{"id":"https://openalex.org/W2139756843","doi":null,"title":"STRUCTURAL REQUIREMENTS OF ORGANIC ANION TRANSPORTING POLYPEPTIDE MEDIATED TRANSPORT","display_name":"STRUCTURAL REQUIREMENTS OF ORGANIC ANION TRANSPORTING POLYPEPTIDE MEDIATED TRANSPORT","publication_year":2010,"publication_date":"2010-04-12","ids":{"openalex":"https://openalex.org/W2139756843","mag":"2139756843"},"language":"en","primary_location":{"id":"pmh:oai:kuscholarworks.ku.edu:1808/7394","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1808/7394","pdf_url":null,"source":{"id":"https://openalex.org/S4377196285","display_name":"KU ScholarWorks (University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055881496","display_name":"Yi M. Weaver","orcid":"https://orcid.org/0000-0002-8993-2001","observed_orcids":["https://orcid.org/0000-0002-8993-2001"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yi M. Weaver","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8993-2001","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5055881496"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organic-anion-transporters","display_name":"organic anion transporters","score":0.8460000157356262},{"id":"https://openalex.org/keywords/oatp1b1","display_name":"OATP1B1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/oatp1a4","display_name":"Oatp1a4","score":0.9070000052452087},{"id":"https://openalex.org/keywords/oatp1a1","display_name":"Oatp1a1","score":0.9039999842643738},{"id":"https://openalex.org/keywords/oatp1a2","display_name":"OATP1A2","score":0.5460000038146973},{"id":"https://openalex.org/keywords/oatp1b2","display_name":"Oatp1b2","score":0.7179999947547913},{"id":"https://openalex.org/keywords/oatp1b3","display_name":"OATP1B3","score":0.7789999842643738},{"id":"https://openalex.org/keywords/oatp1c1","display_name":"OATP1C1","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.696684718132019},{"id":"https://openalex.org/C2776678969","wikidata":"https://www.wikidata.org/wiki/Q28209167","display_name":"Organic anion-transporting polypeptide","level":4,"score":0.654362142086029},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.6227797269821167},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.5242003202438354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5178406834602356},{"id":"https://openalex.org/C115448650","wikidata":"https://www.wikidata.org/wiki/Q409205","display_name":"Xenobiotic","level":3,"score":0.5128174424171448},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.4645189046859741},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4532521665096283},{"id":"https://openalex.org/C2777992278","wikidata":"https://www.wikidata.org/wiki/Q705605","display_name":"Aromatic amino acids","level":3,"score":0.41689008474349976},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4146798849105835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39266201853752136},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3775971531867981},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.34436357021331787},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18643507361412048},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1134103536605835}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:kuscholarworks.ku.edu:1808/7394","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1808/7394","pdf_url":null,"source":{"id":"https://openalex.org/S4377196285","display_name":"KU ScholarWorks (University of Kansas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I146416000","host_organization_name":"University of Kansas","host_organization_lineage":["https://openalex.org/I146416000"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2139756843","doi":null,"is_oa":false,"landing_page_url":"https://kuscholarworks.ku.edu/bitstream/1808/7394/1/Weaver_ku_0099D_10764_DATA_1.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":241,"referenced_works":["https://openalex.org/W170029080","https://openalex.org/W176267894","https://openalex.org/W1530261659","https://openalex.org/W1592442520","https://openalex.org/W1707091457","https://openalex.org/W1788032165","https://openalex.org/W1802502124","https://openalex.org/W1825036120","https://openalex.org/W1848455019","https://openalex.org/W1870382400","https://openalex.org/W1882050418","https://openalex.org/W1912107272","https://openalex.org/W1964411566","https://openalex.org/W1964637145","https://openalex.org/W1964767165","https://openalex.org/W1966233022","https://openalex.org/W1968605474","https://openalex.org/W1970561042","https://openalex.org/W1970728251","https://openalex.org/W1970999561","https://openalex.org/W1971075428","https://openalex.org/W1971564809","https://openalex.org/W1971580188","https://openalex.org/W1971901938","https://openalex.org/W1972282528","https://openalex.org/W1973033693","https://openalex.org/W1973663488","https://openalex.org/W1974376686","https://openalex.org/W1974880060","https://openalex.org/W1977045356","https://openalex.org/W1977260692","https://openalex.org/W1977839873","https://openalex.org/W1978116407","https://openalex.org/W1979072037","https://openalex.org/W1979232837","https://openalex.org/W1980170383","https://openalex.org/W1980288379","https://openalex.org/W1981267560","https://openalex.org/W1982232403","https://openalex.org/W1984597339","https://openalex.org/W1986656184","https://openalex.org/W1986885996","https://openalex.org/W1988348116","https://openalex.org/W1988869301","https://openalex.org/W1990524769","https://openalex.org/W1990542385","https://openalex.org/W1992983589","https://openalex.org/W1993650845","https://openalex.org/W1993689132","https://openalex.org/W1994100890","https://openalex.org/W1995238258","https://openalex.org/W1995297514","https://openalex.org/W1995416991","https://openalex.org/W1995872849","https://openalex.org/W1997349791","https://openalex.org/W1997601514","https://openalex.org/W1998005238","https://openalex.org/W1998095254","https://openalex.org/W1998275215","https://openalex.org/W1998668911","https://openalex.org/W2000123189","https://openalex.org/W2000478673","https://openalex.org/W2000484916","https://openalex.org/W2003509188","https://openalex.org/W2004158373","https://openalex.org/W2004424126","https://openalex.org/W2006964441","https://openalex.org/W2009992738","https://openalex.org/W2010446878","https://openalex.org/W2010991241","https://openalex.org/W2011120016","https://openalex.org/W2011821683","https://openalex.org/W2012314742","https://openalex.org/W2012812422","https://openalex.org/W2014283537","https://openalex.org/W2014565106","https://openalex.org/W2015755153","https://openalex.org/W2016366167","https://openalex.org/W2019532583","https://openalex.org/W2022232632","https://openalex.org/W2023176820","https://openalex.org/W2024699130","https://openalex.org/W2025416665","https://openalex.org/W2025760569","https://openalex.org/W2026524951","https://openalex.org/W2027559635","https://openalex.org/W2028444358","https://openalex.org/W2029588853","https://openalex.org/W2029875444","https://openalex.org/W2030581259","https://openalex.org/W2031595392","https://openalex.org/W2031627853","https://openalex.org/W2031804178","https://openalex.org/W2033250114","https://openalex.org/W2033670502","https://openalex.org/W2036054066","https://openalex.org/W2039141364","https://openalex.org/W2039986849","https://openalex.org/W2042416548","https://openalex.org/W2043672781","https://openalex.org/W2045567622","https://openalex.org/W2045917526","https://openalex.org/W2046490934","https://openalex.org/W2048161285","https://openalex.org/W2048521506","https://openalex.org/W2048593300","https://openalex.org/W2053849036","https://openalex.org/W2054294062","https://openalex.org/W2054539670","https://openalex.org/W2054931112","https://openalex.org/W2056271204","https://openalex.org/W2057519783","https://openalex.org/W2058154283","https://openalex.org/W2058859643","https://openalex.org/W2059981792","https://openalex.org/W2061003736","https://openalex.org/W2061222476","https://openalex.org/W2061481904","https://openalex.org/W2062203984","https://openalex.org/W2064401742","https://openalex.org/W2067650742","https://openalex.org/W2069315083","https://openalex.org/W2070128988","https://openalex.org/W2071101614","https://openalex.org/W2072005379","https://openalex.org/W2074636518","https://openalex.org/W2076194172","https://openalex.org/W2076385318","https://openalex.org/W2077246315","https://openalex.org/W2079307415","https://openalex.org/W2079528717","https://openalex.org/W2079748137","https://openalex.org/W2081282242","https://openalex.org/W2082188851","https://openalex.org/W2083116825","https://openalex.org/W2084553493","https://openalex.org/W2084711681","https://openalex.org/W2085047894","https://openalex.org/W2085335377","https://openalex.org/W2085448380","https://openalex.org/W2085560810","https://openalex.org/W2087213057","https://openalex.org/W2088776629","https://openalex.org/W2091234451","https://openalex.org/W2092025136","https://openalex.org/W2092910855","https://openalex.org/W2093446645","https://openalex.org/W2094110689","https://openalex.org/W2096104144","https://openalex.org/W2098293164","https://openalex.org/W2098837867","https://openalex.org/W2099227195","https://openalex.org/W2099384461","https://openalex.org/W2099575771","https://openalex.org/W2100808729","https://openalex.org/W2102866872","https://openalex.org/W2104908006","https://openalex.org/W2106456872","https://openalex.org/W2108292264","https://openalex.org/W2109137493","https://openalex.org/W2109318635","https://openalex.org/W2110649308","https://openalex.org/W2111493612","https://openalex.org/W2113498013","https://openalex.org/W2113760896","https://openalex.org/W2115562189","https://openalex.org/W2121335499","https://openalex.org/W2123694920","https://openalex.org/W2124363222","https://openalex.org/W2124879342","https://openalex.org/W2125108480","https://openalex.org/W2125399228","https://openalex.org/W2125542198","https://openalex.org/W2126348132","https://openalex.org/W2126698884","https://openalex.org/W2128455207","https://openalex.org/W2129067173","https://openalex.org/W2129331232","https://openalex.org/W2129940653","https://openalex.org/W2130381741","https://openalex.org/W2130538167","https://openalex.org/W2130843593","https://openalex.org/W2131010809","https://openalex.org/W2132810155","https://openalex.org/W2132957145","https://openalex.org/W2133257033","https://openalex.org/W2135290874","https://openalex.org/W2137913927","https://openalex.org/W2138071206","https://openalex.org/W2139121124","https://openalex.org/W2141019400","https://openalex.org/W2142234431","https://openalex.org/W2143189887","https://openalex.org/W2143945489","https://openalex.org/W2144438205","https://openalex.org/W2145804243","https://openalex.org/W2146324132","https://openalex.org/W2147039462","https://openalex.org/W2147241123","https://openalex.org/W2148070209","https://openalex.org/W2148458070","https://openalex.org/W2148639453","https://openalex.org/W2148820240","https://openalex.org/W2149001407","https://openalex.org/W2149786401","https://openalex.org/W2150991974","https://openalex.org/W2151309633","https://openalex.org/W2151696031","https://openalex.org/W2152319353","https://openalex.org/W2152532254","https://openalex.org/W2152702915","https://openalex.org/W2152732346","https://openalex.org/W2153754829","https://openalex.org/W2154399286","https://openalex.org/W2157721092","https://openalex.org/W2158457081","https://openalex.org/W2158892441","https://openalex.org/W2159555667","https://openalex.org/W2159562550","https://openalex.org/W2159578159","https://openalex.org/W2159832606","https://openalex.org/W2159939387","https://openalex.org/W2160034626","https://openalex.org/W2162210366","https://openalex.org/W2163841301","https://openalex.org/W2163969245","https://openalex.org/W2164751588","https://openalex.org/W2166796013","https://openalex.org/W2167450468","https://openalex.org/W2167567374","https://openalex.org/W2169474553","https://openalex.org/W2171167058","https://openalex.org/W2243119196","https://openalex.org/W2256986800","https://openalex.org/W2265446852","https://openalex.org/W2274797767","https://openalex.org/W2292239568","https://openalex.org/W2335206699","https://openalex.org/W2345392495","https://openalex.org/W2410297581","https://openalex.org/W2491716621"],"related_works":["https://openalex.org/W4405185408","https://openalex.org/W2956134457","https://openalex.org/W2124014236","https://openalex.org/W825254127","https://openalex.org/W2325847953","https://openalex.org/W3176987889","https://openalex.org/W2508277070","https://openalex.org/W2808072275","https://openalex.org/W2137037573","https://openalex.org/W4311533492"],"abstract_inverted_index":{"The":[0,110,190,260,290,355,411],"organic":[1,336],"anion":[2,337],"transporting":[3],"polypeptides":[4],"(human:":[5],"OATP;":[6],"other:":[7],"Oatp)":[8],"form":[9],"a":[10,44],"mammalian":[11],"transporter":[12],"superfamily":[13,29],"that":[14,121,157,221,251,332,439,481],"mediates":[15],"the":[16,23,32,82,104,132,136,149,155,179,213,219,306,309,313,324,330,340,352,363,375,406,448,471],"transport":[17,87,129,168,206,223,266,284,304,346,388,456],"of":[18,37,46,52,64,84,88,108,113,135,181,207,225,262,285,293,316,339,357,367,378,389,405,457],"structurally":[19],"unrelated":[20],"compounds":[21],"across":[22],"cell":[24],"membrane.":[25],"Members":[26],"in":[27,31,127,166,203,236,283],"this":[28,114,141,172,358,373,436],"participate":[30],"absorption,":[33],"distribution":[34],"and":[35,40,48,90,106,130,178,196,210,234,274,288,295,305,312,342,369,398,418,428,433,447,469],"excretion":[36],"many":[38],"endogenous":[39],"exogenous":[41],"substances":[42],"including":[43],"number":[45],"medications":[47],"environmental":[49],"toxicants.":[50],"Polymorphisms":[51],"OATPs":[53],"have":[54,462],"been":[55],"shown":[56],"clinically":[57],"to":[58,61,96,102,200,244,280,299,361,385],"give":[59],"rise":[60],"inter-individual":[62],"variabilities":[63],"drug":[65,98],"efficacy":[66,99],"and/or":[67,247,258],"toxicity.":[68,109],"Furthermore,":[69,402],"as":[70,426],"multi-specific":[71],"transporters,":[72],"they":[73],"are":[74,252,451],"potential":[75],"sites":[76,465],"for":[77,254,302,320,414,453,466,475,482],"drug-drug":[78],"interactions.":[79],"Therefore,":[80],"understanding":[81],"mechanism":[83],"OATP/Oatp":[85,454],"mediated":[86,205,228,455],"endo-":[89],"xenobiotics":[91],"will":[92],"not":[93],"only":[94],"help":[95],"improve":[97,103],"but":[100],"also":[101],"prediction":[105],"prevention":[107],"overall":[111],"goal":[112],"dissertation":[115,437],"is":[116,318,477],"identifying":[117],"key":[118],"amino":[119,161,186,193,249,445],"acids":[120,162,187,194,250,446],"may":[122],"play":[123,163],"an":[124],"important":[125,164,202,253,282,301,452],"role":[126],"OATP/Oatp-mediated":[128],"investigating":[131],"spatial":[133],"size":[134,365,474],"substrate":[137,256,269,364,473],"binding/translocation":[138,464],"pocket.":[139],"In":[140,148,212,323],"dissertation,":[142],"I":[143,153,217,328],"defended":[144],"three":[145],"specific":[146,151,215,326],"aims.":[147],"first":[150],"aim,":[152,173,216,327,374],"evaluated":[154,218,329],"hypothesis":[156,220,331],"conserved":[158,183,442],"positively":[159,184,443],"charged":[160,185,444],"roles":[165],"OATP1B1":[167,204],"function.":[169],"To":[170,371],"address":[171,372],"site-directed":[174,239],"mutagenesis":[175,240],"was":[176,297,360,400,409],"employed":[177],"mutants":[180],"several":[182,463],"were":[188,198,268,278,416],"studied.":[189],"two":[191],"extracellular":[192],"R57":[195],"K361":[197],"found":[199,298],"be":[201,281,300],"estradiol-17\u03b2-glucuronide,":[208],"estrone-3-sulfate":[209],"BSP.":[211],"second":[214],"quantifying":[222],"activities":[224],"different":[226,333,467],"substrates":[227,391,413,468],"by":[229,392],"chimeras":[230],"between":[231,308],"rat":[232,334,393],"Oatp1a1":[233,296,399,421],"Oatp1a4":[235,294,317],"combination":[237],"with":[238,380],"should":[241],"allow":[242],"us":[243],"identify":[245],"regions":[246],"individual":[248],"Oatp1a4-mediated":[255],"recognition":[257],"transport.":[259,322],"effects":[261,377],"chimeric":[263],"proteins":[264],"on":[265,351,387],"activity":[267],"dependent.":[270],"Extracellular":[271],"loop":[272],"4":[273],"transmembrane":[275],"domain":[276],"8":[277],"identified":[279],"digoxin,":[286],"taurocholate":[287],"estradiol-17\u03b2-glucuronide.":[289],"C-terminal":[291,314,449],"half":[292,311,315,450],"BSP":[303],"interactions":[307],"N-terminal":[310],"essential":[319],"DPDPE":[321],"third":[325],"renal":[335],"transporters":[338],"Oat":[341],"Oatp":[343],"families":[344],"selectively":[345],"perfluorinated":[347],"carboxylates":[348],"(PFCAs)":[349],"depending":[350],"chain":[353,381],"lengths.":[354],"purpose":[356],"study":[359],"determine":[362],"selectivity":[366],"Oats":[368,415],"Oatp1a1.":[370],"inhibitory":[376],"PFCAs":[379,424],"length":[382],"from":[383],"C2":[384],"C18":[386],"model":[390],"Oat1,":[394],"Oat2,":[395],"Oat3,":[396],"Urat1":[397],"quantified.":[401],"direct":[403],"uptake":[404],"best":[407,412],"inhibitors":[408],"characterized.":[410],"C7":[417],"C8,":[419],"whereas":[420],"transported":[422],"longer":[423],"such":[425],"C9":[427],"C10":[429],"better":[430],"than":[431,480],"C8":[432],"C7.":[434],"Altogether,":[435],"reveals":[438],"(1)":[440],"some":[441],"certain":[458],"substrates;":[459],"(2)":[460],"OATP/Oatps":[461,476],"(3)":[470],"preferred":[472],"slightly":[478],"bigger":[479],"Oats.":[483]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
