{"id":"https://openalex.org/W2139689812","doi":"https://doi.org/10.1128/jvi.79.21.13310-13316.2005","title":"Evolution of Hepatitis Delta Virus RNA Genome following Long-Term Replication in Cell Culture","display_name":"Evolution of Hepatitis Delta Virus RNA Genome following Long-Term Replication in Cell Culture","publication_year":2005,"publication_date":"2005-10-14","ids":{"openalex":"https://openalex.org/W2139689812","doi":"https://doi.org/10.1128/jvi.79.21.13310-13316.2005","mag":"2139689812","pmid":"https://pubmed.ncbi.nlm.nih.gov/16227253","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1262577"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.79.21.13310-13316.2005","doi":"https://doi.org/10.1128/jvi.79.21.13310-13316.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.79.21.13310-13316.2005","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1262577","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023737081","display_name":"Jinhong Chang","orcid":"https://orcid.org/0000-0002-6723-494X","observed_orcids":["https://orcid.org/0000-0002-6723-494X"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinhong Chang","raw_affiliation_strings":["Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065074773","display_name":"Severin O. Gudima","orcid":"https://orcid.org/0000-0003-3824-8952","observed_orcids":["https://orcid.org/0000-0003-3824-8952"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Severin O. Gudima","raw_affiliation_strings":["Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088766033","display_name":"John M. Taylor","orcid":"https://orcid.org/0000-0002-4275-077X","observed_orcids":["https://orcid.org/0000-0002-4275-077X"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Taylor","raw_affiliation_strings":["Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1289437631"],"apc_list":null,"apc_paid":null,"fwci":2.3893,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.88502287,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"79","issue":"21","first_page":"13310","last_page":"13316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.028599999845027924,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-delta-virus","display_name":"hepatitis delta virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nucleotide-substitution","display_name":"nucleotide substitution","score":0.7160000205039978},{"id":"https://openalex.org/keywords/adenosine-deaminase","display_name":"adenosine deaminase","score":0.953000009059906},{"id":"https://openalex.org/keywords/neutral-evolution","display_name":"neutral evolution","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8833107352256775},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6617476344108582},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6283539533615112},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5315710306167603},{"id":"https://openalex.org/C21786251","wikidata":"https://www.wikidata.org/wiki/Q14886350","display_name":"RNA editing","level":4,"score":0.5138269066810608},{"id":"https://openalex.org/C144001008","wikidata":"https://www.wikidata.org/wiki/Q458226","display_name":"Helper virus","level":4,"score":0.49366793036460876},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.49326270818710327},{"id":"https://openalex.org/C58337764","wikidata":"https://www.wikidata.org/wiki/Q976651","display_name":"Origin of replication","level":4,"score":0.4836072027683258},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4507635831832886},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.4271901845932007},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33277738094329834},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33028218150138855},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.25981026887893677},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003698","descriptor_name":"Hepatitis Delta Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003698","descriptor_name":"Hepatitis Delta Virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.79.21.13310-13316.2005","doi":"https://doi.org/10.1128/jvi.79.21.13310-13316.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.79.21.13310-13316.2005","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1262577","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1262577","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:16227253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16227253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.324.7037","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.324.7037","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jvi.asm.org/content/79/21/13310.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1262577","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1262577","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3253785729","display_name":null,"funder_award_id":"AI-26522","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4038086905","display_name":"Structure and Replication of Hepatitis Delta Virus","funder_award_id":"R01AI026522","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000027172","display_name":null,"funder_award_id":"CA-06927","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000285491","display_name":"Comprehensive Cancer Center Program at Fox Chase","funder_award_id":"P30CA006927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G921727105","display_name":null,"funder_award_id":"CA06927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W756058222","https://openalex.org/W1489870681","https://openalex.org/W1532982349","https://openalex.org/W1585582285","https://openalex.org/W1597496822","https://openalex.org/W1608621108","https://openalex.org/W1799645680","https://openalex.org/W1938880095","https://openalex.org/W1946946449","https://openalex.org/W1996322944","https://openalex.org/W1998961564","https://openalex.org/W1999148628","https://openalex.org/W2000174554","https://openalex.org/W2006076593","https://openalex.org/W2020769208","https://openalex.org/W2028509576","https://openalex.org/W2041784112","https://openalex.org/W2047808466","https://openalex.org/W2068393381","https://openalex.org/W2078762639","https://openalex.org/W2096558833","https://openalex.org/W2102785551","https://openalex.org/W2108670087","https://openalex.org/W2110403176","https://openalex.org/W2114837212","https://openalex.org/W2115465004","https://openalex.org/W2117498376","https://openalex.org/W2130123901","https://openalex.org/W2131136045","https://openalex.org/W2131753705","https://openalex.org/W2132982999","https://openalex.org/W2142391696","https://openalex.org/W2149458214","https://openalex.org/W2152575791","https://openalex.org/W2156945424","https://openalex.org/W2157441620","https://openalex.org/W2164587376","https://openalex.org/W2165457619"],"related_works":["https://openalex.org/W162259529","https://openalex.org/W2150109400","https://openalex.org/W1497883188","https://openalex.org/W1938880095","https://openalex.org/W2053751955","https://openalex.org/W4300923088","https://openalex.org/W2557674991","https://openalex.org/W2131959860","https://openalex.org/W7097102492","https://openalex.org/W2028625367"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"have":[2],"defined":[3],"a":[4,11,24,36,104],"novel":[5],"cell":[6],"culture":[7],"system":[8],"in":[9,186,210,221],"which":[10],"modified":[12],"RNA":[13,75,85,130,193],"genome":[14,86,201,232],"of":[15,27,42,52,66,79,83,100,107,128,141,156,173,180,223,229,238],"hepatitis":[16],"delta":[17,48],"virus":[18],"(HDV)":[19],"is":[20,54,205],"able":[21],"to":[22,56,152,168,198,207,233],"maintain":[23],"low":[25],"level":[26],"continuous":[28],"replication":[29,53,181,187],"for":[30,44,90],"at":[31,119],"least":[32,120],"1":[33,77,178],"year,":[34],"using":[35],"separate":[37],"and":[38,94,148],"limited":[39],"DNA-directed":[40],"source":[41],"mRNA":[43],"the":[45,67,73,84,116,126,142,145,154,171,174,189,200,214,227,230],"essential":[46],"small":[47],"protein.":[49],"This":[50],"mode":[51],"analogous":[55],"that":[57,70,170,195],"used":[58,167,197],"by":[59,132],"plant":[60],"viroids.":[61],"An":[62],"examination":[63],"was":[64,87,97,166,196],"made":[65],"nucleotide":[68],"changes":[69,217],"accumulated":[71],"on":[72,137,226],"HDV":[74,192,231],"during":[76,158],"year":[78,179],"replication.":[80,202,239],"The":[81,139],"length":[82],"maintained,":[88],"except":[89],"some":[91],"single-nucleotide":[92,101,146,216],"deletions":[93],"insertions.":[95],"There":[96],"an":[98,133,162],"abundance":[99],"substitutions,":[102],"with":[103,124],"22-fold":[105],"excess":[106],"these":[108],"being":[109,125],"base":[110],"transitions":[111],"rather":[112],"than":[113],"transversions.":[114],"Of":[115],"detected":[117],"transitions,":[118],"70%":[121],"were":[122,182,218],"consistent":[123],"consequences":[127],"posttranscriptional":[129],"editing":[131],"adenosine":[134],"deaminase":[135],"acting":[136],"RNA.":[138],"remainder":[140],"changes,":[143],"including":[144],"insertions":[147],"deletions,":[149],"are":[150],"likely":[151],"be":[153],"consequence":[155],"misincorporation":[157],"transcription.":[159],"In":[160],"addition,":[161],"intermolecular":[163],"competition":[164],"assay":[165],"show":[169],"majority":[172],"genomes":[175],"present":[176],"after":[177],"essentially":[183,219],"as":[184,188],"competent":[185],"original":[190],"single":[191],"sequence":[194],"initiate":[199],"A":[203],"model":[204],"provided":[206],"explain":[208],"how,":[209],"this":[211],"experimental":[212],"system,":[213],"observed":[215],"neutral":[220],"terms":[222],"their":[224],"effect":[225],"ability":[228],"carry":[234],"out":[235],"continued":[236],"rounds":[237]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}