{"id":"https://openalex.org/W2139686528","doi":"https://doi.org/10.1186/1745-6215-14-101","title":"Ondansetron and simvastatin added to treatment as usual in patients with schizophrenia: study protocol for a randomized controlled trial","display_name":"Ondansetron and simvastatin added to treatment as usual in patients with schizophrenia: study protocol for a randomized controlled trial","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2139686528","doi":"https://doi.org/10.1186/1745-6215-14-101","mag":"2139686528","pmid":"https://pubmed.ncbi.nlm.nih.gov/23782463","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3680972"},"language":"en","primary_location":{"id":"doi:10.1186/1745-6215-14-101","doi":"https://doi.org/10.1186/1745-6215-14-101","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1745-6215-14-101","pdf_url":"https://trialsjournal.biomedcentral.com/track/pdf/10.1186/1745-6215-14-101","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://trialsjournal.biomedcentral.com/track/pdf/10.1186/1745-6215-14-101","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047579218","display_name":"Imran Bashir Chaudhry","orcid":"https://orcid.org/0000-0003-4028-1831","observed_orcids":["https://orcid.org/0000-0003-4028-1831","https://orcid.org/0000-0001-7493-7515"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Imran B Chaudhry","raw_affiliation_strings":["University of Manchester and Lancashire Care Early Intervention Service, The Mount Whalley Road, Accrington BB5 5DE, UK. imran.chaudhry@manchester.ac.uk","University of Manchester and Lancashire Care Early Intervention Service, Accrington, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Manchester and Lancashire Care Early Intervention Service, The Mount Whalley Road, Accrington BB5 5DE, UK. imran.chaudhry@manchester.ac.uk","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"University of Manchester and Lancashire Care Early Intervention Service, Accrington, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019095577","display_name":"Nusrat Husain","orcid":"https://orcid.org/0000-0002-9493-0721","observed_orcids":["https://orcid.org/0000-0002-9493-0721"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nusrat Husain","raw_affiliation_strings":["University of Manchester and Lancashire Care Early Intervention Service, The Mount Whalley Road, Accrington, BB5 5DE, UK","University of Manchester and Lancashire Care Early Intervention Service, Accrington, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Manchester and Lancashire Care Early Intervention Service, The Mount Whalley Road, Accrington, BB5 5DE, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"University of Manchester and Lancashire Care Early Intervention Service, Accrington, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113829078","display_name":"Mohammad Omair Husain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mohammad O Husain","raw_affiliation_strings":["St Georges University, Cranmer Terrace, London, SW 17 ORE, UK","St Georges University London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Georges University, Cranmer Terrace, London, SW 17 ORE, UK","institution_ids":["https://openalex.org/I165862685"]},{"raw_affiliation_string":"St Georges University London, UK","institution_ids":["https://openalex.org/I165862685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055285583","display_name":"Jamie Hallak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jamie Hallak","raw_affiliation_strings":["University of San Paulo, Rua da praca Relogio, 109 Sao Paulo, BR, 05508-900, Brazil","University of San Paulo, Rua da praca Relogio, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of San Paulo, Rua da praca Relogio, 109 Sao Paulo, BR, 05508-900, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"University of San Paulo, Rua da praca Relogio, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080581341","display_name":"Richard Drake","orcid":"https://orcid.org/0000-0003-0220-4835","observed_orcids":["https://orcid.org/0000-0003-0220-4835"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Drake","raw_affiliation_strings":["University of Manchester and Lancashire Care Early Intervention Service, The Mount Whalley Road, Accrington, BB5 5DE, UK","University of Manchester and Lancashire Care Early Intervention Service, Accrington, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Manchester and Lancashire Care Early Intervention Service, The Mount Whalley Road, Accrington, BB5 5DE, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"University of Manchester and Lancashire Care Early Intervention Service, Accrington, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111947476","display_name":"Ajmal Kazmi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ajmal Kazmi","raw_affiliation_strings":["KPT and Karwan e Hyat \u201cPsychiatric Care and Rehabilitation Cent34 (PCRC)\u201d Near KPT hospital, Keamari, Karachi, Pakistan","KPT and Karwan e Hyat \u201cPsychiatric Care and Rehabilitation Cent34 (PCRC)\u201d Near KPT hospital, Keamari, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KPT and Karwan e Hyat \u201cPsychiatric Care and Rehabilitation Cent34 (PCRC)\u201d Near KPT hospital, Keamari, Karachi, Pakistan","institution_ids":[]},{"raw_affiliation_string":"KPT and Karwan e Hyat \u201cPsychiatric Care and Rehabilitation Cent34 (PCRC)\u201d Near KPT hospital, Keamari, Pakistan","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Raza ur Rahman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39727005","display_name":"Dow University of Health Sciences","ror":"https://ror.org/01h85hm56","country_code":"PK","type":"education","lineage":["https://openalex.org/I39727005"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Raza ur Rahman","raw_affiliation_strings":["Dow University of Health Sciences, Baba-E-Urdu Road, Karachi, 74200, Pakistan","Dow University of Health Sciences, Karachi Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dow University of Health Sciences, Baba-E-Urdu Road, Karachi, 74200, Pakistan","institution_ids":["https://openalex.org/I39727005"]},{"raw_affiliation_string":"Dow University of Health Sciences, Karachi Pakistan","institution_ids":["https://openalex.org/I39727005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110123719","display_name":"Munir M. Hamirani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801788457","display_name":"Abbasi Shaheed Hospital","ror":"https://ror.org/02b72da46","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I2801788457"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Mohammad M Hamirani","raw_affiliation_strings":["Abbassi Shaheed Hospital, Block M, North Nazimabad, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbassi Shaheed Hospital, Block M, North Nazimabad, Karachi, Pakistan","institution_ids":["https://openalex.org/I2801788457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109592552","display_name":"Tayyaba Kiran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148250","display_name":"Pakistan Institute of Learning and Living","ror":"https://ror.org/046aqw930","country_code":"PK","type":"other","lineage":["https://openalex.org/I4210148250"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Tayyaba Kiran","raw_affiliation_strings":["Pakistan Institute of Learning & Living, D-9, Block I, Northnazimabad, Karachi, 74700, Pakistan","Pakistan Institute of Learning & Living, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pakistan Institute of Learning & Living, D-9, Block I, Northnazimabad, Karachi, 74700, Pakistan","institution_ids":["https://openalex.org/I4210148250"]},{"raw_affiliation_string":"Pakistan Institute of Learning & Living, Karachi, Pakistan","institution_ids":["https://openalex.org/I4210148250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089682497","display_name":"Nasir Mehmood","orcid":"https://orcid.org/0000-0002-0229-7966","observed_orcids":["https://orcid.org/0000-0002-0229-7966"]},"institutions":[{"id":"https://openalex.org/I4210148250","display_name":"Pakistan Institute of Learning and Living","ror":"https://ror.org/046aqw930","country_code":"PK","type":"other","lineage":["https://openalex.org/I4210148250"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Nasir Mehmood","raw_affiliation_strings":["Pakistan Institute of Learning & Living, D-9, Block I, Northnazimabad, Karachi, 74700, Pakistan","Pakistan Institute of Learning & Living, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pakistan Institute of Learning & Living, D-9, Block I, Northnazimabad, Karachi, 74700, Pakistan","institution_ids":["https://openalex.org/I4210148250"]},{"raw_affiliation_string":"Pakistan Institute of Learning & Living, Karachi, Pakistan","institution_ids":["https://openalex.org/I4210148250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116034334","display_name":"John Stirling","orcid":"https://orcid.org/0000-0003-1189-8306","observed_orcids":["https://orcid.org/0000-0003-1189-8306"]},"institutions":[{"id":"https://openalex.org/I11983389","display_name":"Manchester Metropolitan University","ror":"https://ror.org/02hstj355","country_code":"GB","type":"education","lineage":["https://openalex.org/I11983389"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Stirling","raw_affiliation_strings":["Manchester Metropolitan University, All Saints Building, All Saints, Manchester, M15 6BH, UK","Manchester Metropolitan University, All Saints, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Manchester Metropolitan University, All Saints Building, All Saints, Manchester, M15 6BH, UK","institution_ids":["https://openalex.org/I11983389"]},{"raw_affiliation_string":"Manchester Metropolitan University, All Saints, UK","institution_ids":["https://openalex.org/I11983389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002936880","display_name":"Graham Dunn","orcid":"https://orcid.org/0000-0001-7091-3161","observed_orcids":["https://orcid.org/0000-0001-7091-3161"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Graham Dunn","raw_affiliation_strings":["University of Manchester and Lancashire Care Early Intervention Service, The Mount Whalley Road, Accrington, BB5 5DE, UK","University of Manchester and Lancashire Care Early Intervention Service, Accrington, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Manchester and Lancashire Care Early Intervention Service, The Mount Whalley Road, Accrington, BB5 5DE, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"University of Manchester and Lancashire Care Early Intervention Service, Accrington, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009512673","display_name":"J.F.W. Deakin","orcid":"https://orcid.org/0000-0002-2750-962X","observed_orcids":["https://orcid.org/0000-0002-2750-962X"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bill Deakin","raw_affiliation_strings":["University of Manchester and Lancashire Care Early Intervention Service, The Mount Whalley Road, Accrington, BB5 5DE, UK","University of Manchester and Lancashire Care Early Intervention Service, Accrington, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Manchester and Lancashire Care Early Intervention Service, The Mount Whalley Road, Accrington, BB5 5DE, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"University of Manchester and Lancashire Care Early Intervention Service, Accrington, UK","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5047579218"],"corresponding_institution_ids":["https://openalex.org/I28407311"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.5748,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.66339967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"14","issue":"1","first_page":"101","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ondansetron","display_name":"ondansetron","score":0.8899999856948853},{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":1.0},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.996999979019165},{"id":"https://openalex.org/keywords/negative-symptoms","display_name":"negative symptoms","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8029999732971191},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.8149999976158142},{"id":"https://openalex.org/keywords/adjunctive-pharmacotherapy","display_name":"adjunctive pharmacotherapy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/5-ht3-receptor-antagonists","display_name":"5-HT3 receptor antagonists","score":0.8240000009536743},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9520000219345093},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8550000190734863},{"id":"https://openalex.org/keywords/schizoaffective-disorder","display_name":"schizoaffective disorder","score":0.9509999752044678},{"id":"https://openalex.org/keywords/psychosis","display_name":"psychosis","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2777170512","wikidata":"https://www.wikidata.org/wiki/Q410011","display_name":"Ondansetron","level":3,"score":0.8714338541030884},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8065477609634399},{"id":"https://openalex.org/C2780325297","wikidata":"https://www.wikidata.org/wiki/Q834047","display_name":"Schizoaffective disorder","level":3,"score":0.5592745542526245},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5563461184501648},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.5288903117179871},{"id":"https://openalex.org/C2779419675","wikidata":"https://www.wikidata.org/wiki/Q416632","display_name":"Nefazodone","level":5,"score":0.47958245873451233},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4648092985153198},{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.417868971824646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3990338444709778},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.3901948928833008},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.30405300855636597},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.28743916749954224},{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.211978018283844},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.1212766170501709},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001938","descriptor_name":"Brazil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002985","descriptor_name":"Clinical Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010154","descriptor_name":"Pakistan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012565","descriptor_name":"Schizophrenic Psychology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017294","descriptor_name":"Ondansetron","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017294","descriptor_name":"Ondansetron","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017294","descriptor_name":"Ondansetron","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D057189","descriptor_name":"Checklist","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1745-6215-14-101","doi":"https://doi.org/10.1186/1745-6215-14-101","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1745-6215-14-101","pdf_url":"https://trialsjournal.biomedcentral.com/track/pdf/10.1186/1745-6215-14-101","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2677768","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3680972","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:23782463","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23782463","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3680972","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3680972/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/4c9b9e3b-68ac-42e1-9023-76439f005e60","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/4c9b9e3b-68ac-42e1-9023-76439f005e60","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chaudhry, I, Husain, N, Husain, M O, Hallak, J, Drake, R, Kazmi, A, Rahman, R U, Hamirani, M M, Kiran, T, Mehmood, N, Stirling, J, Dunn, G, Deakin, B & Haggis, B 2013, 'Ondansetron and simvastatin added to treatment as usual in patients with schizophrenia: study protocol for a randomized controlled trial.', Trials, vol. 14, 101. https://doi.org/10.1186/1745-6215-14-101","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.60692/1h7s7-enx61","doi":"https://doi.org/10.60692/1h7s7-enx61","is_oa":true,"landing_page_url":"https://doi.org/10.60692/1h7s7-enx61","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/7dp4v-qb240","doi":"https://doi.org/10.60692/7dp4v-qb240","is_oa":true,"landing_page_url":"https://doi.org/10.60692/7dp4v-qb240","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/1745-6215-14-101","doi":"https://doi.org/10.1186/1745-6215-14-101","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1745-6215-14-101","pdf_url":"https://trialsjournal.biomedcentral.com/track/pdf/10.1186/1745-6215-14-101","source":{"id":"https://openalex.org/S109512841","display_name":"Trials","issn_l":"1745-6215","issn":["1745-6215"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trials","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/study-protocol","display_name":"Study Protocol"}],"awards":[{"id":"https://openalex.org/G4501718753","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0509-10229","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320309530","display_name":"Stanley Medical Research Institute","ror":"https://ror.org/01pj5nn22"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139686528.pdf","grobid_xml":"https://content.openalex.org/works/W2139686528.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W936667257","https://openalex.org/W1595667478","https://openalex.org/W1978508380","https://openalex.org/W2010407531","https://openalex.org/W2020773530","https://openalex.org/W2024555504","https://openalex.org/W2030396834","https://openalex.org/W2039733943","https://openalex.org/W2050038709","https://openalex.org/W2059922970","https://openalex.org/W2068011539","https://openalex.org/W2068144727","https://openalex.org/W2072102207","https://openalex.org/W2130326256","https://openalex.org/W2140606211","https://openalex.org/W2149639459","https://openalex.org/W2327612061","https://openalex.org/W2500007653","https://openalex.org/W2520316538"],"related_works":["https://openalex.org/W2134599331","https://openalex.org/W2064015823","https://openalex.org/W4402288570","https://openalex.org/W4380853986","https://openalex.org/W3213916632","https://openalex.org/W649430973","https://openalex.org/W2237070820","https://openalex.org/W7149889067","https://openalex.org/W2898314338","https://openalex.org/W2096889872"],"abstract_inverted_index":{"BACKGROUND:":[0],"Negative":[1],"symptoms":[2,106,271,291],"and":[3,21,47,62,83,175,181,193,200,207,262],"cognitive":[4],"deficits":[5],"are":[6,51,63],"two":[7,113],"partially-related":[8],"features":[9],"of":[10,24,107,122,162,267,279,287,295],"schizophrenia":[11,46],"which":[12],"have":[13,29,42,55,93,250,254],"a":[14,73,112,148,160,171,173,268],"major":[15,48],"negative":[16,201,290],"impact":[17,31],"on":[18,32],"social":[19],"function":[20],"objective":[22],"quality":[23],"life.":[25],"Standard":[26],"drug":[27,102],"treatments":[28,249],"little":[30],"either.":[33],"There":[34,168],"is":[35,72,97,111,282],"some":[36,255,265],"evidence":[37,266],"that":[38,54,95],"anti-inflammatory":[39,60],"treatment":[40,128,274,300],"may":[41],"beneficial":[43,256],"effects":[44,209,257],"in":[45,85,103,156,242,258,270,289],"depression.":[49],"Statins":[50],"cholesterol-lowering":[52],"agents":[53,61],"been":[56,251],"found":[57],"to":[58,66,80,127,232,253,273,283,299],"be":[59,147,170,185,212,220,230,240],"also":[64],"known":[65],"decrease":[67],"C-reactive":[68],"protein":[69],"(CRP).":[70],"Ondansetron":[71,238],"serotonin":[74],"(5-HT3)":[75],"receptor":[76],"antagonist":[77],"widely":[78],"used":[79],"prevent":[81],"nausea":[82],"vomiting":[84],"patients":[86,132,155,164],"receiving":[87],"chemotherapy":[88],"for":[89,131],"cancer.":[90],"Small":[91],"studies":[92],"suggested":[94],"ondansetron":[96,123,263,296],"effective":[98],"as":[99,129,275,301],"an":[100,243],"adjunct":[101],"improving":[104],"the":[105,198,285,293],"schizophrenia.":[108,259],"METHODS/DESIGN:":[109],"This":[110,145],"center,":[114],"six-month,":[115],"double-blind":[116],"placebo":[117],"controlled,":[118],"factorial":[119],"design":[120],"study":[121,281],"and/or":[124,297],"simvastatin":[125,261,298],"added":[126],"usual":[130],"suffering":[133],"from":[134],"schizophrenia,":[135],"schizoaffective":[136],"disorder,":[137],"psychosis":[138],"not":[139],"otherwise":[140],"specified":[141],"or":[142],"schizophreniform":[143],"disorder.":[144],"will":[146,169,184,211,219,229,239],"2":[149,151],"\u00d7":[150],"design,":[152],"with":[153,292],"54":[154],"each":[157],"cell,":[158],"giving":[159],"total":[161],"216":[163],"over":[165],"three":[166],"years.":[167],"screening,":[172],"randomization":[174],"seven":[176],"follow-up":[177],"visits.":[178],"Full":[179],"clinical":[180],"neurocognitive":[182],"assessments":[183],"carried":[186,213],"out":[187,214],"at":[188,194,215,222],"baseline":[189],"(randomization),":[190],"14":[191],"weeks":[192],"26":[195],"weeks,":[196],"while":[197],"positive":[199],"syndrome":[202],"scale":[203],"(PANSS),":[204],"pill":[205],"count":[206],"side":[208],"checklist":[210],"every":[216],"visit.":[217],"Simvastatin":[218],"started":[221],"20":[223],"mg":[224,234,245],"once":[225],"daily":[226],"(OD),":[227],"this":[228,280],"increased":[231],"40":[233],"after":[235],"four":[236],"weeks.":[237],"administered":[241],"8":[244],"dose.":[246],"DISCUSSION:":[247],"Anti-inflammatory":[248],"shown":[252],"Both":[260],"provide":[264],"reduction":[269],"compared":[272],"usual.":[276,302],"The":[277],"aim":[278],"establish":[284],"degree":[286],"improvement":[288],"addition":[294],"TRIAL":[303],"REGISTRATION:":[304],"[corrected]":[305],"ClinicalTrials.gov":[306],"NCT01602029.":[307]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}