{"id":"https://openalex.org/W2139579296","doi":"https://doi.org/10.1128/aac.00045-08","title":"Evaluation of the Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Hydroxychavicol for Its Potential Use as an Oral Care Agent","display_name":"Evaluation of the Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Hydroxychavicol for Its Potential Use as an Oral Care Agent","publication_year":2008,"publication_date":"2008-06-24","ids":{"openalex":"https://openalex.org/W2139579296","doi":"https://doi.org/10.1128/aac.00045-08","mag":"2139579296","pmid":"https://pubmed.ncbi.nlm.nih.gov/18573934"},"language":"en","primary_location":{"id":"doi:10.1128/aac.00045-08","doi":"https://doi.org/10.1128/aac.00045-08","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.00045-08","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2612173","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024327747","display_name":"Sandeep Sharma","orcid":"https://orcid.org/0000-0001-9172-8512","observed_orcids":["https://orcid.org/0000-0001-9172-8512"]},"institutions":[{"id":"https://openalex.org/I4210108071","display_name":"Indian Institute of Integrative Medicine","ror":"https://ror.org/01zw2nq07","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210108071","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sandeep Sharma","raw_affiliation_strings":["Biotechnology Division","Biotechnology Division, Indian Institute of Integrative Medicine, Jammu Tawi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Division","institution_ids":[]},{"raw_affiliation_string":"Biotechnology Division, Indian Institute of Integrative Medicine, Jammu Tawi, India","institution_ids":["https://openalex.org/I4210108071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012791508","display_name":"Inshad Ali Khan","orcid":"https://orcid.org/0000-0003-4445-199X","observed_orcids":["https://orcid.org/0000-0003-4445-199X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Inshad Ali Khan","raw_affiliation_strings":["Biotechnology Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Division","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085702444","display_name":"Intzar Ali","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Intzar Ali","raw_affiliation_strings":["Biotechnology Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Division","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051197099","display_name":"Furqan Haider Mohammed Ali","orcid":"https://orcid.org/0000-0001-8172-0701","observed_orcids":["https://orcid.org/0000-0001-8172-0701","https://orcid.org/0009-0004-5491-3224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Furqan Ali","raw_affiliation_strings":["Biotechnology Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Division","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100670052","display_name":"Manoj Kumar","orcid":"https://orcid.org/0000-0001-6911-6907","observed_orcids":["https://orcid.org/0000-0001-6911-6907"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manoj Kumar","raw_affiliation_strings":["Biotechnology Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Division","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100636301","display_name":"Ashwani Kumar","orcid":"https://orcid.org/0000-0001-8587-1929","observed_orcids":["https://orcid.org/0000-0001-8587-1929"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashwani Kumar","raw_affiliation_strings":["Biotechnology Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Division","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111623186","display_name":"Rakesh Kamal Johri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rakesh Kamal Johri","raw_affiliation_strings":["Pharmacology Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Division","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027997504","display_name":"Sheikh Tasduq Abdullah","orcid":"https://orcid.org/0000-0001-6474-1009","observed_orcids":["https://orcid.org/0000-0001-6474-1009"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheikh Tasduq Abdullah","raw_affiliation_strings":["Pharmacology Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Division","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109255182","display_name":"Sarang Bani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarang Bani","raw_affiliation_strings":["Pharmacology Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Division","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063895679","display_name":"Anjali Pandey","orcid":"https://orcid.org/0000-0002-0507-0556","observed_orcids":["https://orcid.org/0000-0002-0507-0556"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anjali Pandey","raw_affiliation_strings":["Pharmacology Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Division","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109148976","display_name":"Krishan Avtar Suri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108071","display_name":"Indian Institute of Integrative Medicine","ror":"https://ror.org/01zw2nq07","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210108071","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Krishan Avtar Suri","raw_affiliation_strings":["Natural Product Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Product Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India","institution_ids":["https://openalex.org/I4210108071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110013534","display_name":"Bishan Datt Gupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108071","display_name":"Indian Institute of Integrative Medicine","ror":"https://ror.org/01zw2nq07","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210108071","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bishan Datt Gupta","raw_affiliation_strings":["Natural Product Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Product Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India","institution_ids":["https://openalex.org/I4210108071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003526243","display_name":"Naresh Kumar Satti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108071","display_name":"Indian Institute of Integrative Medicine","ror":"https://ror.org/01zw2nq07","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210108071","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Naresh Kumar Satti","raw_affiliation_strings":["Natural Product Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Product Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India","institution_ids":["https://openalex.org/I4210108071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110281014","display_name":"Prabhu Dutt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108071","display_name":"Indian Institute of Integrative Medicine","ror":"https://ror.org/01zw2nq07","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210108071","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prabhu Dutt","raw_affiliation_strings":["Natural Product Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Product Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India","institution_ids":["https://openalex.org/I4210108071"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113580266","display_name":"Ghulam Nabi Qazi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ghulam Nabi Qazi","raw_affiliation_strings":["Biotechnology Division"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Division","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.4301,"has_fulltext":false,"cited_by_count":130,"citation_normalized_percentile":{"value":0.93919292,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"53","issue":"1","first_page":"216","last_page":"222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.1046999990940094,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.09989999979734421,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxychavicol","display_name":"hydroxychavicol","score":1.0},{"id":"https://openalex.org/keywords/piper-betle","display_name":"Piper betle","score":0.968999981880188},{"id":"https://openalex.org/keywords/streptococcus-mutans","display_name":"Streptococcus mutans","score":0.9039999842643738},{"id":"https://openalex.org/keywords/actinomyces-viscosus","display_name":"Actinomyces viscosus","score":1.0},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.8790000081062317},{"id":"https://openalex.org/keywords/postantibiotic-effect","display_name":"post-antibiotic effect","score":0.7369999885559082},{"id":"https://openalex.org/keywords/biofilm-inhibition","display_name":"biofilm inhibition","score":0.8970000147819519},{"id":"https://openalex.org/keywords/water-insoluble-glucan","display_name":"water-insoluble glucan","score":0.8709999918937683},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8349999785423279},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6830000281333923},{"id":"https://openalex.org/keywords/mouthwash","display_name":"mouthwash","score":0.8169999718666077},{"id":"https://openalex.org/keywords/oral-care","display_name":"oral care","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C2778430296","wikidata":"https://www.wikidata.org/wiki/Q131452","display_name":"Streptococcus mutans","level":3,"score":0.9302474856376648},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7235683798789978},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.626506507396698},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.6103965044021606},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5394666194915771},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.4622694253921509},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.44359290599823},{"id":"https://openalex.org/C2992270614","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Membrane permeability","level":3,"score":0.4241776466369629},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.42071208357810974},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.39150726795196533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2998276352882385},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22422826290130615},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0966532826423645},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005054","descriptor_name":"Eugenol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005054","descriptor_name":"Eugenol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005054","descriptor_name":"Eugenol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005054","descriptor_name":"Eugenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005054","descriptor_name":"Eugenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005054","descriptor_name":"Eugenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005054","descriptor_name":"Eugenol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005054","descriptor_name":"Eugenol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005054","descriptor_name":"Eugenol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009055","descriptor_name":"Mouth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009055","descriptor_name":"Mouth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009055","descriptor_name":"Mouth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013295","descriptor_name":"Streptococcus mutans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013295","descriptor_name":"Streptococcus mutans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013295","descriptor_name":"Streptococcus mutans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016924","descriptor_name":"Actinomyces viscosus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016924","descriptor_name":"Actinomyces viscosus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016924","descriptor_name":"Actinomyces viscosus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/aac.00045-08","doi":"https://doi.org/10.1128/aac.00045-08","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.00045-08","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-3","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmid:18573934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18573934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2612173","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2612173","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2612173","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2612173","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","score":0.6499999761581421,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1487366254","https://openalex.org/W1498663909","https://openalex.org/W1499823044","https://openalex.org/W1566830009","https://openalex.org/W1581962345","https://openalex.org/W1976089952","https://openalex.org/W1976849388","https://openalex.org/W1978236306","https://openalex.org/W1982329319","https://openalex.org/W1988317345","https://openalex.org/W2027629482","https://openalex.org/W2038661189","https://openalex.org/W2045878113","https://openalex.org/W2074180225","https://openalex.org/W2074386221","https://openalex.org/W2089277072","https://openalex.org/W2091794394","https://openalex.org/W2102838174","https://openalex.org/W2103222135","https://openalex.org/W2115205587","https://openalex.org/W2127511522","https://openalex.org/W2129744517","https://openalex.org/W2150319593","https://openalex.org/W2152323052","https://openalex.org/W2153486676","https://openalex.org/W2169341243"],"related_works":["https://openalex.org/W2143170784","https://openalex.org/W2387633364","https://openalex.org/W2581603352","https://openalex.org/W2035337314","https://openalex.org/W2154818633","https://openalex.org/W3190861746","https://openalex.org/W3175115899","https://openalex.org/W2052458935","https://openalex.org/W2619415615","https://openalex.org/W2761826491"],"abstract_inverted_index":{"Hydroxychavicol":[0,52,157],"isolated":[1],"from":[2,168],"the":[3,28,49,68,87,108,121,147,150,199,212],"chloroform":[4],"extraction":[5],"of":[6,9,27,34,56,70,80,89,91,110,129,135,149,153,172,178,192,201,214],"aqueous":[7],"extract":[8],"Piper":[10],"betle":[11],"leaves":[12],"showed":[13],"inhibitory":[14,23,50],"activity":[15],"against":[16,189,217],"oral":[17,29,218,234],"cavity":[18,30],"pathogens.":[19],"It":[20],"exhibited":[21,53,75,159],"an":[22,76],"effect":[24,79],"on":[25],"all":[26],"pathogens":[31,219],"tested":[32],"(MICs":[33],"62.5":[35],"to":[36,62,82],"500":[37],"microg/ml)":[38],"with":[39],"a":[40,208],"minimal":[41],"bactericidal":[42],"concentration":[43],"that":[44,142,204,221],"was":[45,166],"twofold":[46],"greater":[47],"than":[48],"concentration.":[51],"concentration-dependent":[54,170],"killing":[55],"Streptococcus":[57],"mutans":[58,93,115,137,194],"ATCC":[59,94,99],"25175":[60,95],"up":[61],"4x":[63],"MIC":[64],"and":[65,85,96,116,119,138,162,175,220,232],"also":[66,106,158],"prevented":[67,86],"formation":[69],"water-insoluble":[71,196],"glucan.":[72],"Interestingly,":[73],"hydroxychavicol":[74,143,205],"extended":[77],"postantibiotic":[78],"6":[81],"7":[83],"h":[84],"emergence":[88],"mutants":[90],"S.":[92,114,136,193],"Actinomyces":[97],"viscosus":[98,118,140],"15987":[100],"at":[101],"2x":[102],"MIC.":[103],"Furthermore,":[104],"it":[105,222],"inhibited":[107],"growth":[109],"biofilms":[111,123],"generated":[112],"by":[113,124,132],"A.":[117,139],"reduced":[120],"preformed":[122],"these":[125],"bacteria.":[126],"Increased":[127],"uptake":[128],"propidium":[130],"iodide":[131],"hydroxychavicol-treated":[133],"cells":[134,191],"indicated":[141],"probably":[144],"works":[145],"through":[146],"disruption":[148],"permeability":[151],"barrier":[152],"microbial":[154],"membrane":[155],"structures.":[156],"potent":[160],"antioxidant":[161],"anti-inflammatory":[163],"activities.":[164],"This":[165],"evident":[167],"its":[169],"inhibition":[171],"lipid":[173],"peroxidation":[174],"significant":[176],"suppression":[177],"tumor":[179],"necrosis":[180],"factor":[181],"alpha":[182],"expression":[183],"in":[184,195,198,228],"human":[185],"neutrophils.":[186],"Its":[187],"efficacy":[188],"adherent":[190],"glucan":[197],"presence":[200],"sucrose":[202],"suggests":[203],"would":[206],"be":[207],"useful":[209],"compound":[210],"for":[211,226,230],"development":[213],"antibacterial":[215],"agents":[216],"has":[223],"great":[224],"potential":[225],"use":[227],"mouthwash":[229],"preventing":[231],"treating":[233],"infections.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2025-10-10T00:00:00"}
