{"id":"https://openalex.org/W2139640191","doi":"https://doi.org/10.1111/j.1743-6109.2010.02096.x","title":"The Effect of Topical Synthetic Prostaglandin E1 (Misoprostol) on Clitoral Hemodynamics","display_name":"The Effect of Topical Synthetic Prostaglandin E1 (Misoprostol) on Clitoral Hemodynamics","publication_year":2010,"publication_date":"2010-11-05","ids":{"openalex":"https://openalex.org/W2139640191","doi":"https://doi.org/10.1111/j.1743-6109.2010.02096.x","mag":"2139640191","pmid":"https://pubmed.ncbi.nlm.nih.gov/21054800"},"language":"en","primary_location":{"id":"doi:10.1111/j.1743-6109.2010.02096.x","doi":"https://doi.org/10.1111/j.1743-6109.2010.02096.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1743-6109.2010.02096.x","pdf_url":null,"source":{"id":"https://openalex.org/S159512450","display_name":"The Journal of Sexual Medicine","issn_l":"1743-6095","issn":["1743-6095","1743-6109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Sexual Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027770123","display_name":"Ayhan Dirim","orcid":"https://orcid.org/0000-0003-2898-485X","observed_orcids":["https://orcid.org/0000-0003-2898-485X"]},"institutions":[{"id":"https://openalex.org/I188740104","display_name":"Ba\u015fkent University","ror":"https://ror.org/02v9bqx10","country_code":"TR","type":"education","lineage":["https://openalex.org/I188740104"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ayhan Dirim","raw_affiliation_strings":["The Department of Urology, Baskent University School of Medicine, Ankara, Turkey. drayhan_dirim@yahoo.com","The Department of Urology, Baskent University School of Medicine, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Urology, Baskent University School of Medicine, Ankara, Turkey. drayhan_dirim@yahoo.com","institution_ids":["https://openalex.org/I188740104"]},{"raw_affiliation_string":"The Department of Urology, Baskent University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I188740104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072064582","display_name":"Mehmet Re\u015fit G\u00f6ren","orcid":"https://orcid.org/0000-0002-2001-1386","observed_orcids":["https://orcid.org/0000-0002-2001-1386"]},"institutions":[{"id":"https://openalex.org/I188740104","display_name":"Ba\u015fkent University","ror":"https://ror.org/02v9bqx10","country_code":"TR","type":"education","lineage":["https://openalex.org/I188740104"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet R. Goren","raw_affiliation_strings":["The Department of Urology, Baskent University School of Medicine, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Urology, Baskent University School of Medicine, Ankara, Turkey","institution_ids":["https://openalex.org/I188740104"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110119864","display_name":"Levent Pe\u015fkircio\u011flu","orcid":"https://orcid.org/0000-0001-9989-403X","observed_orcids":["https://orcid.org/0000-0001-9989-403X"]},"institutions":[{"id":"https://openalex.org/I188740104","display_name":"Ba\u015fkent University","ror":"https://ror.org/02v9bqx10","country_code":"TR","type":"education","lineage":["https://openalex.org/I188740104"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Levent Peskircioglu","raw_affiliation_strings":["The Department of Urology, Baskent University School of Medicine , Ankara , Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Urology, Baskent University School of Medicine , Ankara , Turkey","institution_ids":["https://openalex.org/I188740104"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027770123"],"corresponding_institution_ids":["https://openalex.org/I188740104"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.3784,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.62687803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"3","first_page":"800","last_page":"805"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12335","display_name":"Sexuality, Behavior, and Technology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/misoprostol","display_name":"misoprostol","score":0.9940000176429749},{"id":"https://openalex.org/keywords/clitoral-blood-flow","display_name":"clitoral blood flow","score":0.9779999852180481},{"id":"https://openalex.org/keywords/female-sexual-dysfunction","display_name":"female sexual dysfunction","score":0.9259999990463257},{"id":"https://openalex.org/keywords/peak-systolic-velocity","display_name":"peak systolic velocity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/female-sexual-function","display_name":"female sexual function","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7454409003257751},{"id":"https://openalex.org/C2779199973","wikidata":"https://www.wikidata.org/wiki/Q416025","display_name":"Misoprostol","level":4,"score":0.6834064722061157},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5411519408226013},{"id":"https://openalex.org/C183021626","wikidata":"https://www.wikidata.org/wiki/Q4620674","display_name":"Sex organ","level":2,"score":0.5002634525299072},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.47129881381988525},{"id":"https://openalex.org/C2779837120","wikidata":"https://www.wikidata.org/wiki/Q579348","display_name":"Prostaglandin E1","level":2,"score":0.46783509850502014},{"id":"https://openalex.org/C2775871022","wikidata":"https://www.wikidata.org/wiki/Q7458776","display_name":"Sexual function","level":2,"score":0.4406643509864807},{"id":"https://openalex.org/C2781207646","wikidata":"https://www.wikidata.org/wiki/Q707674","display_name":"Uterine artery","level":4,"score":0.436907559633255},{"id":"https://openalex.org/C2776016352","wikidata":"https://www.wikidata.org/wiki/Q873072","display_name":"Clitoris","level":2,"score":0.4255087375640869},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.32483959197998047},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2662631869316101},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.18836015462875366},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1862947642803192},{"id":"https://openalex.org/C2778642596","wikidata":"https://www.wikidata.org/wiki/Q8452","display_name":"Abortion","level":3,"score":0.08771622180938721},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06235659122467041},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.06198030710220337},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002987","descriptor_name":"Clitoris","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D002987","descriptor_name":"Clitoris","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D002987","descriptor_name":"Clitoris","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002987","descriptor_name":"Clitoris","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010120","descriptor_name":"Oxytocics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010120","descriptor_name":"Oxytocics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012735","descriptor_name":"Sexual Dysfunction, Physiological","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012735","descriptor_name":"Sexual Dysfunction, Physiological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016595","descriptor_name":"Misoprostol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016595","descriptor_name":"Misoprostol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1743-6109.2010.02096.x","doi":"https://doi.org/10.1111/j.1743-6109.2010.02096.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1743-6109.2010.02096.x","pdf_url":null,"source":{"id":"https://openalex.org/S159512450","display_name":"The Journal of Sexual Medicine","issn_l":"1743-6095","issn":["1743-6095","1743-6109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Sexual Medicine","raw_type":"journal-article"},{"id":"pmid:21054800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21054800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of sexual medicine","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W26175460","https://openalex.org/W185817670","https://openalex.org/W1977921356","https://openalex.org/W1985548662","https://openalex.org/W1988974695","https://openalex.org/W2004635749","https://openalex.org/W2006239717","https://openalex.org/W2037647348","https://openalex.org/W2044938775","https://openalex.org/W2046081490","https://openalex.org/W2052243820","https://openalex.org/W2067814588","https://openalex.org/W2074693545","https://openalex.org/W2095976035","https://openalex.org/W2120385927","https://openalex.org/W2123449208","https://openalex.org/W2135650147","https://openalex.org/W2163119141","https://openalex.org/W2163721198","https://openalex.org/W2314125128","https://openalex.org/W2326581107","https://openalex.org/W2406556971","https://openalex.org/W2585015296","https://openalex.org/W4237504098"],"related_works":["https://openalex.org/W1581887345","https://openalex.org/W1977921356","https://openalex.org/W2163721198","https://openalex.org/W2148005587","https://openalex.org/W4414842857","https://openalex.org/W1555383458","https://openalex.org/W4229368202","https://openalex.org/W3169901216","https://openalex.org/W2063650969","https://openalex.org/W2023701978"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Genital":[1],"blood":[2,16,43,243],"flow":[3,17,244],"plays":[4],"an":[5],"important":[6],"role":[7],"on":[8,41,52,128],"female":[9,24,49,56,261],"sexual":[10,25,50,57,100,262],"function.":[11],"Measures":[12],"that":[13],"increase":[14,188,214,221,241],"genital":[15],"may":[18,252],"be":[19,253],"a":[20,38,151,186],"therapeutic":[21],"approach":[22],"for":[23,255],"dysfunction.":[26,263],"AIM:":[27],"This":[28,149],"study":[29,153],"aims":[30],"to":[31,194,228,260],"show":[32],"the":[33,53,64,155,158],"effect":[34],"of":[35,55,86,115,145,162],"topical":[36],"misoprostol,":[37],"synthetic":[39],"prostaglandin,":[40],"clitoral":[42,112,190,203,216,223,242],"flow.":[44],"METHODS:":[45],"Seventeen":[46],"volunteers":[47],"with":[48,82,206,258],"dysfunction":[51],"basis":[54],"function":[58,101],"index":[59,102],"scores":[60,103],"were":[61,68,78,97,104,118,126,160,234],"included":[62],"in":[63,136,147,189,202,215,222],"study.":[65],"All":[66],"women":[67,117],"premenopausal":[69],"and":[70,93,111,133,139,141,157,179,219,249],"within":[71],"their":[72],"sexually":[73],"active":[74,166],"ages.":[75],"Hormonal":[76],"profiles":[77],"also":[79],"normal.":[80],"Those":[81],"suspected":[83],"pregnancy,":[84],"history":[85],"pelvic":[87],"or":[88,91,95,165],"vaginal":[89],"surgery":[90],"radiotherapy,":[92],"diabetes":[94],"hypertension":[96],"excluded.":[98],"Female":[99],"determined.":[105],"Clitoral":[106,176],"peak":[107,180],"systolic":[108,181],"velocity":[109],"(PSV)":[110],"artery":[113,177,191,204,217,224],"diameter":[114,178,225],"all":[116],"measured":[119],"by":[120],"using":[121],"Doppler":[122],"ultrasound.":[123],"The":[124],"measurements":[125],"done":[127],"two":[129],"occasions":[130],"as":[131],"before":[132,140,171],"after":[134,142],"placebo":[135,164,207],"one":[137],"session":[138],"100":[143],"\u00b5g":[144],"misoprostol":[146,211,238],"another.":[148],"is":[150],"double-blind":[152],"where":[154],"patient":[156],"ultrasonographist":[159],"unaware":[161],"either":[163],"drug":[167],"has":[168],"been":[169],"applied":[170],"measurements.":[172],"MAIN":[173],"OUTCOME":[174],"MEASURES:":[175],"velocity.":[182],"RESULTS:":[183],"Misoprostol":[184],"caused":[185,212],"significant":[187],"PSV":[192,205,218],"compared":[193,227],"basal":[195,229],"level":[196],"(P":[197],"=":[198],"0.0001),":[199],"while":[200],"changes":[201],"remained":[208],"insignificant.":[209],"Remarkably,":[210],"118.3%":[213],"47.5%":[220],"when":[226],"levels.":[230],"No":[231],"side":[232],"effects":[233,248],"observed.":[235],"CONCLUSION:":[236],"Topical":[237],"can":[239],"significantly":[240],"without":[245],"any":[246],"unwanted":[247],"this":[250],"finding":[251],"promising":[254],"future":[256],"investigations":[257],"relevance":[259]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
