{"id":"https://openalex.org/W2139762920","doi":"https://doi.org/10.1189/jlb.0305139","title":"Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development","display_name":"Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development","publication_year":2005,"publication_date":"2005-08-26","ids":{"openalex":"https://openalex.org/W2139762920","doi":"https://doi.org/10.1189/jlb.0305139","mag":"2139762920","pmid":"https://pubmed.ncbi.nlm.nih.gov/16126843"},"language":"en","primary_location":{"id":"doi:10.1189/jlb.0305139","doi":"https://doi.org/10.1189/jlb.0305139","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.0305139","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041208782","display_name":"Yasunari Morimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasunari Morimoto","raw_affiliation_strings":["Department of Oncology, Graduate School of Medicine , Japan","Graduate School of Dentistry, Osaka University , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Graduate School of Medicine , Japan","institution_ids":[]},{"raw_affiliation_string":"Graduate School of Dentistry, Osaka University , Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017150775","display_name":"Yang Bian","orcid":"https://orcid.org/0000-0002-6784-3841","observed_orcids":["https://orcid.org/0000-0002-6784-3841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Bian","raw_affiliation_strings":["Department of Oncology, Graduate School of Medicine , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Graduate School of Medicine , Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070584914","display_name":"Ping Hui Gao","orcid":"https://orcid.org/0000-0003-1383-3290","observed_orcids":["https://orcid.org/0000-0003-1383-3290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ping Gao","raw_affiliation_strings":["Department of Oncology, Graduate School of Medicine , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Graduate School of Medicine , Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077778242","display_name":"Yumi Yashiro\u2013Ohtani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yumi Yashiro-Ohtani","raw_affiliation_strings":["Department of Oncology, Graduate School of Medicine , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Graduate School of Medicine , Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049165439","display_name":"Xuyu Zhou","orcid":"https://orcid.org/0000-0002-6626-0898","observed_orcids":["https://orcid.org/0000-0002-6626-0898"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xu-Yu Zhou","raw_affiliation_strings":["Department of Oncology, Graduate School of Medicine , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Graduate School of Medicine , Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110759693","display_name":"Shiro Ono","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shiro Ono","raw_affiliation_strings":["Department of Oncology, Graduate School of Medicine , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Graduate School of Medicine , Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049969219","display_name":"Hirokazu Nakahara","orcid":"https://orcid.org/0000-0002-4538-3071","observed_orcids":["https://orcid.org/0000-0002-4538-3071"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirokazu Nakahara","raw_affiliation_strings":["Graduate School of Dentistry, Osaka University , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Dentistry, Osaka University , Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042312215","display_name":"Mikihiko Kogo","orcid":"https://orcid.org/0000-0002-4556-2491","observed_orcids":["https://orcid.org/0000-0002-4556-2491"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mikihiko Kogo","raw_affiliation_strings":["Graduate School of Dentistry, Osaka University , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Dentistry, Osaka University , Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104592908","display_name":"Toshiyuki Hamaoka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshiyuki Hamaoka","raw_affiliation_strings":["Department of Oncology, Graduate School of Medicine , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Graduate School of Medicine , Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103381008","display_name":"Hiromi Fujiwara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiromi Fujiwara","raw_affiliation_strings":["Department of Oncology, Graduate School of Medicine , Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Graduate School of Medicine , Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110759693"],"corresponding_institution_ids":[],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.1727,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.55810785,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"78","issue":"3","first_page":"753","last_page":"761"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ccr4","display_name":"CCR4","score":0.996999979019165},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":0.6899999976158142},{"id":"https://openalex.org/keywords/th2-differentiation","display_name":"Th2 differentiation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cxcr3","display_name":"CXCR3","score":0.9779999852180481},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.7960000038146973},{"id":"https://openalex.org/keywords/stat6-signaling","display_name":"STAT6 signaling","score":0.9539999961853027},{"id":"https://openalex.org/keywords/chemokine-binding","display_name":"chemokine binding","score":0.7699999809265137},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.7440000176429749},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7480000257492065},{"id":"https://openalex.org/keywords/il-4-deficient-mice","display_name":"IL-4-deficient mice","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8825578689575195},{"id":"https://openalex.org/C2775866117","wikidata":"https://www.wikidata.org/wiki/Q21102300","display_name":"CCR4","level":5,"score":0.6202766299247742},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47594738006591797},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3600347340106964},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3367171287536621},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.14108598232269287},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.12425816059112549},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050800","descriptor_name":"STAT6 Transcription Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054367","descriptor_name":"Receptors, CXCR3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054398","descriptor_name":"Receptors, CCR4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1189/jlb.0305139","doi":"https://doi.org/10.1189/jlb.0305139","is_oa":false,"landing_page_url":"https://doi.org/10.1189/jlb.0305139","pdf_url":null,"source":{"id":"https://openalex.org/S199011235","display_name":"Journal of Leukocyte Biology","issn_l":"0741-5400","issn":["0741-5400","1938-3673"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Leukocyte Biology","raw_type":"journal-article"},{"id":"pmid:16126843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16126843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of leukocyte biology","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.492.7250","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.492.7250","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jleukbio.org/content/78/3/753.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1500954694","https://openalex.org/W1552117335","https://openalex.org/W1602344543","https://openalex.org/W1648671938","https://openalex.org/W1942668068","https://openalex.org/W1971994001","https://openalex.org/W1974210099","https://openalex.org/W2001433846","https://openalex.org/W2017828665","https://openalex.org/W2022606988","https://openalex.org/W2029860358","https://openalex.org/W2031501484","https://openalex.org/W2031652873","https://openalex.org/W2037061225","https://openalex.org/W2042626190","https://openalex.org/W2062811432","https://openalex.org/W2062922499","https://openalex.org/W2067714902","https://openalex.org/W2070379407","https://openalex.org/W2077776648","https://openalex.org/W2081596482","https://openalex.org/W2087717265","https://openalex.org/W2089262366","https://openalex.org/W2091040274","https://openalex.org/W2095213901","https://openalex.org/W2097117885","https://openalex.org/W2099675490","https://openalex.org/W2103384599","https://openalex.org/W2117342688","https://openalex.org/W2124116262","https://openalex.org/W2128789112","https://openalex.org/W2146439590","https://openalex.org/W2154057475","https://openalex.org/W2160129587","https://openalex.org/W2171634948","https://openalex.org/W2412941035","https://openalex.org/W2418345671","https://openalex.org/W4313331406","https://openalex.org/W4313333788","https://openalex.org/W4313342428"],"related_works":["https://openalex.org/W2031652873","https://openalex.org/W6990236888","https://openalex.org/W1729103553","https://openalex.org/W2149116434","https://openalex.org/W1939683868","https://openalex.org/W4313341452","https://openalex.org/W2149037336","https://openalex.org/W2124861256","https://openalex.org/W2154057475","https://openalex.org/W2078535398"],"abstract_inverted_index":{"T":[0,81,97,115,200,214],"helper":[1],"cell":[2,116],"type":[3],"1":[4],"(Th1)":[5],"and":[6,50,61,90,111,143,180,192,195,204,225],"Th2":[7,26,39,173,258],"cells":[8,82,98,137,215],"express":[9],"distinct":[10],"sets":[11],"of":[12,46,70,108,132,148,162,172,177,183,197,219,227,244,257],"chemokine":[13,19,27,32,59,73,76,141],"receptors.":[14],"In":[15],"contrast":[16],"to":[17,139],"Th1":[18,72],"receptors,":[20],"it":[21],"is":[22],"largely":[23],"unknown":[24],"how":[25],"receptors":[28],"such":[29,57],"as":[30,58],"CC":[31],"receptor":[33,77,117],"4":[34],"(CCR4)":[35],"are":[36,229],"induced":[37,124,168,230],"during":[38],"differentiation.":[40,259],"Here,":[41],"we":[42],"investigated":[43],"the":[44,106,130,146,156,160,181,217,233,237,242],"induction":[45,176],"CCR4":[47,122,150,165,178,184,202,228,245,250],"surface":[48,149,223],"expression":[49,89,151,179,203,224,251],"ligand":[51,91],"responsiveness":[52,92,166,185],"evaluated":[53],"by":[54,216],"functional":[55],"assays":[56],"binding":[60,142],"chemotaxis.":[62,144],"This":[63],"was":[64,123,167],"done":[65],"in":[66,105,129,159,169,189,208,212],"comparison":[67],"with":[68,101,249],"those":[69],"a":[71],"receptor,":[74],"CXC":[75],"3":[78],"(CXCR3).":[79],"Resting":[80],"expressed":[83],"neither":[84],"CXCR3":[85,88],"nor":[86],"CCR4.":[87],"were":[93,99,152,206],"observed":[94],"when":[95],"resting":[96],"stimulated":[100],"anti-CD3":[102],"plus":[103],"anti-CD28":[104],"presence":[107,131],"[interleukin":[109],"(IL)-12+anti-IL-4]":[110],"then":[112],"recultured":[113],"without":[114],"(TCR)":[118],"stimulation.":[119],"Unlike":[120],"CXCR3,":[121],"immediately":[125],"after":[126,155],"anti-CD3/anti-CD28":[127],"stimulation":[128],"(IL-4+anti-interferon-gamma+anti-IL-12).":[133],"However,":[134],"these":[135],"CCR4-positive":[136],"failed":[138],"exhibit":[140],"Although":[145,222],"levels":[147],"not":[153,187,211,247],"increased":[154],"subsequent":[157],"reculture":[158],"absence":[161],"TCR":[163],"stimulation,":[164],"this":[170],"stage":[171],"cells.":[174,201],"The":[175],"acquisition":[182],"did":[186],"occur":[188],"IL-4-deficient":[190],"(IL-4(-/-))":[191],"signal":[193],"transducer":[194],"activator":[196],"transcription":[198],"(STAT)6(-/-)":[199],"functionality":[205,226,243],"regained":[207],"IL-4(-/-)":[209],"but":[210,252],"STAT6(-/-)":[213],"addition":[218],"recombinant":[220],"IL-4.":[221],"depending":[231],"on":[232],"IL-4/STAT6":[234],"signaling":[235],"pathway,":[236],"present":[238],"results":[239],"indicate":[240],"that":[241],"does":[246],"correlate":[248],"emerges":[253],"at":[254],"later":[255],"stages":[256]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}