{"id":"https://openalex.org/W2139559322","doi":"https://doi.org/10.1034/j.1399-0039.2002.600211.x","title":"Characterization of a new HLA\u2010DRB3 allele, DRB3*0217, by direct sequencing","display_name":"Characterization of a new HLA\u2010DRB3 allele, DRB3*0217, by direct sequencing","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W2139559322","doi":"https://doi.org/10.1034/j.1399-0039.2002.600211.x","mag":"2139559322","pmid":"https://pubmed.ncbi.nlm.nih.gov/12392515"},"language":"en","primary_location":{"id":"doi:10.1034/j.1399-0039.2002.600211.x","doi":"https://doi.org/10.1034/j.1399-0039.2002.600211.x","is_oa":true,"landing_page_url":"https://doi.org/10.1034/j.1399-0039.2002.600211.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1034/j.1399-0039.2002.600211.x","source":{"id":"https://openalex.org/S141055564","display_name":"Tissue Antigens","issn_l":"0001-2815","issn":["0001-2815","1399-0039"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Antigens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1034/j.1399-0039.2002.600211.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009886944","display_name":"Sara Frison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803066834","display_name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico","ror":"https://ror.org/016zn0y21","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I189158943","https://openalex.org/I2803066834","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Frison","raw_affiliation_strings":["Centro Transfusionale e di Immunologia dei Trapianti, Ospedale Maggiore, Policinico IRCCS, Milano, Italy","Centro Trasfusionale e di Immunologia dei Trapianti"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Transfusionale e di Immunologia dei Trapianti, Ospedale Maggiore, Policinico IRCCS, Milano, Italy","institution_ids":["https://openalex.org/I2803066834"]},{"raw_affiliation_string":"Centro Trasfusionale e di Immunologia dei Trapianti","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"E. Longhi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Longhi","raw_affiliation_strings":["Centro Trasfusionale e di Immunologia dei Trapianti"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Trasfusionale e di Immunologia dei Trapianti","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111721197","display_name":"Francesca Poli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"F. Poli","raw_affiliation_strings":["Centro Trasfusionale e di Immunologia dei Trapianti"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Trasfusionale e di Immunologia dei Trapianti","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020388069","display_name":"Alejandro Espadas de Arias","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Espadas de Arias","raw_affiliation_strings":["Centro Trasfusionale e di Immunologia dei Trapianti"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Trasfusionale e di Immunologia dei Trapianti","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110004799","display_name":"M. Scalamogna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Scalamogna","raw_affiliation_strings":["Servizio per il Prelievo e la Conservazione di Organi e Tessuti, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servizio per il Prelievo e la Conservazione di Organi e Tessuti, Milano, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111721197"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20868697,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"60","issue":"2","first_page":"189","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.478300005197525,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.478300005197525,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.34860000014305115,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.10890000313520432,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-drb3","display_name":"HLA-DRB3","score":0.9240000247955322},{"id":"https://openalex.org/keywords/novel-hla-allele","display_name":"novel HLA allele","score":0.9409999847412109},{"id":"https://openalex.org/keywords/sequence-based-typing","display_name":"sequence-based typing","score":0.8180000185966492},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.7960000038146973},{"id":"https://openalex.org/keywords/amino-acid-substitutions","display_name":"amino acid substitutions","score":0.8220000267028809},{"id":"https://openalex.org/keywords/exon-2","display_name":"exon 2","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.6771632432937622},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5970897078514099},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.5698468089103699},{"id":"https://openalex.org/C2781209916","wikidata":"https://www.wikidata.org/wiki/Q3215756","display_name":"Typing","level":2,"score":0.5685727596282959},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5638379454612732},{"id":"https://openalex.org/C2993683473","wikidata":"https://www.wikidata.org/wiki/Q30693176","display_name":"Amino acid substitution","level":4,"score":0.5508806109428406},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5405070185661316},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5271235108375549},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.48973989486694336},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.4633062481880188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41472917795181274},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3947301506996155},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35420095920562744},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.33896273374557495},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2318626046180725},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.1009984016418457}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D006684","descriptor_name":"HLA-DR Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059826","descriptor_name":"HLA-DRB3 Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1034/j.1399-0039.2002.600211.x","doi":"https://doi.org/10.1034/j.1399-0039.2002.600211.x","is_oa":true,"landing_page_url":"https://doi.org/10.1034/j.1399-0039.2002.600211.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1034/j.1399-0039.2002.600211.x","source":{"id":"https://openalex.org/S141055564","display_name":"Tissue Antigens","issn_l":"0001-2815","issn":["0001-2815","1399-0039"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Antigens","raw_type":"journal-article"},{"id":"pmid:12392515","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12392515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue antigens","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1034/j.1399-0039.2002.600211.x","doi":"https://doi.org/10.1034/j.1399-0039.2002.600211.x","is_oa":true,"landing_page_url":"https://doi.org/10.1034/j.1399-0039.2002.600211.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1034/j.1399-0039.2002.600211.x","source":{"id":"https://openalex.org/S141055564","display_name":"Tissue Antigens","issn_l":"0001-2815","issn":["0001-2815","1399-0039"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Antigens","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139559322.pdf","grobid_xml":"https://content.openalex.org/works/W2139559322.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W1993039529","https://openalex.org/W2074762640","https://openalex.org/W2155565670","https://openalex.org/W2163521262","https://openalex.org/W4210975199"],"related_works":["https://openalex.org/W4254342706","https://openalex.org/W4391261124","https://openalex.org/W4386023479","https://openalex.org/W4386032124","https://openalex.org/W4289731557","https://openalex.org/W4249951008","https://openalex.org/W4250150789","https://openalex.org/W4402193526","https://openalex.org/W4242954376","https://openalex.org/W2912446994"],"abstract_inverted_index":{"We":[0],"report":[1],"the":[2,37],"identification":[3],"of":[4,26,39],"a":[5,27,40,50,55],"novel":[6],"DRB3*02":[7],"using":[8],"sequence-based":[9],"typing":[10,25],"(SBT).":[11],"This":[12,57],"new":[13],"allele,":[14],"officially":[15],"named":[16],"DRB3*0217,":[17],"was":[18,52],"detected":[19],"while":[20],"performing":[21],"HLA":[22],"high":[23],"resolution":[24],"bone":[28],"marrow":[29],"recipient":[30],"and":[31],"his":[32],"siblings.":[33],"DNA":[34],"sequencing":[35],"demonstrated":[36],"presence":[38],"nucleotide":[41],"substitution":[42,70],"in":[43,66],"exon":[44],"2":[45],"at":[46,60],"position":[47],"199":[48],"where":[49],"C":[51],"substituted":[53],"by":[54],"T.":[56],"point":[58],"mutation":[59],"codon":[61],"67":[62],"(CTC-->TTC)":[63],"has":[64],"resulted":[65],"an":[67],"amino":[68],"acid":[69],"from":[71],"Leucine":[72],"to":[73],"Phenylalanine.":[74]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}