{"id":"https://openalex.org/W2139746972","doi":"https://doi.org/10.2174/156800911795538039","title":"Novel Strategies in Therapy of Head and Neck Cancer","display_name":"Novel Strategies in Therapy of Head and Neck Cancer","publication_year":2011,"publication_date":"2011-05-01","ids":{"openalex":"https://openalex.org/W2139746972","doi":"https://doi.org/10.2174/156800911795538039","mag":"2139746972","pmid":"https://pubmed.ncbi.nlm.nih.gov/21247379"},"language":"en","primary_location":{"id":"doi:10.2174/156800911795538039","doi":"https://doi.org/10.2174/156800911795538039","is_oa":false,"landing_page_url":"https://doi.org/10.2174/156800911795538039","pdf_url":null,"source":{"id":"https://openalex.org/S26162253","display_name":"Current Cancer Drug Targets","issn_l":"1568-0096","issn":["1568-0096","1873-5576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Cancer Drug Targets","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054115710","display_name":"Ravi Mehrotra","orcid":"https://orcid.org/0000-0001-9453-1408","observed_orcids":["https://orcid.org/0000-0001-9453-1408"]},"institutions":[{"id":"https://openalex.org/I3056136","display_name":"Motilal Nehru Medical College","ror":"https://ror.org/03jmdp146","country_code":"IN","type":"education","lineage":["https://openalex.org/I3056136"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R. Mehrotra","raw_affiliation_strings":["Department of Pathology, Moti Lal Nehru Medical College, Allahabad, India. rm8509@gmail.com","Department of Pathology, Moti Lal Nehru Medical College, Allahabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Moti Lal Nehru Medical College, Allahabad, India. rm8509@gmail.com","institution_ids":["https://openalex.org/I3056136"]},{"raw_affiliation_string":"Department of Pathology, Moti Lal Nehru Medical College, Allahabad, India","institution_ids":["https://openalex.org/I3056136"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Ibrahim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Ibrahim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021376039","display_name":"Andr\u00e9 Michael Eckardt","orcid":"https://orcid.org/0000-0002-1753-9390","observed_orcids":["https://orcid.org/0000-0002-1753-9390"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Eckardt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034384400","display_name":"Oliver Driemel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O. Driemel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5102833873","display_name":"Mamata Singh","orcid":"https://orcid.org/0000-0001-9604-5139","observed_orcids":["https://orcid.org/0000-0001-9604-5139"]},"institutions":[{"id":"https://openalex.org/I3056136","display_name":"Motilal Nehru Medical College","ror":"https://ror.org/03jmdp146","country_code":"IN","type":"education","lineage":["https://openalex.org/I3056136"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"M. Singh","raw_affiliation_strings":["Department of Pathology, Moti Lal Nehru Medical College, Allahabad, India.,India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Moti Lal Nehru Medical College, Allahabad, India.,India","institution_ids":["https://openalex.org/I3056136"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102833873"],"corresponding_institution_ids":["https://openalex.org/I3056136"],"apc_list":null,"apc_paid":null,"fwci":4.2247,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.94648622,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"4","first_page":"465","last_page":"478"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":1.0},{"id":"https://openalex.org/keywords/novel-cancer-therapies","display_name":"novel cancer therapies","score":0.609000027179718},{"id":"https://openalex.org/keywords/intra-arterial-chemotherapy","display_name":"intra-arterial chemotherapy","score":0.8289999961853027},{"id":"https://openalex.org/keywords/induction-chemotherapy","display_name":"induction chemotherapy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":1.0},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.984000027179718},{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.9810000061988831},{"id":"https://openalex.org/keywords/vegf-inhibitors","display_name":"VEGF inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9010000228881836},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.797722578048706},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6590338349342346},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5948769450187683},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.5944555997848511},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.5933701992034912},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5910961627960205},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.5172077417373657},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4762040376663208},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4542948305606842},{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.4206249415874481},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41774022579193115},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.41450974345207214},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3923614025115967},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3752576410770416},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.07253798842430115},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2174/156800911795538039","doi":"https://doi.org/10.2174/156800911795538039","is_oa":false,"landing_page_url":"https://doi.org/10.2174/156800911795538039","pdf_url":null,"source":{"id":"https://openalex.org/S26162253","display_name":"Current Cancer Drug Targets","issn_l":"1568-0096","issn":["1568-0096","1873-5576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Cancer Drug Targets","raw_type":"journal-article"},{"id":"pmid:21247379","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21247379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current cancer drug targets","raw_type":"Journal Article"},{"id":"pmh:oai:epub.uni-regensburg.de:64966","doi":null,"is_oa":false,"landing_page_url":"http://orcid.org/0000-0001-9453-1408>,","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2119142349","https://openalex.org/W3048529979","https://openalex.org/W2402209997","https://openalex.org/W3000060024","https://openalex.org/W6442918","https://openalex.org/W2040786394","https://openalex.org/W3209971188","https://openalex.org/W2405449358","https://openalex.org/W3161996844","https://openalex.org/W3166635706"],"abstract_inverted_index":{"In":[0,41],"addition":[1],"to":[2,48,53,192],"the":[3,94,138,145,156,164,180,193],"currently":[4,190],"available":[5,191],"conventional":[6,134],"therapeutic":[7],"modalities":[8,162],"i.e.":[9],"chemotherapy,":[10,64,152],"radiotherapy":[11],"and":[12,22,28,36,52,81,126,178,187],"surgery,":[13],"there":[14],"is":[15,92,100,111],"a":[16,37,49,56],"desperate":[17],"need":[18],"for":[19,26],"more":[20,168],"effective":[21],"less":[23],"toxic":[24],"therapies":[25],"head":[27],"neck":[29],"malignancies.":[30],"Chemotherapy":[31],"alone":[32,129],"shows":[33],"high":[34],"toxicity":[35],"low":[38],"survival":[39,89,139],"rate.":[40,90],"some":[42,86],"cases,":[43],"malignant":[44],"cells":[45],"develop":[46],"resistance":[47],"particular":[50],"drug":[51,159],"combat":[54],"this,":[55],"variety":[57],"of":[58,106,124,141,158,166,182],"approaches":[59],"like":[60,79],"intra-arterial":[61,80],"therapy,":[62,135],"induction":[63,82],"immunotherapy,":[65],"photodynamic":[66,98],"therapy":[67,73,99],"as":[68,70],"well":[69],"targeted":[71],"molecular":[72,117],"have":[74,84],"recently":[75],"been":[76],"employed.":[77],"Techniques":[78],"chemotherapy":[83],"showed":[85],"improvement":[87],"in":[88,93,131,199],"Immununotherapy":[91],"experimental":[95],"stages":[96],"while":[97],"being":[101,167],"clinically":[102],"applied,":[103],"but":[104],"because":[105],"its":[107],"side":[108,176],"effects":[109,177],"it":[110],"not":[112],"very":[113],"popular.":[114],"Utilizing":[115],"specific":[116],"targets":[118],"with":[119,133,149],"their":[120],"inhibitors":[121,123],"(like":[122],"EGFR":[125],"VEGF);":[127],"either":[128],"or":[130,150],"combination":[132],"may":[136,153],"improve":[137],"rate":[140],"these":[142],"patients.":[143],"Blocking":[144],"signaling":[146],"pathway":[147],"(P13k/Akt/mTOR),":[148],"without":[151],"also":[154],"overcome":[155],"problem":[157],"resistance.":[160],"These":[161],"hold":[163],"promise":[165],"selective":[169],"-":[170],"harming":[171],"fewer":[172],"normal":[173],"cells,":[174],"reducing":[175],"improving":[179],"quality":[181],"life.":[183],"The":[184],"various":[185],"options":[186],"novel":[188],"strategies":[189],"treating":[194],"physician":[195],"are":[196],"critically":[197],"examined":[198],"this":[200],"review.":[201]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}