{"id":"https://openalex.org/W2139673280","doi":"https://doi.org/10.1186/1745-6673-5-29","title":"Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines","display_name":"Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines","publication_year":2010,"publication_date":"2010-10-27","ids":{"openalex":"https://openalex.org/W2139673280","doi":"https://doi.org/10.1186/1745-6673-5-29","mag":"2139673280","pmid":"https://pubmed.ncbi.nlm.nih.gov/20979644","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2987375"},"language":"en","primary_location":{"id":"doi:10.1186/1745-6673-5-29","doi":"https://doi.org/10.1186/1745-6673-5-29","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1745-6673-5-29","pdf_url":"https://occup-med.biomedcentral.com/counter/pdf/10.1186/1745-6673-5-29","source":{"id":"https://openalex.org/S61677374","display_name":"Journal of Occupational Medicine and Toxicology","issn_l":"1745-6673","issn":["1745-6673"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Occupational Medicine and Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://occup-med.biomedcentral.com/counter/pdf/10.1186/1745-6673-5-29","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016162562","display_name":"C\u00e9line Gasnier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9line Gasnier","raw_affiliation_strings":["Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France. criigen@unicaen.fr","Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France. criigen@unicaen.fr","institution_ids":["https://openalex.org/I98702875"]},{"raw_affiliation_string":"Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France","institution_ids":["https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063020426","display_name":"Nora B\u00e9nachour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nora Benachour","raw_affiliation_strings":["CRIIGEN and Risk Pole MRSH, CNRS, University of Caen, 14032, France","Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRIIGEN and Risk Pole MRSH, CNRS, University of Caen, 14032, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I98702875"]},{"raw_affiliation_string":"Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France","institution_ids":["https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091786713","display_name":"Emilie Clair A","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emilie Clair","raw_affiliation_strings":["CRIIGEN and Risk Pole MRSH, CNRS, University of Caen, 14032, France","Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRIIGEN and Risk Pole MRSH, CNRS, University of Caen, 14032, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I98702875"]},{"raw_affiliation_string":"Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France","institution_ids":["https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019732154","display_name":"Carine Travert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Carine Travert","raw_affiliation_strings":["Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France","institution_ids":["https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fr\u00e9d\u00e9ric Langlois","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Langlois","raw_affiliation_strings":["Sevene Pharma, 30170, Monoblet, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sevene Pharma, 30170, Monoblet, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108522923","display_name":"Claire Laurant","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claire Laurant","raw_affiliation_strings":["Sevene Pharma, 30170, Monoblet, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sevene Pharma, 30170, Monoblet, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031882018","display_name":"C\u00e9cile Decroix-Laporte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e9cile Decroix-Laporte","raw_affiliation_strings":["Sevene Pharma, 30170, Monoblet, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sevene Pharma, 30170, Monoblet, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091150707","display_name":"Gilles\u2010\u00c9ric S\u00e9ralini","orcid":"https://orcid.org/0000-0002-1673-1006","observed_orcids":["https://orcid.org/0000-0002-1673-1006","https://orcid.org/0000-0002-4428-5592"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Gilles-Eric S\u00e9ralini","raw_affiliation_strings":["CRIIGEN and Risk Pole MRSH, CNRS, University of Caen, 14032, France","Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRIIGEN and Risk Pole MRSH, CNRS, University of Caen, 14032, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I98702875"]},{"raw_affiliation_string":"Laboratory of Biochemistry EA2608, Institute of Biology, University of Caen, France","institution_ids":["https://openalex.org/I98702875"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091150707"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I98702875"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":3.3947,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.91393826,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"29","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13639","display_name":"Paraquat toxicity studies and treatments","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11180","display_name":"Pesticide and Herbicide Environmental Studies","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glyphosate-based-herbicides","display_name":"glyphosate-based herbicides","score":0.9829999804496765},{"id":"https://openalex.org/keywords/roundup","display_name":"Roundup","score":0.9480000138282776},{"id":"https://openalex.org/keywords/herbicide-adjuvants","display_name":"herbicide adjuvants","score":0.8930000066757202},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.7820000052452087},{"id":"https://openalex.org/keywords/hepatocyte-death","display_name":"hepatocyte death","score":0.6740000247955322},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7170000076293945},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/caspase-3-7-activation","display_name":"caspase-3/7 activation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.859000027179718},{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.9580000042915344},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.8709999918937683},{"id":"https://openalex.org/keywords/medicinal-plant-extracts","display_name":"medicinal plant extracts","score":0.6790000200271606},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.8069999814033508},{"id":"https://openalex.org/keywords/hep3b-cells","display_name":"Hep3B cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/xenobiotic-detoxification","display_name":"xenobiotic detoxification","score":0.6740000247955322},{"id":"https://openalex.org/keywords/pesticide-toxicity","display_name":"pesticide toxicity","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.7138859033584595},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.6687579154968262},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.667837917804718},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.6261081099510193},{"id":"https://openalex.org/C2780910873","wikidata":"https://www.wikidata.org/wiki/Q407232","display_name":"Glyphosate","level":2,"score":0.5386971831321716},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5139610171318054},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5083317160606384},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47898387908935547},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4382888078689575},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43529051542282104},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4281248450279236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38268381357192993},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34308570623397827},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2247067391872406},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1786884069442749},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.15709567070007324},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09613919258117676}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1186/1745-6673-5-29","doi":"https://doi.org/10.1186/1745-6673-5-29","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1745-6673-5-29","pdf_url":"https://occup-med.biomedcentral.com/counter/pdf/10.1186/1745-6673-5-29","source":{"id":"https://openalex.org/S61677374","display_name":"Journal of Occupational Medicine and Toxicology","issn_l":"1745-6673","issn":["1745-6673"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Occupational Medicine and Toxicology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2987375","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2987375","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Occup Med Toxicol","raw_type":"Text"},{"id":"pmid:20979644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20979644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of occupational medicine and toxicology (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.293.1545","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.293.1545","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/64/c0/J_Occup_Med_Toxicol_2010_Oct_27_5_29.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a6da479685b246d596e8e804a048b965","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a6da479685b246d596e8e804a048b965","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Occupational Medicine and Toxicology, Vol 5, Iss 1, p 29 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1745-6673-5-29","doi":"https://doi.org/10.1186/1745-6673-5-29","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1745-6673-5-29","pdf_url":"https://occup-med.biomedcentral.com/counter/pdf/10.1186/1745-6673-5-29","source":{"id":"https://openalex.org/S61677374","display_name":"Journal of Occupational Medicine and Toxicology","issn_l":"1745-6673","issn":["1745-6673"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Occupational Medicine and Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312284","display_name":"Fondation Denis Guichard","ror":"https://ror.org/00c4ykh56"},{"id":"https://openalex.org/F4320329938","display_name":"R\u00e9gion Normandie","ror":"https://ror.org/03cq89j92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139673280.pdf","grobid_xml":"https://content.openalex.org/works/W2139673280.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1581414347","https://openalex.org/W1629179716","https://openalex.org/W1965380529","https://openalex.org/W1967824978","https://openalex.org/W1972934590","https://openalex.org/W1979084622","https://openalex.org/W1980609495","https://openalex.org/W2003082106","https://openalex.org/W2008902243","https://openalex.org/W2011257176","https://openalex.org/W2015758632","https://openalex.org/W2016992017","https://openalex.org/W2024611583","https://openalex.org/W2027299002","https://openalex.org/W2036819659","https://openalex.org/W2037034011","https://openalex.org/W2047957855","https://openalex.org/W2049881395","https://openalex.org/W2050462724","https://openalex.org/W2052006868","https://openalex.org/W2054116878","https://openalex.org/W2060273477","https://openalex.org/W2063424177","https://openalex.org/W2067027699","https://openalex.org/W2070451131","https://openalex.org/W2072585523","https://openalex.org/W2080958300","https://openalex.org/W2084462922","https://openalex.org/W2089780996","https://openalex.org/W2093229118","https://openalex.org/W2094110446","https://openalex.org/W2096364120","https://openalex.org/W2107978933","https://openalex.org/W2110097278","https://openalex.org/W2111903453","https://openalex.org/W2114918609","https://openalex.org/W2118088886","https://openalex.org/W2120475447","https://openalex.org/W2129046210","https://openalex.org/W2133954410","https://openalex.org/W2134236053","https://openalex.org/W2136259692","https://openalex.org/W2140369540","https://openalex.org/W2147373429","https://openalex.org/W2155268095","https://openalex.org/W2163656090","https://openalex.org/W2165731382","https://openalex.org/W2167581965","https://openalex.org/W2168802892","https://openalex.org/W2292753725"],"related_works":["https://openalex.org/W7097565253","https://openalex.org/W7095083805","https://openalex.org/W7095452826","https://openalex.org/W2134236053","https://openalex.org/W2163670032","https://openalex.org/W2506222128","https://openalex.org/W2592231967","https://openalex.org/W7096587821","https://openalex.org/W366874168","https://openalex.org/W1982703807"],"abstract_inverted_index":{"BACKGROUND:":[0],"Worldwide":[1],"used":[2,197],"pesticides":[3,25],"containing":[4],"different":[5,286],"adjuvants":[6,146],"like":[7],"Roundup":[8,39,139,170,179,190,274],"formulations,":[9],"which":[10],"are":[11,26,154,164],"glyphosate-based":[12,83],"herbicides,":[13],"can":[14,296],"provoke":[15,141,278],"some":[16,175,299],"in":[17,21,29,167,198,230,263,281],"vivo":[18],"toxicity":[19],"and":[20,34,65,93,107,113,125,127,174,217,255,258,317],"human":[22,88,301],"cells.":[23],"These":[24],"commonly":[27],"found":[28],"the":[30,131,137],"environment,":[31],"surface":[32],"waters":[33],"as":[35,117,119],"food":[36],"residues":[37],"of":[38,63,79,82,133,238,291],"tolerant":[40],"genetically":[41],"modified":[42],"plants.":[43],"In":[44,245],"order":[45],"to":[46,97,129,204,225,240,277,298],"know":[47],"their":[48,61],"effects":[49,149],"on":[50],"cells":[51],"from":[52],"liver,":[53],"a":[54,205,231,289,311],"major":[55],"detoxification":[56],"organ,":[57],"we":[58,247],"have":[59],"studied":[60,86],"mechanism":[62,132],"action":[64],"possible":[66,181],"protection":[67,114],"by":[68,115,169,178,189,221],"precise":[69],"medicinal":[70,292],"plant":[71,293],"extracts":[72,294],"called":[73],"Dig1.":[74],"METHODS:":[75],"The":[76],"cytotoxicity":[77],"pathways":[78],"four":[80,138],"formulations":[81,140],"herbicides":[84],"were":[85],"using":[87],"hepatic":[89,282],"cell":[90,111,143,228,283,302],"lines":[91,284,303],"HepG2":[92,168],"Hep3B,":[94],"known":[95],"models":[96],"study":[98],"xenobiotic":[99],"effects.":[100],"We":[101],"monitored":[102],"mitochondrial":[103],"succinate":[104],"dehydrogenase":[105],"activity":[106],"caspases":[108,220],"3/7":[109,163,253],"for":[110,313],"mortality":[112],"Dig1,":[116],"well":[118],"cytochromes":[120],"P450":[121],"1A1,":[122],"1A2,":[123],"3A4":[124],"2C9":[126],"glutathione-S-transferase":[128,210],"approach":[130],"actions.":[134],"RESULTS:":[135],"All":[136,307],"liver":[142,315],"death,":[144],"with":[145,183,209,234],"having":[147],"stronger":[148],"than":[150,196],"glyphosate":[151],"alone.":[152],"Hep3B":[153],"3-5":[155],"times":[156,194],"more":[157],"sensitive":[158],"over":[159],"48":[160,243],"h.":[161,244],"Caspases":[162,252],"greatly":[165],"activated":[166],"at":[171,191,285],"non-cytotoxic":[172],"levels,":[173,287],"apoptosis":[176],"induction":[177],"is":[180,186,202,223,275],"together":[182,208],"necrosis.":[184],"CYP3A4":[185,256],"specifically":[187],"enhanced":[188],"doses":[192],"400":[193],"less":[195],"agriculture":[199],"(2%).":[200],"CYP1A2":[201],"increased":[203],"lesser":[206],"extent":[207,300],"(GST)":[211],"down-regulation.":[212],"Dig":[213],"1,":[214],"non":[215],"cytotoxic":[216],"not":[218,259],"inducing":[219],"itself,":[222],"able":[224,276],"prevent":[226],"Roundup-induced":[227],"death":[229],"time-dependant":[232],"manner":[233],"an":[235],"important":[236],"efficiency":[237],"up":[239],"89%,":[241],"within":[242],"addition,":[246],"evidenced":[248],"that":[249],"it":[250,265],"prevents":[251],"activation":[254],"enhancement,":[257],"GST":[260],"reduction,":[261],"but":[262,288],"turn":[264],"slightly":[266],"inhibited":[267],"CYP2C9":[268],"when":[269],"added":[270],"before":[271],"Roundup.":[272],"CONCLUSION:":[273],"intracellular":[279],"disruption":[280],"mixture":[290],"Dig1":[295],"protect":[297],"against":[304],"this":[305,308],"pollutants.":[306],"system":[309],"constitutes":[310],"tool":[312],"studying":[314],"intoxication":[316],"detoxification.":[318]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}