{"id":"https://openalex.org/W2139695381","doi":"https://doi.org/10.1158/0008-5472.can-05-1949","title":"Inhibition of Intestinal Tumorigenesis in Apcmin/+ Mice by (\u2212)-Epigallocatechin-3-Gallate, the Major Catechin in Green Tea","display_name":"Inhibition of Intestinal Tumorigenesis in Apcmin/+ Mice by (\u2212)-Epigallocatechin-3-Gallate, the Major Catechin in Green Tea","publication_year":2005,"publication_date":"2005-11-15","ids":{"openalex":"https://openalex.org/W2139695381","doi":"https://doi.org/10.1158/0008-5472.can-05-1949","mag":"2139695381","pmid":"https://pubmed.ncbi.nlm.nih.gov/16288056"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-05-1949","doi":"https://doi.org/10.1158/0008-5472.can-05-1949","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-05-1949","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/65/22/10623/2538316/10623-10631.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerres/article-pdf/65/22/10623/2538316/10623-10631.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014570496","display_name":"Jihyeung Ju","orcid":"https://orcid.org/0000-0002-1078-6196","observed_orcids":["https://orcid.org/0000-0002-1078-6196"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jihyeung Ju","raw_affiliation_strings":["1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;","Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065732535","display_name":"Jungil Hong","orcid":"https://orcid.org/0000-0002-3878-6059","observed_orcids":["https://orcid.org/0000-0002-3878-6059"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jungil Hong","raw_affiliation_strings":["1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110241970","display_name":"Jian-nian Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian-nian Zhou","raw_affiliation_strings":["1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025549159","display_name":"Zui Pan","orcid":"https://orcid.org/0000-0003-4105-901X","observed_orcids":["https://orcid.org/0000-0003-4105-901X"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zui Pan","raw_affiliation_strings":["2Department of Physiology, Robert Wood Johnson Medical School, Piscataway, New Jersey;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Physiology, Robert Wood Johnson Medical School, Piscataway, New Jersey;","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025183048","display_name":"Mousumi Bose","orcid":"https://orcid.org/0000-0002-0913-7738","observed_orcids":["https://orcid.org/0000-0002-0913-7738"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mousumi Bose","raw_affiliation_strings":["1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102823999","display_name":"Jie Liao","orcid":"https://orcid.org/0000-0002-7295-7384","observed_orcids":["https://orcid.org/0000-0002-7295-7384"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Liao","raw_affiliation_strings":["1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006641884","display_name":"Guang\u2010Yu Yang","orcid":"https://orcid.org/0000-0002-5987-7750","observed_orcids":["https://orcid.org/0000-0002-5987-7750","https://orcid.org/0009-0005-4874-8960"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guang-yu Yang","raw_affiliation_strings":["1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ying Ying Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Ying Liu","raw_affiliation_strings":["1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhe Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhe Hou","raw_affiliation_strings":["1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005424988","display_name":"Yong Lin","orcid":"https://orcid.org/0000-0002-5710-5036","observed_orcids":["https://orcid.org/0000-0002-5710-5036"]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Lin","raw_affiliation_strings":["3Cancer Institute of New Jersey, New Brunswick, New Jersey; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Cancer Institute of New Jersey, New Brunswick, New Jersey; and","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015264004","display_name":"Jianjie Ma","orcid":"https://orcid.org/0000-0003-3865-6112","observed_orcids":["https://orcid.org/0000-0003-3865-6112"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianjie Ma","raw_affiliation_strings":["2Department of Physiology, Robert Wood Johnson Medical School, Piscataway, New Jersey;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Physiology, Robert Wood Johnson Medical School, Piscataway, New Jersey;","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012792790","display_name":"Weichung Joe Shih","orcid":"https://orcid.org/0000-0003-1167-6121","observed_orcids":["https://orcid.org/0000-0003-1167-6121"]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weichung Joe Shih","raw_affiliation_strings":["3Cancer Institute of New Jersey, New Brunswick, New Jersey; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Cancer Institute of New Jersey, New Brunswick, New Jersey; and","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071988795","display_name":"Adelaide M. Carothers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101825","display_name":"Strang Cancer Prevention Institute","ror":"https://ror.org/01d7ffm04","country_code":"US","type":"education","lineage":["https://openalex.org/I4210101825"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adelaide M. Carothers","raw_affiliation_strings":["4Strang Cancer Prevention Center, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Strang Cancer Prevention Center, New York, New York","institution_ids":["https://openalex.org/I4210101825"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086188593","display_name":"Chung Shu Yang","orcid":"https://orcid.org/0000-0001-6713-4837","observed_orcids":["https://orcid.org/0000-0001-6713-4837"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chung S. Yang","raw_affiliation_strings":["1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey;","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":19.2379,"has_fulltext":true,"cited_by_count":223,"citation_normalized_percentile":{"value":0.99757292,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"65","issue":"22","first_page":"10623","last_page":"10631"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.9599999785423279},{"id":"https://openalex.org/keywords/green-tea-catechins","display_name":"green tea catechins","score":0.9549999833106995},{"id":"https://openalex.org/keywords/intestinal-tumorigenesis","display_name":"intestinal tumorigenesis","score":0.890999972820282},{"id":"https://openalex.org/keywords/apcmin-mice","display_name":"ApcMin/+ mice","score":0.8579999804496765},{"id":"https://openalex.org/keywords/small-intestine-neoplasms","display_name":"small intestine neoplasms","score":0.8360000252723694},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8100000023841858},{"id":"https://openalex.org/keywords/beta-catenin-nuclear-translocation","display_name":"\u03b2-catenin nuclear translocation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9779999852180481},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8309999704360962},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/colon-cancer-cells","display_name":"colon cancer cells","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ht-29-cells","display_name":"HT-29 cells","score":0.6909999847412109},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7630820870399475},{"id":"https://openalex.org/C2777192995","wikidata":"https://www.wikidata.org/wiki/Q393339","display_name":"Epigallocatechin gallate","level":4,"score":0.6230774521827698},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5803762078285217},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4842092990875244},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4561774432659149},{"id":"https://openalex.org/C2779431889","wikidata":"https://www.wikidata.org/wiki/Q415007","display_name":"Catechin","level":4,"score":0.4484078884124756},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42084386944770813},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.4116702079772949},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3651895821094513},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36462509632110596},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35785916447639465},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3498803973197937},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3203028440475464},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31125614047050476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30827486515045166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1843561828136444},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.17778411507606506},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.15627402067184448},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.09276247024536133},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.06683081388473511},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007414","descriptor_name":"Intestinal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007414","descriptor_name":"Intestinal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007414","descriptor_name":"Intestinal Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007975","descriptor_name":"Leukotriene B4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017491","descriptor_name":"Genes, APC","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.can-05-1949","doi":"https://doi.org/10.1158/0008-5472.can-05-1949","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-05-1949","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/65/22/10623/2538316/10623-10631.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:16288056","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16288056","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.335.4788","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.4788","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/65/22/10623.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.can-05-1949","doi":"https://doi.org/10.1158/0008-5472.can-05-1949","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-05-1949","pdf_url":"https://aacrjournals.org/cancerres/article-pdf/65/22/10623/2538316/10623-10631.pdf","source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5020471793","display_name":"INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS","funder_award_id":"P01CA088961","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320312581","display_name":"Rutgers, The State University of New Jersey","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139695381.pdf","grobid_xml":"https://content.openalex.org/works/W2139695381.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W59197697","https://openalex.org/W633735835","https://openalex.org/W1484020898","https://openalex.org/W1487239501","https://openalex.org/W1494491432","https://openalex.org/W1554815317","https://openalex.org/W1567766289","https://openalex.org/W1568317880","https://openalex.org/W1677573439","https://openalex.org/W1907972050","https://openalex.org/W1926855831","https://openalex.org/W1967137553","https://openalex.org/W1975760767","https://openalex.org/W1993743405","https://openalex.org/W1994141644","https://openalex.org/W2000889184","https://openalex.org/W2002404925","https://openalex.org/W2004193319","https://openalex.org/W2006775147","https://openalex.org/W2012095617","https://openalex.org/W2017233732","https://openalex.org/W2018348035","https://openalex.org/W2018884883","https://openalex.org/W2034018110","https://openalex.org/W2045939602","https://openalex.org/W2052870426","https://openalex.org/W2057830803","https://openalex.org/W2060942394","https://openalex.org/W2071697240","https://openalex.org/W2074675419","https://openalex.org/W2078576765","https://openalex.org/W2078764973","https://openalex.org/W2081758458","https://openalex.org/W2082387343","https://openalex.org/W2083568522","https://openalex.org/W2093531978","https://openalex.org/W2095046939","https://openalex.org/W2097466434","https://openalex.org/W2100124291","https://openalex.org/W2102150100","https://openalex.org/W2106763792","https://openalex.org/W2119999174","https://openalex.org/W2121245276","https://openalex.org/W2130705422","https://openalex.org/W2132349680","https://openalex.org/W2134860789","https://openalex.org/W2137119117","https://openalex.org/W2138153315","https://openalex.org/W2140908517","https://openalex.org/W2141376284","https://openalex.org/W2146008295","https://openalex.org/W2146167376","https://openalex.org/W2148883613","https://openalex.org/W2165512846","https://openalex.org/W2165901622","https://openalex.org/W2166137435","https://openalex.org/W2397052542","https://openalex.org/W2431640091","https://openalex.org/W2614443566","https://openalex.org/W4233070887","https://openalex.org/W7097257549"],"related_works":["https://openalex.org/W7100487220","https://openalex.org/W3042704018","https://openalex.org/W1535493100","https://openalex.org/W1582834335","https://openalex.org/W2154849502","https://openalex.org/W2290136054","https://openalex.org/W2001689917","https://openalex.org/W2010692661","https://openalex.org/W2130705422","https://openalex.org/W1987841769"],"abstract_inverted_index":{"The":[0],"present":[1],"study":[2],"was":[3,98],"designed":[4],"to":[5,35,115,169,178],"investigate":[6],"the":[7,41,45,172,209,212],"effects":[8],"of":[9,13,44,53,57,80,107,113,119,125,130,146,165,174,211],"two":[10],"main":[11],"constituents":[12],"green":[14],"tea,":[15],"(-)-epigallocatechin-3-gallate":[16],"(EGCG)":[17],"and":[18,34,127,135,180,183,186,220,223],"caffeine,":[19],"on":[20],"intestinal":[21,32,67,90,96,143,202],"tumorigenesis":[22,97,203],"in":[23,40,61,82,100,109,122,141,204],"Apc(min/+)":[24,205],"mice,":[25,206],"a":[26,78,101,110],"recognized":[27],"mouse":[28],"model":[29],"for":[30,192],"human":[31,148],"cancer,":[33],"elucidate":[36],"possible":[37],"mechanisms":[38],"involved":[39],"inhibitory":[42,87],"action":[43],"active":[46],"constituent.":[47],"We":[48],"found":[49],"that":[50,198],"p.o.":[51,105],"administration":[52,106,118],"EGCG":[54,108,120,153,191,199],"at":[55,77,158],"doses":[56],"0.08%":[58],"or":[59,72,155],"0.16%":[60],"drinking":[62,83],"fluid":[63,84],"significantly":[64],"decreased":[65,128,184],"small":[66,95,142],"tumor":[68],"formation":[69],"by":[70,104,167],"37%":[71],"47%,":[73],"respectively,":[74],"whereas":[75],"caffeine":[76],"dose":[79,111],"0.044%":[81],"had":[85],"no":[86],"activity":[88],"against":[89],"tumorigenesis.":[91],"In":[92],"another":[93],"experiment,":[94],"inhibited":[99,201],"dose-dependent":[102],"manner":[103],"range":[112],"0.02%":[114],"0.32%.":[116],"P.o.":[117],"resulted":[121],"increased":[123,162],"levels":[124,129,164],"E-cadherin":[126,166],"nuclear":[131,218],"beta-catenin,":[132],"c-Myc,":[133],"phospho-Akt,":[134],"phospho-extracellular":[136],"signal-regulated":[137],"kinase":[138],"1/2":[139],"(ERK1/2)":[140],"tumors.":[144],"Treatment":[145],"HT29":[147],"colon":[149],"cancer":[150],"cells":[151],"with":[152],"(12.5":[154],"20":[156],"micromol/L":[157,190],"different":[159],"times)":[160],"also":[161],"protein":[163],"27%":[168],"58%,":[170],"induced":[171],"translocation":[173],"beta-catenin":[175,219],"from":[176],"nucleus":[177],"cytoplasm":[179],"plasma":[181],"membrane,":[182],"c-Myc":[185],"cyclin":[187],"D1":[188],"(20":[189],"24":[193],"hours).":[194],"These":[195],"results":[196],"indicate":[197],"effectively":[200],"possibly":[207],"through":[208],"attenuation":[210],"carcinogenic":[213],"events,":[214],"which":[215],"include":[216],"aberrant":[217],"activated":[221],"Akt":[222],"ERK":[224],"signaling.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
