{"id":"https://openalex.org/W2139712795","doi":"https://doi.org/10.1016/j.ijrobp.2012.07.023","title":"Radiation of Potential Local Cancer Stem Cell Niches Improves Survival of Patients With Glioblastoma Multiforme","display_name":"Radiation of Potential Local Cancer Stem Cell Niches Improves Survival of Patients With Glioblastoma Multiforme","publication_year":2012,"publication_date":"2012-10-25","ids":{"openalex":"https://openalex.org/W2139712795","doi":"https://doi.org/10.1016/j.ijrobp.2012.07.023","mag":"2139712795"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijrobp.2012.07.023","doi":"https://doi.org/10.1016/j.ijrobp.2012.07.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2012.07.023","pdf_url":"http://www.redjournal.org/article/S0360301612009674/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.redjournal.org/article/S0360301612009674/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088797923","display_name":"Jung Julie Kang","orcid":"https://orcid.org/0000-0001-9773-5481","observed_orcids":["https://orcid.org/0000-0001-9773-5481"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Kang","raw_affiliation_strings":["University of California Los Angeles, Los Angeles, CA",", University of California Los Angeles, Los Angeles, CA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":", University of California Los Angeles, Los Angeles, CA#TAB#","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111808491","display_name":"Michael T. Selch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Selch","raw_affiliation_strings":["University of California Los Angeles, Los Angeles, CA",", University of California Los Angeles, Los Angeles, CA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":", University of California Los Angeles, Los Angeles, CA#TAB#","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063511816","display_name":"Timothy Francis Cloughesy","orcid":"https://orcid.org/0000-0002-8656-7483","observed_orcids":["https://orcid.org/0000-0002-8656-7483"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Cloughesy","raw_affiliation_strings":["University of California Los Angeles, Los Angeles, CA",", University of California Los Angeles, Los Angeles, CA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":", University of California Los Angeles, Los Angeles, CA#TAB#","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046347338","display_name":"P.A. Kupelian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Kupelian","raw_affiliation_strings":["University of California Los Angeles, Los Angeles, CA",", University of California Los Angeles, Los Angeles, CA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":", University of California Los Angeles, Los Angeles, CA#TAB#","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044488631","display_name":"Frank Pajonk","orcid":"https://orcid.org/0000-0003-4067-9751","observed_orcids":["https://orcid.org/0000-0003-4067-9751"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Pajonk","raw_affiliation_strings":["University of California Los Angeles, Los Angeles, CA",", University of California Los Angeles, Los Angeles, CA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":", University of California Los Angeles, Los Angeles, CA#TAB#","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056186611","display_name":"Jia Wang","orcid":"https://orcid.org/0000-0001-7025-6464","observed_orcids":["https://orcid.org/0000-0001-7025-6464"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Wang","raw_affiliation_strings":["University of California Los Angeles, Los Angeles, CA",", University of California Los Angeles, Los Angeles, CA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":", University of California Los Angeles, Los Angeles, CA#TAB#","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064969499","display_name":"Nzhde Agazaryan","orcid":"https://orcid.org/0000-0002-1221-7616","observed_orcids":["https://orcid.org/0000-0002-1221-7616"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Agazaryan","raw_affiliation_strings":["University of California Los Angeles, Los Angeles, CA",", University of California Los Angeles, Los Angeles, CA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":", University of California Los Angeles, Los Angeles, CA#TAB#","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006353545","display_name":"Percy P. Lee","orcid":"https://orcid.org/0000-0001-6004-840X","observed_orcids":["https://orcid.org/0000-0001-6004-840X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Lee","raw_affiliation_strings":["University of California Los Angeles, Los Angeles, CA",", University of California Los Angeles, Los Angeles, CA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Los Angeles, Los Angeles, CA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":", University of California Los Angeles, Los Angeles, CA#TAB#","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":null,"fwci":0.1444,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.5341827,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"84","issue":"3","first_page":"S6","last_page":"S7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.5830000042915344},{"id":"https://openalex.org/keywords/high-dose-radiotherapy","display_name":"high-dose radiotherapy","score":0.7049999833106995},{"id":"https://openalex.org/keywords/stem-cell-niche","display_name":"stem cell niche","score":0.6729999780654907},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7149999737739563},{"id":"https://openalex.org/keywords/periventricular-zone","display_name":"periventricular zone","score":0.8820000290870667},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8330000042915344},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9100000262260437},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9420018196105957},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.8917025327682495},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5559226274490356},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5075808763504028},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4843343496322632},{"id":"https://openalex.org/C2987992536","wikidata":"https://www.wikidata.org/wiki/Q3026015","display_name":"Radiation tolerance","level":3,"score":0.4363919496536255},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4132688045501709},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40438202023506165},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3688400685787201},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31162384152412415},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.046782344579696655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ijrobp.2012.07.023","doi":"https://doi.org/10.1016/j.ijrobp.2012.07.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2012.07.023","pdf_url":"http://www.redjournal.org/article/S0360301612009674/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ijrobp.2012.07.023","doi":"https://doi.org/10.1016/j.ijrobp.2012.07.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2012.07.023","pdf_url":"http://www.redjournal.org/article/S0360301612009674/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139712795.pdf","grobid_xml":"https://content.openalex.org/works/W2139712795.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2465168811","https://openalex.org/W1995194817","https://openalex.org/W2164437708","https://openalex.org/W2315583967","https://openalex.org/W2058671405","https://openalex.org/W2139728715","https://openalex.org/W2016421142","https://openalex.org/W2758334442","https://openalex.org/W2586071327","https://openalex.org/W2145305204"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}