{"id":"https://openalex.org/W2139684832","doi":"https://doi.org/10.1002/biof.552210127","title":"Regulation of interleukin\u20108 secretion in human intestinal epithelial Caco\u20102 cells by \u03b1\u2010humulene","display_name":"Regulation of interleukin\u20108 secretion in human intestinal epithelial Caco\u20102 cells by \u03b1\u2010humulene","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2139684832","doi":"https://doi.org/10.1002/biof.552210127","mag":"2139684832","pmid":"https://pubmed.ncbi.nlm.nih.gov/15630185"},"language":"en","primary_location":{"id":"doi:10.1002/biof.552210127","doi":"https://doi.org/10.1002/biof.552210127","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biof.552210127","pdf_url":null,"source":{"id":"https://openalex.org/S75531928","display_name":"BioFactors","issn_l":"0951-6433","issn":["0951-6433","1872-8081"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioFactors","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072336031","display_name":"Hideo Satsu","orcid":"https://orcid.org/0000-0003-3912-7554","observed_orcids":["https://orcid.org/0000-0003-3912-7554"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hideo Satsu","raw_affiliation_strings":["Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. asatsu@mail.ecc.u-tokyo.ac.jp","Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. asatsu@mail.ecc.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan,","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102824401","display_name":"Tomoko Matsuda","orcid":"https://orcid.org/0000-0001-9426-2973","observed_orcids":["https://orcid.org/0000-0001-9426-2973"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Matsuda","raw_affiliation_strings":["Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015850496","display_name":"Takayuki Toshimitsu","orcid":"https://orcid.org/0000-0003-0506-4743","observed_orcids":["https://orcid.org/0000-0003-0506-4743"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Toshimitsu","raw_affiliation_strings":["Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061716797","display_name":"Akira Mori","orcid":"https://orcid.org/0000-0002-8422-1198","observed_orcids":["https://orcid.org/0000-0002-8422-1198"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Mori","raw_affiliation_strings":["Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110795388","display_name":"Tatsumasa Mae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131637","display_name":"Kaneka (Japan)","ror":"https://ror.org/038ckz871","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210131637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsumasa Mae","raw_affiliation_strings":["Kaneka Co. Ltd., 1\u20138 Miyamae-machi, Takasago-cho, Takasago, Hyogo 676\u20138688, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaneka Co. Ltd., 1\u20138 Miyamae-machi, Takasago-cho, Takasago, Hyogo 676\u20138688, Japan","institution_ids":["https://openalex.org/I4210131637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069633558","display_name":"Misuzu Tsukagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131637","display_name":"Kaneka (Japan)","ror":"https://ror.org/038ckz871","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210131637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Misuzu Tsukagawa","raw_affiliation_strings":["Kaneka Co. Ltd., 1\u20138 Miyamae-machi, Takasago-cho, Takasago, Hyogo 676\u20138688, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaneka Co. Ltd., 1\u20138 Miyamae-machi, Takasago-cho, Takasago, Hyogo 676\u20138688, Japan","institution_ids":["https://openalex.org/I4210131637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079704856","display_name":"Mikio Kitahara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131637","display_name":"Kaneka (Japan)","ror":"https://ror.org/038ckz871","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210131637"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mikio Kitahara","raw_affiliation_strings":["Kaneka Co. Ltd., 1\u20138 Miyamae-machi, Takasago-cho, Takasago, Hyogo 676\u20138688, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaneka Co. Ltd., 1\u20138 Miyamae-machi, Takasago-cho, Takasago, Hyogo 676\u20138688, Japan","institution_ids":["https://openalex.org/I4210131637"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024068935","display_name":"Makoto Shimizu","orcid":"https://orcid.org/0000-0003-0467-9594","observed_orcids":["https://orcid.org/0000-0003-0467-9594"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Shimizu","raw_affiliation_strings":["Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1\u20131\u20131 Yayoi, Bunkyo-ku, Tokyo 113\u20138657, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072336031"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.1589,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.76885147,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"1-4","first_page":"137","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13798","display_name":"Hops Chemistry and Applications","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13798","display_name":"Hops Chemistry and Applications","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9279999732971191},{"id":"https://openalex.org/keywords/alpha-humulene","display_name":"\u03b1-humulene","score":0.9919999837875366},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.828000009059906},{"id":"https://openalex.org/keywords/peppermint","display_name":"peppermint","score":0.9520000219345093},{"id":"https://openalex.org/keywords/food-derived-compounds","display_name":"food-derived compounds","score":0.703000009059906},{"id":"https://openalex.org/keywords/il-8-mrna-expression","display_name":"IL-8 mRNA expression","score":0.8880000114440918},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.8283908367156982},{"id":"https://openalex.org/C2777291603","wikidata":"https://www.wikidata.org/wiki/Q1995108","display_name":"Humulene","level":3,"score":0.5670176148414612},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5362343788146973},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47603514790534973},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.4554235339164734},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4411105513572693},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43904542922973633},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.36867713928222656},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34569352865219116},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3446264863014221},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33706480264663696},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3235214054584503},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23817014694213867},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.23662543296813965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17795592546463013},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.08274120092391968},{"id":"https://openalex.org/C2777278459","wikidata":"https://www.wikidata.org/wiki/Q170885","display_name":"Essential oil","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000081222","descriptor_name":"Monocyclic Sesquiterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005504","descriptor_name":"Food Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/biof.552210127","doi":"https://doi.org/10.1002/biof.552210127","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biof.552210127","pdf_url":null,"source":{"id":"https://openalex.org/S75531928","display_name":"BioFactors","issn_l":"0951-6433","issn":["0951-6433","1872-8081"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioFactors","raw_type":"journal-article"},{"id":"pmid:15630185","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15630185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioFactors (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1530019568","https://openalex.org/W1780460389","https://openalex.org/W2018136584","https://openalex.org/W2055921251","https://openalex.org/W2079968415","https://openalex.org/W4296792904"],"related_works":["https://openalex.org/W1640670825","https://openalex.org/W2568755663","https://openalex.org/W2078270207","https://openalex.org/W2055996728","https://openalex.org/W2093566767","https://openalex.org/W1589696729","https://openalex.org/W2075287426","https://openalex.org/W2033247222","https://openalex.org/W2138659919","https://openalex.org/W2095243418"],"abstract_inverted_index":{"It":[0],"is":[1,43,159],"well":[2],"known":[3,93],"that":[4,25,126,152],"various":[5],"cytokines":[6,27,42],"such":[7,115],"as":[8,119],"interleukin-8":[9],"(IL-8)":[10],"and":[11,18,24,78,83,99],"tumor":[12],"necrosis":[13],"factor-alpha":[14],"(TNF-alpha":[15],"are":[16],"expressed":[17],"secreted":[19],"from":[20],"intestinal":[21,34,65],"epithelial":[22,35,66],"cells":[23,31],"these":[26,41],"affect":[28],"the":[29,33,38,59,79,87,91,104,112,127,153,162],"immune":[30],"beneath":[32],"monolayers.":[36],"As":[37],"secretion":[39,60,113,154],"of":[40,61,81,114,129,139,155],"likely":[44],"to":[45,94],"be":[46,95],"regulated":[47,160],"by":[48,145,157],"food-derived":[49],"substances,":[50],"we":[51],"focused":[52],"on":[53,111],"those":[54],"food":[55,70],"substances":[56],"which":[57],"regulate":[58],"IL-8":[62,88,105,134,140,156],"in":[63,97],"human":[64],"Caco-2":[67],"cells.":[68],"72":[69],"samples":[71],"extracted":[72],"with":[73,147],"40%":[74],"ethanol":[75],"were":[76],"tested,":[77],"extracts":[80],"peppermint":[82,98],"dokudami":[84],"significantly":[85,143],"increased":[86,103,144],"secretion.":[89,135],"Among":[90],"compounds":[92],"contained":[96],"dokudami,":[100],"alpha-humulene":[101,130,158],"substantially":[102],"secretion.alpha-Humulene":[106],"had":[107],"no":[108],"significant":[109],"effect":[110,128],"other":[116],"soluble":[117],"factors":[118],"TNF-alpha,":[120],"IL-1beta,":[121],"IL-6,":[122],"or":[123],"NGF,":[124],"suggesting":[125],"was":[131,142],"specific":[132],"for":[133],"The":[136],"expression":[137],"level":[138],"mRNA":[141],"treating":[146],"alpha-humulene.":[148],"These":[149],"results":[150],"suggest":[151],"at":[161],"transcriptional":[163],"level.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}