{"id":"https://openalex.org/W2139581029","doi":null,"title":"Soluble Tie 2: Mechanisms of Regulation and Role in Modulating Angiogenesis","display_name":"Soluble Tie 2: Mechanisms of Regulation and Role in Modulating Angiogenesis","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2139581029","mag":"2139581029"},"language":"en","primary_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/1077","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/1077","pdf_url":"http://hdl.handle.net/10161/1077","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10161/1077","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027862661","display_name":"Clarence M. Findley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Clarence M. Findley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5027862661"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.800000011920929},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9940000176429749},{"id":"https://openalex.org/keywords/adam15","display_name":"ADAM15","score":0.902999997138977},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8119999766349792},{"id":"https://openalex.org/keywords/angiopoietin-2","display_name":"angiopoietin-2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/peripheral-arterial-disease","display_name":"peripheral arterial disease","score":0.8399999737739563},{"id":"https://openalex.org/keywords/critical-limb-ischemia","display_name":"critical limb ischemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation-and-migration","display_name":"endothelial cell proliferation and migration","score":0.6230000257492065},{"id":"https://openalex.org/keywords/capillary-morphogenesis","display_name":"capillary morphogenesis","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7167714834213257},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37859728932380676},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32704252004623413},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3143694996833801},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3120386600494385}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dukespace.lib.duke.edu:10161/1077","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/1077","pdf_url":"http://hdl.handle.net/10161/1077","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:2139581029","doi":null,"is_oa":false,"landing_page_url":"https://dukespace.lib.duke.edu/dspace/bitstream/10161/1077/1/D_Findley_Clarence_a_200904.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/1077","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/1077","pdf_url":"http://hdl.handle.net/10161/1077","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139581029.pdf","grobid_xml":"https://content.openalex.org/works/W2139581029.grobid-xml"},"referenced_works_count":125,"referenced_works":["https://openalex.org/W12963118","https://openalex.org/W84556570","https://openalex.org/W1495287184","https://openalex.org/W1516410466","https://openalex.org/W1546756989","https://openalex.org/W1562608139","https://openalex.org/W1587494584","https://openalex.org/W1869320174","https://openalex.org/W1875554126","https://openalex.org/W1967018492","https://openalex.org/W1970415778","https://openalex.org/W1970614272","https://openalex.org/W1971653265","https://openalex.org/W1971928235","https://openalex.org/W1972320565","https://openalex.org/W1973262582","https://openalex.org/W1977225005","https://openalex.org/W1980969801","https://openalex.org/W1982085952","https://openalex.org/W1982092344","https://openalex.org/W1985222413","https://openalex.org/W1985564012","https://openalex.org/W1986558615","https://openalex.org/W1987197699","https://openalex.org/W1988851886","https://openalex.org/W1990112482","https://openalex.org/W1992380657","https://openalex.org/W1992628345","https://openalex.org/W1992660677","https://openalex.org/W1995624383","https://openalex.org/W1996526210","https://openalex.org/W1996859043","https://openalex.org/W2000292756","https://openalex.org/W2003291578","https://openalex.org/W2004472806","https://openalex.org/W2004891705","https://openalex.org/W2007883695","https://openalex.org/W2010715204","https://openalex.org/W2014377192","https://openalex.org/W2014410152","https://openalex.org/W2018526639","https://openalex.org/W2020547160","https://openalex.org/W2020968632","https://openalex.org/W2026038921","https://openalex.org/W2028415754","https://openalex.org/W2029044279","https://openalex.org/W2030246164","https://openalex.org/W2030729823","https://openalex.org/W2032407944","https://openalex.org/W2038015881","https://openalex.org/W2041821288","https://openalex.org/W2043517681","https://openalex.org/W2044157798","https://openalex.org/W2045247659","https://openalex.org/W2046516822","https://openalex.org/W2046981506","https://openalex.org/W2047387280","https://openalex.org/W2047682144","https://openalex.org/W2048132767","https://openalex.org/W2049184213","https://openalex.org/W2051487747","https://openalex.org/W2052882793","https://openalex.org/W2054957750","https://openalex.org/W2056943748","https://openalex.org/W2057558955","https://openalex.org/W2058170218","https://openalex.org/W2059108446","https://openalex.org/W2063057279","https://openalex.org/W2064360454","https://openalex.org/W2065268256","https://openalex.org/W2065512819","https://openalex.org/W2065646518","https://openalex.org/W2066888615","https://openalex.org/W2067192846","https://openalex.org/W2070565041","https://openalex.org/W2075086348","https://openalex.org/W2075517727","https://openalex.org/W2076076619","https://openalex.org/W2076415360","https://openalex.org/W2077129920","https://openalex.org/W2083922905","https://openalex.org/W2084452119","https://openalex.org/W2085054303","https://openalex.org/W2086127405","https://openalex.org/W2098430424","https://openalex.org/W2100425244","https://openalex.org/W2101831526","https://openalex.org/W2104849624","https://openalex.org/W2106677523","https://openalex.org/W2116027412","https://openalex.org/W2116384002","https://openalex.org/W2116675423","https://openalex.org/W2119241431","https://openalex.org/W2119803906","https://openalex.org/W2120322843","https://openalex.org/W2120530060","https://openalex.org/W2122274177","https://openalex.org/W2129172826","https://openalex.org/W2132692865","https://openalex.org/W2134384575","https://openalex.org/W2134551566","https://openalex.org/W2136480937","https://openalex.org/W2137812597","https://openalex.org/W2137981987","https://openalex.org/W2138281999","https://openalex.org/W2140136269","https://openalex.org/W2140459348","https://openalex.org/W2146194904","https://openalex.org/W2147074779","https://openalex.org/W2149109717","https://openalex.org/W2150675666","https://openalex.org/W2152215024","https://openalex.org/W2153005454","https://openalex.org/W2153461920","https://openalex.org/W2157603347","https://openalex.org/W2158767022","https://openalex.org/W2165591693","https://openalex.org/W2166435943","https://openalex.org/W2166841658","https://openalex.org/W2167903579","https://openalex.org/W2202197998","https://openalex.org/W2296074182","https://openalex.org/W2416503809","https://openalex.org/W2416644446","https://openalex.org/W2470520357"],"related_works":["https://openalex.org/W2149109717","https://openalex.org/W2515960821","https://openalex.org/W2517498730","https://openalex.org/W2134384575","https://openalex.org/W2022751707","https://openalex.org/W1473619958","https://openalex.org/W2416948912","https://openalex.org/W2361931275","https://openalex.org/W2076076619","https://openalex.org/W7033531142"],"abstract_inverted_index":{"Angiogenesis,":[0],"the":[1,45,90,115,124,199,214,229],"production":[2],"of":[3,20,52,94,117,126,141,207,218],"new":[4],"vessels":[5],"from":[6],"pre-existing":[7],"vasculature,":[8],"is":[9,15,66,78,149],"a":[10,18,50,82,138,174,223],"complex":[11],"biological":[12],"process":[13],"that":[14,76,146],"dependent":[16],"on":[17,123,213],"series":[19],"regulated":[21,48],"events,":[22],"including":[23],"endothelial":[24,61],"cell":[25],"(EC)":[26],"proliferation,":[27],"migration,":[28],"survival,":[29],"and":[30,44,56,70,92,105,121,151,153,158,160,165,177,216,221],"capillary":[31],"morphogenesis":[32],"(tube":[33],"formation).":[34],"These":[35,209],"events":[36],"are":[37,47],"required":[38,67],"for":[39,68,109,225],"angiogenesis":[40],"to":[41,183,188],"occur":[42],"properly":[43],"steps":[46],"by":[49],"variety":[51],"vascular":[53],"growth":[54,119],"factors":[55,120],"their":[57],"receptors.":[58],"Tie2,":[59],"an":[60],"receptor":[62,86],"tyrosine":[63],"kinase":[64],"(RTK),":[65],"embryonic":[69],"postnatal":[71],"angiogenesis.":[72],"Studies":[73],"have":[74,96],"demonstrated":[75,145],"Tie2":[77,110,127,147,163,172,219],"proteolytically":[79],"cleaved,":[80],"producing":[81],"75":[83],"kDa":[84],"soluble":[85],"fragment":[87],"(sTie2).":[88],"However,":[89],"mechanisms":[91],"function":[93,217],"sTie2":[95,132,154,192,226],"not":[97],"been":[98],"elucidated.":[99],"Here,":[100],"we":[101,113,130],"investigated":[102,114],"signaling":[103],"pathways":[104],"effector":[106],"molecule(s)":[107],"responsible":[108],"cleavage.":[111,128],"Additionally,":[112],"role":[116,224],"other":[118],"conditions":[122],"degree":[125],"Finally,":[129],"examined":[131],"levels":[133,193],"in":[134,173,198,227],"peripheral":[135,189],"artery":[136,190],"disease,":[137,191],"human":[139],"model":[140],"ischemic":[142],"disease.":[143],"We":[144],"cleavage":[148,220],"VEGF-":[150],"PI3K/Akt-dependent":[152],"can":[155],"bind":[156],"Ang1":[157],"Ang2":[159],"prevent":[161],"ligand-mediated":[162],"activation":[164],"downstream":[166],"cellular":[167],"responses.":[168],"Also,":[169],"ADAM15":[170],"cleaves":[171],"hypoxia-dependent":[175],"manner":[176],"this":[178],"response":[179],"was":[180],"also":[181],"observed":[182],"be":[184],"VEGF-mediated.":[185],"With":[186],"respect":[187],"were":[194],"only":[195],"significantly":[196],"elevated":[197],"most":[200],"angiogenically":[201],"compromised":[202],"group":[203],"(critical":[204],"limb":[205],"ischemia)":[206],"patients.":[208],"data":[210],"shed":[211],"light":[212],"mechanism":[215],"suggest":[222],"mediating":[228],"angiogenic":[230],"process.":[231]},"counts_by_year":[],"updated_date":"2026-09-01T08:31:24.195828","created_date":"2016-06-24T00:00:00"}