{"id":"https://openalex.org/W2139760197","doi":"https://doi.org/10.1093/genetics/165.4.1675","title":"Destabilizing Interactions Among [PSI +] and [PIN +] Yeast Prion Variants","display_name":"Destabilizing Interactions Among [PSI +] and [PIN +] Yeast Prion Variants","publication_year":2003,"publication_date":"2003-12-01","ids":{"openalex":"https://openalex.org/W2139760197","doi":"https://doi.org/10.1093/genetics/165.4.1675","mag":"2139760197","pmid":"https://pubmed.ncbi.nlm.nih.gov/14704158","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1462903"},"language":"en","primary_location":{"id":"doi:10.1093/genetics/165.4.1675","doi":"https://doi.org/10.1093/genetics/165.4.1675","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/165.4.1675","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111655027","display_name":"Michael E. Bradley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael E Bradley","raw_affiliation_strings":["Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois, Chicago, Illinois 60607, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois, Chicago, Illinois 60607, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073859263","display_name":"Susan Weiss Liebman","orcid":"https://orcid.org/0000-0002-5845-4633","observed_orcids":["https://orcid.org/0000-0002-5845-4633"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susan W Liebman","raw_affiliation_strings":["Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois, Chicago, Illinois 60607"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois, Chicago, Illinois 60607","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073859263"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":1.1493,"has_fulltext":true,"cited_by_count":83,"citation_normalized_percentile":{"value":0.75856752,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"165","issue":"4","first_page":"1675","last_page":"1685"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yeast-prions","display_name":"yeast prions","score":0.777999997138977},{"id":"https://openalex.org/keywords/psi-prion","display_name":"[PSI+] prion","score":0.9100000262260437},{"id":"https://openalex.org/keywords/sup35","display_name":"Sup35","score":0.9459999799728394},{"id":"https://openalex.org/keywords/rnq1","display_name":"Rnq1","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7458818554878235},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6224622130393982},{"id":"https://openalex.org/C118963712","wikidata":"https://www.wikidata.org/wiki/Q5509170","display_name":"Fungal prion","level":4,"score":0.6177986264228821},{"id":"https://openalex.org/C2780902518","wikidata":"https://www.wikidata.org/wiki/Q6033780","display_name":"Inheritance (genetic algorithm)","level":3,"score":0.6171237826347351},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.6116205453872681},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.5240214467048645},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.46138909459114075},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.45356082916259766},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.43349191546440125},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.4302389919757843},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3336537480354309},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08600786328315735},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008164","descriptor_name":"Luminescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010454","descriptor_name":"Peptide Termination Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/genetics/165.4.1675","doi":"https://doi.org/10.1093/genetics/165.4.1675","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/165.4.1675","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"pmid:14704158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14704158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4347917473","display_name":"Exploring the toxicity of aggregates associated with protein-misfolding diseases","funder_award_id":"R01GM056350","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5505574032","display_name":null,"funder_award_id":"GM-56350","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1872122","https://openalex.org/W1485738800","https://openalex.org/W1500847022","https://openalex.org/W1518618901","https://openalex.org/W1521738036","https://openalex.org/W1522008919","https://openalex.org/W1526043578","https://openalex.org/W1527059519","https://openalex.org/W1600651336","https://openalex.org/W1619710608","https://openalex.org/W1857855090","https://openalex.org/W1894729831","https://openalex.org/W1905321087","https://openalex.org/W1926513104","https://openalex.org/W1938969372","https://openalex.org/W1939575473","https://openalex.org/W1970792825","https://openalex.org/W1979643175","https://openalex.org/W1980941432","https://openalex.org/W1987327305","https://openalex.org/W1989172027","https://openalex.org/W2000204824","https://openalex.org/W2005152235","https://openalex.org/W2010745676","https://openalex.org/W2013679718","https://openalex.org/W2022614447","https://openalex.org/W2022696371","https://openalex.org/W2023529808","https://openalex.org/W2028728539","https://openalex.org/W2035776094","https://openalex.org/W2039293222","https://openalex.org/W2043676526","https://openalex.org/W2044996749","https://openalex.org/W2046445620","https://openalex.org/W2049890739","https://openalex.org/W2080138031","https://openalex.org/W2086404414","https://openalex.org/W2087296147","https://openalex.org/W2095583219","https://openalex.org/W2098898403","https://openalex.org/W2099997349","https://openalex.org/W2103725642","https://openalex.org/W2106533005","https://openalex.org/W2111456013","https://openalex.org/W2123535252","https://openalex.org/W2131286471","https://openalex.org/W2136758030","https://openalex.org/W2137158072","https://openalex.org/W2137168266","https://openalex.org/W2137530170","https://openalex.org/W2137778625","https://openalex.org/W2139986094","https://openalex.org/W2140368248","https://openalex.org/W2158196309","https://openalex.org/W2160553469","https://openalex.org/W2169333620","https://openalex.org/W2284316917","https://openalex.org/W2316999566","https://openalex.org/W2324660492","https://openalex.org/W2327641970","https://openalex.org/W2440118406","https://openalex.org/W3187806412","https://openalex.org/W6629912150"],"related_works":["https://openalex.org/W2005152235","https://openalex.org/W2254239089","https://openalex.org/W2000556776","https://openalex.org/W2045601614","https://openalex.org/W1984568200","https://openalex.org/W2099661489","https://openalex.org/W1989596063","https://openalex.org/W2111456013","https://openalex.org/W2612203959","https://openalex.org/W2015120719"],"abstract_inverted_index":{"The":[0],"yeast":[1],"Sup35":[2],"and":[3,39,57,106],"Rnq1":[4,105],"proteins":[5],"can":[6],"exist":[7],"in":[8],"either":[9],"the":[10,19,68,75,82,137],"noninfectious":[11],"soluble":[12],"forms,":[13],"[psi-]":[14],"or":[15,18,26],"[pin-],":[16],"respectively,":[17],"multiple":[20],"infectious":[21],"amyloid-like":[22],"forms":[23,116],"called":[24],"[PSI+]":[25,38,56,65,86,90,126],"[PIN+]":[27,40,58,72,79,94,113],"prion":[28,31,53],"variants":[29,54,80,95,138],"(or":[30],"strains).":[32],"It":[33],"was":[34],"previously":[35],"shown":[36],"that":[37,51],"prions":[41,131,134],"enhance":[42],"one":[43],"another's":[44],"de":[45],"novo":[46],"appearance.":[47],"Here":[48],"we":[49],"show":[50],"specific":[52],"of":[55,70,77,84,104,130],"disrupt":[59],"each":[60],"other's":[61],"stable":[62],"inheritance.":[63,127],"Acquiring":[64],"often":[66],"impedes":[67],"inheritance":[69,83],"particular":[71],"variants.":[73,91],"Conversely,":[74],"presence":[76],"some":[78],"impairs":[81],"weak":[85],"but":[87],"not":[88,124],"strong":[89],"These":[92,140],"same":[93],"generate":[96],"a":[97,102,117],"single-dot":[98],"fluorescence":[99,121],"pattern":[100],"when":[101],"fusion":[103],"green":[107],"fluorescent":[108],"protein":[109],"is":[110],"expressed.":[111],"Another":[112],"variant,":[114],"which":[115],"distinctly":[118],"different":[119],"multiple-dot":[120],"pattern,":[122],"does":[123],"impair":[125],"Thus,":[128],"destabilization":[129],"by":[132],"heterologous":[133],"depends":[135],"upon":[136],"involved.":[139],"findings":[141],"may":[142],"have":[143],"implications":[144],"for":[145],"understanding":[146],"interactions":[147],"among":[148],"other":[149],"amyloid-forming":[150],"proteins,":[151],"including":[152],"those":[153],"associated":[154],"with":[155],"certain":[156],"human":[157],"diseases.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
