{"id":"https://openalex.org/W2139759811","doi":"https://doi.org/10.1081/hem-120021542","title":"Molecular Characterization of Hereditary Persistence of Fetal Hemoglobin in the Karen People of Thailand","display_name":"Molecular Characterization of Hereditary Persistence of Fetal Hemoglobin in the Karen People of Thailand","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2139759811","doi":"https://doi.org/10.1081/hem-120021542","mag":"2139759811","pmid":"https://pubmed.ncbi.nlm.nih.gov/12779271"},"language":"en","primary_location":{"id":"doi:10.1081/hem-120021542","doi":"https://doi.org/10.1081/hem-120021542","is_oa":false,"landing_page_url":"https://doi.org/10.1081/hem-120021542","pdf_url":null,"source":{"id":"https://openalex.org/S81929299","display_name":"Hemoglobin","issn_l":"0363-0269","issn":["0363-0269","1532-432X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hemoglobin","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062186145","display_name":"Objoon Trachoo","orcid":"https://orcid.org/0000-0001-7867-3238","observed_orcids":["https://orcid.org/0000-0001-7867-3238"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4210140007","display_name":"Ramathibodi Hospital","ror":"https://ror.org/04884sy85","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4210140007"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Objoon Trachoo","raw_affiliation_strings":["Department of Medicine, Division of Medical Genetics and Molecular Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. objootra@ccme.or.th","Department of Medicine, Division of Medical Genetics and Molecular Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama 6 Road, Rajtevi, Bangkok, 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Medical Genetics and Molecular Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. objootra@ccme.or.th","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210140007"]},{"raw_affiliation_string":"Department of Medicine, Division of Medical Genetics and Molecular Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama 6 Road, Rajtevi, Bangkok, 10400, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210140007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026314721","display_name":"Thanyachai Sura","orcid":"https://orcid.org/0000-0002-5558-781X","observed_orcids":["https://orcid.org/0000-0002-5558-781X"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4210140007","display_name":"Ramathibodi Hospital","ror":"https://ror.org/04884sy85","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4210140007"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Thanyachai Sura","raw_affiliation_strings":["Department of Medicine, Division of Medical Genetics and Molecular Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama 6 Road, Rajtevi, Bangkok, 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Medical Genetics and Molecular Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Rama 6 Road, Rajtevi, Bangkok, 10400, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210140007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007097198","display_name":"Anavaj Sakuntabhai","orcid":"https://orcid.org/0000-0001-9099-6937","observed_orcids":["https://orcid.org/0000-0001-9099-6937"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anavaj Sakuntabhai","raw_affiliation_strings":["Genetic of Infectious Diseases and Autoimmunes, Institute Pasteur, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic of Infectious Diseases and Autoimmunes, Institute Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060343662","display_name":"Pratap Singhasivanon","orcid":"https://orcid.org/0000-0002-9759-1702","observed_orcids":["https://orcid.org/0000-0002-9759-1702"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4405277806","display_name":"Hospital for Tropical Diseases","ror":"https://ror.org/03yzqsb38","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4405277806"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Pratap Singhasivanon","raw_affiliation_strings":["Department of Tropical Hygiene, Hospital for Tropical Disease, Mahidol University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tropical Hygiene, Hospital for Tropical Disease, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4405277806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105889836","display_name":"Srivicha Krudsood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4405277806","display_name":"Hospital for Tropical Diseases","ror":"https://ror.org/03yzqsb38","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4405277806"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Srivicha Krudsood","raw_affiliation_strings":["Department of Tropical Hygiene, Hospital for Tropical Disease, Mahidol University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tropical Hygiene, Hospital for Tropical Disease, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4405277806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021680859","display_name":"Waraphon Phimpraphi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4405277806","display_name":"Hospital for Tropical Diseases","ror":"https://ror.org/03yzqsb38","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4405277806"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Waraphon Phimpraphi","raw_affiliation_strings":["Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Hospital for Tropical Disease, Mahidol University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Hospital for Tropical Disease, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4405277806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013222249","display_name":"Somporn Krasaesub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4210140007","display_name":"Ramathibodi Hospital","ror":"https://ror.org/04884sy85","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4210140007"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Somporn Krasaesub","raw_affiliation_strings":["Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand","Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210140007"]},{"raw_affiliation_string":"Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210140007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018330853","display_name":"Suporn Chanjarunee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4210140007","display_name":"Ramathibodi Hospital","ror":"https://ror.org/04884sy85","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4210140007"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Suporn Chanjarunee","raw_affiliation_strings":["Department of Medicine, Division of Hematology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Hematology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4210140007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109200500","display_name":"Sornchai Looareesuwan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]},{"id":"https://openalex.org/I4405277806","display_name":"Hospital for Tropical Diseases","ror":"https://ror.org/03yzqsb38","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4405277806"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Sornchai Looareesuwan","raw_affiliation_strings":["Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Hospital for Tropical Disease, Mahidol University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Hospital for Tropical Disease, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I25399158","https://openalex.org/I4405277806"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2991,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.63694915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"27","issue":"2","first_page":"97","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-persistence-of-fetal-hemoglobin","display_name":"hereditary persistence of fetal hemoglobin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/beta-globin-gene","display_name":"beta-globin gene","score":0.8289999961853027},{"id":"https://openalex.org/keywords/karen-people","display_name":"Karen people","score":0.7749999761581421},{"id":"https://openalex.org/keywords/compound-heterozygosity","display_name":"compound heterozygosity","score":0.7360000014305115},{"id":"https://openalex.org/keywords/beta-thalassemia","display_name":"beta-thalassemia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hemoglobin-switching","display_name":"hemoglobin switching","score":0.5640000104904175},{"id":"https://openalex.org/keywords/gamma-globin-gene-expression","display_name":"gamma-globin gene expression","score":0.6840000152587891},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.43799999356269836},{"id":"https://openalex.org/keywords/southeast-asia","display_name":"Southeast Asia","score":0.3790000081062317},{"id":"https://openalex.org/keywords/thailand","display_name":"Thailand","score":0.34200000762939453},{"id":"https://openalex.org/keywords/prenatal-diagnosis","display_name":"prenatal diagnosis","score":0.6309999823570251},{"id":"https://openalex.org/keywords/ethnic-population-genetics","display_name":"ethnic population genetics","score":0.32100000977516174},{"id":"https://openalex.org/keywords/hemoglobinopathies","display_name":"hemoglobinopathies","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.6203006505966187},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.6117933392524719},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5723642706871033},{"id":"https://openalex.org/C2776317666","wikidata":"https://www.wikidata.org/wiki/Q2496436","display_name":"Fetal hemoglobin","level":4,"score":0.55832439661026},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4925878643989563},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4766279458999634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4473598599433899},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.4091198146343231},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.17961162328720093},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0806252658367157},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.06898960471153259}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005006","descriptor_name":"Ethnicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005006","descriptor_name":"Ethnicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005006","descriptor_name":"Ethnicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005319","descriptor_name":"Fetal Hemoglobin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005319","descriptor_name":"Fetal Hemoglobin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005319","descriptor_name":"Fetal Hemoglobin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013785","descriptor_name":"Thailand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013785","descriptor_name":"Thailand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013785","descriptor_name":"Thailand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044466","descriptor_name":"Asian People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1081/hem-120021542","doi":"https://doi.org/10.1081/hem-120021542","is_oa":false,"landing_page_url":"https://doi.org/10.1081/hem-120021542","pdf_url":null,"source":{"id":"https://openalex.org/S81929299","display_name":"Hemoglobin","issn_l":"0363-0269","issn":["0363-0269","1532-432X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hemoglobin","raw_type":"journal-article"},{"id":"pmid:12779271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12779271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hemoglobin","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.550000011920929}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W170837666","https://openalex.org/W188484398","https://openalex.org/W1488164488","https://openalex.org/W1497309065","https://openalex.org/W1604503695","https://openalex.org/W1913813704","https://openalex.org/W1972642606","https://openalex.org/W1979627561","https://openalex.org/W1985238975","https://openalex.org/W2015548262","https://openalex.org/W2026882106","https://openalex.org/W2043634525","https://openalex.org/W2062396202","https://openalex.org/W2068098439","https://openalex.org/W2076787181","https://openalex.org/W2094742463","https://openalex.org/W2181845894","https://openalex.org/W2245575916","https://openalex.org/W2426575466","https://openalex.org/W3158286353","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2015924858","https://openalex.org/W2070488645","https://openalex.org/W4242968924","https://openalex.org/W1984664967","https://openalex.org/W1969917888","https://openalex.org/W1920239827","https://openalex.org/W2092037221","https://openalex.org/W2026873950","https://openalex.org/W2257228458","https://openalex.org/W2055893366"],"abstract_inverted_index":{"Hereditary":[0,55,91],"persistence":[1,56,92,294,320],"of":[2,46,57,74,93,117,166,174,186,199,241,253,280,289,295,301,321],"fetal":[3,19,58,94],"hemoglobin":[4,20,59],"(HPFH)":[5],"is":[6,112,325],"the":[7,118,124,145,167,179,184,195,200,281,299],"condition":[8,111,135],"whereby":[9],"a":[10,151,161,192,242,259,268],"continuously":[11],"active":[12],"gamma-globin":[13,121],"gene":[14],"expression":[15],"leads":[16],"to":[17,246],"elevated":[18],"(Hb":[21],"F)":[22],"levels":[23,173],"in":[24,178,258,304],"adult":[25],"life":[26],"[Stamatoyannopoulos":[27],"G,":[28,35],"Grosveld":[29],"F.":[30],"Hemoglobin":[31],"switching.":[32],"In:":[33,63,96],"Stamatoyannopoulos":[34],"Majerus":[36],"PW,":[37],"Perlmutter":[38],"RM,":[39],"Varmus":[40],"H,":[41],"eds.":[42,72,101],"The":[43,102,110,286],"Molecular":[44,236],"Basis":[45],"Blood":[47],"Diseases.":[48],"Philadelphia:":[49],"W.B.":[50],"Saunders,":[51],"2001:135-182;":[52],"Wood":[53],"WG.":[54],"and":[60,78,86,120,142,144,163,188,238,267,292],"delta(beta)":[61],"thalassemia.":[62],"Steinberg":[64],"MH,":[65],"Forget":[66],"BG,":[67],"Higgs":[68],"DR,":[69],"Nagel":[70],"RL,":[71],"Disorders":[73],"Hemoglobin:":[75],"Genetics,":[76],"Pathophysiology,":[77],"Clinical":[79],"Management.":[80],"Cambridge:":[81],"Cambridge":[82],"University":[83],"Press,":[84],"2001:356-388;":[85],"Weatherall":[87,97],"DJ,":[88,98],"Clegg":[89,99],"JB.":[90],"hemoglobin.":[95],"JB,":[100],"Thalassaemia":[103],"Syndromes.":[104],"Oxford:":[105],"Blackwell":[106],"Scientific":[107],"Publishers,":[108],"1981:450-507].":[109],"caused":[113],"either":[114],"by":[115,208,220],"mutation":[116,148],"beta-":[119],"genes,":[122],"or":[123],"gamma-gene":[125],"controlled":[126],"region":[127],"on":[128,160,183],"other":[129],"chromosomes.":[130],"Several":[131],"families":[132],"with":[133,171,214,256],"this":[134,254,308],"have":[136,205],"been":[137,206,276],"reported":[138],"from":[139,284],"Vietnam,":[140],"Cambodia":[141],"China,":[143],"Southeast":[146],"Asian":[147],"(or":[149],"HPFH-6),":[150],"27":[152,196],"kb":[153,197],"deletion,":[154],"was":[155],"demonstrated.":[156],"Here":[157],"we":[158],"report":[159,279],"mother":[162],"her":[164],"daughter":[165],"Karen":[168],"ethnic":[169],"group":[170],"high":[172],"Hb":[175,296,322],"F,":[176],"living":[177],"Suan":[180],"Pueng":[181],"District":[182],"border":[185],"Thailand":[187],"Myanmar.":[189],"Genotyping":[190],"showed":[191],"heterozygosity":[193,288],"for":[194,250,307,318,327],"deletion":[198],"beta-globin":[201],"gene.":[202],"Their":[203],"conditions":[204],"confirmed":[207],"gap":[209],"polymerase":[210],"chain":[211],"reaction":[212],"(PCR)":[213],"three":[215],"oligonucleotide":[216],"primers":[217],"recently":[218],"developed":[219],"Xu":[221],"et":[222],"al.":[223],"[Xu":[224],"X-M,":[225],"Li":[226],"Z-Q,":[227],"Liu":[228],"Z-Y,":[229],"Zhong":[230],"X-L,":[231],"Zhao":[232],"Y-Z,":[233],"Mo":[234],"Q-H.":[235],"characterization":[237],"PCR":[239],"detection":[240],"deletional":[243],"HPFH:":[244],"application":[245],"rapid":[247],"prenatal":[248],"diagnosis":[249],"compound":[251,287],"heterozygotes":[252],"defect":[255],"beta-thalassemia":[257,290],"Chinese":[260],"family.":[261],"Am":[262],"J":[263],"Hematol":[264],"2000;":[265],"65:183-188.],":[266],"DNA":[269],"sequencing":[270],"method.":[271],"Thus":[272],"far":[273],"there":[274],"has":[275],"no":[277],"official":[278],"HPFH-6":[282],"anomaly":[283,309],"Thailand.":[285],"(thal)":[291],"hereditary":[293,319],"F":[297,323],"causes":[298],"phenotype":[300],"thalassemia":[302],"intermedia;":[303],"contrast,":[305],"homozygotes":[306],"show":[310],"only":[311],"mild":[312],"microcytic":[313],"anemia.":[314],"Hence,":[315],"genetic":[316],"counseling":[317],"carriers":[324],"needed":[326],"family":[328],"planning.":[329]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
