{"id":"https://openalex.org/W2139553721","doi":"https://doi.org/10.1034/j.1600-0609.2003.02811.x","title":"Quantitative real\u2010time reverse\u2010transcription polymerase chain reaction for diagnosis of BCR\u2010ABL positive leukemias and molecular monitoring following allogeneic stem cell transplantation","display_name":"Quantitative real\u2010time reverse\u2010transcription polymerase chain reaction for diagnosis of BCR\u2010ABL positive leukemias and molecular monitoring following allogeneic stem cell transplantation","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2139553721","doi":"https://doi.org/10.1034/j.1600-0609.2003.02811.x","mag":"2139553721","pmid":"https://pubmed.ncbi.nlm.nih.gov/12631253"},"language":"en","primary_location":{"id":"doi:10.1034/j.1600-0609.2003.02811.x","doi":"https://doi.org/10.1034/j.1600-0609.2003.02811.x","is_oa":true,"landing_page_url":"https://doi.org/10.1034/j.1600-0609.2003.02811.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1034/j.1600-0609.2003.02811.x","source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1034/j.1600-0609.2003.02811.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101817047","display_name":"Frank Neumann","orcid":"https://orcid.org/0000-0002-5669-0421","observed_orcids":["https://orcid.org/0000-0002-5669-0421"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Neumann","raw_affiliation_strings":["Department of Hematology, Oncology and Clinical Immunology, University of Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Clinical Immunology, University of Duesseldorf, Moorenstrasse 5, 40225 Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050560509","display_name":"Caroline Herold","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caroline Herold","raw_affiliation_strings":["Department of Hematology, Oncology and Clinical Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Clinical Immunology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109150459","display_name":"Barbara Hildebrandt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Barbara Hildebrandt","raw_affiliation_strings":["Institute of Human Genetics and Anthropology, University of Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Genetics and Anthropology, University of Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111890288","display_name":"Guido Kobbe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guido Kobbe","raw_affiliation_strings":["Department of Hematology, Oncology and Clinical Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Clinical Immunology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018540281","display_name":"Manuel A. Aivado","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manuel Aivado","raw_affiliation_strings":["Department of Hematology, Oncology and Clinical Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Clinical Immunology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111805925","display_name":"Astrid Rong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Astrid Rong","raw_affiliation_strings":["Department of Hematology, Oncology and Clinical Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Clinical Immunology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061309191","display_name":"Maren Free","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maren Free","raw_affiliation_strings":["Department of Hematology, Oncology and Clinical Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Clinical Immunology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005908189","display_name":"Renate R\u00f6ssig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renate R\u00f6ssig","raw_affiliation_strings":["Department of Hematology, Oncology and Clinical Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Clinical Immunology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090048856","display_name":"Roland R. Fenk","orcid":"https://orcid.org/0000-0001-7594-6288","observed_orcids":["https://orcid.org/0000-0001-7594-6288"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roland Fenk","raw_affiliation_strings":["Department of Hematology, Oncology and Clinical Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Clinical Immunology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peter Schneider","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Schneider","raw_affiliation_strings":["Department of Hematology, Oncology and Clinical Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Clinical Immunology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042020284","display_name":"Norbert Gattermann","orcid":"https://orcid.org/0000-0002-9792-2495","observed_orcids":["https://orcid.org/0000-0002-9792-2495"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norbert Gattermann","raw_affiliation_strings":["Department of Hematology, Oncology and Clinical Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Clinical Immunology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011160875","display_name":"Brigitte Royer\u2010Pokora","orcid":"https://orcid.org/0000-0001-5114-7801","observed_orcids":["https://orcid.org/0000-0001-5114-7801"]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Brigitte Royer\u2010Pokora","raw_affiliation_strings":["Institute of Human Genetics and Anthropology, University of Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Genetics and Anthropology, University of Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061663931","display_name":"Rainer R. Haas","orcid":"https://orcid.org/0000-0002-3652-6595","observed_orcids":["https://orcid.org/0000-0002-3652-6595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rainer Haas","raw_affiliation_strings":["Department of Hematology, Oncology and Clinical Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Clinical Immunology and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018297283","display_name":"Ralf Kronenwett","orcid":"https://orcid.org/0000-0002-8494-6981","observed_orcids":["https://orcid.org/0000-0002-8494-6981"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ralf Kronenwett","raw_affiliation_strings":["Department of Hematology, Oncology and Clinical Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Clinical Immunology and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018297283"],"corresponding_institution_ids":[],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":3.7529,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.93392995,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"70","issue":"1","first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.9079999923706055},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9649999737739563},{"id":"https://openalex.org/keywords/molecular-monitoring","display_name":"molecular monitoring","score":0.6060000061988831},{"id":"https://openalex.org/keywords/allogeneic-stem-cell-transplantation","display_name":"allogeneic stem cell transplantation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/donor-chimerism","display_name":"donor chimerism","score":0.8980000019073486},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.8040000200271606},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.8270000219345093},{"id":"https://openalex.org/keywords/donor-lymphocyte-infusion","display_name":"donor lymphocyte infusion","score":0.7580000162124634},{"id":"https://openalex.org/keywords/blast-crisis","display_name":"blast crisis","score":0.5059999823570251},{"id":"https://openalex.org/keywords/accelerated-phase","display_name":"accelerated phase","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.6974270343780518},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.6071683168411255},{"id":"https://openalex.org/C125418893","wikidata":"https://www.wikidata.org/wiki/Q587961","display_name":"ABL","level":4,"score":0.58021080493927},{"id":"https://openalex.org/C2778904597","wikidata":"https://www.wikidata.org/wiki/Q1129111","display_name":"Philadelphia chromosome","level":4,"score":0.5603987574577332},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.5366396903991699},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5319056510925293},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.505207359790802},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5048752427101135},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.4739154279232025},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.4713784158229828},{"id":"https://openalex.org/C4692481","wikidata":"https://www.wikidata.org/wiki/Q169526","display_name":"Reverse transcription polymerase chain reaction","level":4,"score":0.45863211154937744},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4437378942966461},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4187663197517395},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.4180060625076294},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4118526875972748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40343648195266724},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25567764043807983},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.1594546139240265},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.1421894133090973},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.11546844244003296},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09875673055648804},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08973973989486694},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07915502786636353},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.05564528703689575}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001752","descriptor_name":"Blast Crisis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001752","descriptor_name":"Blast Crisis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009360","descriptor_name":"Neoplastic Cells, Circulating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D016044","descriptor_name":"Fusion Proteins, bcr-abl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018183","descriptor_name":"Transplantation Chimera","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D025202","descriptor_name":"Molecular Diagnostic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1034/j.1600-0609.2003.02811.x","doi":"https://doi.org/10.1034/j.1600-0609.2003.02811.x","is_oa":true,"landing_page_url":"https://doi.org/10.1034/j.1600-0609.2003.02811.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1034/j.1600-0609.2003.02811.x","source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:12631253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12631253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of haematology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1034/j.1600-0609.2003.02811.x","doi":"https://doi.org/10.1034/j.1600-0609.2003.02811.x","is_oa":true,"landing_page_url":"https://doi.org/10.1034/j.1600-0609.2003.02811.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1034/j.1600-0609.2003.02811.x","source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320312956","display_name":"Leuka","ror":"https://ror.org/016a7mx14"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2139553721.pdf","grobid_xml":"https://content.openalex.org/works/W2139553721.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W24911164","https://openalex.org/W65831105","https://openalex.org/W1479909146","https://openalex.org/W1483173437","https://openalex.org/W1497974883","https://openalex.org/W1540355515","https://openalex.org/W1928548710","https://openalex.org/W1973394001","https://openalex.org/W1982778574","https://openalex.org/W1994652359","https://openalex.org/W2002904896","https://openalex.org/W2011474502","https://openalex.org/W2016656445","https://openalex.org/W2022682658","https://openalex.org/W2031255542","https://openalex.org/W2036718018","https://openalex.org/W2038048752","https://openalex.org/W2038990138","https://openalex.org/W2039978091","https://openalex.org/W2047192298","https://openalex.org/W2049611823","https://openalex.org/W2054448483","https://openalex.org/W2059271501","https://openalex.org/W2072227357","https://openalex.org/W2075084712","https://openalex.org/W2082858272","https://openalex.org/W2091849791","https://openalex.org/W2100418051","https://openalex.org/W2109359347","https://openalex.org/W2117782490","https://openalex.org/W2131706663","https://openalex.org/W2139462813","https://openalex.org/W2187708799","https://openalex.org/W2190162667","https://openalex.org/W2313524135","https://openalex.org/W2330930577","https://openalex.org/W2331184083","https://openalex.org/W2394816133","https://openalex.org/W2396398508","https://openalex.org/W2401486119","https://openalex.org/W2412200153"],"related_works":["https://openalex.org/W2031255542","https://openalex.org/W1924483703","https://openalex.org/W2313524135","https://openalex.org/W1998811121","https://openalex.org/W2348067182","https://openalex.org/W2318278155","https://openalex.org/W2589870341","https://openalex.org/W2133347844","https://openalex.org/W163910395","https://openalex.org/W3145691117"],"abstract_inverted_index":{"Real-time":[0],"reverse-transcription":[1],"polymerase":[2],"chain":[3],"reaction":[4],"(RT-PCR)":[5],"(qPCR)":[6],"of":[7,19,73,84,94,124,194,207,213,219,230,244],"the":[8,17,38,69,97,103,115,211,242,251],"BCR-ABL":[9,74,116,184,195,208,226,231],"mRNA":[10,117],"is":[11,258],"a":[12,33,82,141,259],"suitable":[13],"technique":[14],"to":[15,67],"measure":[16],"amount":[18],"circulating":[20],"leukemic":[21],"cells":[22,197],"in":[23,41,55,96,102,110,149,255,268],"chronic":[24,99],"myelogenous":[25],"leukemia":[26,49],"(CML).":[27],"In":[28,228,249],"this":[29,256],"study,":[30],"we":[31],"evaluated":[32],"BCR-ABL-specific":[34],"qPCR":[35,145,166,202,252],"method":[36,263],"using":[37],"LightCycler":[39],"technology":[40],"95":[42],"patients":[43,150,159,178],"with":[44,81,152,160,210,221],"Philadelphia":[45],"chromosome":[46],"positive":[47,196],"acute":[48,136],"(n":[50,58],"=":[51,59],"7)":[52],"or":[53,155,169],"CML":[54,125,161],"different":[56,122],"stages":[57,123],"88).":[60],"Primers":[61],"and":[62,88,108,134,147,182,237,261],"hybridization":[63],"probes":[64],"were":[65,162,225],"chosen":[66],"detect":[68],"most":[70],"prevalent":[71],"variants":[72],"(b2a2,":[75],"b3a2,":[76],"b2a3,":[77],"b3a3,":[78],"e19a2,":[79],"e1a2)":[80],"sensitivity":[83],"10-5":[85],"for":[86,264],"b2a2":[87],"b3a2.":[89],"With":[90],"median":[91],"BCR-ABL/G6PDH":[92],"ratios":[93],"10.7%":[95],"untreated":[98,135],"phase,":[100,107],"43.2%":[101],"newly":[104,111],"diagnosed":[105,112],"accelerated":[106],"131.4%":[109],"blast":[113,132],"crisis":[114,133],"levels":[118,209],"varied":[119],"significantly":[120],"between":[121,131,144,235],"whereas":[126],"no":[127],"difference":[128],"was":[129,140,239],"found":[130],"leukemias":[137],"(136.9%).":[138],"There":[139],"strong":[142],"relationship":[143],"results":[146],"cytogenetics":[148],"treated":[151],"imatinib,":[153],"interferon-alpha,":[154],"following":[156,167,203],"allografting.":[157],"Thirteen":[158],"sequentially":[163],"examined":[164],"by":[165,188,201],"myeloablative":[168],"non-myeloablative":[170,204],"allogeneic":[171],"peripheral":[172],"blood":[173],"stem":[174],"cell":[175],"transplantation.":[176,205],"Five":[177],"received":[179],"donor":[180,214,223],"lymphocytes":[181],"became":[183],"negative":[185,232],"as":[186],"confirmed":[187],"nested":[189],"RT-PCR.":[190],"The":[191],"gradual":[192],"disappearance":[193],"could":[198],"be":[199],"monitored":[200],"Comparison":[206],"degree":[212],"chimerism":[215,224,234],"showed":[216],"that":[217],"91%":[218],"samples":[220,233],"complete":[222],"negative.":[227],"22%":[229],"71%":[236],"98%":[238],"observed,":[240],"indicating":[241],"persistence":[243],"normal":[245],"recipient's":[246],"hematopoietic":[247],"cells.":[248],"conclusion,":[250],"protocol":[253],"used":[254],"study":[257],"reliable":[260],"fast":[262],"monitoring":[265],"molecular":[266],"response":[267],"CML.":[269]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
