{"id":"https://openalex.org/W2139671452","doi":"https://doi.org/10.1152/japplphysiol.91644.2008","title":"Bubble-induced platelet aggregation in a rat model of decompression sickness","display_name":"Bubble-induced platelet aggregation in a rat model of decompression sickness","publication_year":2009,"publication_date":"2009-10-23","ids":{"openalex":"https://openalex.org/W2139671452","doi":"https://doi.org/10.1152/japplphysiol.91644.2008","mag":"2139671452","pmid":"https://pubmed.ncbi.nlm.nih.gov/19850726"},"language":"en","primary_location":{"id":"doi:10.1152/japplphysiol.91644.2008","doi":"https://doi.org/10.1152/japplphysiol.91644.2008","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.91644.2008","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113492294","display_name":"Jean-Michel Pontier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I3203470602","display_name":"Service de Sant\u00e9 des Arm\u00e9es","ror":"https://ror.org/0103yxp25","country_code":"FR","type":"government","lineage":["https://openalex.org/I3203470602"]},{"id":"https://openalex.org/I4403928184","display_name":"Marine nationale","ror":"https://ror.org/051dhry29","country_code":"FR","type":"government","lineage":["https://openalex.org/I2799681489","https://openalex.org/I2802818602","https://openalex.org/I4403928184"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jean-Michel Pontier","raw_affiliation_strings":["Institut de Recherche Biom\u00e9dicale des Arm\u00e9es\u2013antenne Toulon and Institut de Medecine Navale du Service de Sante des Armees, and Underwater and Marine Research Department, Toulon Cedex; and","Laboratoire de Physiologie et de Physiopathologie en Condition d'Oxyg\u00e9nation Extr\u00eame, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France","Medicine Department, French Navy Diving School, Toulon Army;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es\u2013antenne Toulon and Institut de Medecine Navale du Service de Sante des Armees, and Underwater and Marine Research Department, Toulon Cedex; and","institution_ids":["https://openalex.org/I3203470602"]},{"raw_affiliation_string":"Laboratoire de Physiologie et de Physiopathologie en Condition d'Oxyg\u00e9nation Extr\u00eame, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France","institution_ids":["https://openalex.org/I21491767"]},{"raw_affiliation_string":"Medicine Department, French Navy Diving School, Toulon Army;","institution_ids":["https://openalex.org/I4403928184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025657279","display_name":"Nicolas Vall\u00e9e","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I3203470602","display_name":"Service de Sant\u00e9 des Arm\u00e9es","ror":"https://ror.org/0103yxp25","country_code":"FR","type":"government","lineage":["https://openalex.org/I3203470602"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Vall\u00e9e","raw_affiliation_strings":["Institut de Recherche Biom\u00e9dicale des Arm\u00e9es\u2013antenne Toulon and Institut de Medecine Navale du Service de Sante des Armees, and Underwater and Marine Research Department, Toulon Cedex; and","Laboratoire de Physiologie et de Physiopathologie en Condition d'Oxyg\u00e9nation Extr\u00eame, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es\u2013antenne Toulon and Institut de Medecine Navale du Service de Sante des Armees, and Underwater and Marine Research Department, Toulon Cedex; and","institution_ids":["https://openalex.org/I3203470602"]},{"raw_affiliation_string":"Laboratoire de Physiologie et de Physiopathologie en Condition d'Oxyg\u00e9nation Extr\u00eame, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France","institution_ids":["https://openalex.org/I21491767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113763922","display_name":"Lionel Bourdon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I3203470602","display_name":"Service de Sant\u00e9 des Arm\u00e9es","ror":"https://ror.org/0103yxp25","country_code":"FR","type":"government","lineage":["https://openalex.org/I3203470602"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lionel Bourdon","raw_affiliation_strings":["Institut de Recherche Biom\u00e9dicale des Arm\u00e9es\u2013antenne Toulon and Institut de Medecine Navale du Service de Sante des Armees, and Underwater and Marine Research Department, Toulon Cedex; and","Laboratoire de Physiologie et de Physiopathologie en Condition d'Oxyg\u00e9nation Extr\u00eame, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es\u2013antenne Toulon and Institut de Medecine Navale du Service de Sante des Armees, and Underwater and Marine Research Department, Toulon Cedex; and","institution_ids":["https://openalex.org/I3203470602"]},{"raw_affiliation_string":"Laboratoire de Physiologie et de Physiopathologie en Condition d'Oxyg\u00e9nation Extr\u00eame, Universit\u00e9 de la M\u00e9diterran\u00e9e, Marseille, France","institution_ids":["https://openalex.org/I21491767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113492294"],"corresponding_institution_ids":["https://openalex.org/I21491767","https://openalex.org/I3203470602","https://openalex.org/I4403928184"],"apc_list":null,"apc_paid":null,"fwci":2.5553,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.89898386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"107","issue":"6","first_page":"1825","last_page":"1829"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.12790000438690186,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decompression-sickness","display_name":"decompression sickness","score":0.9990000128746033},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/platelet-factor-4","display_name":"platelet factor 4","score":0.9589999914169312},{"id":"https://openalex.org/keywords/thrombin-generation","display_name":"thrombin generation","score":0.968999981880188},{"id":"https://openalex.org/keywords/thrombin-antithrombin-complex","display_name":"thrombin-antithrombin complex","score":0.9580000042915344},{"id":"https://openalex.org/keywords/platelet-consumption","display_name":"platelet consumption","score":0.7580000162124634},{"id":"https://openalex.org/keywords/hyperbaric-exposure","display_name":"hyperbaric exposure","score":0.8610000014305115},{"id":"https://openalex.org/keywords/blood-coagulation-system","display_name":"coagulation system","score":0.7429999709129333},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7793383598327637},{"id":"https://openalex.org/C2776957369","wikidata":"https://www.wikidata.org/wiki/Q460591","display_name":"Decompression sickness","level":3,"score":0.7230195999145508},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.6358100175857544},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.5584798455238342},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.5256187319755554},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.46182897686958313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4283585548400879},{"id":"https://openalex.org/C88676905","wikidata":"https://www.wikidata.org/wiki/Q75794","display_name":"Liquid bubble","level":3,"score":0.424015074968338},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4121091067790985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40520209074020386},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3285597562789917},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28314393758773804},{"id":"https://openalex.org/C2779480328","wikidata":"https://www.wikidata.org/wiki/Q1183684","display_name":"Decompression","level":2,"score":0.26848304271698},{"id":"https://openalex.org/C157915830","wikidata":"https://www.wikidata.org/wiki/Q2928001","display_name":"Bubble","level":2,"score":0.18221837282180786},{"id":"https://openalex.org/C173608175","wikidata":"https://www.wikidata.org/wiki/Q232661","display_name":"Parallel computing","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000399","descriptor_name":"Air Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000990","descriptor_name":"Antithrombin III","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003665","descriptor_name":"Decompression Sickness","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004618","descriptor_name":"Embolism, Air","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010978","descriptor_name":"Platelet Factor 4","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019038","descriptor_name":"Platelet Glycoprotein GPIb-IX Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/japplphysiol.91644.2008","doi":"https://doi.org/10.1152/japplphysiol.91644.2008","is_oa":false,"landing_page_url":"https://doi.org/10.1152/japplphysiol.91644.2008","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:19850726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19850726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320323495","display_name":"D\u00e9l\u00e9gation G\u00e9n\u00e9rale pour l'Armement","ror":"https://ror.org/025er3q23"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W45534371","https://openalex.org/W45986678","https://openalex.org/W46776844","https://openalex.org/W182643756","https://openalex.org/W191732252","https://openalex.org/W197097027","https://openalex.org/W1507920703","https://openalex.org/W1844854471","https://openalex.org/W1903457199","https://openalex.org/W1959223640","https://openalex.org/W1963872716","https://openalex.org/W1982059083","https://openalex.org/W2011112383","https://openalex.org/W2024216296","https://openalex.org/W2074672809","https://openalex.org/W2135056861","https://openalex.org/W2180707099","https://openalex.org/W2183719091","https://openalex.org/W2240737616","https://openalex.org/W2269713247","https://openalex.org/W2271151197","https://openalex.org/W2271736206","https://openalex.org/W2318700446","https://openalex.org/W2321574830","https://openalex.org/W2328563748","https://openalex.org/W2332220803","https://openalex.org/W2396151287","https://openalex.org/W2409059639","https://openalex.org/W2414909468","https://openalex.org/W2418096838","https://openalex.org/W2430899749","https://openalex.org/W4239202739","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1963872716","https://openalex.org/W2163174934","https://openalex.org/W2418926671","https://openalex.org/W2046980950","https://openalex.org/W3109173947","https://openalex.org/W2074672809","https://openalex.org/W2061898561","https://openalex.org/W1560250311","https://openalex.org/W4410540596","https://openalex.org/W2328734907"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"have":[2],"highlighted":[3],"that":[4],"bubble-induced":[5,222,241],"platelet":[6,42,108,113,133,163,192,219,223,238],"aggregation":[7],"is":[8],"a":[9,23,60,97,132,156,195],"predictor":[10],"index":[11,197],"of":[12,37,48,88,170,211,229,237],"decompression":[13,200],"sickness":[14],"(DCS)":[15],"severity":[16],"in":[17,27,44,162,184,214,221],"animals":[18],"and":[19,41,63,91,122,135,145,165,172,202,218,245],"bubble":[20],"formation":[21],"after":[22,101,150,177],"single":[24],"air":[25],"dive":[26],"humans.":[28],"The":[29,86,188,205],"present":[30,189],"study":[31,190],"attempted":[32],"to":[33,55,74,208],"investigate":[34],"plasmatic":[35],"indexes":[36,106],"the":[38,126,142,147,159,178,185,209,215,231,235],"coagulation":[39,127,216],"system":[40],"activation":[43,220,239],"our":[45,226],"rat":[46],"model":[47,228],"DCS.":[49],"Male":[50],"Sprague-Dawley":[51],"rats":[52,102,151],"were":[53,72,94,107,137,174],"assigned":[54],"one":[56,64],"experimental":[57,143],"group":[58,66],"with":[59,181],"hyperbaric":[61,179],"exposure":[62],"control":[65,186],"maintained":[67],"at":[68],"atmospheric":[69],"pressure.":[70],"Rats":[71],"compressed":[73],"1,000":[75],"kPa":[76],"(90":[77],"m":[78],"saltwater)":[79],"for":[80,112,119,125,131,198],"45":[81],"min":[82,149],"while":[83],"breathing":[84],"air.":[85],"onset":[87],"death":[89],"time":[90],"DCS":[92,166,203],"symptoms":[93],"recorded":[95],"during":[96],"30-min":[98],"observed":[99],"period":[100],"had":[103,152],"surfaced.":[104,153],"Plasmatic":[105,168],"factor":[109],"4":[110],"(PF4)":[111],"activation,":[114],"soluble":[115],"glycoprotein":[116],"V":[117],"(sGPV)":[118],"thrombin":[120,212],"generation,":[121],"thrombin-antithrombin":[123],"complexes":[124],"system.":[128],"Blood":[129],"samples":[130],"count":[134,164],"markers":[136],"taken":[138],"3":[139],"wk":[140],"before":[141],"protocol":[144],"within":[146],"30":[148],"We":[154],"confirmed":[155],"correlation":[157],"between":[158,240],"percent":[160],"fall":[161],"severity.":[167,204],"levels":[169],"sGPV":[171],"PF4":[173],"significantly":[175],"increased":[176],"exposure,":[180],"no":[182],"change":[183],"group.":[187],"confirms":[191],"consumption":[193],"as":[194],"potential":[196],"evaluating":[199],"stress":[201],"results":[206,232],"point":[207],"participation":[210],"generation":[213],"cascade":[217],"aggregation.":[224],"In":[225],"animal":[227],"DCS,":[230],"cannot":[233],"prejudge":[234],"mechanisms":[236],"vessel":[242],"wall":[243],"injury":[244],"bubble-blood":[246],"component":[247],"interactions.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
