{"id":"https://openalex.org/W2139668415","doi":"https://doi.org/10.1128/cvi.00263-10","title":"Intranasal Vaccination with Chitosan-DNA Nanoparticles Expressing Pneumococcal Surface Antigen A Protects Mice against Nasopharyngeal Colonization by Streptococcus pneumoniae","display_name":"Intranasal Vaccination with Chitosan-DNA Nanoparticles Expressing Pneumococcal Surface Antigen A Protects Mice against Nasopharyngeal Colonization by Streptococcus pneumoniae","publication_year":2010,"publication_date":"2010-11-04","ids":{"openalex":"https://openalex.org/W2139668415","doi":"https://doi.org/10.1128/cvi.00263-10","mag":"2139668415","pmid":"https://pubmed.ncbi.nlm.nih.gov/21047997","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3019786"},"language":"en","primary_location":{"id":"doi:10.1128/cvi.00263-10","doi":"https://doi.org/10.1128/cvi.00263-10","is_oa":true,"landing_page_url":"https://doi.org/10.1128/cvi.00263-10","pdf_url":null,"source":{"id":"https://openalex.org/S114575275","display_name":"Clinical and Vaccine Immunology","issn_l":"1556-679X","issn":["1556-679X","1556-6811"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-100"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Vaccine Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1128/cvi.00263-10","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102201662","display_name":"Jianghong Xu","orcid":"https://orcid.org/0009-0001-6228-4585","observed_orcids":["https://orcid.org/0009-0001-6228-4585"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210106542","display_name":"Shanghai Public Health Clinical Center","ror":"https://ror.org/01nnwyz44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106542"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianghong Xu","raw_affiliation_strings":["Department of Otology and Skull Base Surgery, Eye, Ear, Nose, & Throat Hospital of Fudan University, Shanghai 200031, China","Shanghai Public Health Clinical Center Affiliated with Fudan University, Shanghai 201508, China","Vaccine Research Laboratory, Shanghai H&G Biotechnology Co. Inc., Shanghai 200436, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otology and Skull Base Surgery, Eye, Ear, Nose, & Throat Hospital of Fudan University, Shanghai 200031, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Public Health Clinical Center Affiliated with Fudan University, Shanghai 201508, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210106542"]},{"raw_affiliation_string":"Vaccine Research Laboratory, Shanghai H&G Biotechnology Co. Inc., Shanghai 200436, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027259334","display_name":"Wen-jia Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210106542","display_name":"Shanghai Public Health Clinical Center","ror":"https://ror.org/01nnwyz44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106542"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjia Dai","raw_affiliation_strings":["Department of Otology and Skull Base Surgery, Eye, Ear, Nose, & Throat Hospital of Fudan University, Shanghai 200031, China","Shanghai Public Health Clinical Center Affiliated with Fudan University, Shanghai 201508, China","Vaccine Research Laboratory, Shanghai H&G Biotechnology Co. Inc., Shanghai 200436, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otology and Skull Base Surgery, Eye, Ear, Nose, & Throat Hospital of Fudan University, Shanghai 200031, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Public Health Clinical Center Affiliated with Fudan University, Shanghai 201508, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210106542"]},{"raw_affiliation_string":"Vaccine Research Laboratory, Shanghai H&G Biotechnology Co. Inc., Shanghai 200436, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026759114","display_name":"Zhengmin Wang","orcid":"https://orcid.org/0000-0002-5141-9851","observed_orcids":["https://orcid.org/0000-0002-5141-9851"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210106542","display_name":"Shanghai Public Health Clinical Center","ror":"https://ror.org/01nnwyz44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106542"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhengmin Wang","raw_affiliation_strings":["Department of Otology and Skull Base Surgery, Eye, Ear, Nose, & Throat Hospital of Fudan University, Shanghai 200031, China","Shanghai Public Health Clinical Center Affiliated with Fudan University, Shanghai 201508, China","Vaccine Research Laboratory, Shanghai H&G Biotechnology Co. Inc., Shanghai 200436, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otology and Skull Base Surgery, Eye, Ear, Nose, & Throat Hospital of Fudan University, Shanghai 200031, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Public Health Clinical Center Affiliated with Fudan University, Shanghai 201508, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210106542"]},{"raw_affiliation_string":"Vaccine Research Laboratory, Shanghai H&G Biotechnology Co. Inc., Shanghai 200436, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443095","display_name":"Bing Chen","orcid":"https://orcid.org/0000-0002-0988-9534","observed_orcids":["https://orcid.org/0000-0002-0988-9534"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210106542","display_name":"Shanghai Public Health Clinical Center","ror":"https://ror.org/01nnwyz44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106542"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Chen","raw_affiliation_strings":["Department of Otology and Skull Base Surgery, Eye, Ear, Nose, & Throat Hospital of Fudan University, Shanghai 200031, China","Shanghai Public Health Clinical Center Affiliated with Fudan University, Shanghai 201508, China","Vaccine Research Laboratory, Shanghai H&G Biotechnology Co. Inc., Shanghai 200436, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otology and Skull Base Surgery, Eye, Ear, Nose, & Throat Hospital of Fudan University, Shanghai 200031, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Public Health Clinical Center Affiliated with Fudan University, Shanghai 201508, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210106542"]},{"raw_affiliation_string":"Vaccine Research Laboratory, Shanghai H&G Biotechnology Co. Inc., Shanghai 200436, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100728385","display_name":"Zhongming Li","orcid":"https://orcid.org/0000-0002-6900-3037","observed_orcids":["https://orcid.org/0000-0002-6900-3037"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210106542","display_name":"Shanghai Public Health Clinical Center","ror":"https://ror.org/01nnwyz44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106542"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongming Li","raw_affiliation_strings":["Department of Otology and Skull Base Surgery, Eye, Ear, Nose, & Throat Hospital of Fudan University, Shanghai 200031, China","Shanghai Public Health Clinical Center Affiliated with Fudan University, Shanghai 201508, China","Vaccine Research Laboratory, Shanghai H&G Biotechnology Co. Inc., Shanghai 200436, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otology and Skull Base Surgery, Eye, Ear, Nose, & Throat Hospital of Fudan University, Shanghai 200031, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Public Health Clinical Center Affiliated with Fudan University, Shanghai 201508, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210106542"]},{"raw_affiliation_string":"Vaccine Research Laboratory, Shanghai H&G Biotechnology Co. Inc., Shanghai 200436, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014942595","display_name":"Xiao\u2010Yong Fan","orcid":"https://orcid.org/0000-0001-6654-3559","observed_orcids":["https://orcid.org/0000-0001-6654-3559"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210106542","display_name":"Shanghai Public Health Clinical Center","ror":"https://ror.org/01nnwyz44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106542"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyong Fan","raw_affiliation_strings":["Department of Otology and Skull Base Surgery, Eye, Ear, Nose, & Throat Hospital of Fudan University, Shanghai 200031, China","Shanghai Public Health Clinical Center Affiliated with Fudan University, Shanghai 201508, China","Vaccine Research Laboratory, Shanghai H&G Biotechnology Co. Inc., Shanghai 200436, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otology and Skull Base Surgery, Eye, Ear, Nose, & Throat Hospital of Fudan University, Shanghai 200031, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Public Health Clinical Center Affiliated with Fudan University, Shanghai 201508, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210106542"]},{"raw_affiliation_string":"Vaccine Research Laboratory, Shanghai H&G Biotechnology Co. Inc., Shanghai 200436, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026759114"],"corresponding_institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210106542"],"apc_list":null,"apc_paid":null,"fwci":4.6006,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.94750096,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"75","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.6851000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.6851000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.22609999775886536,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9350000023841858},{"id":"https://openalex.org/keywords/intranasal-immunization","display_name":"intranasal immunization","score":0.8240000009536743},{"id":"https://openalex.org/keywords/chitosan-dna-nanoparticles","display_name":"chitosan-DNA nanoparticles","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mucosal-immunization","display_name":"mucosal immunization","score":0.6570000052452087},{"id":"https://openalex.org/keywords/nasopharyngeal-carriage","display_name":"nasopharyngeal carriage","score":0.9639999866485596},{"id":"https://openalex.org/keywords/pvax1","display_name":"pVAX1","score":0.597000002861023},{"id":"https://openalex.org/keywords/iga","display_name":"IgA","score":0.593999981880188},{"id":"https://openalex.org/keywords/igg-response","display_name":"IgG antibody response","score":0.7400000095367432},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7139999866485596},{"id":"https://openalex.org/keywords/il-17a","display_name":"IL-17A","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/serotype-3","display_name":"serotype 3","score":0.6650000214576721},{"id":"https://openalex.org/keywords/pneumococcal-vaccine","display_name":"pneumococcal vaccine","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.6948642730712891},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.680469810962677},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6592472791671753},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6122457981109619},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.5934802293777466},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5661047697067261},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5284445285797119},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5235751867294312},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.5074130892753601},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4720141589641571},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3698168098926544},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.09855231642723083}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009305","descriptor_name":"Nasopharynx","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009305","descriptor_name":"Nasopharynx","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018829","descriptor_name":"Adhesins, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018829","descriptor_name":"Adhesins, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018829","descriptor_name":"Adhesins, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022242","descriptor_name":"Pneumococcal Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D022242","descriptor_name":"Pneumococcal Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/cvi.00263-10","doi":"https://doi.org/10.1128/cvi.00263-10","is_oa":true,"landing_page_url":"https://doi.org/10.1128/cvi.00263-10","pdf_url":null,"source":{"id":"https://openalex.org/S114575275","display_name":"Clinical and Vaccine Immunology","issn_l":"1556-679X","issn":["1556-679X","1556-6811"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-100"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Vaccine Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3019786","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3019786","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Vaccine Immunol","raw_type":"Text"},{"id":"pmid:21047997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21047997","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and vaccine immunology : CVI","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/cvi.00263-10","doi":"https://doi.org/10.1128/cvi.00263-10","is_oa":true,"landing_page_url":"https://doi.org/10.1128/cvi.00263-10","pdf_url":null,"source":{"id":"https://openalex.org/S114575275","display_name":"Clinical and Vaccine Immunology","issn_l":"1556-679X","issn":["1556-679X","1556-6811"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-100"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Vaccine Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321851","display_name":"Fudan University","ror":"https://ror.org/013q1eq08"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1511118087","https://openalex.org/W1606853210","https://openalex.org/W1964139041","https://openalex.org/W1966635341","https://openalex.org/W1968766773","https://openalex.org/W1972776485","https://openalex.org/W1976910068","https://openalex.org/W1980530313","https://openalex.org/W1981321530","https://openalex.org/W1983401418","https://openalex.org/W1998142817","https://openalex.org/W2000615700","https://openalex.org/W2001285947","https://openalex.org/W2005541865","https://openalex.org/W2009419433","https://openalex.org/W2012643500","https://openalex.org/W2013103459","https://openalex.org/W2013168158","https://openalex.org/W2015245677","https://openalex.org/W2016148953","https://openalex.org/W2018340655","https://openalex.org/W2019267098","https://openalex.org/W2040350179","https://openalex.org/W2051351115","https://openalex.org/W2058256392","https://openalex.org/W2060801960","https://openalex.org/W2065936046","https://openalex.org/W2071835034","https://openalex.org/W2073836026","https://openalex.org/W2075077578","https://openalex.org/W2075577776","https://openalex.org/W2076893605","https://openalex.org/W2083747544","https://openalex.org/W2103637444","https://openalex.org/W2105204683","https://openalex.org/W2105668129","https://openalex.org/W2108561767","https://openalex.org/W2108838669","https://openalex.org/W2110730271","https://openalex.org/W2122051212","https://openalex.org/W2123093428","https://openalex.org/W2123348438","https://openalex.org/W2126723350","https://openalex.org/W2128721558","https://openalex.org/W2134811962","https://openalex.org/W2137351720","https://openalex.org/W2138424202","https://openalex.org/W2139420153","https://openalex.org/W2144235181","https://openalex.org/W2145435157","https://openalex.org/W2147372635","https://openalex.org/W2148365260","https://openalex.org/W2168613507","https://openalex.org/W2168623314","https://openalex.org/W2168923140"],"related_works":["https://openalex.org/W2029883997","https://openalex.org/W3029368786","https://openalex.org/W2810902168","https://openalex.org/W2158158313","https://openalex.org/W3135538825","https://openalex.org/W1971384237","https://openalex.org/W2164411621","https://openalex.org/W4286834599","https://openalex.org/W2123348438","https://openalex.org/W2103611024"],"abstract_inverted_index":{"Streptococcus":[0],"pneumoniae":[1],"is":[2],"a":[3,11,169],"respiratory":[4],"pathogen,":[5],"and":[6,32,74,99,105,159,163],"mucosal":[7,37,78,106,151,158],"immune":[8,116,161],"response":[9],"plays":[10],"significant":[12],"role":[13],"in":[14,61,72,77,83,93,102],"the":[15,127,136],"defense":[16],"against":[17],"pneumococcal":[18,53,165,174,186],"infections.":[19,187],"Thus,":[20],"intranasal":[21,140,179],"vaccination":[22],"may":[23,155],"be":[24,182],"an":[25],"alternative":[26],"approach":[27],"to":[28,36,59,184],"current":[29],"immunization":[30,152],"strategies,":[31],"effective":[33],"delivery":[34],"systems":[35],"organism":[38],"are":[39],"necessary.":[40],"In":[41],"this":[42],"study,":[43],"BALB/c":[44],"mice":[45,62,84,109,130],"were":[46,80,118,124],"immunized":[47,63,85,110,131],"intranasally":[48],"with":[49,64,86,111,132,142,153],"chitosan-DNA":[50,170],"nanoparticles":[51],"expressing":[52,173],"surface":[54],"antigen":[55],"A":[56],"(PsaA).":[57],"Compared":[58],"levels":[60,101],"naked":[65],"DNA":[66],"or":[67],"chitosan-pVAX1,":[68],"anti-PsaA":[69],"IgG":[70],"antibody":[71,76,91],"serum":[73],"anti-IgA":[75],"lavages":[79],"elevated":[81],"significantly":[82,121],"chitosan-psaA.":[87],"The":[88],"balanced":[89],"IgG1/IgG2a":[90],"ratio":[92],"serum,":[94],"enhanced":[95],"gamma":[96],"interferon":[97],"(IFN-\u03b3)":[98],"IL-17A":[100],"spleen":[103],"lymphocytes,":[104],"washes":[107],"of":[108,129],"chitosan-psaA":[112,133,154],"suggested":[113],"that":[114,150],"cellular":[115],"responses":[117,162],"induced.":[119],"Furthermore,":[120],"fewer":[122],"pneumococci":[123],"recovered":[125],"from":[126],"nasopharynx":[128],"than":[134],"for":[135],"control":[137],"group":[138],"following":[139],"challenge":[141],"ATCC":[143],"6303":[144],"(serotype":[145],"3).":[146],"These":[147],"results":[148],"demonstrated":[149],"successfully":[156],"generate":[157],"systemic":[160],"prevent":[164,185],"nasopharyngeal":[166],"colonization.":[167],"Hence,":[168],"nanoparticle":[171],"vaccine":[172],"major":[175],"immunodominant":[176],"antigens":[177],"after":[178],"administration":[180],"could":[181],"developed":[183]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}