{"id":"https://openalex.org/W2139551674","doi":"https://doi.org/10.1016/j.pediatrneurol.2003.12.012","title":"Hemophagocytic syndrome associated with antiepileptic drug","display_name":"Hemophagocytic syndrome associated with antiepileptic drug","publication_year":2004,"publication_date":"2004-05-01","ids":{"openalex":"https://openalex.org/W2139551674","doi":"https://doi.org/10.1016/j.pediatrneurol.2003.12.012","mag":"2139551674","pmid":"https://pubmed.ncbi.nlm.nih.gov/15165641"},"language":"en","primary_location":{"id":"doi:10.1016/j.pediatrneurol.2003.12.012","doi":"https://doi.org/10.1016/j.pediatrneurol.2003.12.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pediatrneurol.2003.12.012","pdf_url":null,"source":{"id":"https://openalex.org/S165686931","display_name":"Pediatric Neurology","issn_l":"0887-8994","issn":["0887-8994","1873-5150"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Neurology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2139551674"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109921136","display_name":"Yu-Chun Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Chun Yang","raw_affiliation_strings":["Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057937159","display_name":"Shiann\u2010Tarng Jou","orcid":"https://orcid.org/0000-0003-1483-0403","observed_orcids":["https://orcid.org/0000-0003-1483-0403"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shiann-Tarng Jou","raw_affiliation_strings":["Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018504208","display_name":"Yue-Hiang Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yue-Hiang Chang","raw_affiliation_strings":["Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025599266","display_name":"Jao\u2010Shwann Liang","orcid":"https://orcid.org/0000-0002-3085-0298","observed_orcids":["https://orcid.org/0000-0002-3085-0298"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jao-Shwann Liang","raw_affiliation_strings":["Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045288222","display_name":"Wang\u2010Tso Lee","orcid":"https://orcid.org/0000-0003-3231-9764","observed_orcids":["https://orcid.org/0000-0003-3231-9764"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Wang-Tso Lee","raw_affiliation_strings":["Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045288222"],"corresponding_institution_ids":["https://openalex.org/I4210131804"],"apc_list":{"value":3520,"currency":"USD","value_usd":3520},"apc_paid":null,"fwci":1.4917,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.81226959,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"30","issue":"5","first_page":"358","last_page":"360"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.11420000344514847,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.03590000048279762,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemophagocytic-lymphohistiocytosis","display_name":"hemophagocytic lymphohistiocytosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lamotrigine","display_name":"lamotrigine","score":0.9509999752044678},{"id":"https://openalex.org/keywords/antiepileptic-drug-side-effects","display_name":"antiepileptic drug adverse effects","score":0.9020000100135803},{"id":"https://openalex.org/keywords/drug-induced-pancytopenia","display_name":"drug-induced pancytopenia","score":0.7929999828338623},{"id":"https://openalex.org/keywords/porencephaly","display_name":"porencephaly","score":0.8349999785423279},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.8550000190734863},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.6179999709129333},{"id":"https://openalex.org/keywords/hypocellular-bone-marrow","display_name":"hypocellular bone marrow","score":0.906000018119812},{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.9100000262260437},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.843999981880188},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C2778802184","wikidata":"https://www.wikidata.org/wiki/Q410346","display_name":"Lamotrigine","level":3,"score":0.9270099401473999},{"id":"https://openalex.org/C2779382419","wikidata":"https://www.wikidata.org/wiki/Q1757427","display_name":"Pancytopenia","level":3,"score":0.9112991094589233},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7988396883010864},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7428797483444214},{"id":"https://openalex.org/C2777363875","wikidata":"https://www.wikidata.org/wiki/Q5712526","display_name":"Hemophagocytosis","level":4,"score":0.7381637692451477},{"id":"https://openalex.org/C2778570526","wikidata":"https://www.wikidata.org/wiki/Q653197","display_name":"Rash","level":2,"score":0.539090096950531},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.48677563667297363},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.384390264749527},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3622605800628662},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3365352153778076},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30777478218078613},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.23428261280059814},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.06519457697868347}],"mesh":[{"descriptor_ui":"D000077213","descriptor_name":"Lamotrigine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015616","descriptor_name":"Histiocytosis, Non-Langerhans-Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015616","descriptor_name":"Histiocytosis, Non-Langerhans-Cell","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.pediatrneurol.2003.12.012","doi":"https://doi.org/10.1016/j.pediatrneurol.2003.12.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pediatrneurol.2003.12.012","pdf_url":null,"source":{"id":"https://openalex.org/S165686931","display_name":"Pediatric Neurology","issn_l":"0887-8994","issn":["0887-8994","1873-5150"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Neurology","raw_type":"journal-article"},{"id":"doi:10.1016/s0887-8994(04)00038-4","doi":"https://doi.org/10.1016/s0887-8994(04)00038-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0887-8994(04)00038-4","pdf_url":null,"source":{"id":"https://openalex.org/S165686931","display_name":"Pediatric Neurology","issn_l":"0887-8994","issn":["0887-8994","1873-5150"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Neurology","raw_type":"journal-article"},{"id":"pmid:15165641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15165641","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric neurology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W44014080","https://openalex.org/W48398079","https://openalex.org/W111290126","https://openalex.org/W1588461233","https://openalex.org/W1973148780","https://openalex.org/W1975585512","https://openalex.org/W1989801730","https://openalex.org/W2015561449","https://openalex.org/W2047901601","https://openalex.org/W2055123193","https://openalex.org/W2065130340","https://openalex.org/W2119093004","https://openalex.org/W2120701544","https://openalex.org/W2136992022","https://openalex.org/W2160944696","https://openalex.org/W2319736176","https://openalex.org/W4241263512"],"related_works":["https://openalex.org/W2133269645","https://openalex.org/W2922021544","https://openalex.org/W1975759789","https://openalex.org/W2205976252","https://openalex.org/W2127029855","https://openalex.org/W4297399735","https://openalex.org/W7007878688","https://openalex.org/W111290126","https://openalex.org/W1993178370","https://openalex.org/W4251527989"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}