{"id":"https://openalex.org/W2139721898","doi":null,"title":"Escherichia coli RNase M is a multiply altered form of RNase I.","display_name":"Escherichia coli RNase M is a multiply altered form of RNase I.","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2139721898","mag":"2139721898","pmid":"https://pubmed.ncbi.nlm.nih.gov/11780627","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1370210"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1370210","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1370210","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1370210","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067176773","display_name":"Pochi R. Subbarayan","orcid":"https://orcid.org/0000-0003-4637-1547","observed_orcids":["https://orcid.org/0000-0003-4637-1547"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P R Subbarayan","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Florida 33101-6129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Florida 33101-6129, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014137523","display_name":"Murray P. Deutscher","orcid":"https://orcid.org/0000-0001-5715-157X","observed_orcids":["https://orcid.org/0000-0001-5715-157X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M P Deutscher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2246,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.78096242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"7","issue":"12","first_page":"1702","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.06279999762773514,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rnase-i","display_name":"RNase I","score":0.9890000224113464},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9380000233650208},{"id":"https://openalex.org/keywords/endoribonuclease","display_name":"endoribonuclease","score":0.9369999766349792},{"id":"https://openalex.org/keywords/mrna-degradation","display_name":"mRNA degradation","score":0.972000002861023},{"id":"https://openalex.org/keywords/amino-acid-substitutions","display_name":"amino acid substitutions","score":0.7710000276565552},{"id":"https://openalex.org/keywords/ribosomal-dna","display_name":"ribosomal DNA","score":0.6370000243186951},{"id":"https://openalex.org/keywords/isoenzymes","display_name":"isozymes","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2780102198","wikidata":"https://www.wikidata.org/wiki/Q3054027","display_name":"Endoribonuclease","level":5,"score":0.9889938831329346},{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.9245237708091736},{"id":"https://openalex.org/C195500695","wikidata":"https://www.wikidata.org/wiki/Q7277299","display_name":"RNase MRP","level":5,"score":0.892998218536377},{"id":"https://openalex.org/C188528350","wikidata":"https://www.wikidata.org/wiki/Q3415271","display_name":"RNase PH","level":5,"score":0.8638787269592285},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7806801795959473},{"id":"https://openalex.org/C69766542","wikidata":"https://www.wikidata.org/wiki/Q3430179","display_name":"RNase H","level":5,"score":0.6331384778022766},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6303387880325317},{"id":"https://openalex.org/C79750893","wikidata":"https://www.wikidata.org/wiki/Q3430180","display_name":"Ribonuclease III","level":5,"score":0.5481163263320923},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.48965364694595337},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.48156288266181946},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46266698837280273},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3525872230529785},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32078099250793457},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.08358228206634521}],"mesh":[{"descriptor_ui":"D004722","descriptor_name":"Endoribonucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004722","descriptor_name":"Endoribonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012259","descriptor_name":"Ribonuclease, Pancreatic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012259","descriptor_name":"Ribonuclease, Pancreatic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1370210","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1370210","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"Text"},{"id":"pmid:11780627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11780627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA (New York, N.Y.)","raw_type":"Comparative Study"},{"id":"mag:2139721898","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11780627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1370210","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1370210","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W158744088","https://openalex.org/W205725875","https://openalex.org/W1507927088","https://openalex.org/W1531374249","https://openalex.org/W1578301275","https://openalex.org/W1827567297","https://openalex.org/W1878070912","https://openalex.org/W2046119126","https://openalex.org/W2073710865","https://openalex.org/W2074411801","https://openalex.org/W2090407047","https://openalex.org/W2118885986","https://openalex.org/W2128635872","https://openalex.org/W2156756059","https://openalex.org/W2339847049","https://openalex.org/W4318599963"],"related_works":["https://openalex.org/W1578301275","https://openalex.org/W2074411801","https://openalex.org/W1487935084","https://openalex.org/W7096308647","https://openalex.org/W2096641315","https://openalex.org/W2036290842","https://openalex.org/W2337507152","https://openalex.org/W7097949420","https://openalex.org/W2003202888","https://openalex.org/W2074427163"],"abstract_inverted_index":{"RNase":[0,16,29,39,67,77,91,96,129,145],"M,":[1],"an":[2,103],"enzyme":[3,62],"previously":[4,136],"purified":[5],"to":[6,13,26,35,81],"homogeneity":[7],"from":[8,102],"Escherichia":[9],"coli,":[10],"was":[11,41],"suggested":[12],"be":[14],"the":[15,27,36,88,94,98],"responsible":[17],"for":[18],"mRNA":[19],"degradation":[20],"in":[21,51,70],"this":[22],"bacterium.":[23],"Although":[24],"related":[25],"endoribonuclease,":[28],"I,":[30,97],"its":[31],"distinct":[32],"properties":[33,89],"led":[34],"conclusion":[37],"that":[38,66,86,106,128,140],"M":[40,68,92,130],"a":[42,72,108,117,120],"second,":[43],"low":[44,121],"molecular":[45],"mass,":[46],"broad":[47],"specificity":[48],"endoribonuclease":[49,138],"present":[50],"E.":[52],"coli.":[53],"However,":[54],"based":[55],"on":[56,93],"sequence":[57],"analysis,":[58],"southern":[59],"hybridization,":[60],"and":[61],"activity,":[63],"we":[64],"show":[65],"is,":[69],"fact,":[71],"multiply":[73],"altered":[74],"form":[75],"of":[76,90,119,123,134,144],"I.":[78,146],"In":[79],"addition":[80],"three":[82],"amino":[83],"acid":[84],"substitutions":[85],"confer":[87],"mutated":[95],"protein":[99],"is":[100,131],"synthesized":[101],"rna":[104],"gene":[105],"contains":[107],"UGA":[109],"nonsense":[110],"codon":[111],"at":[112],"position":[113],"5,":[114],"apparently":[115],"as":[116],"result":[118],"level":[122],"readthrough.":[124],"We":[125],"also":[126],"suggest":[127],"just":[132],"one":[133],"several":[135],"described":[137],"activities":[139],"are":[141],"actually":[142],"manifestations":[143]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}