{"id":"https://openalex.org/W2139746780","doi":"https://doi.org/10.1128/jvi.01775-08","title":"Evaluation of Live Attenuated Influenza A Virus H6 Vaccines in Mice and Ferrets","display_name":"Evaluation of Live Attenuated Influenza A Virus H6 Vaccines in Mice and Ferrets","publication_year":2008,"publication_date":"2008-10-23","ids":{"openalex":"https://openalex.org/W2139746780","doi":"https://doi.org/10.1128/jvi.01775-08","mag":"2139746780","pmid":"https://pubmed.ncbi.nlm.nih.gov/18945773","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2612304"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.01775-08","doi":"https://doi.org/10.1128/jvi.01775-08","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01775-08","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2612304","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010669809","display_name":"Yuyan Chen","orcid":"https://orcid.org/0000-0002-2894-1430","observed_orcids":["https://orcid.org/0000-0002-2894-1430"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhongying Chen","raw_affiliation_strings":["MedImmune, Mountain View, California 94043","Laboratory of Infectious Diseases, NIAID, NIH, Bldg. 33/Room 3E13C.1, 33 North Dr., MSC 3203, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune, Mountain View, California 94043","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Infectious Diseases, NIAID, NIH, Bldg. 33/Room 3E13C.1, 33 North Dr., MSC 3203, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103067370","display_name":"Celia P. Santos","orcid":"https://orcid.org/0000-0003-2915-2879","observed_orcids":["https://orcid.org/0000-0003-2915-2879"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Celia Santos","raw_affiliation_strings":["Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011695517","display_name":"Amy Aspelund","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy Aspelund","raw_affiliation_strings":["MedImmune, Mountain View, California 94043"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune, Mountain View, California 94043","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042899435","display_name":"Laura Gillim-Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Gillim-Ross","raw_affiliation_strings":["Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064066871","display_name":"Hong Jin","orcid":"https://orcid.org/0000-0003-0574-2604","observed_orcids":["https://orcid.org/0000-0003-0574-2604","https://orcid.org/0000-0001-8887-6792"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Jin","raw_affiliation_strings":["MedImmune, Mountain View, California 94043"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune, Mountain View, California 94043","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010601658","display_name":"George\u00a0W. Kemble","orcid":"https://orcid.org/0000-0003-4225-8774","observed_orcids":["https://orcid.org/0000-0003-4225-8774"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Kemble","raw_affiliation_strings":["MedImmune, Mountain View, California 94043"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedImmune, Mountain View, California 94043","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074126857","display_name":"Kanta Subbarao","orcid":"https://orcid.org/0000-0003-1713-3056","observed_orcids":["https://orcid.org/0000-0003-1713-3056"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kanta Subbarao","raw_affiliation_strings":["Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074126857"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"],"apc_list":null,"apc_paid":null,"fwci":4.2059,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.93834062,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"83","issue":"1","first_page":"65","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/live-attenuated-influenza-vaccine","display_name":"live attenuated influenza vaccine","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cross-protection","display_name":"cross-protection","score":0.5920000076293945},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pandemic-influenza-preparedness","display_name":"pandemic influenza preparedness","score":0.531000018119812},{"id":"https://openalex.org/keywords/temperature-response","display_name":"temperature sensitivity","score":0.4699999988079071},{"id":"https://openalex.org/keywords/intranasal-immunization","display_name":"intranasal immunization","score":0.6470000147819519},{"id":"https://openalex.org/keywords/ferrets","display_name":"ferrets","score":0.5630000233650208},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.9430000185966492}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8650734424591064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8069793581962585},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.7779224514961243},{"id":"https://openalex.org/C519248777","wikidata":"https://www.wikidata.org/wiki/Q160122","display_name":"Influenza A virus subtype H5N1","level":3,"score":0.628287136554718},{"id":"https://openalex.org/C54602769","wikidata":"https://www.wikidata.org/wiki/Q1810913","display_name":"Attenuated vaccine","level":4,"score":0.604671835899353},{"id":"https://openalex.org/C16154277","wikidata":"https://www.wikidata.org/wiki/Q2004399","display_name":"Reassortment","level":5,"score":0.5668258666992188},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.5257034301757812},{"id":"https://openalex.org/C133239900","wikidata":"https://www.wikidata.org/wiki/Q2043512","display_name":"Live attenuated influenza vaccine","level":4,"score":0.5227798819541931},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.5191185474395752},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.47559651732444763},{"id":"https://openalex.org/C2780689484","wikidata":"https://www.wikidata.org/wiki/Q383260","display_name":"Influenza vaccine","level":3,"score":0.43545767664909363},{"id":"https://openalex.org/C82988372","wikidata":"https://www.wikidata.org/wiki/Q5628866","display_name":"H5N1 genetic structure","level":5,"score":0.43020206689834595},{"id":"https://openalex.org/C2776872762","wikidata":"https://www.wikidata.org/wiki/Q3560939","display_name":"Inactivated vaccine","level":3,"score":0.4263353645801544},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39430665969848633},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.35243701934814453},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14132186770439148},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.12153801321983337},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09808006882667542},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.07806241512298584},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06571656465530396},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.06065016984939575},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005289","descriptor_name":"Ferrets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009296","descriptor_name":"Nasal Cavity","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.01775-08","doi":"https://doi.org/10.1128/jvi.01775-08","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01775-08","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1479838","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2612304","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2612304","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2612304","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:18945773","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18945773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1479838","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2612304","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1864741535","display_name":null,"funder_award_id":"K04 AI000155","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G93931096","display_name":"Clinical Studies Of Abnormal Host Defense","funder_award_id":"Z01AI000155","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W146939554","https://openalex.org/W1811768630","https://openalex.org/W1886202267","https://openalex.org/W1967362690","https://openalex.org/W1971178088","https://openalex.org/W1993047642","https://openalex.org/W1996396050","https://openalex.org/W1996627711","https://openalex.org/W1997343899","https://openalex.org/W2016365074","https://openalex.org/W2019759746","https://openalex.org/W2024430413","https://openalex.org/W2024970913","https://openalex.org/W2024994988","https://openalex.org/W2030147825","https://openalex.org/W2030375768","https://openalex.org/W2032332121","https://openalex.org/W2037859752","https://openalex.org/W2040635697","https://openalex.org/W2045934762","https://openalex.org/W2063490058","https://openalex.org/W2087557652","https://openalex.org/W2091527885","https://openalex.org/W2092283636","https://openalex.org/W2097580384","https://openalex.org/W2102104628","https://openalex.org/W2111323042","https://openalex.org/W2112408527","https://openalex.org/W2114918588","https://openalex.org/W2116630939","https://openalex.org/W2122385379","https://openalex.org/W2126309815","https://openalex.org/W2138922466","https://openalex.org/W2141436865","https://openalex.org/W2145159378","https://openalex.org/W2163960578","https://openalex.org/W2165113409","https://openalex.org/W2168020376","https://openalex.org/W2170330566","https://openalex.org/W2193554202","https://openalex.org/W2256756668","https://openalex.org/W3217730596"],"related_works":["https://openalex.org/W2075318332","https://openalex.org/W2032332121","https://openalex.org/W2165113409","https://openalex.org/W2019759746","https://openalex.org/W2899011366","https://openalex.org/W2031099047","https://openalex.org/W2022051899","https://openalex.org/W1997806906","https://openalex.org/W1742145174","https://openalex.org/W2334651646"],"abstract_inverted_index":{"Avian":[0],"influenza":[1,20,47,64,148],"A":[2],"virus":[3,28,114,124,140,149,208,219],"A/teal/HK/W312/97":[4,217,242],"(H6N1)":[5],"possesses":[6],"seven":[7],"gene":[8,119,129,173],"segments":[9,120,130,174],"that":[10,24,141],"are":[11],"highly":[12,17],"homologous":[13,205],"to":[14,56,61,96,144],"those":[15],"of":[16,36,46,104,161,180,184],"pathogenic":[18],"human":[19],"H5N1":[21,39],"viruses,":[22],"suggesting":[23],"a":[25,110,181],"W312-like":[26],"H6N1":[27],"might":[29],"have":[30],"been":[31],"involved":[32],"in":[33,51,194,245],"the":[34,37,54,68,73,105,126,137,171,185,211,216,221,236,241],"generation":[35],"A/HK/97":[38],"viruses.":[40,70,232],"The":[41],"continuous":[42],"circulation":[43],"and":[44,86,92,117,125,166,196,198,202],"reassortment":[45],"H6":[48,59,69,82,100,106,123,155,187,213,230],"subtype":[49],"viruses":[50,83,190],"birds":[52],"highlight":[53],"need":[55],"develop":[57],"an":[58,122],"vaccine":[60,107,156,189,214,244],"prevent":[62],"potential":[63],"pandemics":[65],"caused":[66],"by":[67,170],"Based":[71],"on":[72],"serum":[74],"antibody":[75],"cross-reactivity":[76],"data":[77,234],"obtained":[78],"from":[79,84,121,131,175,204],"14":[80],"different":[81],"Eurasian":[85],"North":[87],"American":[88],"lineages,":[89],"A/duck/HK/182/77,":[90],"A/teal/HK/W312/97,":[91],"A/mallard/Alberta/89/85":[93],"were":[94],"selected":[95],"produce":[97],"live":[98,146],"attenuated":[99,147],"candidate":[101],"vaccines.":[102],"Each":[103],"strains":[108],"is":[109,142],"6:2":[111],"reassortant":[112],"ca":[113,188,218,243],"containing":[115],"HA":[116],"NA":[118],"six":[127],"internal":[128,172],"cold-adapted":[132],"A/Ann":[133],"Arbor/6/60":[134],"(AA":[135],"ca),":[136],"master":[138],"donor":[139],"used":[143],"make":[145],"FluMist":[150],"(intranasal)":[151],"vaccine.":[152],"All":[153],"three":[154,186,212,227],"candidates":[157],"exhibited":[158],"phenotypic":[159],"properties":[160],"temperature":[162],"sensitivity":[163],"(ts),":[164],"ca,":[165],"attenuation":[167],"(att)":[168],"conferred":[169],"AA":[176],"ca.":[177],"Intranasal":[178],"administration":[179],"single":[182],"dose":[183],"induced":[191],"neutralizing":[192],"antibodies":[193],"mice":[195,201],"ferrets":[197,203],"fully":[199],"protected":[200],"wild-type":[206],"(wt)":[207],"challenge.":[209],"Among":[210],"candidates,":[215],"provided":[220],"broadest":[222],"cross-protection":[223],"against":[224],"challenge":[225],"with":[226],"antigenically":[228],"distinct":[229],"wt":[231],"These":[233],"support":[235],"rationale":[237],"for":[238],"further":[239],"evaluating":[240],"humans.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}