{"id":"https://openalex.org/W2139668405","doi":"https://doi.org/10.2174/1566524015666150330143613","title":"Region-Specific Dendritic Spine Loss of Pyramidal Neurons in Dopamine Transporter Knockout Mice","display_name":"Region-Specific Dendritic Spine Loss of Pyramidal Neurons in Dopamine Transporter Knockout Mice","publication_year":2015,"publication_date":"2015-05-04","ids":{"openalex":"https://openalex.org/W2139668405","doi":"https://doi.org/10.2174/1566524015666150330143613","mag":"2139668405","pmid":"https://pubmed.ncbi.nlm.nih.gov/25817859"},"language":"en","primary_location":{"id":"doi:10.2174/1566524015666150330143613","doi":"https://doi.org/10.2174/1566524015666150330143613","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1566524015666150330143613","pdf_url":null,"source":{"id":"https://openalex.org/S50220609","display_name":"Current Molecular Medicine","issn_l":"1566-5240","issn":["1566-5240","1875-5666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Molecular Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2139668405"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020478238","display_name":"Yoshiyuki Kasahara","orcid":"https://orcid.org/0000-0002-9508-2218","observed_orcids":["https://orcid.org/0000-0002-9508-2218"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Kasahara","raw_affiliation_strings":[",0","Disaster Medical Science Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]},{"raw_affiliation_string":"Disaster Medical Science Division","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089954018","display_name":"Yosefu Arime","orcid":"https://orcid.org/0000-0001-5801-4550","observed_orcids":["https://orcid.org/0000-0001-5801-4550"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Arime","raw_affiliation_strings":[",0","University of Toledo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]},{"raw_affiliation_string":"University of Toledo","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013053391","display_name":"Frank Scott Hall","orcid":"https://orcid.org/0000-0002-0822-4063","observed_orcids":["https://orcid.org/0000-0002-0822-4063"]},"institutions":[{"id":"https://openalex.org/I4210154741","display_name":"New Mexico VA Health Care System","ror":"https://ror.org/04n9z8z70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210154741"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F.S. Hall","raw_affiliation_strings":[",0","NMVAHCS and Biomedical Institute of New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]},{"raw_affiliation_string":"NMVAHCS and Biomedical Institute of New Mexico","institution_ids":["https://openalex.org/I4210154741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061872948","display_name":"George R. Uhl","orcid":"https://orcid.org/0000-0002-5632-2426","observed_orcids":["https://orcid.org/0000-0002-5632-2426","https://orcid.org/0000-0001-8758-7913"]},"institutions":[{"id":"https://openalex.org/I4210154741","display_name":"New Mexico VA Health Care System","ror":"https://ror.org/04n9z8z70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138663","https://openalex.org/I4210154741"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.R. Uhl","raw_affiliation_strings":[",0","NMVAHCS and Biomedical Institute of New Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]},{"raw_affiliation_string":"NMVAHCS and Biomedical Institute of New Mexico","institution_ids":["https://openalex.org/I4210154741"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034723746","display_name":"Ichiro Sora","orcid":"https://orcid.org/0000-0003-0741-8373","observed_orcids":["https://orcid.org/0000-0003-0741-8373"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I65837984","display_name":"Kobe University","ror":"https://ror.org/03tgsfw79","country_code":"JP","type":"education","lineage":["https://openalex.org/I65837984"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"I. Sora","raw_affiliation_strings":["Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. sora@med.tohoku.ac.jp","Kobe University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. sora@med.tohoku.ac.jp","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Kobe University","institution_ids":["https://openalex.org/I65837984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9039,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.82723577,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"3","first_page":"237","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.3522999882698059,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.08910000324249268,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-transporter-knockout-mice","display_name":"dopamine transporter knockout mice","score":0.8759999871253967},{"id":"https://openalex.org/keywords/dendritic-spine-density","display_name":"dendritic spine density","score":0.9380000233650208},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.9950000047683716},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.7440000176429749},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hippocampal-ca1","display_name":"hippocampal CA1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/motor-cortex","display_name":"motor cortex","score":0.7699999809265137},{"id":"https://openalex.org/keywords/basolateral-amygdala","display_name":"basolateral amygdala","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prepulse-inhibition","display_name":"prepulse inhibition","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.6859999895095825},{"id":"https://openalex.org/keywords/dopaminergic-signaling","display_name":"dopaminergic signaling","score":0.8190000057220459},{"id":"https://openalex.org/keywords/neuronal-dystrophy","display_name":"neuronal dystrophy","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.768497109413147},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7128990292549133},{"id":"https://openalex.org/C141421786","wikidata":"https://www.wikidata.org/wiki/Q1128897","display_name":"Prepulse inhibition","level":3,"score":0.6366774439811707},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.6231443881988525},{"id":"https://openalex.org/C2780451725","wikidata":"https://www.wikidata.org/wiki/Q4867818","display_name":"Basolateral amygdala","level":3,"score":0.6138558983802795},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5675647258758545},{"id":"https://openalex.org/C2778437258","wikidata":"https://www.wikidata.org/wiki/Q2116409","display_name":"Pyramidal cell","level":3,"score":0.5108529925346375},{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.4549810290336609},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.41717201471328735},{"id":"https://openalex.org/C2780681696","wikidata":"https://www.wikidata.org/wiki/Q3705416","display_name":"Apical dendrite","level":3,"score":0.4164121150970459},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3778896927833557},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.36823374032974243},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3425193428993225},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.30636024475097656},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.27934157848358154},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.20327937602996826},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.06893840432167053},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009044","descriptor_name":"Motor Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D050483","descriptor_name":"Dopamine Plasma Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050483","descriptor_name":"Dopamine Plasma Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D057507","descriptor_name":"Mice, 129 Strain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/1566524015666150330143613","doi":"https://doi.org/10.2174/1566524015666150330143613","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1566524015666150330143613","pdf_url":null,"source":{"id":"https://openalex.org/S50220609","display_name":"Current Molecular Medicine","issn_l":"1566-5240","issn":["1566-5240","1875-5666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:25817859","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25817859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current molecular medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2063369985","https://openalex.org/W2061407859","https://openalex.org/W2146936296","https://openalex.org/W2008481231","https://openalex.org/W1899243102","https://openalex.org/W1963906552","https://openalex.org/W2146264275","https://openalex.org/W2587404365","https://openalex.org/W2098747537","https://openalex.org/W2008682443"],"abstract_inverted_index":{"Dopamine":[0],"transporter":[1],"(DAT)":[2],"knockout":[3],"(KO)":[4],"mice":[5,113,145],"show":[6],"numerous":[7],"behavioral":[8,197],"alterations,":[9],"including":[10,204],"hyperlocomotion,":[11],"cognitive":[12,205],"deficits,":[13],"impulsivity":[14],"and":[15,98,135,190,193,222],"impairment":[16],"of":[17,20,39,53,58,80,95,129,139,163,187,220],"prepulse":[18],"inhibition":[19],"the":[21,43,50,68,84,89,92,96,99,133,136,140,153,167,171,188,191,196],"startle":[22],"reflex":[23],"(PPI),":[24],"phenotypes":[25],"that":[26,62,148,180,210],"may":[27,214],"be":[28],"relevant":[29],"to":[30,147,195],"frontostriatal":[31],"disorders":[32],"such":[33],"as":[34],"schizophrenia.":[35,59,227],"Dendritic":[36],"spine":[37,78,127,161,182],"changes":[38,66,217],"pyramidal":[40,81,130,164,224],"neurons":[41,82,107,131,165,225],"in":[42,55,67,70,83,102,126,132,142,149,160,166,200,218,226],"dorsolateral":[44],"prefrontal":[45,86],"cortex":[46,87,169],"(DLPFC)":[47],"are":[48,72],"among":[49],"most":[51],"replicated":[52],"findings":[54],"postmortem":[56],"studies":[57],"The":[60],"mechanisms":[61],"account":[63],"for":[64],"dendritic":[65],"DLPFC":[69],"schizophrenia":[71],"unclear.":[73],"Here,":[74],"we":[75],"report":[76],"basal":[77],"density":[79,128,162,183],"medial":[85],"(mPFC),":[88],"motor":[90,168],"cortex,":[91],"CA1":[93,137],"region":[94,138],"hippocampus,":[97,192],"basolateral":[100,172],"amygdala":[101,173],"DAT":[103,111,143,175,201],"KO":[104,112,144,202],"mice.":[105,151],"Pyramidal":[106],"were":[108],"visualized":[109],"using":[110],"crossbred":[114],"with":[115],"a":[116,123],"Thy1-GFP":[117],"transgenic":[118],"mouse":[119],"line.":[120],"We":[121],"observed":[122,159,199],"significant":[124],"decrease":[125],"mPFC":[134,189],"hippocampus":[141],"compared":[146],"WT":[150],"On":[152],"other":[154],"hand,":[155],"no":[156],"difference":[157],"was":[158],"or":[170],"between":[174],"genotypes.":[176],"These":[177],"results":[178],"suggest":[179,209],"decreased":[181],"could":[184],"cause":[185],"hypofunction":[186],"contribute":[194],"abnormalities":[198],"mice,":[203],"deficits.":[206],"This":[207],"might":[208],"aberrant":[211],"dopaminergic":[212],"signaling":[213],"trigger":[215],"dystrophic":[216],"dendrites":[219],"hippocampal":[221],"prefrontocortical":[223]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
