{"id":"https://openalex.org/W2139763370","doi":"https://doi.org/10.1152/ajpendo.00231.2011","title":"Smooth muscle myosin expression, isoform composition, and functional activities in rat corpus cavernosum altered by the streptozotocin-induced type 1 diabetes","display_name":"Smooth muscle myosin expression, isoform composition, and functional activities in rat corpus cavernosum altered by the streptozotocin-induced type 1 diabetes","publication_year":2011,"publication_date":"2011-09-14","ids":{"openalex":"https://openalex.org/W2139763370","doi":"https://doi.org/10.1152/ajpendo.00231.2011","mag":"2139763370","pmid":"https://pubmed.ncbi.nlm.nih.gov/21917637","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3328089"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.00231.2011","doi":"https://doi.org/10.1152/ajpendo.00231.2011","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00231.2011","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3328089","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100380936","display_name":"Xinhua Zhang","orcid":"https://orcid.org/0000-0003-0267-428X","observed_orcids":["https://orcid.org/0000-0003-0267-428X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I4210089330","display_name":"Cooper Medical School of Rowan University","ror":"https://ror.org/007evha27","country_code":"US","type":"education","lineage":["https://openalex.org/I4210089330","https://openalex.org/I4210157085","https://openalex.org/I44265643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinhua Zhang","raw_affiliation_strings":["Department of Urology, Albert Einstein College of Medicine, Bronx, New York; and","Division of Urology/Department of Surgery, Cooper Medical School of Rowan University, Camden, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Albert Einstein College of Medicine, Bronx, New York; and","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Division of Urology/Department of Surgery, Cooper Medical School of Rowan University, Camden, New Jersey","institution_ids":["https://openalex.org/I4210089330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015215025","display_name":"Nirmala Devi Kanika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nirmala D. Kanika","raw_affiliation_strings":["Department of Urology, Albert Einstein College of Medicine, Bronx, New York; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Albert Einstein College of Medicine, Bronx, New York; and","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091034590","display_name":"Arnold Melman","orcid":"https://orcid.org/0000-0002-4213-9794","observed_orcids":["https://orcid.org/0000-0002-4213-9794"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnold Melman","raw_affiliation_strings":["Department of Urology, Albert Einstein College of Medicine, Bronx, New York; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Albert Einstein College of Medicine, Bronx, New York; and","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080783084","display_name":"Michael E. DiSanto","orcid":"https://orcid.org/0000-0003-4754-7794","observed_orcids":["https://orcid.org/0000-0003-4754-7794"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I4210089330","display_name":"Cooper Medical School of Rowan University","ror":"https://ror.org/007evha27","country_code":"US","type":"education","lineage":["https://openalex.org/I4210089330","https://openalex.org/I4210157085","https://openalex.org/I44265643"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael E. DiSanto","raw_affiliation_strings":["Department of Urology, Albert Einstein College of Medicine, Bronx, New York; and","Division of Urology/Department of Surgery, Cooper Medical School of Rowan University, Camden, New Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Albert Einstein College of Medicine, Bronx, New York; and","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Division of Urology/Department of Surgery, Cooper Medical School of Rowan University, Camden, New Jersey","institution_ids":["https://openalex.org/I4210089330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080783084"],"corresponding_institution_ids":["https://openalex.org/I129975664","https://openalex.org/I4210089330"],"apc_list":null,"apc_paid":null,"fwci":1.1007,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.78416754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"302","issue":"1","first_page":"E32","last_page":"E42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smooth-muscle-myosin","display_name":"smooth muscle myosin","score":0.7799999713897705},{"id":"https://openalex.org/keywords/myosin-heavy-chain-isoforms","display_name":"myosin heavy chain isoforms","score":0.9330000281333923},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.9020000100135803},{"id":"https://openalex.org/keywords/essential-light-chain","display_name":"essential light chain","score":0.7609999775886536},{"id":"https://openalex.org/keywords/corpus-cavernosum-smooth-muscle","display_name":"corpus cavernosum smooth muscle","score":0.8259999752044678},{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":0.8379999995231628},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9269999861717224},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/blebbistatin","display_name":"blebbistatin","score":0.9350000023841858},{"id":"https://openalex.org/keywords/myosin-ii-inhibition","display_name":"myosin II inhibition","score":0.8859999775886536},{"id":"https://openalex.org/keywords/myocardin","display_name":"myocardin","score":0.7950000166893005},{"id":"https://openalex.org/keywords/smooth-muscle-contractility","display_name":"smooth muscle contractility","score":0.7860000133514404},{"id":"https://openalex.org/keywords/intracavernosal-pressure","display_name":"intracavernous pressure","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.9141639471054077},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7425506114959717},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.7307276725769043},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5832394957542419},{"id":"https://openalex.org/C40231798","wikidata":"https://www.wikidata.org/wiki/Q1333743","display_name":"Composition (language)","level":2,"score":0.5451903939247131},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.543279767036438},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.5339205265045166},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.382915198802948},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3806157410144806},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.36866092681884766},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36392301321029663},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3276578187942505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24040308594703674},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17894092202186584},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08957690000534058},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.060306400060653687},{"id":"https://openalex.org/C124952713","wikidata":"https://www.wikidata.org/wiki/Q8242","display_name":"Literature","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099251","descriptor_name":"Myocardin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006576","descriptor_name":"Heterocyclic Compounds, 4 or More Rings","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018994","descriptor_name":"Myosin Light Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018994","descriptor_name":"Myosin Light Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018994","descriptor_name":"Myosin Light Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018994","descriptor_name":"Myosin Light Chains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018994","descriptor_name":"Myosin Light Chains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018994","descriptor_name":"Myosin Light Chains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018995","descriptor_name":"Myosin Heavy Chains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024462","descriptor_name":"Myosin Type II","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D024462","descriptor_name":"Myosin Type II","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D024462","descriptor_name":"Myosin Type II","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D024745","descriptor_name":"Smooth Muscle Myosins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024745","descriptor_name":"Smooth Muscle Myosins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024745","descriptor_name":"Smooth Muscle Myosins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024745","descriptor_name":"Smooth Muscle Myosins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024745","descriptor_name":"Smooth Muscle Myosins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024745","descriptor_name":"Smooth Muscle Myosins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajpendo.00231.2011","doi":"https://doi.org/10.1152/ajpendo.00231.2011","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00231.2011","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2531954","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3328089","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3328089","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3328089","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Endocrinol Metab","raw_type":"Text"},{"id":"pmid:21917637","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21917637","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2531954","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3328089","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.800000011920929,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2690811934","display_name":null,"funder_award_id":"5R01DK077116","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5177051958","display_name":"Role of calcium sensitization in diabetes-induced erectile dysfunction","funder_award_id":"7r01dk077116-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W291497415","https://openalex.org/W1489511851","https://openalex.org/W1505317991","https://openalex.org/W1515141336","https://openalex.org/W1581643045","https://openalex.org/W1698954587","https://openalex.org/W1864513115","https://openalex.org/W1893146433","https://openalex.org/W1968367442","https://openalex.org/W1980056833","https://openalex.org/W1981194148","https://openalex.org/W1983149972","https://openalex.org/W1986702198","https://openalex.org/W1993812460","https://openalex.org/W1997804320","https://openalex.org/W1997825003","https://openalex.org/W1998687037","https://openalex.org/W2005754285","https://openalex.org/W2008218748","https://openalex.org/W2018741746","https://openalex.org/W2019966456","https://openalex.org/W2028370850","https://openalex.org/W2035731780","https://openalex.org/W2036938051","https://openalex.org/W2040500952","https://openalex.org/W2045360381","https://openalex.org/W2046505242","https://openalex.org/W2053047722","https://openalex.org/W2065449221","https://openalex.org/W2071156256","https://openalex.org/W2073856944","https://openalex.org/W2076928132","https://openalex.org/W2076937488","https://openalex.org/W2093020946","https://openalex.org/W2094376274","https://openalex.org/W2096156307","https://openalex.org/W2098909725","https://openalex.org/W2101508556","https://openalex.org/W2103680698","https://openalex.org/W2105257087","https://openalex.org/W2107277218","https://openalex.org/W2115107206","https://openalex.org/W2120208564","https://openalex.org/W2127404126","https://openalex.org/W2128162731","https://openalex.org/W2129938192","https://openalex.org/W2141849555","https://openalex.org/W2157734672","https://openalex.org/W2164189667","https://openalex.org/W2281388947","https://openalex.org/W2297358297","https://openalex.org/W2337839977","https://openalex.org/W2466728185"],"related_works":["https://openalex.org/W2033030575","https://openalex.org/W2077863235","https://openalex.org/W2028821367","https://openalex.org/W2520914129","https://openalex.org/W2389813794","https://openalex.org/W2189462778","https://openalex.org/W2158122425","https://openalex.org/W3031072028","https://openalex.org/W2088190826","https://openalex.org/W2039736455"],"abstract_inverted_index":{"Diabetes":[0],"mellitus":[1],"(DM)":[2],"is":[3,16],"a":[4,72,229,247,252,260,290],"quite":[5],"common":[6],"chronic":[7],"disease,":[8],"and":[9,48,125,141,145,182,191,196,203,223,241,255],"the":[10,31,156,237,273],"prevalence":[11],"of":[12,160,236],"erectile":[13],"dysfunction":[14],"(ED)":[15],"three":[17],"times":[18],"higher":[19],"in":[20,114,126,216,221,224,275],"this":[21,85],"large":[22],"population.":[23],"Although":[24],"diabetes-related":[25],"ED":[26,172],"has":[27],"been":[28],"studied":[29],"extensively,":[30],"actin-myosin":[32],"contractile":[33,62,178,262],"apparatus":[34],"was":[35,136,163,212,264,278],"not":[36],"examined.":[37],"The":[38],"mRNAs":[39],"encoding":[40],"smooth":[41,81],"muscle":[42,82],"myosin":[43,74],"(SMM)":[44],"heavy":[45,239],"chains":[46,51],"(MHC)":[47],"essential":[49,242],"light":[50,243],"(LC(17))":[52],"exist":[53],"as":[54,289],"several":[55],"different":[56],"alternatively":[57],"spliced":[58],"isoforms":[59,205],"with":[60,208,280],"distinct":[61],"properties.":[63],"Recently,":[64],"we":[65,87,227],"provided":[66],"novel":[67,230,291],"data":[68],"that":[69,155],"blebbistatin":[70],"(BLEB),":[71],"specific":[73],"II":[75],"inhibitor,":[76],"potently":[77],"relaxed":[78],"corpus":[79],"cavernosum":[80],"(CCSM).":[83],"In":[84],"study,":[86],"examine":[88],"whether":[89],"diabetes":[90],"alters":[91],"SMM":[92,133,147,238,248,269],"expression,":[93],"alternative":[94,234],"splicing,":[95],"and/or":[96],"functional":[97,110],"activities,":[98],"including":[99],"sensitivity":[100,283],"to":[101,180,246,259,284],"BLEB.":[102],"By":[103],"using":[104],"streptozotocin":[105],"(STZ)-induced":[106],"2-mo":[107],"diabetic":[108],"rats,":[109,188],"activities":[111],"were":[112,206],"tested":[113],"vivo":[115],"by":[116,138,150,174,267],"intracavernous":[117],"pressure":[118],"(ICP)":[119],"recording":[120],"during":[121],"cavernous":[122],"nerve":[123],"stimulation":[124],"vitro":[127,222],"via":[128],"organ":[129],"bath":[130],"contractility":[131,254],"studies.":[132],"isoform":[134,249],"composition":[135,250],"analyzed":[137],"competitive":[139],"RT-PCR":[140],"total":[142,194,268],"SMM,":[143,195],"myocardin,":[144],"embryonic":[146],"(SMemb)":[148],"expression":[149,198,270],"real-time":[151],"RT-PCR.":[152],"Results":[153],"revealed":[154],"blood":[157],"glucose":[158],"level":[159],"STZ":[161,169,187,218],"rats":[162,170],"407.0":[164],"vs.":[165],"129.5":[166],"mg/dl":[167],"(control).":[168],"exhibited":[171],"confirmed":[173],"significantly":[175,213],"increased":[176,282],"CCSM":[177,219,276],"response":[179],"phenylephrine":[181],"decreased":[183],"ICP":[184],"response.":[185],"For":[186],"SM-B,":[189],"LC(17a)":[190],"SM2":[192],"isoforms,":[193],"myocardin":[197],"increased,":[199],"whereas":[200],"SM-A,":[201],"LC(17b),":[202],"SM1":[204],"decreased,":[207],"SMemb":[209],"unchanged.":[210],"BLEB":[211],"more":[214,261],"effective":[215],"relaxing":[217],"both":[220],"vivo.":[225],"Thus":[226],"demonstrated":[228],"diabetes-specific":[231],"effect":[232],"on":[233],"splicing":[235],"chain":[240,244],"genes":[245],"favoring":[251],"heightened":[253],"ED.":[256,294],"A":[257],"switch":[258],"phenotype":[263,277],"supported":[265],"further":[266],"increase.":[271],"Moreover,":[272],"change":[274],"associated":[279],"an":[281],"BLEB,":[285],"which":[286],"may":[287],"serve":[288],"pharmacotherapy":[292],"for":[293]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}