,":[142],"or":[143],"lower":[145],"four":[146],"levels":[148],"COL,":[150],"even":[151],"after":[152],"one":[153],"million":[154],"analysed.":[157],"When":[158],"animal":[160],"unit,":[166],"only":[167],"top":[169],"group":[171],"chemical":[174],"showed":[175],"micronucleated":[179],"frequency.":[181],"As":[182],"non-linear":[183],"curves":[185],"obtained":[187],"three":[192],"chemicals":[193],"studied,":[194],"these":[195],"observations":[196],"provide":[197],"evidence":[198],"existence":[201],"practical":[204],"threshold":[205],"well":[212],"studied.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
