{"id":"https://openalex.org/W2139659669","doi":"https://doi.org/10.1002/rcm.5162","title":"Unexpected linear ion trap collision\u2010induced dissociation and Fourier transform ion cyclotron resonance infrared multi\u2010photon dissociation fragmentation of a hydrated C \u2010glycoside of 5\u2010fluorouridine formed by the action of the pseudouridine synthases RluA and TruB","display_name":"Unexpected linear ion trap collision\u2010induced dissociation and Fourier transform ion cyclotron resonance infrared multi\u2010photon dissociation fragmentation of a hydrated C \u2010glycoside of 5\u2010fluorouridine formed by the action of the pseudouridine synthases RluA and TruB","publication_year":2011,"publication_date":"2011-08-22","ids":{"openalex":"https://openalex.org/W2139659669","doi":"https://doi.org/10.1002/rcm.5162","mag":"2139659669","pmid":"https://pubmed.ncbi.nlm.nih.gov/23657957","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5728650"},"language":"en","primary_location":{"id":"doi:10.1002/rcm.5162","doi":"https://doi.org/10.1002/rcm.5162","is_oa":false,"landing_page_url":"https://doi.org/10.1002/rcm.5162","pdf_url":null,"source":{"id":"https://openalex.org/S89689683","display_name":"Rapid Communications in Mass Spectrometry","issn_l":"0951-4198","issn":["0951-4198","1097-0231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rapid Communications in Mass Spectrometry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5728650","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083359412","display_name":"Edward J. Miracco","orcid":"https://orcid.org/0000-0003-3364-2942","observed_orcids":["https://orcid.org/0000-0003-3364-2942"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward J. Miracco","raw_affiliation_strings":["University of Delaware Department of Chemistry and Biochemistry Newark DE 19716 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware Department of Chemistry and Biochemistry Newark DE 19716 USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011245217","display_name":"Bogdan Bogdanov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119942576","display_name":"University of the Pacific","ror":"https://ror.org/05ma4gw77","country_code":"US","type":"education","lineage":["https://openalex.org/I119942576"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bogdan Bogdanov","raw_affiliation_strings":["University of the Pacific Department of Chemistry 3601 Pacific Avenue Stockton CA 95211 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of the Pacific Department of Chemistry 3601 Pacific Avenue Stockton CA 95211 USA","institution_ids":["https://openalex.org/I119942576"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038290059","display_name":"Eugene G. Mueller","orcid":"https://orcid.org/0000-0002-4023-2020","observed_orcids":["https://orcid.org/0000-0002-4023-2020"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene G. Mueller","raw_affiliation_strings":["University of Louisville, Department of Chemistry, Louisville, KY 40292, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Louisville, Department of Chemistry, Louisville, KY 40292, USA","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.12792491,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"25","issue":"18","first_page":"2627","last_page":"2632"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouridine","display_name":"5-fluorouridine","score":0.9449999928474426},{"id":"https://openalex.org/keywords/dinucleotides","display_name":"dinucleotides","score":0.5950000286102295},{"id":"https://openalex.org/keywords/collision-induced-dissociation","display_name":"collision-induced dissociation","score":0.6209999918937683},{"id":"https://openalex.org/keywords/infrared-multiphoton-dissociation","display_name":"infrared multiphoton dissociation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/rna-modification","display_name":"RNA modification","score":0.421999990940094},{"id":"https://openalex.org/keywords/mechanistic-probes","display_name":"mechanistic probes","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9357402324676514},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.7351962924003601},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.5907642245292664},{"id":"https://openalex.org/C3896420","wikidata":"https://www.wikidata.org/wiki/Q3710339","display_name":"Infrared multiphoton dissociation","level":3,"score":0.5459597706794739},{"id":"https://openalex.org/C170552419","wikidata":"https://www.wikidata.org/wiki/Q2400735","display_name":"Fourier transform ion cyclotron resonance","level":3,"score":0.536631166934967},{"id":"https://openalex.org/C102931765","wikidata":"https://www.wikidata.org/wiki/Q189673","display_name":"Dissociation (chemistry)","level":2,"score":0.5260986089706421},{"id":"https://openalex.org/C176107965","wikidata":"https://www.wikidata.org/wiki/Q3710336","display_name":"Collision-induced dissociation","level":4,"score":0.5079575181007385},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.45035961270332336},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.43995317816734314},{"id":"https://openalex.org/C2781259782","wikidata":"https://www.wikidata.org/wiki/Q422573","display_name":"Uridine","level":4,"score":0.43471720814704895},{"id":"https://openalex.org/C2779810333","wikidata":"https://www.wikidata.org/wiki/Q420445","display_name":"Pseudouridine","level":5,"score":0.43177324533462524},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3942939043045044},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.3665742576122284},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.21907731890678406},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.17021116614341736},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1305343508720398},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006027","descriptor_name":"Glycosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006836","descriptor_name":"Hydro-Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009005","descriptor_name":"Monosaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009005","descriptor_name":"Monosaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011560","descriptor_name":"Pseudouridine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011560","descriptor_name":"Pseudouridine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014529","descriptor_name":"Uridine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014529","descriptor_name":"Uridine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014529","descriptor_name":"Uridine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019751","descriptor_name":"Intramolecular Transferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019751","descriptor_name":"Intramolecular Transferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/rcm.5162","doi":"https://doi.org/10.1002/rcm.5162","is_oa":false,"landing_page_url":"https://doi.org/10.1002/rcm.5162","pdf_url":null,"source":{"id":"https://openalex.org/S89689683","display_name":"Rapid Communications in Mass Spectrometry","issn_l":"0951-4198","issn":["0951-4198","1097-0231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rapid Communications in Mass Spectrometry","raw_type":"journal-article"},{"id":"pmid:23657957","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23657957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rapid communications in mass spectrometry : RCM","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5728650","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5728650","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Rapid Commun Mass Spectrom","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5728650","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5728650","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Rapid Commun Mass Spectrom","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.4699999988079071,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1705509089","display_name":null,"funder_award_id":"GM-59636S1","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G415729831","display_name":null,"funder_award_id":"GM59636","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4232487749","display_name":"Pseudouridine Synthases","funder_award_id":"R01GM059636","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1964635764","https://openalex.org/W1974858234","https://openalex.org/W1979043599","https://openalex.org/W1991344082","https://openalex.org/W2013152304","https://openalex.org/W2019832209","https://openalex.org/W2020255687","https://openalex.org/W2040152367","https://openalex.org/W2043924890","https://openalex.org/W2050365875","https://openalex.org/W2050504273","https://openalex.org/W2056254910","https://openalex.org/W2059393896","https://openalex.org/W2061005137","https://openalex.org/W2068791684","https://openalex.org/W2074320299","https://openalex.org/W2082300861","https://openalex.org/W2084702323","https://openalex.org/W2088004170","https://openalex.org/W2112472128","https://openalex.org/W2124846492","https://openalex.org/W2124921910","https://openalex.org/W2147329079","https://openalex.org/W2321199515","https://openalex.org/W2886382167"],"related_works":["https://openalex.org/W2050365875","https://openalex.org/W2040152367","https://openalex.org/W2084702323","https://openalex.org/W1974858234","https://openalex.org/W2151349811","https://openalex.org/W2083616223","https://openalex.org/W1964635764","https://openalex.org/W2088004170","https://openalex.org/W2949078580","https://openalex.org/W2415606549"],"abstract_inverted_index":{"As":[0],"part":[1,27],"of":[2,5,22,28,44,59,85,104,108],"the":[3,6,41,47,57,68,78,83,89,101,105,109,118],"investigation":[4],"pseudouridine":[7,64],"synthases,":[8],"5-fluorouridine":[9,23],"in":[10,82],"RNA":[11],"was":[12,24],"employed":[13],"as":[14,26],"a":[15,29,96],"mechanistic":[16],"probe.":[17],"The":[18],"hydrated,":[19],"rearranged":[20],"product":[21,48,84,110],"isolated":[25],"dinucleotide":[30],"and":[31,63,92],"found":[32],"to":[33,72,115],"undergo":[34],"unusual":[35],"fragmentation":[36,74],"during":[37],"mass":[38],"spectrometry,":[39],"with":[40,77],"facile":[42,120],"loss":[43,58],"HNCO":[45,60],"from":[46,61],"pyrimidine":[49,80,111],"ring":[50,81,112],"favored":[51],"over":[52],"phosphodiester":[53],"bond":[54],"rupture.":[55],"Although":[56],"uridine":[62],"is":[65,113],"well":[66],"established,":[67],"pericyclic":[69],"process":[70],"leading":[71],"their":[73],"cannot":[75],"operate":[76],"saturated":[79],"5-fluorouridine.":[86],"Based":[87],"on":[88,100],"MS(n)":[90],"results":[91],"calculations":[93],"reported":[94],"here,":[95],"new":[97],"mechanism":[98],"relying":[99],"peculiar":[102],"disposition":[103],"functional":[106],"groups":[107],"proposed":[114],"account":[116],"for":[117],"unusually":[119],"fragmentation.":[121]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}