{"id":"https://openalex.org/W2139644639","doi":"https://doi.org/10.2174/157340641202160209102839","title":"Calcium Handling and Arrhythmogenesis","display_name":"Calcium Handling and Arrhythmogenesis","publication_year":2016,"publication_date":"2016-02-08","ids":{"openalex":"https://openalex.org/W2139644639","doi":"https://doi.org/10.2174/157340641202160209102839","mag":"2139644639","pmid":"https://pubmed.ncbi.nlm.nih.gov/26411600"},"language":"en","primary_location":{"id":"doi:10.2174/157340641202160209102839","doi":"https://doi.org/10.2174/157340641202160209102839","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157340641202160209102839","pdf_url":null,"source":{"id":"https://openalex.org/S155723790","display_name":"Medicinal Chemistry","issn_l":"1573-4064","issn":["1573-4064","1875-6638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2139644639"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005561700","display_name":"Georgios C. Bompotis","orcid":"https://orcid.org/0000-0002-7469-2631","observed_orcids":["https://orcid.org/0000-0002-7469-2631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georgios C. Bompotis","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039037480","display_name":"Loukas K. Pappas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105465","display_name":"General Hospital of Athens G. Genimatas","ror":"https://ror.org/00zq17821","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210105465"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Loukas K. Pappas","raw_affiliation_strings":["Cardiology Department and Cardiac Catheterization Laboratory, Athens General Hospital \"G. Gennimatas\", Athens, Greece. lukepappas@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Department and Cardiac Catheterization Laboratory, Athens General Hospital \"G. Gennimatas\", Athens, Greece. lukepappas@hotmail.com","institution_ids":["https://openalex.org/I4210105465"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064075227","display_name":"Christos Angelidis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christos Angelidis","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033988894","display_name":"Charalampos Kossyvakis","orcid":"https://orcid.org/0000-0001-8890-0879","observed_orcids":["https://orcid.org/0000-0001-8890-0879"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charalampos Kossyvakis","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019337241","display_name":"\u0393\u03b5\u03ce\u03c1\u03b3\u03b9\u03bf\u03c2 \u0393\u03b9\u03b1\u03bd\u03bd\u03cc\u03c0\u03bf\u03c5\u03bb\u03bf\u03c2","orcid":"https://orcid.org/0000-0002-7287-3850","observed_orcids":["https://orcid.org/0000-0002-7287-3850"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georgios Giannopoulos","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021242489","display_name":"Spyridon G. Deftereos","orcid":"https://orcid.org/0000-0001-9611-5002","observed_orcids":["https://orcid.org/0000-0001-9611-5002"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Spyridon Deftereos","raw_affiliation_strings":[",0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":",0","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2134,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.55517175,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"2","first_page":"170","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracellular-calcium-homeostasis","display_name":"intracellular calcium homeostasis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/calcium-handling","display_name":"calcium handling","score":0.7210000157356262},{"id":"https://openalex.org/keywords/arrhythmogenesis","display_name":"arrhythmogenesis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"cardiac electrophysiology","score":0.8019999861717224},{"id":"https://openalex.org/keywords/action-potential","display_name":"action potential","score":0.7009999752044678},{"id":"https://openalex.org/keywords/cardiac-automaticity","display_name":"cardiac automaticity","score":0.7710000276565552},{"id":"https://openalex.org/keywords/atrioventricular-conduction","display_name":"atrioventricular conduction","score":0.9440000057220459},{"id":"https://openalex.org/keywords/inherited-arrhythmia-syndromes","display_name":"inherited arrhythmia","score":0.6930000185966492},{"id":"https://openalex.org/keywords/calcium-dysregulation","display_name":"calcium dysregulation","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.7083488702774048},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3437538146972656},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3206339180469513},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27281904220581055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20233464241027832}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012508","descriptor_name":"Sarcolemma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012519","descriptor_name":"Sarcoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/157340641202160209102839","doi":"https://doi.org/10.2174/157340641202160209102839","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157340641202160209102839","pdf_url":null,"source":{"id":"https://openalex.org/S155723790","display_name":"Medicinal Chemistry","issn_l":"1573-4064","issn":["1573-4064","1875-6638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:26411600","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26411600","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal chemistry (Shariqah (United Arab Emirates))","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3007000614","https://openalex.org/W4414018887","https://openalex.org/W3120865924","https://openalex.org/W7099397196","https://openalex.org/W2623904994","https://openalex.org/W2033244065","https://openalex.org/W2018260333","https://openalex.org/W2022886707","https://openalex.org/W1998446737","https://openalex.org/W2131825257"],"abstract_inverted_index":{"Intracellular":[0],"calcium":[1,39],"homeostasis":[2],"plays":[3],"a":[4],"fundamental":[5],"role":[6],"in":[7],"the":[8,14,42,46,72],"electric":[9],"and":[10,21,31,48,56,59,63,76],"mechanical":[11],"function":[12],"of":[13,37,45],"heart":[15,47],"by":[16,23,32],"modulating":[17],"action":[18],"potential":[19],"pattern":[20],"duration,":[22],"linking":[24,79],"cell":[25],"membrane":[26],"depolarization":[27],"to":[28,86],"myocardial":[29],"contraction":[30],"regulating":[33],"cardiac":[34,61],"automaticity.":[35],"Abnormalities":[36],"intracellular":[38,83],"regulation":[40],"disrupt":[41],"electrophysiological":[43,77],"properties":[44],"create":[49],"an":[50],"arrhythmogenic":[51],"milieu,":[52],"which":[53],"promotes":[54],"atrial":[55],"ventricular":[57],"arrhythmogenesis":[58],"impairs":[60],"automaticity":[62],"atrioventricular":[64],"conduction.":[65],"In":[66],"this":[67],"brief":[68],"review,":[69],"we":[70],"summarize":[71],"basic":[73],"genetic,":[74],"molecular":[75],"mechanisms":[78],"inherited":[80],"or":[81],"acquired":[82],"Ca(2+)":[84],"dysregulation":[85],"arrhythmogenesis.":[87]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}